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Chloroquine phosphate is an antimalarial drug and weak intercalating agent. It inhibits TLR signalling in plasmacytoid dendritic cells (pDCs). It has been used in emergency of COVID-19. Uses: Anti-inflammatory agents, non-steroidal. Group: Pharmaceutical. CAS No. 50-63-5. Pack Sizes: 100 g. Product ID: B2693-344737. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Geranylgeraniol
An intermediate in the lipidation of proteins, which plays a great importance for a variety of biological processes such as cell signalling. Group: Pharmaceutical. CAS No. 24034-73-9. Pack Sizes: 5 g. Product ID: 24034-73-9. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
GNE-6776
GNE-6776 is a potent and non-covalent USP7 inhibitor with IC50 of 1.34 uM. GNE-6776 targets cellular USP7, MDM2, and p53 signalling pathways, and induces tumor cell death. Group: Pharmaceutical. CAS No. 2009273-71-4. Pack Sizes: 5 mg. Product ID: B0084-284761. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Homoplantaginin
Homoplantaginin is a flavonoid glycoside found in Scoparia dulcis. Homoplantaginin ameliorates endothelial insulin resistance by inhibiting inflammation and modulating cell signalling via the IKKβ/IRS-1/pAkt/peNOS pathway, suggesting it may be used for the prevention and treatment of endothelial dysfunction associated with insulin resistance. Group: Pharmaceutical. CAS No. 17680-84-1. Pack Sizes: 25 mg. Product ID: B2703-465489. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Tricirbine
Triciribine is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity. Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival. Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3. It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways. Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 μM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day. Group: Pharmaceutical. CAS No. 35943-35-2. Pack Sizes: 100 mg. Product ID: B1370-090988. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
1-(5-Carboxypentyl)-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate, a highly sought-after fluorescent probe, has gained immense popularity in biomedical research due to its ability to detect minute cellular anomalies associated with cancer and other life-threatening diseases. Its application extends beyond its diagnostic potential and is frequently utilized in drug discovery initiatives aimed at identifying novel therapeutics that target specific and often elusive signaling pathways involved in disease progression. Its remarkable attributes and versatility have made it an indispensable tool in the ever-expanding realm of medical research. Group: Pharmaceutical. CAS No. 146368-08-3. Pack Sizes: 100 mg. Product ID: B2699-050005. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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17-DMAG hydrochloride
17-DMAG hydrochloride (Alvespimycin hydrochloride) is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to Hsp90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Group: Pharmaceutical. CAS No. 467214-21-7. Pack Sizes: 100 mg. Product ID: BBF-05796. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
1-Butyl-2-[5-(1-butyl-1H-benzo[cd]indol-2-ylidene)-penta-1,3-dienyl]-benzo[cd]indolium tetrafluoroborate is a tetrafluoroborate compound that widely utilized within the field of biomedicine owing to its exceptional antitumor attributes. Through selective targeting of intricate signaling pathways implicated in the tumorigenesis process, it efficaciously impedes the proliferation of malignant cells. Furthermore, it exhibits remarkably encouraging therapeutic efficacy in combatting a diverse range of cancers, encompassing breast, prostate, and colon malignancies. Group: Pharmaceutical. CAS No. 1135933-68-4. Pack Sizes: 100 mg. Product ID: B1370-285592. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
9-Ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, a promising therapeutic agent for the treatment of select neoplastic disorders, functions as a highly proficient suppressor of pathogenic kinase enzymes that exhibit heightened expression levels in malignant neoplastic cells. This mechanism of action, whereby key cellular signaling pathways are disrupted, culminates in the prevention of tumor growth and impairs the metastatic process. Group: Pharmaceutical. CAS No. 1256584-80-1. Pack Sizes: 100 mg. Product ID: B2699-281515. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
AC-55541
