Cytochrome P45 Suppliers UK
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Product | Description | |
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5-Hydroxy-6-methoxy (S)-duloxetine Quick enquiry Where to buy Suppliers range | 5-Hydroxy-6-methoxy (S)-duloxetine is a metabolite of (S)-duloxetine. It is formed from (S)-duloxetine via a 5- or 6-hydroxy duloxetine intermediate, which is formed by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2D6, and a catechol duloxetine intermediate. Group: Pharmaceuticals. Alternative Names: 2-methoxy-5-[(1S)-3-(methylamino)-1-thiophen-2-ylpropoxy]naphthalen-1-ol. CAS No. 741693-79-8. Pack Sizes: 1mg; 1g; 10g. Product ID: 741693-79-8. Custom synthesis is available. Send your inquiries for more information. | London |
6-Hydroxy Chlorzoxazone Quick enquiry Where to buy Suppliers range | A major metabolite of chlorzoxazone. Formed by the actions of cytochrome P450IIE1. Group: Pharmaceuticals. Alternative Names: 5-Chloro-6-hydroxy-2(3H)-benzoxazolone; 6-Hydroxychlorzoxazone; NSC 24955. CAS No. 1750-45-4. Pack Sizes: 1mg; 1g; 10g. Product ID: 1750-45-4. Custom synthesis is available. Send your inquiries for more information. | London |
Avanafil metabolite M4 Quick enquiry Where to buy Suppliers range | Avanafil metabolite M4 is a major active metabolite of the phosphodiesterase 5 (PDE5) inhibitor avanafil. Avanafil is metabolized by the cytochrome P450 (CYP450) isoforms CYP3A4 and CYP2C to the major metabolites avanafil metabolite M4 and avanafil metabolite M16, as well as minor metabolites. Avanafil metabolite M4 inhibits PDE5 with 18% of the potency of avanafil. Group: Pharmaceuticals. Pack Sizes: 1mg; 1g; 10g. Product ID: N0001-011059. Custom synthesis is available. Send your inquiries for more information. | London |
Δ4-Abiraterone Quick enquiry Where to buy Suppliers range | Δ4-Abiraterone (D4A) is an active metabolite of the CYP17A1 inhibitor abiraterone (Item No. 9002768).1 D4A is an androgen receptor antagonist (IC50 = 5.3 nM) that reduces expression of the androgen receptor target genes PSA, TMPRSS2, and FKBP5 in LNCaP, LAPC4, and C4-2 cell lines. It inhibits the cytochrome P450 (CYP) isoform CYP17A1 by 66.5% when used at a concentration of 1 nM. D4A (10 μM) also blocks SRD5A conversion of Δ4-androstenedione to 5α-androstanedione in LAPC4 cells. In vivo, D4A delays tumor progression in a VCaP mouse xenograft model and increases progression-free survival in a C4-2 mouse xenograft model. Group: Pharmaceuticals. Alternative Names: CB 7627; D4A. CAS No. 154229-21-7. Pack Sizes: 1mg; 1g; 10g. Product ID: 154229-21-7. Custom synthesis is available. Send your inquiries for more information. | London |
(S)-(+)-Mephenytoin Quick enquiry Where to buy Suppliers range | Mephenytoin is known to target sodium channel protein type 5 subunit alpha. It is a hydantoin-derivative anticonvulsant used to control various partial seizures. It may cause blood dyscrasias. It is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. It can be used to screen for such mutations by assaying its metabolites in urine. It is still studied largely because of its interesting hydroxylation polymorphism. It has been listed. Group: Pharmaceuticals. Alternative Names: (S)-5-Ethyl-3-methyl-5-phenylhydantoin; (+)-Mephenytoin; (5S)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione. CAS No. 70989-04-7. Pack Sizes: 50mg. Product ID: 70989-04-7. Custom synthesis is available. Send your inquiries for more information. | London |
Talarozole Quick enquiry Where to buy Suppliers range | Talarozole, a retinoic acid metabolism blocking agent (RAMBA), is a potent and selective inhibitor of cytochrome P450 26 to treat dermatalogical diseases including psoriasis and acne. Group: Pharmaceuticals. Alternative Names: N-[4-[2-Ethyl-1-(1H-1,2,4-triazol-1-yl)butyl]phenyl]-2-benzothiazolamine; Rambazole; R 115866; R-115866; R115866. CAS No. 201410-53-9. Pack Sizes: 1mg; 1g; 10g. Product ID: 201410-53-9. Custom synthesis is available. Send your inquiries for more information. | London |