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| Product | Description | |
|---|---|---|
| A66 | Inhibition of p110α alone by A66 treatment is sufficient to block insulin signalling to Akt/PKB in certain cell lines that harbor H1047R mutations in PIK3CA and have high levels of p110α and class-Ia PI3K activity. Group: Pharmaceutical. Alternative Names: A66; A-66; A 66. CAS No. 1166227-08-2. Pack Sizes: 1mg;1g;10g. Product ID: 1166227-08-2. Molecular formula: C17H23N5O2S2. Mole weight: 393.53. Custom synthesis is available. Send your inquiries for more information. |  London |
| Amarogentin | Amarogentin exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways and displays immunomodulatory effects in human mast cells and keratinocytes. It inhibits the growth of SNU-16 human gastric cancer cells (IC50 = 12.4 μM) and increases apoptosis when used at a concentration of 50 μM. Amarogentin dose-dependently reduces tumor growth in a SNU-16 nude mouse xenograft model. Amarogentin may offer therapeutic potential for preventing or treating thromboembolic disorders, it prevents platelet activation through the inhibition of PLC γ2-PKC cascade and MAPK pathway. Group: Pharmaceutical. Alternative Names: sweroside-2'-(3'',5'',3'''-trihydroxydiphenyl)-2''-carboxylic acid ester; (4aS)-6α-[2-O-[(3,3',5-Trihydroxy-1,1'-biphenyl-2-yl)carbonyl]-β-D-glucopyranosyloxy]-5β-vinyl-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-1-one. CAS No. 21018-84-8. Pack Sizes: 50 mg. Product ID: B1370-062768. Molecular formula: C29H30O13. Mole weight: 586.54. Custom synthesis is available. Send your inquiries for more information. | London |
| Chloroquine phosphate | Chloroquine phosphate is an antimalarial drug and weak intercalating agent. It inhibits TLR signalling in plasmacytoid dendritic cells (pDCs). It has been used in emergency of COVID-19. Uses: Anti-inflammatory agents, non-steroidal. Group: Pharmaceutical. Alternative Names: N4-(7-Chloro-4-quinolinyl)-N1,N1-dimethyl-1,4-pentanediamine diphosphate salt; Aralen diphosphate; C2301; C 2301; C-2301; Chloroquine Diphosphate. CAS No. 50-63-5. Pack Sizes: 100 g. Product ID: B2693-344737. Molecular formula: C18H32ClN3O8P2. Mole weight: 515.86. Custom synthesis is available. Send your inquiries for more information. | London |
| Geranylgeraniol | An intermediate in the lipidation of proteins, which plays a great importance for a variety of biological processes such as cell signalling. Group: Pharmaceutical. Alternative Names: Tetraprenol; Geranyl geraniol; (E,E,E)-Geranylgeraniol; trans-Geranylgeraniol; 3,7,11,15-tetramethylhexadeca-2E,6E,10E,14-tetraen-1-ol. CAS No. 24034-73-9. Pack Sizes: 5 g. Product ID: B2692-059518. Molecular formula: C20H34O. Mole weight: 290.48. Custom synthesis is available. Send your inquiries for more information. | London |
| GNE-6776 | GNE-6776 is a potent and non-covalent USP7 inhibitor with IC50 of 1.34 uM. GNE-6776 targets cellular USP7, MDM2, and p53 signalling pathways, and induces tumor cell death. Group: Pharmaceutical. Alternative Names: GNE 6776; GNE-6776; GNE6776; 5-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridyl]-N-methyl-pyridine-2-carboxamide. CAS No. 2009273-71-4. Pack Sizes: 5 mg. Product ID: B0084-284761. Molecular formula: C20H20N4O2. Mole weight: 348.406. Custom synthesis is available. Send your inquiries for more information. | London |
| Homoplantaginin | Homoplantaginin is a flavonoid glycoside found in Scoparia dulcis. Homoplantaginin ameliorates endothelial insulin resistance by inhibiting inflammation and modulating cell signalling via the IKKβ/IRS-1/pAkt/peNOS pathway, suggesting it may be used for the prevention and treatment of endothelial dysfunction associated with insulin resistance. Group: Pharmaceutical. Alternative Names: 5-hydroxy-2-(4-hydroxyphenyl)-6-methoxy-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside. CAS No. 17680-84-1. Pack Sizes: 25 mg. Product ID: B2703-465489. Molecular formula: C22H22O11. Mole weight: 462.4. Custom synthesis is available. Send your inquiries for more information. | London |
| Tricirbine | Triciribine is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity. Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival. Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3. It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways. Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 μM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day. Group: Pharmaceutical. Alternative Names: VQD-002; VQD 002; VQD002; API-2; Akt Inhibitor V; Pentaazacentopthylene; Tricyclic nucleoside; 1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine. CAS No. 35943-35-2. Pack Sizes: 100 mg. Product ID: B1370-090988. Molecular formula: C13H16N6O4. Mol | London |
| 1-(5-Carboxypentyl)-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate | 1-(5-Carboxypentyl)-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate, a highly sought-after fluorescent probe, has gained immense popularity in biomedical research due to its ability to detect minute cellular anomalies associated with cancer and other life-threatening diseases. Its application extends beyond its diagnostic potential and is frequently utilized in drug discovery initiatives aimed at identifying novel therapeutics that target specific and often elusive signaling pathways involved in disease progression. Its remarkable attributes and versatility have made it an indispensable tool in the ever-expanding realm of medical research. Group: Pharmaceutical. Alternative Names: 1-(5-carboxypentyl)-2,3,3-trimethyl-3H-indolium-5-sulfonate (IM OCS). CAS No. 146368-08-3. Pack Sizes: 100 mg. Product ID: B2699-050005. Molecular formula: C17H23NO5S. Mole weight: 353.4. Custom synthesis is available. Send your inquiries for more information. | London |
| 17-DMAG hydrochloride | 17-DMAG hydrochloride (Alvespimycin hydrochloride) is the hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to Hsp90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction. Group: Pharmaceutical. Alternative Names: 17-DMAG HCl; Alvespimycin HCl; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin Hydrochloride; 17-N-(2-Dimethylaminoethylamino)-17-demethoxy Geldanamycin Hydrochloride; 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin Hydrochloride; 17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin Hydrochloride; Alvespimycin Hydrochloride; DMAG Hydrochloride; NSC 707545 Hydrochloride; 17-DMAG Hydrochloride. CAS No. 467214-21-7. Pack Sizes: 100 mg. Product ID: BBF-05796. Molecular formula: C32H48N4O8.HCl. Mole weight: 653.21. Custom synthesis is available. Send your inquiries for more information. | London |
