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CHIA - Our signature range of liquid botanical extracts
England, Scotland
3-(Methylseleno)-L-alanine
3-(Methylseleno)-L-alanine, a metabolite found in Escherichia coli (strain K12, MG1655), is an inhibitor of DMBA-induced mammary tumors. It has oral bioavailability and can induce cell apoptosis. Group: Pharmaceutical. CAS No. 26046-90-2. Pack Sizes: 1 g. Product ID: BBF-05851. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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4-thiouridine
Nucleotide analogue is essential to cell growth in certain bacterial species, which is also able to chelate with certain metal ions, and in tRNA. It can act as a built-in antiphotomutagenic agent protecting Escherichia coli cells against mutagenesis. Uses: Affinity labels. Group: Pharmaceutical. CAS No. 13957-31-8. Pack Sizes: 1 g. Product ID: B2706-009850. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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7α,15-Dihydroxydehydroabietic acid
7α,15-Dihydroxydehydroabietic acid is extracted from the caulis and leaves of Callicarpa kochiana. It has significant cytotoxic activity. Group: Pharmaceutical. CAS No. 155205-64-4. Pack Sizes: 1 mg. Product ID: NP1683. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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7-Xylosyl-10-deacetyltaxol B
7-Xylosyl-10-deacetyltaxol B is extracted from the barks of Taxus wallichiana Zucc. Group: Pharmaceutical. CAS No. 90332-64-2. Pack Sizes: 5 mg. Product ID: NP1423. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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7-Xylosyl-10-deacetyltaxol C
7-Xylosyl-10-deacetyltaxol C is extracted from the barks of Taxus wallichiana Zucc. Group: Pharmaceutical. CAS No. 90332-65-3. Pack Sizes: 50 mg. Product ID: NP1502. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Actinamine Dihydrochloride
Actinamine dihydrochloride is an impurity of Spectinomycin (HCl salt-S680250), an antibiotic that selectively inhibits protein synthesis in cells of Escherichia coli, and is also commonly used to treat patients with uncomplicated cases of gonorrhea. Group: Pharmaceutical. CAS No. 52049-70-4. Pack Sizes: 1mg; 1g; 10g. Product ID: BB075375. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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ARISTOLACTAM-AII
Aristolactam AII is an alkaloid compound found in the herbs of Aristolochia debilis Sieb. et Zucc. Aristolactam AII exhibits the activities of antiinflammatory and antimicrobial. Aristolactam AII also has platelet aggregation inhibitory activity. Uses: Antiinflammatory, antimicrobial. Group: Pharmaceutical. CAS No. 53948-07-5. Pack Sizes: 1 mg. Product ID: NP0491. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Aristolochic Acid B
Aristolochic acids occur in Aristolochiaceae and in butterflies feeding on these plants. One of a group of fourteen known, substituted 1-phenanthrenecarboxylic acids. Group: Pharmaceutical. CAS No. 475-80-9. Pack Sizes: 5 mg. Product ID: B2703-350870. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Aristololactam BII
Aristolactam BII, a natural alkaloid isolated from the herbs of Aristolochia debilis Sieb. et Zucc exhibits significant activities in the anti-syncytium assay using (ΔTat/Rev)MC99 virus and 1A2 cell line system. By directly inhibiting the production of nitric oxide, aristolactam BII exerts its significant neuroprotective effects on glutamate-injured primary cultures of rat cortical cells. Uses: Anti-syncytium. Group: Pharmaceutical. CAS No. 53948-09-7. Pack Sizes: 1 mg. Product ID: NP0328. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Asenapine Impurities
Asenapine Impurities, acting as essential reference markers, occupy a crucial niche in biomedical endeavors. They ensure the purity, efficacy, and safety of asenapine formulations vital for psychiatric treatments, particularly schizophrenia and bipolar disorder. These impurities aid in drug formulation, highlight regulatory compliance, and unveil synthesis and degradation pathways. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Benzamide Impurities
Benzamide impurities are pivotal in the pharmaceutical industry as analytical standards, ensuring the purity and efficacy of benzamide-based drugs. These impurities are crucial in the development and quality control of medications for psychiatric disorders, such as schizophrenia and bipolar disorder, enhancing overall drug safety and effectiveness. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Betahistine
Betahistine is a H1 receptor agonist, which serves as a vasodilator. It is used in Meniere disease and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers. It is an antivertigo drug first used for treating vertigo. It is also commonly used for patients with balance disorders. It is believed to act by reducing the asymmetrical functioning of sensory vestibular organs as well as by increasing vestibulocochlear blood flow. It also acts as a histamine H3-receptor antagonist which causes an increased output of histamine from histaminergic nerve endings which can further increase the direct H1-agonist activity. It has been listed. Uses: Betahistine is used in meniere disease and in vascular headaches. it is an antivertigo drug first used for treating vertigo. it is also commonly used for patients with balance disorders. Group: Pharmaceutical. CAS No. 5638-76-6. Pack Sizes: 2 g. Product ID: B0084-329466. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Brexpiprazole Impurity 10