AC-55541 is a novel small-molecule protease-activated receptor 2(PAR2) agonist which displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. It activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM. It was well absorbed when administered intraperitoneally to rats, reaching micromolar peak plasma concentrations. It was stable to metabolism by liver microsomes and maintained sustained exposure in rats. Uses: Ac-55541 stimulates cell proliferation, phosphatidylinositol hydrolysis, and calcium mobilization. Group: Pharmaceutical. CAS No. 916170-19-9. Pack Sizes: 300 mg. Product ID: B0084-271988. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-aldehyde, a potent and reversible caspase-8 inhibitor, enables cell permeability by linking to a nonpolar CPP corresponding to the Kaposi fibroblast growth factor (FGF) signaling peptide sequence. Group: Pharmaceutical. CAS No. 886462-83-5. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-014679. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Acalabrutinib
Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. Group: Pharmaceutical. CAS No. 1420477-60-6. Pack Sizes: 250 mg. Product ID: B0084-470855. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Acalabrutinib-[d4]
Acalabrutinib-[d4] is a labelled version of Acalabrutinib. Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. Group: Pharmaceutical. Pack Sizes: 5 mg. Product ID: BLP-003188. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Acetyl-Heme-Binding Protein 1 (1-21) (human)
Acetyl-Heme-Binding Protein 1 (1-21) (human), an acetylated peptide corresponding to the N-terminal fragment of human heme-binding protein, specifically promotes calcium mobilization and chemotaxis in dendritic cells and monocytes via the FPR-like receptor 2 (FPRL 2). In neutrophils, it inhibits FPR and FPRL1-mediated signaling. Group: Pharmaceutical. CAS No. 946571-77-3. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-015350. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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AG 126
Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM. AG 126 may represent a new approach for the therapy of inflammation. Uses: Anti- inflammation. Group: Pharmaceutical. CAS No. 118409-62-4. Pack Sizes: 100 mg. Product ID: B1370-195904. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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AG-490
Tyrphostin AG490 is a JAK-2 specific inhibitor, which inhibits phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 133550-30-8. Pack Sizes: 25 mg. Product ID: B0084-164022. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
ALK5 Inhibitor II hydrochloride
ALK5 inhibitor II was identified as a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (ALK5 autophosphorylation, IC50s = 4 nM, TGF-β cellular assay, IC50s = 18 nM, ALK5 binding in HepG2 cells, IC50s = 23 nM). This compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription. This product is a hydrochloride form. Group: Pharmaceutical. CAS No. 446859-33-2. Pack Sizes: 50 mg. Product ID: B0084-068993. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Alpelisib
Alpelisib, also known as BLY719, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BYL719 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. Group: Pharmaceutical. CAS No. 1217486-61-7. Pack Sizes: 100 mg. Product ID: B0084-457654. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Altiratinib
Altiratinib, also known as DCC-270, DP-5164, is an oral, selective and highly potent inhibitor of MET, TIE2, VEGFR2 and TRK kinases with potential anticancer activity. DCC-2701 effectively reduces tumor burden in vivo and blocks c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro. Importantly, DCC-2701's anti-proliferative activity was dependent on c-MET activation induced by stromal human fibroblasts and to a lesser extent exogenous HGF. DCC-2701 may be superior to HGF antagonists that are in clinical trials and that pTyr(1349) levels might be a good indicator of c-MET activation and likely response to targeted therapy as a result of signals from the microenvironment. Group: Pharmaceutical. CAS No. 1345847-93-9. Pack Sizes: 50 mg. Product ID: B2693-463181. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Avicularin
Avicularin, a natural plant flavonoid isolated from the herbs of Polygonum aviculare, exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 macrophage cells. By decreasing C/EBPα-activated GLUT4-mediated glucose uptake in adipocytes and potently inhibiting fatty acid synthase, avicularin can inhibit the accumulation of the intracellular lipids. Uses: Anti-inflammatory. Group: Pharmaceutical. CAS No. 572-30-5. Pack Sizes: 10 mg. Product ID: NP1949. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