| 1-Butyl-2-[5-(1-butyl-1H-benzo[cd]indol-2-ylidene)-penta-1,3-dienyl]-benzo[cd]indolium tetrafluoroborate | 1-Butyl-2-[5-(1-butyl-1H-benzo[cd]indol-2-ylidene)-penta-1,3-dienyl]-benzo[cd]indolium tetrafluoroborate is a tetrafluoroborate compound that widely utilized within the field of biomedicine owing to its exceptional antitumor attributes. Through selective targeting of intricate signaling pathways implicated in the tumorigenesis process, it efficaciously impedes the proliferation of malignant cells. Furthermore, it exhibits remarkably encouraging therapeutic efficacy in combatting a diverse range of cancers, encompassing breast, prostate, and colon malignancies. Group: Pharmaceutical. Alternative Names: Infrared absorber 858; Benz[cd]indolium, 1-butyl-2-[5-(1-butylbenz[cd]indol-2(1H)-ylidene)-1,3-pentadien-1-yl]-, tetrafluoroborate(1-). CAS No. 1135933-68-4. Pack Sizes: 100 mg. Product ID: B1370-285592. Molecular formula: C35H35BF4N2. Mole weight: 570.48. Custom synthesis is available. Send your inquiries for more information. | London |
| 4-Nitrophenyl 2-acetamido-2-deoxy-3-O-(b-D-galactopyranosyl)-a-D-galactopyranoside | 4-Nitrophenyl 2-acetamido-2-deoxy-3-O-(b-D-galactopyranosyl)-a-D-galactopyranoside is a biomedical compound that is used in research for studying cellular signaling pathways and carbohydrate metabolism. It can be used to investigate the role of specific enzymes in glycosylation processes and to explore their potential as therapeutic targets in diseases related to abnormal glycosylation patterns such as cancer, diabetes and genetic disorders. Group: Pharmaceutical. Alternative Names: Gal-b-1-3-GalNAc-a-PNP; 4-Nitrophenyl galacto-N-bioside; p-NP galacto-N-bioside; PNP-aGal-b1,3-GalNAc; 4-Nitrophenyl 2-(acetylamino)-2-deoxy-3-O-β-D-galactopyranosyl-α-D-galactopyranoside; p-Nitrophenyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside. CAS No. 59837-14-8. Pack Sizes: 10 mg. Product ID: B1370-128837. Molecular formula: C20H28N2O13. Mole weight: 504.44. Custom synthesis is available. Send your inquiries for more information. | London |
| 9-ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile | 9-Ethyl-8-iodo-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, a promising therapeutic agent for the treatment of select neoplastic disorders, functions as a highly proficient suppressor of pathogenic kinase enzymes that exhibit heightened expression levels in malignant neoplastic cells. This mechanism of action, whereby key cellular signaling pathways are disrupted, culminates in the prevention of tumor growth and impairs the metastatic process. Group: Pharmaceutical. CAS No. 1256584-80-1. Pack Sizes: 100 mg. Product ID: B2699-281515. Molecular formula: C21H17IN2O. Mole weight: 440.28. Custom synthesis is available. Send your inquiries for more information. | London |
| A01 | A01 is a high affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM), which attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Study showed that it potentiated BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells. Group: Pharmaceutical. Alternative Names: Smurf1-IN-A01; Smurf1INA01; Smurf1 IN A01; Smurf1 inhibitor A01; Smurf1-inhibitor-A01; A01; A 01; A-01; [4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone; SMURF1 inhibitor A01. CAS No. 1007647-73-5. Pack Sizes: 1mg;1g;10g. Product ID: 1007647-73-5. Molecular formula: C22H20ClF3N4O3S. Mole weight: 512.93. Custom synthesis is available. Send your inquiries for more information. | London |
| a1,3-Galactobiosyl b-methyl glycoside | a1,3-Galactobiosyl b-methyl glycoside is regarded as a fundamental instrument in compound, enabling elucidation of the intricate mechanisms underlying distinct glycosylation patterns. Furthermore, it representing an invaluable asset in the realm of glycoside research and development and the investigation of their manifold impacting on cellular signaling pathways, particularly those intertwined with galactosidase deficiency and galactosemia. Group: Pharmaceutical. Alternative Names: Gala1-3Galb1-O-Me. Pack Sizes: 1mg;1g;10g. Molecular formula: C13H24O11. Mole weight: 356.32. Custom synthesis is available. Send your inquiries for more information. | London |
| A1F N-Glycan | A1F N-Glycan, the versatile biomolecule employed by the biomedical industry, is the key player in the in-depth scrutiny and diagnosis of diverse disorders - think cancer, Alzheimer's, and rheumatoid arthritis. Its multifaceted involvement in cell signaling pathways has made it a go-to diagnostic marker in countless clinical settings. Furthermore, the therapeutic potential of A1F N-Glycan has not gone unexploited; it forms the crux of several drug formulations aimed at combating these afflictions. Group: Pharmaceutical. Alternative Names: Monosialo (2,6), fucosylated biantennary (A1F); A1F glycan; FA2G2S1 Glycan; Mono-sialylated, galactosylated, core-fucosylated, bi-antennary N-linked glycan; Mannotriose-(fucosyl-di-[N-acetylglucosamine]), mono-sialyl-bis(galactosyl-N-acetylglucosaminyl); NeuNAc(Gal-GlcNAc)2Man3(GlcNAc)2Fuc; β-D-Glucopyranose, O-(N-acetyl-α-neuraminosyl)-[2→3(or 2→6)]-O-β-D-galactopyranosyl-(1→4)-O-2-(acetylamino)-2-deoxy-β-D-glucopyranosyl-(1→2)-O-α-D-mannopyranosyl-[1→3(or 1→6)]-O-[O-β-D-galactopyranosyl-(1→4)-O-2-(acetylamino)-2-deoxy-β-D-glucopyranosyl-(1→2)-α-D-mannopyranosyl-[1→6(or 1→3)]]-O-β-D-mannopyranosyl-(1→4)-O-2-(acetylamino)-2-deoxy-β-D-glucopyranosyl-(1→4)-O-[6-deoxy-α-L-galactopyranosyl-(1→6)]-2-(acetylamino)-2-deoxy-. CAS No. 571188-30-2. Pack Sizes: 1mg;1g;10g. Produc | London |
| A3 N-Glycan | A3 N-Glycan is a vital biomolecule commonly found on the surface of many cells. It plays a crucial role in various biological processes, such as cell signaling, immune response, and disease progression. This particular N-glycan is extensively studied in the biomedical industry due to its involvement in numerous diseases, including cancer, autoimmune disorders, and infectious diseases. Group: Pharmaceutical. Alternative Names: Trisialylated, galactosylated, triantennary (A3); A3 glycan; A3G3S3 Glycan; (NeuNAc-Gal-GlcNAc)3Man3(GlcNAc)2; Tri-sialylated, galactosylated, tri-antennary N-linked glycan; Mannotriose-di-(N-acetyl-D-glucosamine), tris(sialyl-galactosyl-N-acetyl-D-glucosaminyl; D-Glucose, O-(N-acetyl-α-neuraminosyl)-[2→3(or 2→6)]-O-β-D-galactopyranosyl-(1→4)-O-2-(acetylamino)-2-deoxy-β-D-glucopyranosyl-(1→2)-O-[O. CAS No. 145164-24-5. Pack Sizes: 1mg;1g;10g. Product ID: 145164-24-5. Molecular formula: C109H178N8O80. Mole weight: 2880.59. Custom synthesis is available. Send your inquiries for more information. | London |
| A-443654 | A-443654 is a potent small-molecule inhibitor of all three Akt serine/threonine kinases, induces Akt Ser-473 phosphorylation in all human cancer cell lines tested, including PTEN- and TSC2-deficient lines. It inhibits Akt-dependent signal transduction in cells and in vivo in a dose-responsive manner. Group: Pharmaceutical. Alternative Names: A443564; A-443564; A 443564. CAS No. 552325-16-3. Pack Sizes: 1mg;1g;10g. Product ID: 552325-16-3. Molecular formula: C24H23N5O. Mole weight: 397.47. Custom synthesis is available. Send your inquiries for more information. | London |