Brexpiprazole Impurity 10 is an impurity of Brexpiprazole, a drug used to counter psychiatric afflictions such as schizophrenia and major depressive disorder. Group: Pharmaceutical. CAS No. 15116-41-3. Pack Sizes: 50 mg. Product ID: B0461-467695. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Calcitonin eel
Calcitonin eel is a peptide hormone produced by the parafollicular C cells of the thyroid or by the ultimobranchial bodies of nonmammalian vertebrates. Group: Pharmaceutical. CAS No. 57014-02-5. Pack Sizes: 2.5 mg. Product ID: BAT-006141. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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CHIR-090
CHIR-090 is a very potent and tight-binding inhibitor of LpxC, which is a zinc-dependent amidase and present in almost all Gram-negative bacteria, and is a promising target for the development of novel antibiotic substances against multigrug-resistant Gram-negative bacteria. Its Ki value is 4.0 nM. It displays two-step time-dependent inhibition and kills a wide range of Gram-negative pathogens as effectively as ciprofloxacin or tobramycin. It has a different selectivity with the reported LpxC inhibitor L-161. It has excellent antibiotic activity against Pseudomonas aeruginosa and Escherichia coli by inhibiting LpxC orthologs at low nM concentrations. It is an excellent lead for the further development of new antibiotics targeting the lipid A pathway. Uses: Chir-090 displays two-step time-dependent inhibition and kills a wide range of gram-negative pathogens as effectively as ciprofloxacin or tobramycin. it has excellent antibiotic activity against pseudomonas aeruginosa and escherichia coli by inhibiting lpxc orthologs at low nm concentrations. Group: Pharmaceutical. CAS No. 728865-23-4. Pack Sizes: 300 mg. Product ID: B0084-474822. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Complanatuside A
Complanatuside A, a flavonoid compound, is isolated from Astragalus complanatus and Lysimachia christinae. Astragalus complanatus R.Brown is a widely used herbal material in traditional Chinese medicine. The total flavonoid (TF) is an active fraction extracted from seeds of Astragalus complanatus R.Brown. Previous studies performed in animals have demonstrated the antihypertensive efficacy of the TF. Group: Pharmaceutical. CAS No. 116183-66-5. Pack Sizes: 20 mg. Product ID: B0005-479850. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Dinoprost
Dinoprost is a widely distributed PG occurring in many species, causing contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity. Group: Pharmaceutical. CAS No. 551-11-1. Pack Sizes: 1 g. Product ID: B2693-071360. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
Dodecyl 2-(N,N-dimethylamino)propionate hydrochloride, a quaternary ammonium compound, finds extensive use as a phase transfer catalyst to create novel drugs and chemical substances. It also serves as a surfactant in biomedical experiments that enhances drug solubility and effectiveness. Its exceptional attribute of crossing the blood-brain barrier suggests future potential in neurological and psychiatric therapies. Group: Pharmaceutical. CAS No. 259685-49-9. Pack Sizes: 250 mg. Product ID: B0001-306554. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Emodin anthrone
Emodin anthrone is a natural product found in Rhamnus prinoides, Paeonia emodi, and Rumex acetosa with data available. Emodinanthrone inhibits respiration-driven solute transport at micromolar concentrations in membrane vesicles of Escherichia coli. Group: Pharmaceutical. CAS No. 491-60-1. Pack Sizes: 1 g. Product ID: B0001-093033. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Ertapenem Sodium
Ertapenem Sodium is the sodium salt of ertapenem. Ertapenem has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of ertapenem results from the inhibition of cell wall synthesis and is mediated through ertapenem binding to penicillin binding proteins (PBPs). In Escherichia coli, it has strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preference for PBPs 2 and 3. Ertapenem is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. Ertapenem is hydrolyzed by metallo-beta-lactamases. Ertapenem has been shown to be active against most isolates of the following microorganisms in vitro and in clinical infections. Group: Pharmaceutical. CAS No. 153773-82-1. Pack Sizes: 1 g. Product ID: BBF-03993. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Flupentixol Impurities
Flupentixol Impurities are integral to the quality assessment and development of antipsychotic medications. These impurities help in understanding drug safety, efficacy, and stability, ensuring that therapeutic agents treating psychiatric disorders, such as schizophrenia and other psychosis-related conditions, maintain their intended pharmaceutical properties without deleterious side effects. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Homovanillic Acid-[d3]
