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| Product | Description | |
|---|---|---|
| Cisplatin | Cisplatin induces cytotoxicity by interaction with DNA to form DNA adducts which activate several signal transduction pathways, including Erk, p53, p73, and MAPK, which culminates in the activation of apoptosis. It is used in several types of cancer. Uses: Antineoplastic agent. Group: Pharmaceutical. CAS No. 15663-27-1. Pack Sizes: 2 g. Product ID: BBF-03995. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Cisplatin (cis-Dichloro diammineplatinum (II) ) | 100mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: Cl2H6N2Pt. CAS No. 15663-27-1. Prepack ID : 52453372-100mg. Molecular Weight : 300.05. |  |
| Cisplatin (cis-Dichloro diammineplatinum (II) ) | 1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: Cl2H6N2Pt. CAS No. 15663-27-1. Prepack ID : 52453372-1g. Molecular Weight : 300.05. | |
| Amifostine Trihydrate | Amifostine is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin. Group: Pharmaceutical. CAS No. 112901-68-5. Pack Sizes: 1 g. Product ID: B2692-338520. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AS101 | AS101 is a synthetic non-toxic tellurium derivative, structurally similar to cisplatin, with immuno-modulating, antiviral, and hair growth-promoting activities. This agent is also a potent inducer of IL-1 and IL-6. Accordingly, ammonium trichlorotellurate may protect against chemotherapy-induced alopecia. Group: Pharmaceutical. CAS No. 106566-58-9. Pack Sizes: 25 mg. Product ID: B0084-256533. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bemcentinib | Bemcentinib is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may play an important role in cancer progression, invasion, metastasis, drug resistance, and patient mortality. R428 inhibits Axl with low nanomolar activity and blocked Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Pharmacologic investigations revealed favorable exposure after oral administration such that R428-treated tumors displayed a dose-dependent reduction in expression of the cytokine granulocyte macrophage colony-stimulating factor and the epithelial-mesenchymal transition transcriptional regulator Snail. In support of an earlier study, R428 inhibited angiogenesis in corneal micropocket and tumor models. R428 administration reduced metastatic burden and extended survival in MDA-MB-231 intracardiac and 4T1 orthotopic (median survival, >80 days compared with 52 days; P < 0.05) mouse models of breast cancer metastasis. Additionally, R428 synergized with cisplatin to enhance suppression of liver micrometastasis. Our results show that Axl signaling regulates breast cancer metastasis at multiple levels in tumor cells and tumor stromal cells and that selective Axl blockade confers therapeutic value in prolonging survival of animals bearing metastÂ… | London |
| Denibulin | Denibulin (MN-029) is a novel vascular-disrupting agent that reversibly inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor vascular endothelial cells. The results of preclinical study demonstrated that MN-029 could cause rapid vascular shutdown in solid tumors, dose-dependent secondary tumor cell killing, and effective enhancement of the antitumor effects of radiation and cisplatin chemotherapy. Group: Pharmaceutical. CAS No. 284019-34-7. Pack Sizes: 1 mg. Product ID: B1370-065073. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate 4-methylbenzenesulfonate | An impurity of Pemetrexed, which has been approved by FDA in 2004 for the treatment of malignant pleural mesothelioma (MPM) in combination with cisplatin, a platinum-containing chemotherapeutic drug. Group: Pharmaceutical. CAS No. 165049-28-5. Pack Sizes: 2.5 g. Product ID: NP3162. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| D-Methionine methylsulfonium bromide | D-Methionine methylsulfonium bromide, a compound renowned for its efficacy in countering acetaminophen-induced liver injury, has also emerged as a promising candidate for shielding against cisplatin-induced nephrotoxicity. Group: Pharmaceutical. CAS No. 212757-14-7. Pack Sizes: 5 mg. Product ID: B2692-102087. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Eriodictyol 7-O-glucoside | Eriodictyol 7-O-glucoside is isolated from the herbs of Dracocephalum rupestre. It has protective effect on cisplatin-induced toxicity. Group: Pharmaceutical. CAS No. 38965-51-4. Pack Sizes: 5 mg. Product ID: NP1941. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Glutathione EP Impurity C | Oxiglutatione is a stabilized formulation of disodium glutathione disulfide (GSSG; oxidized glutathione) and cisplatin (1000:1) with potential chemoprotective and immunomodulating activities. Mimicking endogenous GSSG, Oxiglutatione acts as a competitive substrate for gamma-glutamyl-transpeptidase (GGT), which may result in the S-glutathionylation of proteins, predominantly actin, a redox stress on endoplasmic reticulum (ER), and ER stress-induced apoptosis. S-glutathionylation may be stimulated by reactive oxygen species (ROS) liberated by an oxiglutatione-induced increase in GGT activity. Oxiglutatione may also induce phosphorylation of proteins such as ERK and p38, two kinases that play critical regulatory roles in cell proliferation and apoptosis. The cisplatin component of this agent does not provide an effective therapeutic concentration of cisplatin in vivo. Group: Pharmaceutical. CAS No. 27025-41-8. Pack Sizes: 25 g. Product ID: B0084-064728. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Pemetrexed Impurity D | An impurity of Pemetrexed which is used to treat mesothelioma in combination with another chemotherapy drug called cisplatin. Group: Pharmaceutical. CAS No. 144051-68-3. Pack Sizes: 50 mg. Product ID: B1494-478643. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Pemetrexed Impurity E Disodium Salt | An impurity of Pemetrexed, which has been approved by FDA in 2004 for the treatment of malignant pleural mesothelioma (MPM) in combination with cisplatin, a platinum-containing chemotherapeutic drug. Group: Pharmaceutical. CAS No. 937370-10-0. Pack Sizes: 50 mg. Product ID: B1494-478645. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Satraplatin | Satraplatin, also known as JM216, is a platinum compound that is currently under investigation as one treatment of patients with advanced prostate cancer who have failed previous chemotherapy. It has not yet received approval from the U.S. Food and Drug Administration. First mentioned in the medical literature in 1993, satraplatin is the first orally active platinum-based chemotherapeutic drug; other available platinum analogues-cisplatin, carboplatin, and oxaliplatin-must be given intravenously. It is made available in the United States jointly by Spectrum Pharmaceuticals and GPC Biotech under the name SPERA (Satraplatin Expanded Rapid Access). The drug has also been used in the treatment of lung and ovarian cancers. The proposed mode of action is that the compound binds to the DNA of cancer cells rendering them incapable of dividing. Group: Pharmaceutical. CAS No. 129580-63-8. Pack Sizes: 50 mg. Product ID: B0084-056858. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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