AZD-4547
AZD4547 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. AZD4547 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, and, so, the inhibition of tumor cell proliferation and tumor cell death. Group: Pharmaceutical. CAS No. 1035270-39-3. Pack Sizes: 100 mg. Product ID: B0084-456576. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Bellidifolin
Bellidifolin is a xanthone that can be isolated from the plants of Gentiana species. Study shows that bellidifolin is a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica. Bellidifolin may contribute to the protective effects associated with nerve injury initiated by hypoxia by mechanisms related to inhibition of cell apoptosis independent of the ERK pathway, but may involve blockade of p38MAPK signaling pathway activation and downstream caspase-3 expression. Group: Pharmaceutical. CAS No. 2798-25-6. Pack Sizes: 5 mg. Product ID: NP7359. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Bemcentinib
Bemcentinib is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may play an important role in cancer progression, invasion, metastasis, drug resistance, and patient mortality. R428 inhibits Axl with low nanomolar activity and blocked Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Pharmacologic investigations revealed favorable exposure after oral administration such that R428-treated tumors displayed a dose-dependent reduction in expression of the cytokine granulocyte macrophage colony-stimulating factor and the epithelial-mesenchymal transition transcriptional regulator Snail. In support of an earlier study, R428 inhibited angiogenesis in corneal micropocket and tumor models. R428 administration reduced metastatic burden and extended survival in MDA-MB-231 intracardiac and 4T1 orthotopic (median survival, >80 days compared with 52 days; P < 0.05) mouse models of breast cancer metastasis. Additionally, R428 synergized with cisplatin to enhance suppression of liver micrometastasis. Our results show that Axl signaling regulates breast cancer metastasis at multiple levels in tumor cells and tumor stromal cells and that selective Axl blockade confers therapeutic value in prolonging survival of animals bearing metastÂ…
London
Birinapant
Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. As a SMAC mimetic and IAP antagonist, TL32711 binds to and inhibits the activity of IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. CAS No. 1260251-31-7. Pack Sizes: 100 mg. Product ID: B0084-462223. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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BML-284
BML-284 is potent, selective and cell-permeable Wnt signaling activator. It induces β-catenin and transcription factor (TCF)-dependent transcriptional activity in 293T cells in a dose dependent manner with an EC50 of 0.7 mM in vitro. Uses: Bml-284 may be a useful tool in the study of physiological processes that involve the wnt pathway. Group: Pharmaceutical. CAS No. 853220-52-7. Pack Sizes: 25 mg. Product ID: B0084-474867. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
BMS-911543
BMS-911543 is an orally available JAK inhibitor with selectivity for JAK2. It inhibts JAK2, thereby preventing the JAK/STAT (signal transducer and activator of transcription) signaling cascade, including activation of STAT3. This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation. Group: Pharmaceutical. CAS No. 1271022-90-2. Pack Sizes: 20 mg. Product ID: B0084-457828. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Brevilin A
Brevilin A, also called 6-O-Angeloylplenolina, is a natural sesquiterpenoid found in the herbs of Centipeda minima, it exhibits the antigiardial activity (IC50 = 16.1 μM) and is similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM). Brevilin A inhibits janus kinase activity and exhibits both strong STAT3 signal inhibition and STAT3 signal dependent cell growth inhibition. Uses: Anti-giardial. Group: Pharmaceutical. CAS No. 16503-32-5. Pack Sizes: 5 mg. Product ID: NP5612. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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C16 Ceramide
