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| Product | Description | |
|---|---|---|
| Bergamottin | Bergamottin (5-geranoxypsoralen) is a natural furanocoumarin found in the pulp of pomelos and grapefruits. It is also found in the peel and pulp of the bergamot orange, from which it was first isolated and from which its name is derived. It shows antiproliferative activity against HepG2 liver, HL-60 leukemia, and BGC-823 gastric cancer cell lines in a dose-dependent manner and induces cell death of CHO cells following near ultraviolet irradiation. Bergamottin inhibits the cytochrome P450 isoform 3A4 with Ki of 7.7 μM and is a mixed inhibitor of simvastatin drug metabolism with Ki of 174 μM. It also increases glucose consumption in HepG2 cells in a dose-dependent manner. Group: Pharmaceutical. CAS No. 7380-40-7. Pack Sizes: 10 mg. Product ID: B2703-097781. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Byakangelicin | Byakangelicin is an effective inhibitor of sex hormones and affects the catabolism of endogenous hormones. It directly affects the cytochrome P450 isoform (CY) P3A4 in human hepatocytes. It is an inhibitor of aldose reductase used in the treatment of diabetic cataracts. Byakangelicin is a natural coumarin compound found in Murraya koenigii, Triphasia trifoliata, and other organisms. Group: Pharmaceutical. CAS No. 482-25-7. Pack Sizes: 10 mg. Product ID: NP1139. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Chalepensin | Chalepensin is a furanocoumarin found in several medicinal Rutaceae plants. Chalepensin acts as a cytochrome P450 (P450, CYP) inhibitor that epoxidation activity is crucial for the potential drug interaction through mechanism-based inhibition. Chalepensin also exhibits an antimicrobial effect against Streptococcus mutans. Group: Pharmaceutical. CAS No. 13164-03-9. Pack Sizes: 5 mg. Product ID: NP1084. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Chamaechromone | Chamaechromone is isolated from the roots of Stellera chamaeja sme. Chamaechromone can undergo extensive phase I and phase II metabolism in rat. Chamaechromone has anti-HBV and insecticidal activity. The hydroxylation of Chamaechromone is inhibited by α-naphthoflavone, and predominantly catalyzed by recombinant human cytochrome P450 1A2. Group: Pharmaceutical. CAS No. 93413-00-4. Pack Sizes: 5 mg. Product ID: NP2301. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cobicistat | Cobicistat is a potent inhibitor of cytochrome P450 3A enzymes, including the important CYP3A4 subtype. It also inhibits intestinal transport proteins, increasing the overall absorption of several HIV medications, including atazanavir, darunavir and tenofovir alafenamide fumarate. Uses: Anti-hiv agents. Group: Pharmaceutical. CAS No. 1004316-88-4. Pack Sizes: 25 mg. Product ID: B0084-456314. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cycloguanil hydrochloride | Cycloguanil is an active metabolite of proguanil, produced by the cytochrome P450 2C19 isoform. It is also an inhibitor of dihydrofolate reductase (DHFR) (Kis = 0.3 and 1.5 nM for Plasmodium and human forms, respectively). Uses: Antimalarials. Group: Pharmaceutical. CAS No. 152-53-4. Pack Sizes: 500 mg. Product ID: B2693-118548. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Diosmetin | Diosmetin is a flavonoid that inhibits cytochrome P450 (CYP) isoforms 1A1 and 1B1 in human liver microsomes (Ki values of 89 and 16 nM, respectively). It exhibits anti-mutagenic and anti-allergic properties. Diosmetin has anti-oxidation, anti-infection, anti-shock and other functional foods, cosmetics and future drugs. Uses: Anti-inflammatory, antioxidant. Group: Pharmaceutical. CAS No. 520-34-3. Pack Sizes: 5 g. Product ID: NP2523. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Elacridar | Elacridar hydrochloride (GF120918A) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog plasma. GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro, with IC(50) values well above concentrations anticipated to be achieved in vivo. Together, these data confirm the utility of GF120918A as a tool P-glycoprotein inhibitor in preclinical species and offer additional guidance on preclinical dose regimens likely to produce P-glycoprotein-mediated effects. Group: Pharmaceutical. CAS No. 143664-11-3. Pack Sizes: 100 mg. Product ID: B0084-311800. