Find where to buy products from UK suppliers, including: distributors, industrial manufacturers, wholesalers, raw ingredients, bulk supplies and finished goods for sale.
Search for products or services, then visit the suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the USA.
| Product | Description | |
|---|---|---|
| Ac-WEHD-AFC | Ac-WEHD-AFC is a fluorogenic substrate for group I caspases including caspase-1, -4, and -5. Caspase activity can be quantified by fluorescent detection of free AFC (7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm. Group: Pharmaceutical. Alternative Names: Caspase 1 (ICE) Substrate 3f; fluorogenic, Ac-WEHD-AFC; N-Acetyl-L-tryptophyl-L-alpha-glutamyl-L-histidyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-alpha-asparagine; N-Acetyl-Trp-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin trifluoroacetate salt. CAS No. 210344-99-3. Pack Sizes: 50 mg. Product ID: BAT-010219. Molecular formula: C38H37F3N8O11. Mole weight: 838.7. Custom synthesis is available. Send your inquiries for more information. |  London |
| Alsterpaullone | Alsterpaullone is a potent glycogen synthase kinase-3 inhibitor and a potential therapeutic agent for the treatment of Parkinson disease. Alsterpaullone is also known as 9-Nitropaullone and NSC 705701, which is a derivative of kenpaullone and an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Alsterpaullone induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Alsterpaullone is a derivative of kenpaullone with slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively. Group: Pharmaceutical. Alternative Names: 9-Nitropaullone; NSC 705701; 7,12-Dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one. CAS No. 237430-03-4. Pack Sizes: 50 mg. Product ID: B2693-103248. Molecular formula: C16H11N3O3. Mole weight: 293.3. Custom synthesis is available. Send your inquiries for more information. | London |
| Belnacasan | Belnacasan is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM. Belnacasan inhibits interlukin-1β biosynthesis. Group: Pharmaceutical. Alternative Names: VX 765, VX765, VX-765, Belnacasan; (2S)-1-[(2S)-2-[(4-amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide. CAS No. 273404-37-8. Pack Sizes: 50 mg. Product ID: B0084-307700. Molecular formula: C24H33ClN4O6. Mole weight: 509. Custom synthesis is available. Send your inquiries for more information. | London |
| Epieriocalyxin A | Epieriocalyxin A (EpiA), a diterpenoid isolated from I. eriocalyx, suppressed Caco-2 colon cancer cell growth. Western blot results showed that both JNK and ERK1/2 activation was decreased after Epieriocalyxin A treatment in a dose-dependent manner. Epieriocalyxin A increased the expression of caspase 3 and Bax, and decreased Bcl2 expression. Our results suggest that Epieriocalyxin A is a novel compound that induces colon cancer apoptosis. Epieriocalyxin A could be a potential drug for colon cancer therapy in the future. Uses: Anti-cancer. Group: Pharmaceutical. Alternative Names: Spiro[1H-7,9a-methanolocyclohepta[c]pyran-4(3H),1'-[3]cyclohexene]-6'-carboxaldehyde, 4a,5,6,7,8,9-hexahydro-5',5',8-trimethyl-1,2',9-trioxo-, (1'S,4aS,6'R,7R,8R,9aS)-. CAS No. 191545-24-1. Pack Sizes: 1 mg. Product ID: NP1352. Molecular formula: C20H24O5. Mole weight: 344.4. Custom synthesis is available. Send your inquiries for more information. | London |
| Glaucocalyxin A | Glaucocalyxin A, which is extracted from the herbs of Rabdosia rubescens, inhibited Akt phosphorylation, suppressed proliferation, and promoted apoptosis in a dose-dependent manner, but not in normal glial cells. Glaucocalyxin A activated caspase-3, decreased BAD phosphorylation, and reduced the expression of X-linked inhibitor of apoptosis protein. Glaucocalyxin A inhibited collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GP? pathway. Uses: Antiplatelet/antithrombotic. Group: Pharmaceutical. Alternative Names: LeukaMenin F; Wangzaozin B; Leucamenin F. CAS No. 79498-31-0. Pack Sizes: 10 mg. Product ID: NP1506. Molecular formula: C20H28O4. Mole weight: 332.43. Custom synthesis is available. Send your inquiries for more information. | London |
| Morin | Morin induces caspase-dependent apoptosis through extrinsic pathway by upregulating Fas receptor as well as through the intrinsic pathway by modulating Bcl-2 and IAP family members. Uses: Anti-cancer. Group: Pharmaceutical. Alternative Names: TIMTEC-BB SBB008853; MORIN; 3,5,7,2',4'-PENTAHYDROXYFLAVONE; 2',3,4',5,7-PENTAHYDROXYFLAVONE; FUSTIC; CI 75660; CI NO 75660; 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4h-1-benzopyran-4-on. CAS No. 480-16-0. Pack Sizes: 100 g. Product ID: B2703-092919. Molecular formula: C15H10O7. Mole weight: 302.24. Custom synthesis is available. Send your inquiries for more information. | London |