| A-770041 | A-770041 is an selective and orally bioavailable pyrazolo[3,4-d]pyrimidine exhibiting selectivity for Lck compared with previously reported compounds. It is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling. It is currently in the preclinical developlent stage and no clinical data are available. Group: Pharmaceutical. Alternative Names: A-770041; A 770041; A770041. CAS No. 869748-10-7. Pack Sizes: 1mg;1g;10g. Product ID: 869748-10-7. Molecular formula: C34H39N9O3. Mole weight: 621.73. Custom synthesis is available. Send your inquiries for more information. | London |
| ABC-1183 | ABC-1183 is an inhibitor of glycogen synthase kinase 3 (GSK-3) alpha, glycogen synthase kinase 3 (GSK-3) beta and cyclin dependent kinase 9 (CDK-9). It can induce cell apoptosis and various signaling pathways. ABC-1183 shows toxicity to many cell lines in humans and mice. Group: Pharmaceutical. Alternative Names: ABC1183; ABC 1183; NSC797769; NSC-797769. CAS No. 1042735-18-1. Pack Sizes: 1mg;1g;10g. Product ID: 1042735-18-1. Molecular formula: C18H14N4OS. Mole weight: 334.39. Custom synthesis is available. Send your inquiries for more information. | London |
| ABC99 | ABC99 is an N-hydroxyhydantoin (NHH) carbamate that inhibits the Wnt-deacylating enzyme NOTUM (IC50 = 13 nM). It preserves Wnt3A signaling in the presence of NOTUM (EC50 = 89 nM in a cell-based reporter assay). Group: Pharmaceutical. CAS No. 2331255-53-7. Pack Sizes: 1mg;1g;10g. Product ID: 2331255-53-7. Molecular formula: C22H21ClN4O5. Mole weight: 456.9. Custom synthesis is available. Send your inquiries for more information. | London |
| a,b-Methyleneguanosine 5'-diphosphate sodium salt | a,b-Methyleneguanosine 5'-diphosphate sodium salt, as a fundamental chemical compound, finds wide applications in the biomedical sector due to its therapeutic potential across diverse diseases. With its significant contribution to vital cellular mechanisms and signal transduction pathways, this compound essentially facilitates the synthesis and metabolism of guanosine triphosphate, a pivotal molecule implicated in numerous biological processes. Group: Pharmaceutical. Alternative Names: GMPCP; GPCP. Pack Sizes: 1mg;1g;10g. Molecular formula: C11H17N5O10P2·xNa. Mole weight: 441.23 (free acid). Custom synthesis is available. Send your inquiries for more information. | London |
| AC 265347 | AC 265347 is a CaSR biased allosteric modulator (pEC50 = 7.8-8.1) that bias signaling towards the accumulation of PERK1/2 and IP1. AC 265347 stimulates CaSR signaling in cellular proliferation and phosphatidyl inositol (PI) hydrolysis assays. It significantly activates human GABAB or type I PTH receptors. Group: Pharmaceutical. Alternative Names: AC 265347; AC-265347; AC265347; α-(2,4-Dimethylphenyl)-α-methyl-2-benzothiazolemethanol; 1-(1,3-benzothiazol-2-yl)-1-(2,4-dimethylphenyl)ethanol. CAS No. 1253901-26-6. Pack Sizes: 1mg;1g;10g. Product ID: 1253901-26-6. Molecular formula: C17H17NOS. Mole weight: 283.39. Custom synthesis is available. Send your inquiries for more information. | London |
| AC-55541 | AC-55541 is a novel small-molecule protease-activated receptor 2(PAR2) agonist which displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. It activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM. It was well absorbed when administered intraperitoneally to rats, reaching micromolar peak plasma concentrations. It was stable to metabolism by liver microsomes and maintained sustained exposure in rats. Uses: Ac-55541 stimulates cell proliferation, phosphatidylinositol hydrolysis, and calcium mobilization. Group: Pharmaceutical. Alternative Names: AC-55541; AC 55541; AC55541. (2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide;AC 55541;alpha-(Benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid (2E)-2-[1-(3-bromophenyl)ethylidene]hydrazide;N-[2-[(2E)-2-[1-(3-bromophenyl)ethylidene]hydrazinyl]-2-oxo-1-(4-oxo-3H-phthalazin-1-yl)ethyl]benzamide. CAS No. 916170-19-9. Pack Sizes: 300 mg. Product ID: B0084-271988. Molecular formula: C25H20BrN5O3. Mole weight: 518.36. Custom synthesis is available. Send your inquiries for more information. | London |
| Acalabrutinib | Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. Group: Pharmaceutical. Alternative Names: ACP-196; ACP196; ACP 196; Acalabrutinib; 4-[8-amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide. CAS No. 1420477-60-6. Pack Sizes: 250 mg. Product ID: B0084-470855. Molecular formula: C26H23N7O2. Mole weight: 465.52. Custom synthesis is available. Send your inquiries for more information. | London |
| Acalabrutinib-[d4] | Acalabrutinib-[d4] is a labelled version of Acalabrutinib. Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. Group: Pharmaceutical. Alternative Names: (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl-d4)benzamide; Acalabrutinib D4; Acalabrutinib-d4; 4-[8-Amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide-d4; ACP 196-d4; Calquence-d4. CAS No. 2699608-18-7. Pack Sizes: 5 mg. Product ID: BLP-003188. Molecular formula: C26H19D4N7O2. Mole weight: 469.53. Custom synthesis is available. Send your inquiries for more information. | London |
| Acalisib | Acalisib, also known as GS-9820, is an inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities. p110beta/delta PI3K inhibitor GS-9820 inhibits the activity of PI3K, thereby preventing the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), which decreases tumor cell proliferation and induces cell death. PI3K-mediated signaling is often dysregulated in cancer cells; the targeted inhibition of PI3K is designed to preserve PI3K signaling in normal, non-neoplastic cells. Group: Pharmaceutical. Alternative Names: GS-9820; GS9820; GS 9820; CAL-120; CAL 120; CAL120; Acalisib; UNII-OVW60IDW1D. CAS No. 870281-34-8. Pack Sizes: 1mg;1g;10g. Product ID: 870281-34-8. Molecular formula: C21H16FN7O. Mole weight: 401.405. Custom synthesis is available. Send your inquiries for more information. | London |
| Afuresertib | Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2110183 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Group: Pharmaceutical. Alternative Names: GSK-2110183; GSK 2110183; GSK2110183; GSK-2110183B; GSK 2110183B; GSK2110183B. CAS No. 1047644-62-1. Pack Sizes: 50 mg. Product ID: B1370-109132. Molecular formula: C18H17Cl2FN4OS. Mole weight: 427.32. Custom synthesis is available. Send your inquiries for more information. | London |
| AG 126 | Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM. AG 126 may represent a new approach for the therapy of inflammation. Uses: Anti- inflammation. Group: Pharmaceutical. Alternative Names: AG126; AG-126; Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile. CAS No. 118409-62-4. Pack Sizes: 100 mg. Product ID: B1370-195904. Molecular formula: C10H5N3O3. Mole weight: 215.16. Custom synthesis is available. Send your inquiries for more information. | London |
