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| Product | Description | |
|---|---|---|
| Cathepsin S inhibitor | Cathepsin S is expressed in antigen-presenting cells and plays a role in invariant chain processing and major histocompatibility complex class II (MHCII) antigen presentation leading to CD4+ T-cell activation. An oral Cathepsin S inhibitor that blocks MHCII antigen presentation could result in a T-cell-selective immunosuppressant agent with improved safety over the current standard of care for the treatment of rheumatoid arthritis, psoriasis, multiple sclerosis and other autoimmune-based inflammatory diseases. Group: Pharmaceutical. Alternative Names: LY3000328; LY-3000328; LY 3000328. Cathepsin S inhibitor. CAS No. 1373215-15-6. Pack Sizes: 10 mg. Product ID: B0084-463202. Molecular formula: C25H29FN4O5. Mole weight: 484.52. Custom synthesis is available. Send your inquiries for more information. |  London |
| L-Arginine 4-nitroanilide dihydrochloride | L-Arginine 4-nitroanilide dihydrochloride is an organic compound used in medical research and laboratory experiments. It is also a chromogenic substrate for cathepsin H and aminopeptidases. Group: Pharmaceutical. Alternative Names: L-Arg-pNA 2HCl; (S)-2-Amino-5-guanidino-N-(4-nitrophenyl)pentanamide dihydrochloride; (2S)-2-amino-5-(diaminomethylideneamino)-N-(4-nitrophenyl)pentanamide,dihydrochloride. CAS No. 40127-11-5. Pack Sizes: 25 g. Product ID: BAT-003957. Molecular formula: C12H20Cl2N6O3. Mole weight: 367.23. Custom synthesis is available. Send your inquiries for more information. | London |
| Odanacatib | Odanacatib, also known as MK-0822, is an inhibitor of cathepsin K with potential anti-osteoporotic activity. Odanacatib selectively binds to and inhibits the activity of cathepsin K, which may result in a reduction in bone resorption, improvement of bone mineral density, and a reversal in osteoporotic changes. Cathepsin K, a tissue-specific cysteine protease that catalyzes degradation of bone matrix proteins such as collagen I/II, elastin, and osteonectin plays an important role in osteoclast function and bone resorption. Uses: For research used only. Group: Pharmaceutical. Alternative Names: MK0822; MK-0822; MK 0822; Odanacatib. CAS No. 603139-19-1. Pack Sizes: 100 mg. Product ID: B0084-095375. Molecular formula: C25H27F4N3O3S. Mole weight: 525.56. Custom synthesis is available. Send your inquiries for more information. | London |
| RETF-4NA | RETF-4NA is a sensitive substrate for chymase when free or bound to α2M. It is selectively hydrolyzed by chymase but not by cathepsin G. Group: Pharmaceutical. Alternative Names: acetyl-L-Arg-Glu-Thr-Phe-4-nitroanilide. CAS No. 1160928-63-1. Pack Sizes: 10 mg. Product ID: BAT-010838. Molecular formula: C32H43N9O10. Mole weight: 713.75. Custom synthesis is available. Send your inquiries for more information. | London |
| TMC-58B | Aurantiamide, a natural alkaloid found in the herbs of Walsura yunnanensis, is used as significant anti-inflammatory and antinociceptive. it can serve as the natural compound for inhibiting cysteine proteinases, in particular, cathepsin L (3.4.22.15) and B (3.4.22.1) with IC50 of 12 microM and 49 microM, respectively. It may suppress the growth of malignant gliomas by blocking autophagic flux. Uses: Anti-neuroinflammatory; anti-inflammatory; antinociceptive. Group: Pharmaceutical. Alternative Names: (S)-α-(Benzoylamino)-N-[(S)-1-(hydroxymethyl)-2-phenylethyl]benzenepropanamide. CAS No. 58115-31-4. Pack Sizes: 1 mg. Product ID: NP0417. Molecular formula: C25H26N2O3. Mole weight: 402.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Ulinastatin | Ulinastatin is an acid-resistant protease inhibitor derived from human urine, acting as a potent anti-inflammatory agent. It was shown to inhibit the activities of a variety of enzymes, including trypsin, chymotrypsin, thrombin, kallikrein, plasmin, elastase, cathepsin, lipase, hyaluronidase, factors IXa, Xa, XIa, and XlIa, and polymorphonuclear leukocyte elastase. Group: Pharmaceutical. Alternative Names: Urinastatin; 2,4-Dioxaspiro[5.5]undec-8-ene, 3-(2-furanyl)-. CAS No. 80449-31-6. Pack Sizes: 1 g. Product ID: B2693-135299. Molecular formula: C13H16O3. Mole weight: 220.26. Custom synthesis is available. Send your inquiries for more information. | London |
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