C16 ceramide is an endogenous ceramide, generated by ceramide synthase 6 (CerS6), that acts as a lipid second messenger to regulate apoptosis and stress signaling. It has also been found to activate NF-κB and PKCζ3. Uses: A predominant, rather hydrophobic natural ceramide. activates a cytosolic serine/threonine protein phosphatase in t9 cells; induces egf receptor phosphorylation in a-431 cells; stimulates ceramide-activated protein kinase. Group: Pharmaceutical. CAS No. 24696-26-2. Pack Sizes: 100 mg. Product ID: B1370-059982. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
C29
C29 is a potential TLR2 inhibitor. C29 inhibited TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. Group: Pharmaceutical. CAS No. 363600-92-4. Pack Sizes: 100 mg. Product ID: B1370-007320. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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CBS9106
CBS9106, also known as BMS-566419, is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity. CRM1 plays an important role in the nuclear export of cargo proteins bearing nuclear exporting signal sequences. CBS9106 inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells, including multiple myeloma cells. CBS9106 reduces CRM1 protein levels significantly without affecting CRM1 mRNA expression. Oral administration of CBS9106 significantly suppresses tumor growth and prolongs survival in mice bearing tumor xenograft without a significant loss in body weight. A reduced level of CRM1 protein is also observed in tumor xenografts isolated from mice treated with CBS9106. Taken together, these results indicate that CBS9106 is a novel reversible CRM1 inhibitor and a promising clinical candidate. Group: Pharmaceutical. CAS No. 1076235-04-5. Pack Sizes: 10 mg. Product ID: B1370-462313. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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CDDO Imidazolide
CDDO Imidozolide is a synthetic triterpenoid as a Nrf2 signaling activator with highly active in suppressing cellular proliferation of human leukemia and breast cancer cell. Uses: Nrf2 signaling activator. Group: Pharmaceutical. CAS No. 443104-02-7. Pack Sizes: 10 mg. Product ID: B2693-474173. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Cerdulatinib HCl
Cerdulatinib is a dual SYK/JAK inhibitor. It significantly reduces cell viability in a subset of NHL cell lines, and induces apoptosis in BCR-signaling competent NHL cell lines. Group: Pharmaceutical. CAS No. 1369761-01-2. Pack Sizes: 10 mg. Product ID: B0084-463402. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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CGM097
CGM097 is an orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival. Group: Pharmaceutical. CAS No. 1313363-54-0. Pack Sizes: 5 mg. Product ID: B0084-462483. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Chicanin
Chicanin is a lignan isolated from the fruits of Osmanthus fragrans. Studies show that chicanine exhibits anti-inflammatory activity on murine macrophage by down-regulating LPS-induced inflammatory cytokines in IκBα/MAPK/ERK signaling pathways and anti-proliferative effect on prostate cells. Group: Pharmaceutical. CAS No. 78919-28-5. Pack Sizes: 5 mg. Product ID: B0005-053763. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Chrysophanol
Chrysophanic acid (Chrysophanol) is a natural anthraquinone with anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells. Chrysophanic acid preferentially blocked proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression. Chrysophanic acid treatment in SNU-C5 cells inhibited EGF-induced phosphorylation of EGFR and suppressed activation of downstream signaling molecules, such as AKT, extracellular signal-regulated kinase (ERK) and the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic acid (80 and 120 μm) significantly blocked cell proliferation when combined with the mTOR inhibitor, rapamycin. These findings offer the first evidence of anticancer activity for chrysophanic acid via EGFR/mTOR mediated signaling transduction pathway. Chrysophanol is a natural compound found in the roots and rhizomes of Rheum palmatum L. It can be used in cosmetics material. Uses: Anti-inflammatory. Group: Pharmaceutical. CAS No. 481-74-3. Pack Sizes: 1 g. Product ID: NP0901. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Cirsilineol
Cirsilineol is a trimethoxyflavone isolated from Artemisia and from Teucrium gnaphalodes. It selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4+ T cells. Group: Pharmaceutical. CAS No. 41365-32-6. Pack Sizes: 50 mg. Product ID: NP2434. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Copanlisib