| AG-490 | Tyrphostin AG490 is a JAK-2 specific inhibitor, which inhibits phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: Tyrphostin AG 490; AG-490; AG490. CAS No. 133550-30-8. Pack Sizes: 25 mg. Product ID: B0084-164022. Molecular formula: C17H14N2O3. Mole weight: 294.31. Custom synthesis is available. Send your inquiries for more information. | London |
| ALK5 Inhibitor II hydrochloride | ALK5 inhibitor II was identified as a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (ALK5 autophosphorylation, IC50s = 4 nM, TGF-β cellular assay, IC50s = 18 nM, ALK5 binding in HepG2 cells, IC50s = 23 nM). This compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription. This product is a hydrochloride form. Group: Pharmaceutical. Alternative Names: E 616452; RepSox; SJN 2511. CAS No. 446859-33-2. Pack Sizes: 50 mg. Product ID: B0084-068993. Molecular formula: C17H13N5·HCl. Mole weight: 323.8. Custom synthesis is available. Send your inquiries for more information. | London |
| Alpelisib | Alpelisib, also known as BLY719, is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor BYL719 specifically inhibits PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in inhibition of tumor cell growth and survival in susceptible tumor cell populations. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents. Group: Pharmaceutical. Alternative Names: BYL-719; BYL719; BYL 719; Alpelisib. CAS No. 1217486-61-7. Pack Sizes: 100 mg. Product ID: B0084-457654. Molecular formula: C19H22F3N5O2S. Mole weight: 441.473. Custom synthesis is available. Send your inquiries for more information. | London |
| Altiratinib | Altiratinib, also known as DCC-270, DP-5164, is an oral, selective and highly potent inhibitor of MET, TIE2, VEGFR2 and TRK kinases with potential anticancer activity. DCC-2701 effectively reduces tumor burden in vivo and blocks c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro. Importantly, DCC-2701's anti-proliferative activity was dependent on c-MET activation induced by stromal human fibroblasts and to a lesser extent exogenous HGF. DCC-2701 may be superior to HGF antagonists that are in clinical trials and that pTyr(1349) levels might be a good indicator of c-MET activation and likely response to targeted therapy as a result of signals from the microenvironment. Group: Pharmaceutical. Alternative Names: DCC2701; DCC 2701; DCC-2701; DP 5164; DP5164; DP-5164; Altiratinib. CAS No. 1345847-93-9. Pack Sizes: 50 mg. Product ID: B2693-463181. Molecular formula: C26H21F3N4O4. Mole weight: 510.46. Custom synthesis is available. Send your inquiries for more information. | London |
| Avermectin B2a | Avermectin B2a is produced by the strain of Streptomyces avermitilis. It stimulates nerve cells to release Y-aminobutyric acid (GABA), which blocks the transmission of signals from the central nervous system to the motor nerve. It is not resistant to bacteria and fungi, but has strong activity to nematode parasites such as ancylostoma and Pteria, as well as insects such as flies. Abamectin B1a has the highest activity. Ivermectin obtained by catalytic hydrogenation contains 22 23- dihydroabamectin B1a (above 80%) and 22 23 dioxabamectin B1b (below 20%). Less active than B1a but less toxic. Used as repellent (subcutaneous or oral) for cattle, sheep and pigs, it is also effective against human filariasis. Group: Pharmaceutical. Alternative Names: Ivermectin EP Impurity C; (23S)-5-O-demethyl-23-hydroxy-22,23-dihydro-avermectin A1a. CAS No. 65195-57-5. Pack Sizes: 1mg;1g;10g. Product ID: BBF-00230. Molecular formula: C48H74O15. Mole weight: 891.09. Custom synthesis is available. Send your inquiries for more information. | London |
| Avicularin | Avicularin, a natural plant flavonoid isolated from the herbs of Polygonum aviculare, exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 macrophage cells. By decreasing C/EBPα-activated GLUT4-mediated glucose uptake in adipocytes and potently inhibiting fatty acid synthase, avicularin can inhibit the accumulation of the intracellular lipids. Uses: Anti-inflammatory. Group: Pharmaceutical. Alternative Names: Fenicularin; Quercetin 3-alpha-L-arabinofuranoside; Avicularoside. CAS No. 572-30-5. Pack Sizes: 10 mg. Product ID: NP1949. Molecular formula: C20H18O11. Mole weight: 434.4. Custom synthesis is available. Send your inquiries for more information. | London |
| AZD-4547 | AZD4547 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. AZD4547 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways, and, so, the inhibition of tumor cell proliferation and tumor cell death. Group: Pharmaceutical. Alternative Names: AZD-4547; AZD 4547; AZD4547; N-{3-[2-(3,5-Dimethoxyphenyl)ethyl]-1h-Pyrazol-5-Yl}-4-[(3r,5s)-3,5-Dimethylpiperazin-1-Yl]benzamide. CAS No. 1035270-39-3. Pack Sizes: 100 mg. Product ID: B0084-456576. Molecular formula: C26H33N5O3. Mole weight: 463.582. Custom synthesis is available. Send your inquiries for more information. | London |
| Bellidifolin | Bellidifolin is a xanthone that can be isolated from the plants of Gentiana species. Study shows that bellidifolin is a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica. Bellidifolin may contribute to the protective effects associated with nerve injury initiated by hypoxia by mechanisms related to inhibition of cell apoptosis independent of the ERK pathway, but may involve blockade of p38MAPK signaling pathway activation and downstream caspase-3 expression. Group: Pharmaceutical. Alternative Names: 1,5,8-Trihydroxy-3-methoxy-9H-xanthen-9-one. CAS No. 2798-25-6. Pack Sizes: 5 mg. Product ID: NP7359. Molecular formula: C14H10O6. Mole weight: 274.228. Custom synthesis is available. Send your inquiries for more information. | London |
| Bemcentinib | Bemcentinib is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may play an important role in cancer progression, invasion, metastasis, drug resistance, and patient mortality. R428 inhibits Axl with low nanomolar activity and blocked Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Pharmacologic investigations revealed favorable exposure after oral administration such that R428-treated tumors displayed a dose-dependent reduction in expression of the cytokine granulocyte macrophage colony-stimulating factor and the epithelial-mesenchymal transition transcriptional regulator Snail. In support of an earlier study, R428 inhibited angiogenesis in corneal micropocket and tumor models. R428 administration reduced metastatic burden and extended survival in MDA-MB-231 intracardiac and 4T1 orthotopic (median survival, >80 days compared with 52 days; P < 0.05) mouse models of breast cancer metastasis. Additionally, R428 synergized with cisplatin to enhance suppression of liver micrometastasis. Our results show that Axl signaling regulates breast cancer metastasis at multiple levels in tumor cells and tumor stromal cells and that selective Axl blockade confers therapeutic value in prolonging survival of animals bearing metast | London |
