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| Product | Description | |
|---|---|---|
| 2',3'-cGAMP | 2',3'-cGAMP was considered to be the metazoan second messenger which is produced by cGAMP synthase (cGAS), the mammalian intrinsic immune DNA sensor. It can activate innate immunity by directly binding the endoplasmic reticulum-resident receptor STING (stimulator of interferon genes). Group: Pharmaceutical. Alternative Names: Cyclic [G(2',5')pA(3',5')p]; 2'-Guanylic acid, adenylyl-(3'→5')-, cyclic nucleotide; 2',3'-Cyclic guanosine adenosine monophosphate; 2',3'-Cyclic guanosine monophosphate-adenosine monophosphate; 2'-3'-cyclic GMP-AMP; cGAMP(2'→5'); c[G(2',5')pA(3',5')p]; Cyclic Gp(2'→5')Ap(3'→5'). CAS No. 1441190-66-4. Pack Sizes: 1 mg. Product ID: B1370-006099. Molecular formula: C20H24N10O13P2. Mole weight: 674.41. Custom synthesis is available. Send your inquiries for more information. |  London |
| 2'3'-cGAMP photo affinity probe | 2'3'-cyclic GMP-AMP (2'3'-cGAMP), generated by cyclic GMP-AMP synthase (cGAS) under activation by cytosolic DNA, has a vital role in innate immune response via its receptor protein stimulator of interferon genes (STING) to fight viral infections and tumors. 2'3'-cGAMP-based photoaffinity probes can capture and isolate 2'3'-cGAMP-binding proteins. Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: B1370-099265. Custom synthesis is available. Send your inquiries for more information. | London |
| Mesaconitine | Mesaconitine has antinociceptive activity through cyclic AMP and stimulation of the central β-adrenergic system. Group: Pharmaceutical. Alternative Names: N-desethyl-N-methylaconitine. CAS No. 2752-64-9. Pack Sizes: 20 mg. Product ID: NP0567. Molecular formula: C33H45NO11. Mole weight: 631.71. Custom synthesis is available. Send your inquiries for more information. | London |
| Octreotide Acetate | Octreotide acetate is a long-acting octapeptide with pharmacologic actions similars to the natural hormone somatostatin. It is a more potent inhibitor of growth hormone, glucagon, and insulin than the natural hormone. It was approved as an injectable depot formulation used for acromegaly, gigantism, thyrotropinoma, diarrhea and flushing episodes associated with carcinoid syndrome, and diarrhea in patients with vasoactive intestinal peptide-secreting tumors. It is a gastric antisecretory agent andcould inhibit the secretion of insulin and glucagon. It reduces production of IGF-1 and IGF-2 by the liver by modulation of growth-hormone secretion from the pituitary gland. It decreased the urinary excretion of uric acid as well as the plasma concentrations of glucagon and insulin. It decreased the urinary excretion of sodium and chloride without significiant influence on creatinine clearance, while the concentrations of lactic acid, pyruvic acid in blood, and cyclic AMP in plasma were not changed. It was first synthesized in 1979 by the chemist Wilfried Bauer and was developed by Novartis Pharmaceuticals. Uses: Antineoplastic agents, hormonal. Group: Pharmaceutical. Alternative Names: L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic (2→7)-disulfide, acetate (1:x); H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr-ol.xCH3CO2H (Disulfide B | London |
| Polygalasaponin XXXI | Polygalasaponin XXXI is a triterpenoid compound found in the herbs of Polygala japonica Houtt. In vivo, Polygalasaponin XXXI exhibits inhibitory effect on proliferation of mouse adapted influenza virus A/PR/8/34 and cyclic AMP phosphodiesterase. Group: Pharmaceutical. Alternative Names: Polygalasaponin XXXI|79103-90-5|Polygalasaponin XXXI;Onjisaponin F|AKOS037514965. CAS No. 79103-90-5. Pack Sizes: 5 mg. Product ID: B0005-053391. Molecular formula: C75H112O36. Mole weight: 1589.685. Custom synthesis is available. Send your inquiries for more information. | London |
| RO1138452 | RO1138452 is one of the most potent high-affinity ligands and functional antagonists for the human IP (prostacyclin) receptor. It exhibits no affinity at other prostanoid receptors (EP1-4, FP and TP) in a radioligand binding assay. RO1138452 antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cyclic AMP accumulation in a dose-dependent manner. Group: Pharmaceutical. Alternative Names: RO-1138452; RO1138452; RO 1138452; CAY10441; CAY-10441; CAY 10441; N-(4-(4-Isopropoxybenzyl)phenyl)-4,5-dihydro-1H-imidazol-2-amine. CAS No. 221529-58-4. Pack Sizes: 50 mg. Product ID: B0084-205752. Molecular formula: C19H23N3O. Mole weight: 309.413. Custom synthesis is available. Send your inquiries for more information. | London |
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