Copanlisib is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. BAY 80-6946 inhibits the activation of the PI3K signaling pathway, which may result in the inhibition of tumor cell growth and survival in susceptible tumor cell populations. Group: Pharmaceutical. CAS No. 1032568-63-0. Pack Sizes: 50 mg. Product ID: B0084-456551. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Corosolic acid
Corosolic acid, that is isolated from the barks of Lagerstroemia speciosa, contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts its anticancer activity against colon cancer cells by promoting the N-terminal phosphorylation and subsequent proteasomal degradation of β-catenin. Besides, Corosolic acid induced apoptosis in colorectal cancer (CRC), rendering this compound a potential anticancer agent for the treatment of CRC. Corosolic acid, as a new plant medicine for preventing and treating obesity and type II diabetes, and a functional natural health food and pharmaceutical raw material, has become a popular product in the market. Uses: Anti-angiogenic/anticancer. Group: Pharmaceutical. CAS No. 4547-24-4. Pack Sizes: 50 mg. Product ID: NP7232. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Crocin
Crocin is a water-soluble carotenoid pigment in saffron (Crocus sativus L.) with anti-inflammatory, antioxidant, anti-apoptosis, anti-asthma, anti-cancer, anti-allergy, relaxation of smooth muscle and hypolipidemic effects. Crocin inhibits tumor necrosis factor (TNF) α-induced pheochromocytoma (PC12) apoptosis by regulating the mRNA expression of Bcl-2 family proteins, which trigger downstream signals that ultimately lead to caspase-3 activation and subsequent cell death. Uses: Antioxidant, anticancer. Group: Pharmaceutical. CAS No. 42553-65-1. Pack Sizes: 100 mg. Product ID: B2703-002922. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
CU-CPT-9b
CU-CPT-9b is a TLR8 inhibitor that inhibits TLR8-mediated proinflammatory signaling in various cell lines and human primary cells. Group: Pharmaceutical. CAS No. 2165340-32-7. Pack Sizes: 10 mg. Product ID: B0084-260289. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
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Cyclopamine Impurities
Cyclopamine Impurities serve a fundamental role in biomedical exploration, crucial for deciphering cancer-associated signaling pathways. These impurities facilitate the development of therapeutic agents targeting the Hedgehog signaling cascade, primarily implicated in basal cell carcinoma and medulloblastoma treatment, significantly advancing oncological therapy research. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Dasatinib
Dasatinib, also known as BMS-354825, is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. Group: Pharmaceutical. CAS No. 302962-49-8. Pack Sizes: 25 g. Product ID: NP3264. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Defactinib
Defactinib, also known as VS-6063 and PF-04554878, is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival. The tyrosine kinase FAK is , a signal transducer for integrins that is upregulated in many tumor cell types and is involved in tumor cell invasion, migration and proliferation. Group: Pharmaceutical. CAS No. 1073154-85-4. Pack Sizes: 200 mg. Product ID: B0084-462762. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
δ-Tocotrienol
δ-Tocotrienol is from palm oil. Delta-tocotrienol is a potential angiogenic inhibitor that significantly suppresses human colorectal adenocarcinoma cells (DLD-1-CM)-induced tube formation, migration, and adhesion on human umbilical vein endothelial cells. Delta-tocotrienol is a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSCLC) cell proliferation, induce apoptosis and inhibit invasion, and thus offer a potential starting point for the design of novel anticancer agents. Delta-tocotrienol displays significant radioprotective effects that protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling. Group: Pharmaceutical. CAS No. 25612-59-3. Pack Sizes: 50 mg. Product ID: NP4617. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Deoxyandrographolide