| Birinapant | Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. As a SMAC mimetic and IAP antagonist, TL32711 binds to and inhibits the activity of IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. Alternative Names: TL-32711; TL32711; TL 32711. Birinapant. CAS No. 1260251-31-7. Pack Sizes: 100 mg. Product ID: B0084-462223. Molecular formula: C42H56F2N8O6. Mole weight: 806.957. Custom synthesis is available. Send your inquiries for more information. | London |
| BML-284 | BML-284 is potent, selective and cell-permeable Wnt signaling activator. It induces β-catenin and transcription factor (TCF)-dependent transcriptional activity in 293T cells in a dose dependent manner with an EC50 of 0.7 mM in vitro. Uses: Bml-284 may be a useful tool in the study of physiological processes that involve the wnt pathway. Group: Pharmaceutical. Alternative Names: BML 284; 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine; 4-N-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2,4-diamine. CAS No. 853220-52-7. Pack Sizes: 25 mg. Product ID: B0084-474867. Molecular formula: C19H18N4O3. Mole weight: 350.37. Custom synthesis is available. Send your inquiries for more information. | London |
| BMS-911543 | BMS-911543 is an orally available JAK inhibitor with selectivity for JAK2. It inhibts JAK2, thereby preventing the JAK/STAT (signal transducer and activator of transcription) signaling cascade, including activation of STAT3. This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation. Group: Pharmaceutical. Alternative Names: BMS 911543. CAS No. 1271022-90-2. Pack Sizes: 20 mg. Product ID: B0084-457828. Molecular formula: C23H28N8O. Mole weight: 432.532. Custom synthesis is available. Send your inquiries for more information. | London |
| Brevilin A | Brevilin A, also called 6-O-Angeloylplenolina, is a natural sesquiterpenoid found in the herbs of Centipeda minima, it exhibits the antigiardial activity (IC50 = 16.1 μM) and is similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM). Brevilin A inhibits janus kinase activity and exhibits both strong STAT3 signal inhibition and STAT3 signal dependent cell growth inhibition. Uses: Anti-giardial. Group: Pharmaceutical. Alternative Names: 6-O-Angeloylplenolin. CAS No. 16503-32-5. Pack Sizes: 5 mg. Product ID: NP5612. Molecular formula: C20H26O5. Mole weight: 346.4. Custom synthesis is available. Send your inquiries for more information. | London |
| C16 Ceramide | C16 ceramide is an endogenous ceramide, generated by ceramide synthase 6 (CerS6), that acts as a lipid second messenger to regulate apoptosis and stress signaling. It has also been found to activate NF-κB and PKCζ3. Uses: A predominant, rather hydrophobic natural ceramide. activates a cytosolic serine/threonine protein phosphatase in t9 cells; induces egf receptor phosphorylation in a-431 cells; stimulates ceramide-activated protein kinase. Group: Pharmaceutical. Alternative Names: C16 Ceramide (d18:1/16:0); N-(hexadecanoyl)-sphing-4-enine; N-Palmitoylsphingosine. CAS No. 24696-26-2. Pack Sizes: 100 mg. Product ID: B1370-059982. Molecular formula: C34H67NO3. Mole weight: 537.9. Custom synthesis is available. Send your inquiries for more information. | London |
| C29 | C29 is a potential TLR2 inhibitor. C29 inhibited TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. Group: Pharmaceutical. Alternative Names: TLR2-IN-C29; TLR2 IN C29; TLR2INC29; TLR2-inhibitor-C29; TLR2 inhibitor-C29; TLR2 inhibitor C29. CAS No. 363600-92-4. Pack Sizes: 100 mg. Product ID: B1370-007320. Molecular formula: C16H15NO4. Mole weight: 285.3. Custom synthesis is available. Send your inquiries for more information. | London |
| CBS9106 | CBS9106, also known as BMS-566419, is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity. CRM1 plays an important role in the nuclear export of cargo proteins bearing nuclear exporting signal sequences. CBS9106 inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells, including multiple myeloma cells. CBS9106 reduces CRM1 protein levels significantly without affecting CRM1 mRNA expression. Oral administration of CBS9106 significantly suppresses tumor growth and prolongs survival in mice bearing tumor xenograft without a significant loss in body weight. A reduced level of CRM1 protein is also observed in tumor xenografts isolated from mice treated with CBS9106. Taken together, these results indicate that CBS9106 is a novel reversible CRM1 inhibitor and a promising clinical candidate. Group: Pharmaceutical. Alternative Names: SL-801; SL801; SL 801; CBS-9106; CBS 9106; BMS-566419; BMS566419; BMS 566419; 1H-Pyrrole-2,5-dione, 1-[[6-chloro-5-(trifluoromethyl)-2-pyridinyl]amino]-3-[(3,3-dimethylbutoxy)methyl]-4-methyl-. CAS No. 1076235-04-5. Pack Sizes: 10 mg. Product ID: B1370-462313. Molecular formula: C18H21ClF3N3O3. Mole weight: 419.83. Custom synthesis is available. Send your inquiries for more information. | London |
| CDDO Imidazolide | CDDO Imidozolide is a synthetic triterpenoid as a Nrf2 signaling activator with highly active in suppressing cellular proliferation of human leukemia and breast cancer cell. Uses: Nrf2 signaling activator. Group: Pharmaceutical. Alternative Names: 1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole; (4aR,6aR,6aS,6bR,8aS,12aS,14bS)-8a-(imidazole-1-carbonyl)-4,4,6a,6b,11,11,14b-heptamethyl-3,13-dioxo-4a,5,6,6a,7,8,9,10,12,12a-decahydropicene-2-carbonitrile. CAS No. 443104-02-7. Pack Sizes: 10 mg. Product ID: B2693-474173. Molecular formula: C34H43N3O3. Mole weight: 541.72. Custom synthesis is available. Send your inquiries for more information. | London |
| Cerdulatinib HCl | Cerdulatinib is a dual SYK/JAK inhibitor. It significantly reduces cell viability in a subset of NHL cell lines, and induces apoptosis in BCR-signaling competent NHL cell lines. Group: Pharmaceutical. Alternative Names: Cerdulatinib hydrochloride; PRT2070 hydrochloride; 4-(cyclopropylamino)-2-[4-(4-ethylsulfonylpiperazin-1-yl)anilino]pyrimidine-5-carboxamide hydrochloride. CAS No. 1369761-01-2. Pack Sizes: 10 mg. Product ID: B0084-463402. Molecular formula: C20H28ClN7O3S. Mole weight: 482. Custom synthesis is available. Send your inquiries for more information. | London |
| CGM097 | CGM097 is an orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival. Group: Pharmaceutical. Alternative Names: CGM097; CGM-097; CGM 097; NVPCGM097; NVPCGM 097; NVPCGM-097; NVP CGM097; NVP CGM 097; NVP CGM-097. CAS No. 1313363-54-0. Pack Sizes: 5 mg. Product ID: B0084-462483. Molecular formula: C38H47ClN4O4. Mole weight: 659.27. Custom synthesis is available. Send your inquiries for more information. | London |