Homovanillic Acid-[d3] is an isotopically-labeled version of Homovanillic Acid (HVA). This important dopamine metabolite is predominantly found in human urine and is a valuable biochemical research tool for investigating the mechanisms underlying neuropsychiatric and neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, and schizophrenia. Its use in these studies is useful, given the marked alterations in dopamine metabolism and function that are observed in these conditions. Uses: A neuroendocrine tumor marker. a labelled metabolite of dihydroxyphenylacetic acid (dopac) by catechol o-methyltransferase. Group: Pharmaceutical. CAS No. 74495-71-9. Pack Sizes: 10 mg. Product ID: BLP-011889. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Inositol Impurities
Inositol Impurities, pivotal in the realm of therapeutic research, significantly influence the development of interventions for mood disorders and metabolic diseases. These impurities facilitate the comprehension of drug stability and efficacy, especially in psychiatric and diabetic medications, thereby bolstering the essential framework for pharmacological advancements. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Isocytidine
An isomer of Cytidine, a constituent of nucleic acid. It is converted to isocytosine and uracil during metabolism in Escherichia coli. Group: Pharmaceutical. CAS No. 489-59-8. Pack Sizes: 50 mg. Product ID: B1370-277261. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Isotaxiresinol
Isotaxiresinol is a natural lignan found in the branch of Taxus wallichiana. Isotaxiresinol is useful for the treatment of postmenopausal osteoporosis, especially for prevention of bone fracture induced by estrogen deficiency. Uses: Anti-cancer; anti-osteoporosis. Group: Pharmaceutical. CAS No. 26194-57-0. Pack Sizes: 1 mg. Product ID: NP3924. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Linezolid
Linezolid inhibits initiation complex formation with either the 30S or the 70S ribosomal subunits from Escherichia coli. Linezolid is a synthetic oxazolidinone antibiotic active against a wide range of Gram-positive bacteria, including resistant strains of several species, such as MRSA and penicillin-resistant pneumococci. Group: Pharmaceutical. CAS No. 165800-03-3. Pack Sizes: 50 mg. Product ID: BBF-04161. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Linezolid Impurity 42
An impurity of Linezolid. Linezolid inhibits initiation complex formation with either the 30S or the 70S ribosomal subunits from Escherichia coli. Group: Pharmaceutical. CAS No. 725676-93-7. Pack Sizes: 10 mg. Product ID: B2694-338786. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Linezolid Impurity 44
An impurity of Linezolid. Linezolid inhibits initiation complex formation with either the 30S or the 70S ribosomal subunits from Escherichia coli. Group: Pharmaceutical. CAS No. 183805-10-9. Pack Sizes: 2 mg. Product ID: B2694-338787. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Luteolin
Luteolin is an anti-inflammatory, antioxidant and free radical scavenger. Luteolin inhibits LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocks NF-κB and AP-1 activation. It also inhibits TNF-α-induced COX-2 expression, and phosphodiesterase with with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM for PDE1-5 respectively. It inhibits proliferation of Lewis lung carcinoma cells in vivo. Luteolin is a natural compound found in the leaves of Dracocephalum ruyschiana L. It can be used in cosmetics material. Uses: Adcs cytotoxin. Group: Pharmaceutical. CAS No. 491-70-3. Pack Sizes: 5 g. Product ID: NP1855. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Maprotiline Impurities
Maprotiline Impurities, arising as by-products in antidepressant Maprotiline synthesis, present a critical focus in pharmaceutical analysis. Comprehending these impurities is essential for drug formulation, purity evaluation, and optimizing therapeutic outcomes, enhancing safety and reliability in treating depression and anxiety, thereby underpinning psychiatric medicinal efficacy. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Menaquinone 7
Menaquinone 7 is a form of vitamin K2, which includes nine related compounds. Menaquinone 7 is a long-chain menaquinone that is synthesized by Escherichia coli bacteria in the gut. It can be used as a supplement for bone health. Menaquinone 7 can be used as vitamin supplement in health care products. Uses: Ingredient of health care products. Group: Pharmaceutical. CAS No. 2124-57-4. Pack Sizes: 20 mg. Product ID: BBF-05784. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Mianserin Impurities
Mianserin Impurities are crucial in evaluating and ensuring the quality and safety of Mianserin hydrochloride, an antidepressant used for treating major depressive disorders. By identifying, characterizing, and quantifying these impurities, researchers can enhance drug efficacy, stability, and safety, ultimately improving therapeutic outcomes in psychiatric treatments. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Nefazodone Impurities
Nefazodone Impurities are critical in pharmaceutical research for analyzing the purity, stability, and formulation of nefazodone, an antidepressant used for treating major depressive disorders. These impurities help in understanding drug safety, efficacy, and potential side effects, thus facilitating the development of safer and more effective psychiatric medications. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Pachyaximine A
Pachyaximine A, isolated from the herbs of Pachysandra axillaris, possesses significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Corynebacterium diphtheriae and Corynebacterium pyrogenes. Uses: Antibacterial; antimicrobial. Group: Pharmaceutical. CAS No. 128255-08-3. Pack Sizes: 5 mg. Product ID: NP0286. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Pipotiazine Impurities