Deoxyandrographolide is a natural compound extracted from the herbs of Andrographis paniculata (Burm. f.) Nees. It could potently inhibit the growth of liver (HepG2 and SK-Hep1) and bile duct (HuCCA-1 and RMCCA-1) cancer cells. It controlled ethanol-induced hepatosteatosis by interfering with dysregulation of lipid metabolism. It was capable of preventing the development of fatty liver through AMPK-mediated regulation of lipid metabolism. It reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner in concentrations between 10-100 microM. It reduced PAF-induced calcium flux in the presence of extracellular calcium. It mediated activation of adenylate cyclase-cAMP signaling leading to up-regulation of cNOS may provide a promising approach in the prevention of liver diseases during chronic alcoholism. Uses: Deoxyandrographolide could potently inhibit the growth of liver (hepg2 and sk-hep1) and bile duct (hucca-1 and rmcca-1) cancer cells. it controlled ethanol-induced hepatosteatosis by interfering with dysregulation of lipid metabolism. it reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner in concentrations between 10-100 microm. it reduced p. Group: Pharmaceutical. CAS No. 79233-15-1. Pack Sizes: 10 mg. Product ID: B2693-098584. Molecular formula: Custom synthesis is available. Send your inquiries for more inf
London
Duvelisib
Duvelisib, also known as IPI-145 and INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration, PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike other isoforms of PI3K, the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases. By selectively targeting these PI3K isoforms, PI3K signaling in normal, non-neoplastic cells is minimally or not affected which would result in a more favorable side effect profile. Uses: For research used only. Group: Pharmaceutical. CAS No. 1201438-56-3. Pack Sizes: 100 mg. Product ID: B0084-462545. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Emodin
Emodin is an anthraquinone found naturally in the roots and barks of numerous plants. It exerts antiproliferative effects in cancer cells that are regulated by different signaling pathways. It has anti-cancer, anti-depressant and anti-microbial effects. Group: Pharmaceutical. CAS No. 518-82-1. Pack Sizes: 50 g. Product ID: BBF-04483. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Encorafenib
Encorafenib, also known as LGX-818, is an orally available Raf kinase inhibitor with potential antineoplastic activity. LGX818 specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival. Group: Pharmaceutical. CAS No. 1269440-17-6. Pack Sizes: 150 mg. Product ID: B0084-462563. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Eriocalyxin B
Eriocalyxin B, isolated from the herbs of Isodon eriocalyx, is a potent NF-kappaB inhibitor. Eriocalyxin B inhibited the NF-kappaB transcriptional activity but not that of cAMP response element-binding protein. eriocalyxin B reversibly interfered with the binding of p65 and p50 subunits to the DNA in a noncompetitive manner. Eriocalyxin B exerts potent antiinflammatory effects through selective modulation of pathogenic Th1 and Th17 cells by targeting critical signaling pathways. Besides, Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways. Eriocalyxin B should be considered a candidate for pancreatic cancer treatment. Uses: Antiinflammatory. Group: Pharmaceutical. CAS No. 84745-95-9. Pack Sizes: 1 mg. Product ID: NP1304. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
EW-7197
EW-7197 is a potent and selective ALK5 inhibitor, displaying antimetastatic and anticancer effects. It inhibits TGF-β/Smad signaling, and abrogates TGF-β1-induced tumor cell migration and invasion. EW-7197 inhibits breast cancer metastasis to the lung. EW-7197 prolongs the life span of BALB/c 4T1 mice via inhibition of EMT. EW-7197 inhibits metastasis and enhances the activity of cytotoxic T lymphocytes (CTLs) in 4T1 orthotopic grafted mice. Group: Pharmaceutical. CAS No. 1352608-82-2. Pack Sizes: 50 mg. Product ID: B0084-462343. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Exherin
Exherin, also known as ADH-1, is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis. N-cadherin, a cell- surface transmembrane glycoprotein of the cadherin superfamily of proteins involved in calcium-mediated cell-cell adhesion and signaling mechanisms; may be upregulated in some aggressive tumors and the endothelial cells and pericytes of some tumor blood vessels. Group: Pharmaceutical. CAS No. 229971-81-7. Pack Sizes: 10 mg. Product ID: BAT-010745. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Ezatiostat
Ezatiostat is a glutathione analog that acts as an inhibitor of glutathione S-transferase (GST) P1-1. TLK117, the active form of ezatiostat, inhibits GSTP1-1, resulting in phosphorylation of JNK, restoring JNK-mediated cellular proliferation and differentiation signaling pathways. Group: Pharmaceutical. CAS No. 168682-53-9. Pack Sizes: 25 mg. Product ID: BAT-010079. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