| Chicanin | Chicanin is a lignan isolated from the fruits of Osmanthus fragrans. Studies show that chicanine exhibits anti-inflammatory activity on murine macrophage by down-regulating LPS-induced inflammatory cytokines in IκBα/MAPK/ERK signaling pathways and anti-proliferative effect on prostate cells. Group: Pharmaceutical. Alternative Names: 4-[(2R,3S,4R,5R)-5-(1,3-benzodioxol-5-yl)-3,4-dimethyloxolan-2-yl]-2-methoxyphenol. CAS No. 78919-28-5. Pack Sizes: 5 mg. Product ID: B0005-053763. Molecular formula: C20H22O5. Mole weight: 342.391. Custom synthesis is available. Send your inquiries for more information. | London |
| Chrysophanol | Chrysophanic acid (Chrysophanol) is a natural anthraquinone with anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells. Chrysophanic acid preferentially blocked proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression. Chrysophanic acid treatment in SNU-C5 cells inhibited EGF-induced phosphorylation of EGFR and suppressed activation of downstream signaling molecules, such as AKT, extracellular signal-regulated kinase (ERK) and the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic acid (80 and 120 μm) significantly blocked cell proliferation when combined with the mTOR inhibitor, rapamycin. These findings offer the first evidence of anticancer activity for chrysophanic acid via EGFR/mTOR mediated signaling transduction pathway. Chrysophanol is a natural compound found in the roots and rhizomes of Rheum palmatum L. It can be used in cosmetics material. Uses: Anti-inflammatory. Group: Pharmaceutical. Alternative Names: 1,8-dihydroxy-3-methylanthracene-9,10-dione. CAS No. 481-74-3. Pack Sizes: 1 g. Product ID: NP0901. Molecular formula: C15H10O4. Mole weight: 254.24. Custom synthesis is available. Send your inquiries for more information. | London |
| Cirsilineol | Cirsilineol is a trimethoxyflavone isolated from Artemisia and from Teucrium gnaphalodes. It selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4+ T cells. Group: Pharmaceutical. Alternative Names: Fastigenin; Cirsileneol; Eupatrin; Anisomelin. CAS No. 41365-32-6. Pack Sizes: 50 mg. Product ID: NP2434. Molecular formula: C18H16O7. Mole weight: 344.32. Custom synthesis is available. Send your inquiries for more information. | London |
| Copanlisib | Copanlisib is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. BAY 80-6946 inhibits the activation of the PI3K signaling pathway, which may result in the inhibition of tumor cell growth and survival in susceptible tumor cell populations. Group: Pharmaceutical. Alternative Names: BAY 80-6946; Aliqopa; BAY-80-6946; 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide. CAS No. 1032568-63-0. Pack Sizes: 50 mg. Product ID: B0084-456551. Molecular formula: C23H28N8O4. Mole weight: 480.529. Custom synthesis is available. Send your inquiries for more information. | London |
| Corosolic acid | Corosolic acid, that is isolated from the barks of Lagerstroemia speciosa, contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts its anticancer activity against colon cancer cells by promoting the N-terminal phosphorylation and subsequent proteasomal degradation of β-catenin. Besides, Corosolic acid induced apoptosis in colorectal cancer (CRC), rendering this compound a potential anticancer agent for the treatment of CRC. Corosolic acid, as a new plant medicine for preventing and treating obesity and type II diabetes, and a functional natural health food and pharmaceutical raw material, has become a popular product in the market. Uses: Anti-angiogenic/anticancer. Group: Pharmaceutical. Alternative Names: 2-A-HYDROXYURSOLIC ACID; 2ALPHA-HYDROXYURSOLIC ACID; 2,3-DIHYDROXYURS-12-EN-28-OIC ACID; HYDROXYURSOLIC ACID; COROSOLIC ACID; Corsolicacid; Corosolic; (2a,3b)-2,3-Dihydroxy-urs-12-en-28-oic acid. CAS No. 4547-24-4. Pack Sizes: 50 mg. Product ID: NP7232. Molecular formula: C30H48O4. Mole weight: 472.7. Custom synthesis is available. Send your inquiries for more information. | London |
| CroCin | Crocin is a water-soluble carotenoid pigment in saffron (Crocus sativus L.) with anti-inflammatory, antioxidant, anti-apoptosis, anti-asthma, anti-cancer, anti-allergy, relaxation of smooth muscle and hypolipidemic effects. Crocin inhibits tumor necrosis factor (TNF) α-induced pheochromocytoma (PC12) apoptosis by regulating the mRNA expression of Bcl-2 family proteins, which trigger downstream signals that ultimately lead to caspase-3 activation and subsequent cell death. Uses: Antioxidant, anticancer. Group: Pharmaceutical. Alternative Names: Crocin (Gardenia Fruits Extract); β-D-Glucopyranose, 6-O-β-D-glucopyranosyl-, 1,1'-[(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate]; 8,8'-Diapo-ψ,ψ-carotenedioic acid, bis(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl) ester; all-trans-Crocetin di-β-D-gentiobiosyl ester; Crocetin bis(gentiobiosyl) ester; Crocetin di(β-D-gentiobiosyl) ester; Crocetin di-β-gentiobiosyl ester; Crocetin digentiobioside; Crocin 1; Crocin 4; Crocin A; Crocin I; Kiriyasu Oil Yellow GY; trans-Crocetin di(β-D-gentiobiosyl) ester; Trans-crocin-1; trans-Crocin-1; Trans-crocin-4; α-Crocin. CAS No. 42553-65-1. Pack Sizes: 100 mg. Product ID: B2703-002922. Molecular formula: C44H64O24. Mole weight: 976.96. Custom synthesis is available. Send your inquiries for more information. | London |
| CU-CPT-9b | CU-CPT-9b is a TLR8 inhibitor that inhibits TLR8-mediated proinflammatory signaling in various cell lines and human primary cells. Group: Pharmaceutical. Alternative Names: CU-CPT9a; 2-Methyl-4-(7-methoxy-4-quinolinyl)phenol; CU CPT 9a; BCP29122; BCP-29122; CUCPT9a; BCP 29122; 4-(7-methoxy-1H-quinolin-4-ylidene)-2-methylcyclohexa-2,5-dien-1-one; Phenol, 4-(7-methoxy-4-quinolinyl)-2-methyl-; 4-(7-Methoxy-4-quinolinyl)-2-methylphenol. CAS No. 2165340-32-7. Pack Sizes: 10 mg. Product ID: B0084-260289. Molecular formula: C17H15NO2. Mole weight: 265.31. Custom synthesis is available. Send your inquiries for more information. | London |
| Dasatinib | Dasatinib, also known as BMS-354825, is an orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases. Dasatinib binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, dasatinib has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. Group: Pharmaceutical. Alternative Names: BMS-354825; BMS354825; BMS354825. CAS No. 302962-49-8. Pack Sizes: 25 g. Product ID: NP3264. Molecular formula: C22H26ClN7O2S. Mole weight: 488.01. Custom synthesis is available. Send your inquiries for more information. | London |