Pipotiazine Impurities, critical in the biomedical field, are predominantly used to assess the purity and efficacy of pipotiazine, a drug employed in managing schizophrenia and bipolar disorder. These impurities aid in ensuring therapeutic efficacy and safety, offering vital insights for drug development and quality control in psychiatric treatments. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Pridopidine
Pridopidine, also known as ACR16, is a dopamine stabilizer used in the treatment of neurologic and psychiatric disorders. Uses: Dopamine d2 receptor antagonists; glutamate modulators; sigma-1 receptor agonists. Group: Pharmaceutical. CAS No. 346688-38-8. Pack Sizes: 100 mg. Product ID: B2693-110584. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Rac-cis-Sertraline Hydrochloride
Rac-cis-Sertraline Hydrochloride is an extensively utilized pharmacological compound within the biomedical sector used in studying psychiatric afflictions, including depression, panic disorder and obsessive-compulsive disorder. Its mechanism of action entails selective inhibition of serotonin reuptake, thereby reestablishing homeostasis of this pivotal neurotransmitter within the cerebral research. Uses: Potent and selective inhibitors of serotonin uptake. Group: Pharmaceutical. CAS No. 79617-95-1. Pack Sizes: 100 mg. Product ID: B1331-134752. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Risperidone Impurities
Risperidone Impurities are crucial in the biomedical industry for analyzing and ensuring the purity of risperidone, an antipsychotic medication used in treating psychiatric disorders such as schizophrenia and bipolar disorder. These impurities play a pivotal role in drug safety assessment, stability testing, and quality control during pharmaceutical development. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
(S)-Praziquantel
S configuration of Praziquantel.Praziquantel can be used for the treatment of a number of types of parasitic worm infections. Specifically it is used for schistosomiasis, clonorchiasis, opisthorchiasis, tapeworm infections, cysticercosis, hydatid disease, and other fluke infections. Group: Pharmaceutical. CAS No. 57452-97-8. Pack Sizes: 100 mg. Product ID: B1739-453193. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Tasimelteon
Tasimelteon (trade name Hetlioz) is a drug approved by the FDA solely for the treatment of non-24-hour sleep-wake disorder (often designated as N24HSWD) in totally blind adults. It is a selective agonist for the melatonin receptors MT1 and MT2 in the suprachiasmatic nucleus of the brain, similar to other members of the melatonin receptor agonist class of which ramelteon (2005) and agomelatine (2009) were the first approved. Uses: Tasimelteon is a novel drug, used in the treatment of non-24 hour sleep-wake disorder. it helps to correct the circadian rhythm disorder often seen in patients who are visually impaired. Group: Pharmaceutical. CAS No. 609799-22-6. Pack Sizes: 100 mg. Product ID: B0084-072984. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Tretazicar
Tretazicar (CB1954) is a dinitrobenzamide prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide (EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. CB1954 has been proposed for use in enzyme-prodrug gene therapy systems with the Escherichia coli enzyme nitroreductase (Ntr). Ntr converts CB1954 to 2- and 4-hydroxylamino derivatives, whereupon the non-enzymatic reaction of the 4-hydroxylamino derivative with cellular thio- esters generates a potent cytotoxic bifunctional alkylating agent capable of cross-linking DNA. Ntr delivery has been achieved in vitro using retroviral and adenoviral vectors and confirmed by immunocytochemical demonstration of Ntr expression. The Ntr-expressing cells have been shown to be sensitized to CB1954 by up to 2000-fold. The Ntr-CB1954 system shows effective bystander killing in mixed populations of Ntr-expressing and non-expressing cells treated with CB1954. The efficacy of this enzyme-prodrug approach in model systems compared with other VDEPT approaches demonstrates the feasibility and future promise of this gene therapy strategy. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 21919-05-1. Pack Sizes: 1 g. Product ID: B2693-366889. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Viloxazine Impurities
Viloxazine Impurities hold paramount importance in pharmaceutical exploration, pivotal for verifying the purity and therapeutic potency of viloxazine, an ADHD medication. Their identification and characterization are crucial in advancing neuropsychiatric therapeutics while ensuring drug formulation integrity and adhering to regulatory standards, thus safeguarding medication development processes. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Wallicoside
Wallicoside, a natural compound extracted from the leaves of Wallichia disticha, presents itself as a promising therapeutic entity for the treatment of neurodegenerative disorders, including Alzheimer's disease. Its anti-inflammatory and antioxidant attributes render it a valuable candidate in the development of novel drug compounds for the treatment and prevention of such debilitating diseases. Group: Pharmaceutical. CAS No. 88797-59-5. Pack Sizes: 1 mg. Product ID: NP6165. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
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