FIPI
FIPI, a derivative of halopemide, is a potent and selective phospholipase D (PLD) inhibitor with IC50 values of 20 and 25 nM for PLD2 and PLD1 respectively. It attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. It rapidly blocks in vivo PA production with subnanomolar potency. It has good pharmacokinetic parameters in rats. It did not significantly inhibit p38 or ERK phosphorylation in bone marrow-derived macrophages stimulated with lipopolysaccharide. It prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis. Group: Pharmaceutical. CAS No. 939055-18-2. Pack Sizes: 100 mg. Product ID: B2693-438324. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Fosbretabulin disodium
Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities. Upon administration, the prodrug fosbretabulin is dephosphorylated to its active metabolite, the microtubule-depolymerizing agent combretastatin A4, which binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, this agent disrupts the engagement of the endothelial cell-specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and so the activity of the VE-cadherin/β-catenin/Akt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation. As a result of fosbretabulin's dual mechanism of action, the tumor vasculature collapses, resulting in reduced tumor blood flow and ischemic necrosis of tumor tissue. Group: Pharmaceutical. CAS No. 168555-66-6. Pack Sizes: 100 mg. Product ID: B0084-085514. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Futibatinib
Futibatinib is an orally bioavailable, selective and irreversible inhibitor of fibroblast growth factor receptors (FGFRs), displaying antineoplastic activity. It inhibits FGFR-mediated signal transduction and tumor cell proliferation. Group: Pharmaceutical. CAS No. 1448169-71-8. Pack Sizes: 250 mg. Product ID: B2693-292398. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
GDC-0152
GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0152 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2, which may inhibit their activities and promote the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Smac, the endogenous IAP antagonist, relies on its N-terminal four amino-acid motif for binding to IAPs. Group: Pharmaceutical. CAS No. 873652-48-3. Pack Sizes: 50 mg. Product ID: B2693-462525. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
GDC-0853
GDC-0853 is a Bruton's tyrosine kinase (BTK) inhibitor originated by Genentech. GDC-0853 can inhibit the activity of BTK and prevent the activation of the B-cell antigen receptor (BCR) signaling pathway. This leads to the inhibition of the growth of malignant B-cells that overexpress BTK. Phase III clinical trials for the treatment of Multiple sclerosis and Phase II clinical trials for the treatment of Chronic urticaria and Systemic lupus erythematosus are on-going. Uses: Rheumatoid arthritis; autoimmune disorders. Group: Pharmaceutical. CAS No. 1434048-34-6. Pack Sizes: 100 mg. Product ID: B2693-475436. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
GDC-0994
GDC-0994, also known as RG7842, is an orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. This prevents ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 1453848-26-4. Pack Sizes: 50 mg. Product ID: B2693-462528. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
GDP-D-glucose disodium salt
GDP-D-glucose sodium salt, a biochemical component for metabolic pathway study and intracellular signaling, plays an imperative role in glucose metabolism. Its potential therapeutic agent property for various diseases is highlighted in recent diabetes and cancer research. And its acknowledged proficiency in regulating the cell differentiation and proliferation further consolidates its prominence. Group: Pharmaceutical. CAS No. 103301-72-0. Pack Sizes: 10 mg. Product ID: B1370-358024. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Ginsenoside F4
Ginsenoside F4 is extracted from the root of Panax ginseng C. A. Mey. It has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis. It was found to strongly inhibit activation of p38 mitogen-activated protein kinase in signal transduction pathways. Group: Pharmaceutical. CAS No. 181225-33-2. Pack Sizes: 10 mg. Product ID: B0005-454183. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Glasdegib
Glasdegib is an orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway that binds to Smoothened (Smo) and inhibits signal transduction. It has been shown to attenuate leukemia stem cell self-renewal and cell cycle progression in primary acute myeloid leukemia cells and in an in vivo Drosophila model. Group: Pharmaceutical. CAS No. 1095173-27-5. Pack Sizes: 50 mg. Product ID: B0084-462711. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Glaucocalyxin A