| Decapeptide-18 | Decapeptide-18, also known as CG-WINT, is a synthetic peptide that plays a significant role in promoting hair growth. It is composed of arginine, cysteine, glutamine, glutamic acid, histidine, threonine and valine. It is derived from the Wnt10 signaling pathway and is designed to stimulate the formation of hair placodes, which are essential for hair follicle development. This peptide exhibits higher stability and skin penetration compared to the natural Wnt10 peptide, making it effective in activating hair follicles and promoting the differentiation of hair follicle epithelial stem cells into hair keratinocytes. Additionally, Decapeptide-18 is recognized for its potential in enhancing hair density and strength, making it a valuable ingredient in hair care formulations aimed at combating hair loss and promoting hair growth. Group: Pharmaceutical. Alternative Names: CG-WINT; Decapeptide 18. CAS No. 3032916-63-2. Pack Sizes: 100 mg. Product ID: BAT-016731. Custom synthesis is available. Send your inquiries for more information. | London |
| Defactinib | Defactinib, also known as VS-6063 and PF-04554878, is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities. FAK inhibitor PF-04554878 inhibits FAK, which may prevent the integrin-mediated activation of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt, thus inhibiting tumor cell migration, proliferation and survival. The tyrosine kinase FAK is , a signal transducer for integrins that is upregulated in many tumor cell types and is involved in tumor cell invasion, migration and proliferation. Group: Pharmaceutical. Alternative Names: N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide; VS6063; VS 6063; VS-6063; PF04554878; PF-04554878; PF 04554878; PF4554878; PF-4554878. CAS No. 1073154-85-4. Pack Sizes: 200 mg. Product ID: B0084-462762. Molecular formula: C20H21F3N8O3S. Mole weight: 510.496. Custom synthesis is available. Send your inquiries for more information. | London |
| δ-Tocotrienol | δ-Tocotrienol is from palm oil. Delta-tocotrienol is a potential angiogenic inhibitor that significantly suppresses human colorectal adenocarcinoma cells (DLD-1-CM)-induced tube formation, migration, and adhesion on human umbilical vein endothelial cells. Delta-tocotrienol is a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSCLC) cell proliferation, induce apoptosis and inhibit invasion, and thus offer a potential starting point for the design of novel anticancer agents. Delta-tocotrienol displays significant radioprotective effects that protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling. Group: Pharmaceutical. Alternative Names: [R-(E,E)]-3,4-Dihydro-2,8-dimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol; (2R)-3,4-Dihydro-2,8-dimethyl-2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-2H-1-benzopyran-6-ol; 2,8-Dimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-6-chromanol; (R)-δ-Tocotrienol; 8-Methyltocotrienol; d-δ-Tocotrienol. CAS No. 25612-59-3. Pack Sizes: 50 mg. Product ID: NP4617. Molecular formula: C27H40O2. Mole weight: 396.6. Custom synthesis is available. Send your inquiries for more information. | London |
| Deoxyandrographolide | Deoxyandrographolide is a natural compound extracted from the herbs of Andrographis paniculata (Burm. f.) Nees. It could potently inhibit the growth of liver (HepG2 and SK-Hep1) and bile duct (HuCCA-1 and RMCCA-1) cancer cells. It controlled ethanol-induced hepatosteatosis by interfering with dysregulation of lipid metabolism. It was capable of preventing the development of fatty liver through AMPK-mediated regulation of lipid metabolism. It reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner in concentrations between 10-100 microM. It reduced PAF-induced calcium flux in the presence of extracellular calcium. It mediated activation of adenylate cyclase-cAMP signaling leading to up-regulation of cNOS may provide a promising approach in the prevention of liver diseases during chronic alcoholism. Uses: Deoxyandrographolide could potently inhibit the growth of liver (hepg2 and sk-hep1) and bile duct (hucca-1 and rmcca-1) cancer cells. it controlled ethanol-induced hepatosteatosis by interfering with dysregulation of lipid metabolism. it reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner in concentrations between 10-100 microm. it reduced p. Group: Pharmaceutical. Alternative Names: 4-[2-[(4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-2,5,8a-trimethyl-3,4,4a,6,7,8-hexahydronaphthalen-1-yl]ethyl]-2H-furan-5-one;2 | London |
| Duvelisib | Duvelisib, also known as IPI-145 and INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration, PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike other isoforms of PI3K, the delta and gamma isoforms are overexpressed primarily in hematologic malignancies and inflammatory and autoimmune diseases. By selectively targeting these PI3K isoforms, PI3K signaling in normal, non-neoplastic cells is minimally or not affected which would result in a more favorable side effect profile. Uses: For research used only. Group: Pharmaceutical. Alternative Names: IPI145; IPI 145; IPI-145. INK-1197; INK 1197; INK1197; Duvelisib. CAS No. 1201438-56-3. Pack Sizes: 100 mg. Product ID: B0084-462545. Molecular formula: C22H17ClN6O. Mole weight: 416.869. Custom synthesis is available. Send your inquiries for more information. | London |
| Emodin | Emodin is an anthraquinone found naturally in the roots and barks of numerous plants. It exerts antiproliferative effects in cancer cells that are regulated by different signaling pathways. It has anti-cancer, anti-depressant and anti-microbial effects. Group: Pharmaceutical. Alternative Names: Emodol; Frangula emodin; HSDB 7093; NSC 408120; NSC 622947; 3-methyl-1,6,8-trihydroxyanthraquinone; 1,3,8-Trihydroxy-6-methyl-9,10-anthracenedione; 1,6,8-Trihydroxy-3-methylanthraquinone; 4,5,7-Trihydroxy-2-methylanthraquinone; Archin; Frangulic Acid; Rheum Emodin; Schuttgelb. CAS No. 518-82-1. Pack Sizes: 50 g. Product ID: BBF-04483. Molecular formula: C15H10O5. Mole weight: 270.24. Custom synthesis is available. Send your inquiries for more information. | London |
| Encorafenib | Encorafenib, also known as LGX-818, is an orally available Raf kinase inhibitor with potential antineoplastic activity. LGX818 specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival. Group: Pharmaceutical. Alternative Names: LGX818; LGX-818; LGX 818; Methyl N-[(2S)-1-[[4-[3-[5-chloro-2-fluoro-3-(methanesulfonamido)phenyl]-1-propan-2-ylpyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate. CAS No. 1269440-17-6. Pack Sizes: 150 mg. Product ID: B0084-462563. Molecular formula: C22H27ClFN7O4S. Mole weight: 540.011. Custom synthesis is available. Send your inquiries for more information. | London |
| Eriocalyxin B | Eriocalyxin B, isolated from the herbs of Isodon eriocalyx, is a potent NF-kappaB inhibitor. Eriocalyxin B inhibited the NF-kappaB transcriptional activity but not that of cAMP response element-binding protein. eriocalyxin B reversibly interfered with the binding of p65 and p50 subunits to the DNA in a noncompetitive manner. Eriocalyxin B exerts potent antiinflammatory effects through selective modulation of pathogenic Th1 and Th17 cells by targeting critical signaling pathways. Besides, Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways. Eriocalyxin B should be considered a candidate for pancreatic cancer treatment. Uses: Antiinflammatory. Group: Pharmaceutical. Alternative Names: Rabdosianone. CAS No. 84745-95-9. Pack Sizes: 1 mg. Product ID: NP1304. Molecular formula: C20H24O5. Mole weight: 344.4. Custom synthesis is available. Send your inquiries for more information. | London |
