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| Product | Description | |
|---|---|---|
| COMBINATION pH ELECTRODE | COMBINATION pH ELECTRODE, UK suppliers of laboratory chemicals and apparatus needed |  |
| 1,4-di-tert-butyl-2,5-bis(2,2,2-trifluoro-ethoxy)benzene | 1,4-Di-tert-butyl-2,5-bis(2,2,2-trifluoro-ethoxy)benzene, a fluorinated aromatic entity, has been studied extensively for its promising potential to augment the efficiency of organic solar cells. As an additive, it imparts exceptional electron mobility while concurrently decreasing the recombination of charge carriers. On another note, it displays self-assembly capabilities into nanostructures, making it a hopeful candidate in the realm of drug delivery systems. Group: Pharmaceutical. CAS No. 1147737-68-5. Pack Sizes: 100 mg. Product ID: B0001-428038. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| 16-Dehydropregnenolone acetate | 16-Dehydropregnenolone acetate is an impurity of Abiraterone, which is a CYP17A1 inhibitor and by extension androgen synthesis inhibitor. In combination with prednisone, it is indicated for the treatment of patients with metastatic castration-resistant prostate cancer who have already received prior chemotherapy containing docetaxel under the trade name Zytiga. Group: Pharmaceutical. CAS No. 979-02-2. Pack Sizes: 25 g. Product ID: NP6241. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 2,5-Dioxopyrrolidine Sacubitril | An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. Group: Pharmaceutical. CAS No. 1038924-97-8. Pack Sizes: 100 mg. Product ID: B1604-479386. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (2R,4S)-4-Amino-5-biphenyl-4-yl-2-methylpentanoic acid hydrochloride | An impurity of Sacubitril, a neprilysin inhibitor that is used in combination with valsartan to treat high blood pressure. Group: Pharmaceutical. CAS No. 1038924-71-8. Pack Sizes: 100 mg. Product ID: B2694-013668. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (2R,4S)-5-Biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid | An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. Group: Pharmaceutical. CAS No. 1012341-50-2. Pack Sizes: 100 mg. Product ID: B1604-479394. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (2S)-Isopropyl 2- ( ( (perfluorophenoxy) (phenoxy)phosphoryl)amino)propanoate | An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Group: Pharmaceutical. CAS No. 1256490-52-4. Pack Sizes: 25 mg. Product ID: B1628-480349. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 3-Deazaneplanocin A | 3-Deazaneplanocin A is an inhibitor of S-adenosylmethionine-dependent methyltransferase. In combination with sodium butyrate, 3-Deazaneplanocin A can induce epigenetically reprogramming of human embryonic stem cells (hESC). Group: Pharmaceutical. CAS No. 102052-95-9. Pack Sizes: 10 mg. Product ID: B0084-462897. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 3-Deoxy-3-acetyl abiraterone-3-ene | An impurity of Abiraterone. Abiraterone acetate is a CYP17A1 inhibitor and by extension androgen synthesis inhibitor. In combination with prednisone, it is indicated for the treatment of patients with metastatic castration-resistant prostate cancer who have already received prior chemotherapy containing docetaxel under the trade name Zytiga. Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: B0038-007224. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 3-Deoxy 3-chloroabiraterone | An impurity of Abiraterone. Abiraterone acetate is a CYP17A1 inhibitor and by extension androgen synthesis inhibitor. In combination with prednisone, it is indicated for the treatment of patients with metastatic castration-resistant prostate cancer who have already received prior chemotherapy containing docetaxel under the trade name Zytiga. Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: B0038-007226. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (3R,5S)-5-Biphenyl-4-ylmethyl-3-methylpyrrolidin-2-one | An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. Group: Pharmaceutical. CAS No. 1038924-70-7. Pack Sizes: 100 mg. Product ID: B1604-479385. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 4,4'-Diaminodiphenylsulfone | Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae, which has anti-inflammatory and immunomodulatory effects. It is an antibacterial most commonly used in combination with rifampicin and clofazimine as multidrug therapy (MDT) for the treatment of Mycobacterium leprae infections (leprosy). It antagonized all of the I/R end points measured, showing a remarkable ability to decrease markers of damage through antioxidant, antiinflammatory, and anti-apoptotic effects. It also inhibits bacterial synthesis of dihydrofolic acid, via competition with para-aminobenzoate for the active site of dihydropteroate synthetase. Uses: Anti-inflammatory agent. Group: Pharmaceutical. CAS No. 80-08-0. Pack Sizes: 1 kg. Product ID: NP2822. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 5,10,15,20-tetrakis(4-aminophenyl)porphyrinatozinc(II) | 5,10,15,20-tetrakis(4-aminophenyl)porphyrinatozinc(II), a porphyrin-derived molecule, has garnered significant scientific interest due to its potential in anticancer therapies. The compounds photochemical properties may be aptly harnessed for photodynamic therapy, effectively shrinking tumors. Moreover, the compounds antioxidant attributes have garnered considerable attention, creating a possibility for treatment of oxidative stress-inflicted ailments. Recent studies have induced optimism for the compounds use in co-treatments, in combination with frontline therapy drugs to better combat cancer. Group: Pharmaceutical. CAS No. 67595-98-6. Pack Sizes: 10 mg. Product ID: B2708-285096. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 5-(5-Chloro-1-(2-fluorophenyl)-2-oxopentyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl Acetate Maleate | An impurity of Prasugrel. Prasugrel is a platelet inhibitor and an irreversible antagonist of P2Y12ADP receptors that prevents the formation of blood clots. It was appoved for the treatment of acute coronary syndrome (ACS), and some cardiovascular diseasess in combination with Aspirin. Group: Pharmaceutical. CAS No. 1373350-61-8. Pack Sizes: 20 mg. Product ID: B0219-007244. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AA3-DLin | AA3-Dlin is an ionizable amino lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA. Group: Pharmaceutical. CAS No. 2832061-33-1. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-3659. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Abil WE09 | Abil WE09 is a liquid nonionic W/O emulsifier that is distinguished by high emulsifying and emulsion-stabilizing action. The extremely favourable usage characteristics are achieved by the combination of a polyglycerol fatty acid ester with a silicone surfactant, the characteristic of which is the polymeric and polyfunctional structure. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ACA-PEG-SCM, MW 1k-10k | ACA-PEG-SCM has two different activated terminal groups, an Acrylamide (ACA) and an activated NHS ester. Heterobifunctionalized PEG derivatives are used in cell culture, pharmaceutical research, drug delivery and release, nanotechnology and new materials. Heterobifunctional PEG can be attached to different molecules or materials to extend the richness of different molecular combinations. Drug PEG modification can alter its dispersion and solubility in aqueous solutions. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-0634. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetal-PEG-NHS, MW 1k-10k | Acetal-PEG-NHS is a linear heterobifunctionalized PEG derivative. Heterobifunctionalized PEG derivatives are used in cell culture, pharmaceutical research, drug delivery and release, nanotechnology and new materials. Heterobifunctional PEG can be attached to different molecules or materials to extend the richness of different molecular combinations. Drug PEG modification can alter its dispersion and solubility in aqueous solutions. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-0639. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AC-PEG-COOH, MW 1k-10k | AC-PEG-COOH has two different activated terminal groups, an acrylate and a carboxylic acid. Heterobifunctionalized PEG derivatives are used in cell culture, pharmaceutical research, drug delivery and release, nanotechnology and new materials. Heterobifunctional PEG can be attached to different molecules or materials to extend the richness of different molecular combinations. PEG modification can create a spatial barrier around the drug, reduce the enzymatic hydrolysis of the drug, avoid the rapid elimination of kidney metabolism, and allow the drug to be recognized by cells of the immune system. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-0644. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AC-PEG-NH2, MW 1k-10k | AC-PEG-NH2 is a linear heterobifunctionalized PEG derivative with an acrylate and an amine. Heterobifunctionalized PEG derivatives are used in cell culture, pharmaceutical research, drug delivery and release, nanotechnology and new materials. Heterobifunctional PEG can be attached to different molecules or materials to extend the richness of different molecular combinations. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-0649. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AC-PEG-NH-Boc, MW 1k-10k | AC-PEG-NH-Boc has two different activated terminal groups, an acrylate and a Boc protected amine. Heterobifunctionalized PEG derivatives are used in cell culture, pharmaceutical research, drug delivery and release, nanotechnology and new materials. Heterobifunctional PEG can be attached to different molecules or materials to extend the richness of different molecular combinations. PEG modification can create a spatial barrier around the drug, reduce the enzymatic hydrolysis of the drug, avoid the rapid elimination of kidney metabolism, and allow the drug to be recognized by cells of the immune system. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-0654. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AC-PEG-OH, MW 1k-10k | AC-PEG-OH with two different activated terminal groups, an acrylate and a hydroxyl, is used in cell culture, pharmaceutical research, drug delivery and release, nanotechnology and new materials. Heterobifunctional PEG can be attached to different molecules or materials to extend the richness of different molecular combinations. PEG modification can create a spatial barrier around the drug, reduce the enzymatic hydrolysis of the drug, avoid the rapid elimination of kidney metabolism, and allow the drug to be recognized by cells of the immune system. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-0659. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AC-PEG-SCM, MW 1k-10k | AC-PEG-SCM with two different activated terminal groups, an Acrylate and an activated NHS ester, is used in cell culture, pharmaceutical research, drug delivery and release, nanotechnology and new materials. Heterobifunctional PEG can be attached to different molecules or materials to extend the richness of different molecular combinations. PEG modification can create a spatial barrier around the drug, reduce the enzymatic hydrolysis of the drug, avoid the rapid elimination of kidney metabolism, and allow the drug to be recognized by cells of the immune system. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-0664. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AC-PEG-Silane, MW 1k-10k | AC-PEG-Silane with two different activated terminal groups, an acrylate and a silane group, is used in cell culture, pharmaceutical research, drug delivery and release, nanotechnology and new materials. Heterobifunctional PEG can be attached to different molecules or materials to extend the richness of different molecular combinations. PEG modification can create a spatial barrier around the drug, reduce the enzymatic hydrolysis of the drug, avoid the rapid elimination of kidney metabolism, and allow the drug to be recognized by cells of the immune system. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-0669. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acrylamide-PEG-SH, MW 1k-10k | Acrylamide-PEG-SH with two different activated terminal groups. The acrylamide group can be used for radical initiator or UV light induced polymerization. Heterobifunctionalized PEG derivatives are used in cell culture, pharmaceutical research, drug delivery and release, nanotechnology and new materials. Heterobifunctional groups can be attached to different molecules or materials to extend the richness of different molecular combinations. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-0674. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Afoxolaner | Afoxolaner is a potent isoxazoline insecticide and acaricide against Ixodes scapularis in dogs. It is indicated for the treatment and prevention of flea infestations, and the treatment and control of tick infestations in dogs and puppies. It is administered orally in meat-flavoured tablets, and poisons fleas once they start feeding. It is used either alone or as a combination treatment with milbemycin oxime. Group: Pharmaceutical. CAS No. 1093861-60-9. Pack Sizes: 100 mg. Product ID: B2692-475054. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Anhydro abiraterone | An impurity of Abiraterone. Abiraterone acetate is a CYP17A1 inhibitor and by extension androgen synthesis inhibitor. In combination with prednisone, it is indicated for the treatment of patients with metastatic castration-resistant prostate cancer who have already received prior chemotherapy containing docetaxel under the trade name Zytiga. Group: Pharmaceutical. CAS No. 154229-20-6. Pack Sizes: 10 mg. Product ID: B0038-007225. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Artemisinin | Artemisinin is a natural product originally isolated from plants of the genus Artemisia. It effectively kills malarial parasites of the genus Plasmodium. It is usually used in combination therapy for the treatment of malaria. Artemisinin is also used against a wide range of trematodes, including Schistosoma. Artemisinin is an inhibitor of human NOS2 (iNOS) with anticancer activity. Group: Pharmaceutical. CAS No. 63968-64-9. Pack Sizes: 100 g. Product ID: BBF-04621. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Astaxanthin | Astaxanthin is a carotenoid pigment found mostly in animal organisms, but also occurring in plants. It is thought to be the precursor of astacin. It is a potent lipid-soluble antioxidant. It has broad application prospects in health products, medicine, cosmetics, food additives and aquaculture. Astaxanthin is a natural antioxidant with the strongest antioxidant and anti-aging ability in nature, and its antioxidant capacity is much higher than VE and β-carotene. It significantly enhances mitochondrial activity required for cell recombination and effectively protects the skin from UVA, UVB and blue light damage. Uses: Ingredient of health care products. Group: Pharmaceutical. CAS No. 472-61-7. Pack Sizes: 10 g. Product ID: BBF-05817. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Avibactam Sodium Salt | Avibactam Sodium Salt, a novel non-?-lactam ?-lactamase inhibitor, binds covalently to Ambler class A ?-lactamases, including KPCs, Ambler class C and some class D b-lactamases. In combination with ceftazidime, Avibactam is a new drug application for avibactam , and was approved by the FDA on February 25, 2015, to treat complicated urinary tract and complicated intra-abdominal Infections caused by antibiotic resistant-pathogens. Avibactam has limited intrinsic antimicrobial activity but restores the in vitro activity of b-lactams including ceftazidime, ceftaroline, the active metabolite of ceftaroline fosamil, and aztreonam against ESBL-producing pathogens. Group: Pharmaceutical. CAS No. 1192491-61-4. Pack Sizes: 500 mg. Product ID: B0084-465274. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AZD0364 | AZD-0364 is a potent and selective ERK2 inhibitor, which has an IC50 value of 0.6 nM. AZD-0364 is measured in the A375 phospho-p90RSK assays with IC50s of 5.7 nM. AZD-0364 can inhibit the growth of a panel of cancer cell lines. The combination of Selumetinib and AZD-0364 ethanesulfonic acid results in a reduction in tumor growth. Group: Pharmaceutical. CAS No. 2097416-76-5. Pack Sizes: 25 mg. Product ID: B2693-291616. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AZD3965 | AZD3965 is a selective inhibitor of monocarboxylate transporter 1 (MCT1) with a binding affinity of 1.6 nM, which is 6-fold selective over MCT2 and does not inhibit MCT4 at 10 μM. Both lactate transport and cell growth are potently inhibited by AZD3965 in lymphoma cell lines that preferentially express MCT1. Lactate transport inhibition in some cell lines also induces a cytotoxic effect. In vitro combination studies show that lactate transport inhibition can enhance the induction of cell death by doxorubicin. Blocking lactate transport in vitro also leads to a rapid inhibition of glucose uptake in the Raji Burkitt's lymphoma cell line. In vivo, AZD3965 is well tolerated and induces a dose- and time-dependent accumulation of lactate in the tumors, suppresses tumor growth and in the Raji model potentiates the effects of Rituxan, doxorubicin and bendamustine. The selective inhibition of lactate transport by the MCT1 inhibitor AZD3965 offers a novel mechanism for targeting the metabolic phenotype in tumors that preferentially express MCT1. Group: Pharmaceutical. CAS No. 1448671-31-5. Pack Sizes: 25 mg. Product ID: B2693-463251. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AZD-5363 | AZD-5363 is an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. AZD-5363 binds to and inhibits all AKT isoforms. This agent may be used as monotherapy or combination therapy for a variety of human cancers. Group: Pharmaceutical. CAS No. 1143532-39-1. Pack Sizes: 10 mg. Product ID: B2693-457058. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BDT-1006 | BDT-1006 is a dendritic acrylate with an average functionality of 6. The hyper-branched structure of BDT-1006 imparts the unique combination of low diluted viscosity with unmatched chemical and thermal resistance, which is ideal in applications where withstanding exposure to the harshest conditions is paramount. Great for high-temperature applications because thermogravimetric analysis indicates the oligomer doesnt decompose until 377 °C. Uses: Graphic arts, coatings, electronics, digital inks. Group: Oligomer. Oligomer Functionality: 6. Viscosity [CP]: 1,500 (Neat). Durometer Hardness: 90D. Tensile Strength [MPa]: 17. Elongation at Break [%]: 3. Elegonation with %: 3%. Categories: Oligomers. |  |
| BDT-1015 | A dendritic acrylate with an average functionality of 15. The hyper-branched structure of BDT-1015 imparts a unique combination of low diluted viscosity with unmatched chemical and thermal resistance. This is ideal in applications where withstanding exposure to the hardest of conditions is paramount. BDT-1015 is also great for high-temperature applications because thermogravimetric analysis indicates the oligomer doesnt decompose until 372°C. Uses: Graphic arts, coatings, electronics, digital inks. Group: Oligomer. Oligomer Functionality: 15. Viscosity [CP]: 31,000 (Neat). Durometer Hardness: 89D. Tensile Strength [MPa]: 30. Elongation at Break [%]: 3. Elegonation with %: 3%. Categories: Oligomers. | |
| BDT-4330 | A dendritic acrylate with an average functionality of 30. The hyper-branched structure of BDT-4330 imparts the unique combination of low diluted viscosity with unmatched chemical and thermal resistance, which is ideal in applications where withstanding exposure to the harshest conditions is paramount. Great for high-temperature applications because thermogravimetric analysis indicates the oligomer doesnt decompose until 397°C. Uses: Graphic arts, coatings, electronics, digital inks. Group: Oligomer. Oligomer Functionality: 30. Viscosity [CP]: 1,500 (Neat). Durometer Hardness: 94D. Tensile Strength [MPa]: 39. Elongation at Break [%]: 1.7. Elegonation with %: 1.7%. Categories: Oligomers. | |
| Bictegravir | Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM for strand transfer activity. Bictegravir is a drug of the integrase inhibitor class that was copied from Dolutegravir by scientists at Gilead Sciences. Bictegravir also inhibits HIV-1 viral infection in MT-2 and MT-4 cells, CD4+ T cells, and macrophages (EC50s = 1.5, 2.5, 1.5, and 6.6 nM, respectively) without exhibiting cytotoxicity (CC50s = 10.3, 3.7, 13, and 29.8 μM, respectively). In 2016, bictegravir was in a Phase 3 trial as part of a single tablet regimen in combination with tenofovir alafenamide (TAF) and emtricitabine (FTC) for the treatment of HIV-1 infection. Group: Pharmaceutical. CAS No. 1611493-60-7. Pack Sizes: 100 mg. Product ID: B2693-058383. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| C12-200 | C12-200 is almost a macromolecule. It contains multiple tertiary amines, the pKa of which should also be close to but no greater than 7. Ionizable lipids in combination with other lipids make up the lipid nanoparticles which are used to deliver RNA-based therapeutics. Group: Pharmaceutical. CAS No. 1220890-25-4. Pack Sizes: 1 g. Product ID: B1370-358162. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CHIR-99021 | CHIR-99021 (CT99021) is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. It enhances reprogramming of mouse embryonic fibroblasts, transduced by Oct4 and Klf4 only, into iPSCs in combination with tranylcypromine. It also induces cardiomyocyte differentiation from human embryonic stem (ES). Uses: Potential antineoplastic agent. Group: Pharmaceutical. CAS No. 252917-06-9. Pack Sizes: 100 mg. Product ID: B0084-462893. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Choline Fenofibrate | Choline Fenofibrate is the choline salt of fenofibric acid under clinical development as a combination therapy with rosuvastatin for the management of dyslipidemia. Group: Pharmaceutical. CAS No. 856676-23-8. Pack Sizes: 5 g. Product ID: B0084-259938. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| dasabuvir | Dasabuvir is an antiviral drug for the treatment of hepatitis C. It inhibits hepatitis C virus (HCV) non-nucleoside NS5B palm polymerase to suppress RNA replicase. Dasabuvir is commonly used in combination with ombitasvir/paritaprevir/ritonavir to effect on HCV type 1. Uses: The treatment of hepatitis c. Group: Pharmaceutical. CAS No. 1132935-63-7. Pack Sizes: 100 mg. Product ID: B0084-462255. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate 4-methylbenzenesulfonate | An impurity of Pemetrexed, which has been approved by FDA in 2004 for the treatment of malignant pleural mesothelioma (MPM) in combination with cisplatin, a platinum-containing chemotherapeutic drug. Group: Pharmaceutical. CAS No. 165049-28-5. Pack Sizes: 2.5 g. Product ID: NP3162. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| DOPE | DOPE, also known as 1,2-Dioleoyl-sn-glycero-3-PE or 1,2-DOPE, is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. 1,2-DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery. Group: Pharmaceutical. CAS No. 4004-5-1. Pack Sizes: 1 g. Product ID: B4059-163865. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| EAI045 | EAI045 is an allosteric, non-ATP competitive inhibitor of mutant EGFR. In vitro studies proved that EAI045 is active and selective for T790M- harboring EGFR mutants that are in a monomer state. In vivo the combination of EAI045 and cetuximab caused a marked tumor shrinkage in a mouse model carrying the EGFR mutant with L858R/T790M/C797S. Therefore, EAI045 is the first allosteric inhibitor that targets T790M and C797S EGFR mutants but it is effective only in combination with cetuximab. Group: Pharmaceutical. CAS No. 1942114-09-1. Pack Sizes: 50 mg. Product ID: B0084-475458. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Eflornithine hydrochloride, hydrate | Eflornithine hydrochloride, hydrate is a drug found to be effective in the treatment of facial hirsutism. It is a "suicide inhibitor," irreversibly binding to Ornithine Decarboxylase (ODC) and preventing the natural substrate ornithine from accessing the active site. It is an irreversible inhibitor of ornithine decarboxylase that suppresses polyamine biosynthesis. It displays antiangiogenic and cytostatic effects in tumor cells but must be used in combination with other chemotherapeutic agents to negate compensatory increases in polyamine content through alternate synthesis pathways. It also demonstrates antiparasitic activity in a model of C. parvum infection. Group: Pharmaceutical. CAS No. 96020-91-6. Pack Sizes: 10 g. Product ID: BAT-008153. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Entacapone | Entacapone is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT) (IC50 = 151 nM), commonly used in combination with other medications for the treatment of Parkinson's disease. Group: Pharmaceutical. CAS No. 130929-57-6. Pack Sizes: 500 mg. Product ID: B0084-057038. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Entinostat | Entinostat is a histone deacetylase (HDAC) inhibitor displaying antiproliferative and antineoplastic effects. Entinostat induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), which slows cell growth, differentiation, and tumor development in vivo. Entinostat is potentially used as an antitumor drug in combination with other drugs like adriamycin, PARP inhibitors and Hsp90 inhibitors. Uses: Histone deacetylase inhibitors. Group: Pharmaceutical. CAS No. 209783-80-2. Pack Sizes: 500 mg. Product ID: B0084-062759. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Hydroxychloroquine Sulfate | Hydroxychloroquine Sulfate is an autophagy inhibitor that induces autophagic cell death. It also inhibits TLR9. Hydroxychloroquine is an antimalarial drug, and in combination with other medications, it can be used in the treatment of some autto-immune diseases. It has been used in emergency of COVID-19. Group: Pharmaceutical. CAS No. 747-36-4. Pack Sizes: 100 g. Product ID: B2693-076365. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Idelalisib | Idelalisib is a kinase inhibitor. In combination with rituximab, it was used for the treatment of relapsed or refractory chronic lymphocytic leukemia (CLL). Uses: The treatment of chronic lymphocytic leukemia (cll). Group: Pharmaceutical. CAS No. 870281-82-6. Pack Sizes: 250 mg. Product ID: B0084-307712. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Isopropyl-β-D-thiogalactopyranoside | IPTG is a galactose analog that is used in combination with X-GAL in cloning procedures requiring expression of β-galactosidase activity. Group: Pharmaceutical. CAS No. 367-93-1. Pack Sizes: 100 g. Product ID: BAT-008017. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Laropiprant | a drug used in combination with niacin to reduce blood cholesterol (LDL and VLDL) that is no longer sold. Uses: A potent, selective dp1 receptor antagonist. Group: Pharmaceutical. CAS No. 571170-77-9. Pack Sizes: 50 mg. Product ID: B0084-474242. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| LEE011 succinate | LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models. Group: Pharmaceutical. CAS No. 1374639-75-4. Pack Sizes: 1 g. Product ID: B2693-463203. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Levamisole Impurity D (HCl salt form) | The hydrochloride of Levamisole Impurity D. Levamisole is a medication used for the treatment of parasitic worm infections. It was also indicated to be effective for colon cancer therapy in combination with fluorouracil. Group: Pharmaceutical. CAS No. 4335-29-9. Pack Sizes: 30 mg. Product ID: B1298-007230. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Lopinavir | An antiretroviral medication acts as a protease inhibitor. It is a co-formulation with a sub-therapeutic dose of ritonavir, as a component of combination therapy to treat HIV/AIDS. Group: Pharmaceutical. CAS No. 192725-17-0. Pack Sizes: 1 g. Product ID: B0084-086623. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| LY2109761 | LY2109761 is a novel inhibitor of TGF-β receptor type I/type II kinases (IC50 = 69 nM), displaying antitumor activity. In vivo study demonstrated that LY2109761, in combination with gemcitabine, significantly reduced the tumor burden, prolonged survival, and reduced spontaneous abdominal metastases. Group: Pharmaceutical. CAS No. 700874-71-1. Pack Sizes: 100 mg. Product ID: B2693-286403. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Magnesium aluminosilicate | Magnesium aluminosilicate has long been used in the formulation of tablets, ointments and creams. It is used as a suspension and stabilizer alone or in combination with other suspension agents in oral and topical formulations. In tablets, it is used as a binder and disintegrating agent in conventional or sustained-release preparations. Group: Pharmaceutical. CAS No. 1327-43-1. Pack Sizes: 100 g. Product ID: B1370-014007. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Manganese | A chemical element with the symbol Mn and atomic number 25. It is a hard, brittle, silvery metal, often found in minerals in combination with iron. Manganese is a transition metal with a multifaceted array of industrial alloy uses, particularly in stainless steels. Uses: Laboratory chemicals, Industrial & for professional use. CAS No. 7439-96-5. |  |
| Matrixyl 3000 | Matrixyl 3000 is an anti-aging ingredient developed by Sederma. Matrixyl 3000 is a combination of palmitoyl oligopeptide and palmitoyl tetrapeptide-7. Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: BAT-006226. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Megestrol | Megestrol is an orally active progestogen. Megestrol is used in combinations as an oral contraceptive and antineoplastic agent. Uses: Antineoplastic agents, hormonal; progestational hormones, synthetic. Group: Pharmaceutical. CAS No. 3562-63-8. Pack Sizes: 10 g. Product ID: B2692-066963. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Mericol | Are a range of casein binders of various different properties and uses, offering a combination of modern, technically advanced, whilst retaining traditional formulatory values. The range is produced with only the highest quality of casein to instil quality and consistency to the product and offer the finishers a complete range to suit all their requirements. Uses: Leather Finishing Chemicals. Pack Sizes: 30, 60, 120, 1000. |  NE England |