Glaucocalyxin A, which is extracted from the herbs of Rabdosia rubescens, inhibited Akt phosphorylation, suppressed proliferation, and promoted apoptosis in a dose-dependent manner, but not in normal glial cells. Glaucocalyxin A activated caspase-3, decreased BAD phosphorylation, and reduced the expression of X-linked inhibitor of apoptosis protein. Glaucocalyxin A inhibited collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GP? pathway. Uses: Antiplatelet/antithrombotic. Group: Pharmaceutical. CAS No. 79498-31-0. Pack Sizes: 10 mg. Product ID: NP1506. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Graveoline
Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway. Group: Pharmaceutical. CAS No. 485-61-0. Pack Sizes: 200 mg. Product ID: B2696-119203. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Guanosine 5'-diphosphate disodium salt
Guanosine 5'-diphosphate disodium salt is an imperative biomolecule esteemed in the biomedical sector, exhibiting noteworthy involvement in cellular signaling and serves as a substrate for diverse nucleic acid metabolism-encompassing enzymes. Its significance is exemplified through extensive employment in research and manufacturing, enabling comprehensive exploration of G-protein coupled receptors, protein synthesis and drug discovery-related signaling pathways, as well as disease research. Group: Pharmaceutical. CAS No. 7415-69-2. Pack Sizes: 10 g. Product ID: B2001-013437. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Guanosine 5-monophosphomorpholidate
Guanosine 5-monophosphomorpholidate - an invaluable biomedical product - finds its application in the treatment of various diseases. As a precursor for synthesizing targeted drugs against viral infections and cancerous cells, it showcases its remarkable potential. Notably, this compound plays a pivotal role in signaling pathways, guiding and governing vital cellular processes concerning DNA synthesis and repair. Its multifaceted involvement in these intricate mechanisms underscores its significance in the realm of biomedical sciences. Group: Pharmaceutical. CAS No. 7361-7-1. Pack Sizes: 10 g. Product ID: B2706-301736. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
HSP990
HSP990 is an orally bioavailable inhibitor of human heat-shock protein 90 (HSP90) with potential antineoplastic activity. HSP990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. HSP90, upregulated in a variety of tumor cells, is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses. Group: Pharmaceutical. CAS No. 934343-74-5. Pack Sizes: 100 mg. Product ID: B1370-460667. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
iCRT 14
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling. It is thought to directly influence the interaction between β-catenin and TCF4. It also induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. Group: Pharmaceutical. CAS No. 677331-12-3. Pack Sizes: 25 mg. Product ID: B0084-272145. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
ILK-IN-1
ILK-IN-1, a ILK inhibitor, has been found to restrain the tumor cell growth through regulating signaling pathways related to oncogenesis and tumor progression. IC50: 0.6 μM. Uses: Ilk-in-1 is a ilk inhibitor that has been found to restrain the tumor cell growth through regulating signaling pathways related to oncogenesis and tumor progression. Group: Pharmaceutical. CAS No. 1333146-24-9. Pack Sizes: 10 mg. Product ID: B2693-474480. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Ipatasertib
Ipatasertib, also known as GDC-0068 is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GDC-0068 binds to and inhibits the activity of Akt in a non-ATP-competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 1001264-89-6. Pack Sizes: 50 mg. Product ID: B2693-456282. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
Isobavachalcone
Isobavachalcone is a naturally occurring chalcone mainly isolated from the seeds of Psoralea corylifolia Linn. Isobavachalcone inhibits Akt signaling pathway, inducing apoptosis in human cancer cells. Uses: Anti-inflammatory. Group: Pharmaceutical. CAS No. 20784-50-3. Pack Sizes: 50 mg. Product ID: B1370-087244. Molecular formula: Custom synthesis is available. Send your inquiries for more information.
London
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