| EW-7197 | EW-7197 is a potent and selective ALK5 inhibitor, displaying antimetastatic and anticancer effects. It inhibits TGF-β/Smad signaling, and abrogates TGF-β1-induced tumor cell migration and invasion. EW-7197 inhibits breast cancer metastasis to the lung. EW-7197 prolongs the life span of BALB/c 4T1 mice via inhibition of EMT. EW-7197 inhibits metastasis and enhances the activity of cytotoxic T lymphocytes (CTLs) in 4T1 orthotopic grafted mice. Group: Pharmaceutical. Alternative Names: Vactosertib; N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1,2,4]triazolo[1,5-a]pyridin-6-yl-1H-imidazole-2-methanamine. CAS No. 1352608-82-2. Pack Sizes: 50 mg. Product ID: B0084-462343. Molecular formula: C22H18FN7. Mole weight: 399.433. Custom synthesis is available. Send your inquiries for more information. | London |
| Exherin | Exherin, also known as ADH-1, is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis. N-cadherin, a cell- surface transmembrane glycoprotein of the cadherin superfamily of proteins involved in calcium-mediated cell-cell adhesion and signaling mechanisms; may be upregulated in some aggressive tumors and the endothelial cells and pericytes of some tumor blood vessels. Group: Pharmaceutical. Alternative Names: NSC729477; ADH-1; NSC7 29477; ADH 1; NSC-729477; ADH1. CAS No. 229971-81-7. Pack Sizes: 10 mg. Product ID: BAT-010745. Molecular formula: C22H34N8O6S2. Mole weight: 570.69. Custom synthesis is available. Send your inquiries for more information. | London |
| Ezatiostat | Ezatiostat is a glutathione analog that acts as an inhibitor of glutathione S-transferase (GST) P1-1. TLK117, the active form of ezatiostat, inhibits GSTP1-1, resulting in phosphorylation of JNK, restoring JNK-mediated cellular proliferation and differentiation signaling pathways. Group: Pharmaceutical. Alternative Names: Telintra; Gamma-Glu-S-BzCys-PhGly diethyl ester; TLK-199; TLK 199. CAS No. 168682-53-9. Pack Sizes: 25 mg. Product ID: BAT-010079. Molecular formula: C27H35N3O6S. Mole weight: 529.652. Custom synthesis is available. Send your inquiries for more information. | London |
| FIPI | FIPI, a derivative of halopemide, is a potent and selective phospholipase D (PLD) inhibitor with IC50 values of 20 and 25 nM for PLD2 and PLD1 respectively. It attenuate mercury-induced lipid signaling leading to protection against cytotoxicity in aortic endothelial cells. It rapidly blocks in vivo PA production with subnanomolar potency. It has good pharmacokinetic parameters in rats. It did not significantly inhibit p38 or ERK phosphorylation in bone marrow-derived macrophages stimulated with lipopolysaccharide. It prevents PLD regulation of F-actin cytoskeleton reorganization, cell spreading, and chemotaxis. Group: Pharmaceutical. Alternative Names: 5-Fluoro-2-Indolyl des-Chlorohalopemide; N-[2-[4-(2,3-Dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-5-fluoro-1H-indole-2-carboxamide; 5-Fluoro-N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)-1H-indole-2-carboxamide. CAS No. 939055-18-2. Pack Sizes: 100 mg. Product ID: B2693-438324. Molecular formula: C23H24FN5O2. Mole weight: 421.47. Custom synthesis is available. Send your inquiries for more information. | London |
| Fosbretabulin disodium | Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combretum caffrum) with potential vascular disrupting and antineoplastic activities. Upon administration, the prodrug fosbretabulin is dephosphorylated to its active metabolite, the microtubule-depolymerizing agent combretastatin A4, which binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, this agent disrupts the engagement of the endothelial cell-specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and so the activity of the VE-cadherin/β-catenin/Akt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation. As a result of fosbretabulin's dual mechanism of action, the tumor vasculature collapses, resulting in reduced tumor blood flow and ischemic necrosis of tumor tissue. Group: Pharmaceutical. Alternative Names: Combretastatin A-4 phosphate disodium, CA4P; CA4DP; Combretastatin A-4 phosphate. CAS No. 168555-66-6. Pack Sizes: 100 mg. Product ID: B0084-085514. Molecular formula: C18H19Na2O8P. Mole weight: 440.295. Custom synthesis is available. Send your inquiries for more information. | London |
| FOXO4-DRI | FOXO4-DRI is a peptide acting as a specific FOXO4 blocker. It has been demonstrated to alleviate age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice.FOXO4-DRI is a peptide acting as a specific FOXO4 blocker. It has been demonstrated to alleviate age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. FOXO4-DRI is a standard FOXO4 protein that is synthesized to prevent normal FOXO4 from binding to p53, thereby eliminating senescent cells and improving organ function and the ''biological age'' of young tissues. FOXO4-DRI affects a variety of cellular processes, including insulin signaling, cell cycle regulation, and oxidative stress signaling pathways, it is a cell-penetrative peptide, meaning it can enter cells from the inside and perform its role, and it has been shown in animal studies to selectively induce apoptosis in senescence cells, potentially reversing some of the effects of aging. Group: Pharmaceutical. Alternative Names: FOXO 4-DRI; Anti-aging peptide FOXO4-DRI; H-D-Leu-D-Thr-D-Leu-D-Arg-D-Lys-D-Glu-D-Pro-D-Ala-D-Ser-D-Glu-D-Ile-D-Ala-D-Gln-D-Ser-D-Ile-D-Leu-D-Glu-D-Ala-D-Tyr-D-Ser-D-Gln-D-Asn-D-Gly-D-Trp-D-Ala-D-Asn-D-Arg-D-Arg-D-Ser-D-Gly-D-Gly-D-Lys-D-Arg-D-Pro-D-Pro-D-Pro-D-Arg-D-Arg-D-Arg-D-Gln-D-Arg-D-Arg-D-Lys-D-Lys-D-Arg-D-Gly-OH; Forkhead box O transcription factor 4-D-Retro-Inverso; Proxofim; D-Retro Inv. CAS No. 2460055 | London |
| Futibatinib | Futibatinib is an orally bioavailable, selective and irreversible inhibitor of fibroblast growth factor receptors (FGFRs), displaying antineoplastic activity. It inhibits FGFR-mediated signal transduction and tumor cell proliferation. Group: Pharmaceutical. Alternative Names: 1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]-1-pyrazolo[3,4-d]pyrimidinyl]-1-pyrrolidinyl]-2-propen-1-one; 1-[(3S)-3-[4-amino-3-[2-(3,5-dimethoxyphenyl)ethynyl]pyrazolo[3,4-d]pyrimidin-1-yl]pyrrolidin-1-yl]prop-2-en-1-one. CAS No. 1448169-71-8. Pack Sizes: 250 mg. Product ID: B2693-292398. Molecular formula: C22H22N6O3. Mole weight: 418.45. Custom synthesis is available. Send your inquiries for more information. | London |
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