| Minocycline hydrochloride | Minocycline (INN) is a semi-synthetic broad-spectrum tetracycline antibiotic. Minocycline hydrochloride is the most lipid-soluble form, which binds to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis. In combination with CHIR 99021, (S)-(+)-Dimethindene maleate and human leukemia inhibitory factor, it induces the formation of extended pluripotent stem (EPS) cells. Group: Pharmaceutical. CAS No. 13614-98-7. Pack Sizes: 5 g. Product ID: BBF-03822. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| MK-5172 | Grazoprevir is a hepatitis C virus protease inhibitor developed for the treatment of hepatitis C. It suppresses NS3 and NS4A, which play a role in the virus splitting its polyprotein into the functional virus proteins. Grazoprevir is often used in combination with elbasvir or ribavirin. Uses: Antiviral agents. Group: Pharmaceutical. CAS No. 1350514-68-9. Pack Sizes: 100 mg. Product ID: B2693-007134. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Pemetrexed Impurity D | An impurity of Pemetrexed which is used to treat mesothelioma in combination with another chemotherapy drug called cisplatin. Group: Pharmaceutical. CAS No. 144051-68-3. Pack Sizes: 50 mg. Product ID: B1494-478643. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Pemetrexed Impurity E Disodium Salt | An impurity of Pemetrexed, which has been approved by FDA in 2004 for the treatment of malignant pleural mesothelioma (MPM) in combination with cisplatin, a platinum-containing chemotherapeutic drug. Group: Pharmaceutical. CAS No. 937370-10-0. Pack Sizes: 50 mg. Product ID: B1494-478645. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Plerixafor Impurity III | Plerixafor Impurity III is an impurity of Plerixafor, an immunostimulant indicated in combination with G-CSF to mobilize hematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in patients with NHL and MM. Group: Pharmaceutical. CAS No. 771464-86-9. Pack Sizes: 5 mg. Product ID: B2694-341919. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Prasugrel Metabolite R | A metabolite of Prasugrel. Prasugrel is a platelet inhibitor and an irreversible antagonist of P2Y12ADP receptors that prevents the formation of blood clots. It was appoved for the treatment of acute coronary syndrome (ACS), and some cardiovascular diseasess in combination with Aspirin. Group: Pharmaceutical. CAS No. 204204-73-9. Pack Sizes: 1 mg. Product ID: B0219-007229. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PRT062607 monohydrochloride | PRT062607, also known as PRT2607, P505-15, and BIIB057, is a novel, highly selective, and orally bioavailable small molecule SYK inhibitor (SYK IC(50) = 1 nM) with anti-SYK activity that is at least 80-fold greater than its affinity for other kinases. PRT062607 successfully inhibited SYK-mediated B-cell receptor signaling and decreased cell viability in NHL and CLL. Oral dosing in mice prevented BCR-mediated splenomegaly and significantly inhibited NHL tumor growth in a xenograft model. In addition, combination treatment of primary CLL cells with PRT062607 plus fludarabine produced synergistic enhancement of activity at nanomolar concentrations. PRT062607 may be a therapeutic agent for B-cell malignancies. A dose finding study in healthy volunteers has been completed. Group: Pharmaceutical. CAS No. 1370261-97-4. Pack Sizes: 10 mg. Product ID: B2693-457962. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Pyronaridine | Pyronaridine is an antimalarial drug. Pyronaridine was first synthesized in 1970 and has been in clinical use in China since the 1980s. It is one of the components of the artemisinin combination therapy pyronaridine artesunate (Pyramax). Uses: Antimalarial. Group: Pharmaceutical. CAS No. 74847-35-1. Pack Sizes: 500 mg. Product ID: B0084-476596. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ((R)-2-Biphenyl-4-yl-1-formylethyl)carbamic Acid t-Butyl Ester | An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. Group: Pharmaceutical. CAS No. 149709-58-0. Pack Sizes: 100 mg. Product ID: B1604-284931. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (R)-Ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoate | An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. Group: Pharmaceutical. CAS No. 149709-59-1. Pack Sizes: 100 mg. Product ID: B1604-284930. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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