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Famotidine | Famotidine is a histamine H2-receptor antagonist that inhibits stomach acid production. It is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease. Unlike cimetidine, the first H2 antagonist, famotidine has no effect on the cytochrome P450 enzyme system, and does not appear to interact with other drugs. Group: Pharmaceutical. CAS No. 76824-35-6. Pack Sizes: 10 g. Product ID: B2693-098225. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Isoimperatorin | Isoimperatorin is a COX-2 inhibitor, and also inhibits cytochrome P450 (CYP) isoform 1A activity. In bone marrow-derived mast cells, isoimperatorin exhibits an inhibitory effect on degranulation. Isoimperatorin suppresses proliferation in melanoma cells. Uses: Antimycobacterial, antimycobacterial. Group: Pharmaceutical. CAS No. 482-45-1. Pack Sizes: 1 g. Product ID: NP1132. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Naringin | Naringin inhibits hepatic P-glycoprotein (P-gp) and some drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions. Naringin can be used as an edible additive, mainly for gum, refreshing drinks, etc. It is a plant polyphenol that can inhibit tyrosinase, block melanin synthesis, reduce skin pigment intensity, absorb UV, prevent photoaging, reduce sun damage and age spot formation, and whiten and lighten spots. It also has the anti-glycation and antibacterial effect, can effectively improve skin tone and skin texture, prevent the generation of age spots, remove red bloodlines, and improve skin blood microcirculation. Uses: Antioxidant, anticancer, anti-atherogenic. Group: Pharmaceutical. CAS No. 10236-47-2. Pack Sizes: 250 g. Product ID: NP1904. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Pioglitazone hydrochloride | Pioglitazone hydrochloride, a thiazolidinedione antidiabetic drug, is a cytochrome P450 (CYP)2C8 and CYP3A4 enzymes inhibitor with Kis of 1.7, 11.8 and 32.1 μM for CYP2C8, CYP3A4 and CYP2C9, respectively. It is an agonist of the peroxisome proliferator-activated receptor &gamma. Uses: Hypoglycemic agents. Group: Pharmaceutical. CAS No. 112529-15-4. Pack Sizes: 250 mg. Product ID: BBF-05868. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Rhodionin | Rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administered drugs. Rhodionin showed inhibitory activity with IC50 values of 0.761 μM and 0.420 μM, respectively. Rhodionin was determined to be non-competitive inhibitors with Ki values of 0.769 μM and 0.535 μM. Group: Pharmaceutical. CAS No. 85571-15-9. Pack Sizes: 5 mg. Product ID: NP1985. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (S)-(+)-Mephenytoin | (S)-(+)-Mephenytoin is an S-isomer of Mephenytoin, which is known to target sodium channel protein type 5 subunit alpha. Mephenytoin is a hydantoin-derivative anticonvulsant used to control various partial seizures. It is a substrate of the cytochrome P450 (CYP) isoform CYP2C19. It can be used to screen for such mutations by assaying its metabolites in urine. Group: Pharmaceutical. CAS No. 70989-04-7. Pack Sizes: 50 mg. Product ID: B1370-204709. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Tetrahydropiperine | Tetrahydropiperine is a piperine alkaloid originally isolated from P. longum. It acts as an agonist of transient receptor potential vanilloid type 1 (TRPV1). It inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH) and 7-methoxycoumarin O-demethylase (MOCD) activity in rat liver microsomes. Group: Pharmaceutical. CAS No. 23434-88-0. Pack Sizes: 100 mg. Product ID: B2703-059108. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Uniconazole | Uniconazole is a plant growth hormone that inhibits cytochrome P450 707As, resulting in a suppression of gibberellin production. Uses: Fungicides, industrial. Group: Pharmaceutical. CAS No. 83657-22-1. Pack Sizes: 25 g. Product ID: B0084-078170. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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