| Morin hydrate | Morin is a natural compound isolated from Maclura pomifera (Osage orange). Morin induces caspase-dependent apoptosis through extrinsic pathway by upregulating Fas receptor as well as through the intrinsic pathway by modulating Bcl-2 and IAP family members. Uses: Anti-cancer. Group: Pharmaceutical. Alternative Names: 4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-, hydrate (1:x); 2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one hydrate (1:x); 4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-, hydrate; Flavone, 2',3,4',5,7-pentahydroxy-, hydrate; 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one hydrate. CAS No. 654055-01-3. Pack Sizes: 100 g. Product ID: B2703-465104. Molecular formula: C15H10O7.xH2O. Mole weight: 302.24 (anhydrous basis). Custom synthesis is available. Send your inquiries for more information. | London |
| Pseudolaric acid B | Pseudolaric acid B (PAB), which comes from the bark of Pseudolarix kaempferi Gordon, has diverse effects that are relevant to cancer therapy, including apoptosis of cancer cells (IC50 = ~1 μM), preventing angiogenesis, and inhibiting tumor growth in vivo. pseudolaric acid B can trigger apoptosis by decreasing Bcl-2 levels and activating caspase-3 protease. The future development of PAB as a cancer therapeutic is ongoing. Besides, PAB significantly suppressed proliferation of DU145 cells in a dose-dependent manner without obvious cytotoxicity. PAB may inhibit growth of HRPC DU145 cells and induce apoptosis through ROS generation and Bcl-2 degradation via the activation of the ubiquitin-proteasome pathway. Uses: Antifungal/antifertility. Group: Pharmaceutical. Alternative Names: PLAB; 1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylicacid,4a-(acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-,7-methyl ester, (3R,4S,4aS,9aR)-; Pseudolarix acid B; Pseudolaric acid. CAS No. 82508-31-4. Pack Sizes: 10 mg. Product ID: NP1536. Molecular formula: C23H28O8. Mole weight: 432.46. Custom synthesis is available. Send your inquiries for more information. | London |
| Silidianin | Silydianin is an active constituent of Silybium marianum and is known the exhibit anti-inflammatory activity which regulates caspase-3 activation which affects cell membranes and acts as a free radical scavenger. Group: Pharmaceutical. Alternative Names: Silidianine; (+)-2,3α,3aα,7a-Tetrahydro-7aα-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-(3α,5,7-trihydroxy-4-oxo-2β-chromanyl)-3,6-methanobenzofuran-7(6αH)-one; [3R-[3α,3aβ,4(2R*,3R*),6α,7aβ,8R*]]-4-(3,4-Dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl)-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-3,6-methanobenzofuran-7(6H)-one; (3R,3aR,6R,7aR,8R)-4-[(2R,3R)-3,4-dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-3,6-methanobenzofuran-7(6H)-one. CAS No. 29782-68-1. Pack Sizes: 100 mg. Product ID: B2703-464840. Molecular formula: C25H22O10. Mole weight: 482.4. Custom synthesis is available. Send your inquiries for more information. | London |
| Spathulenol | Spathulenol is isolated from the herbs of Salvia sclarea. It shows the capacity to inhibit proliferation in the lymphocytes, inducing apoptosis in these cells possibly through a caspase-3 independent pathway. Uses: Immunoinhibitory effect. Group: Pharmaceutical. Alternative Names: (1aR,4aR,7S,7aR,7bR)-1,1,7-Trimethyl-4-methylenedecahydro-1H-cyclopropa[e]azulen-7-ol; 10(14)-aromadendren-4-ol. CAS No. 6750-60-3. Pack Sizes: 5 mg. Product ID: NP5608. Molecular formula: C15H24O. Mole weight: 220.35. Custom synthesis is available. Send your inquiries for more information. | London |
| VER-155008 | VER-155008 is an adenosine-derived inhibitor of heat shock protein 70 (Hsp70; IC50 = 0.5 μM) that is selective over Hsp90. It targets the nucleotide-binding domain (NBD) of Hsp70 and similarly binds the NBDs of Hsp70 cognates Hsc70 (Ki = 10 μM) and glucose-regulated protein 78 (Grp78; KD = 80 nM). VER-155008 inhibits the proliferation of human breast and colon cancer cell lines, inducing apoptosis or caspase-independent cell death. It induces the proteasome-dependent degradation of Hsp90 client proteins and potentiates the apoptotic activity of Hsp90 inhibitors. VER-15508 also triggers paraptosis in anaplastic thyroid carcinoma cells. Group: Pharmaceutical. Alternative Names: 8-(3,4-Dichlorobenzyl)amino-5'-O-(4-cyanobenzyl)adenosine; C07; VER 155008; VER155008; 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-Adenosine; 4-((((2R,3S,4R,5R)-5-(6-amino-8-(3,4-dichlorobenzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)methyl)benzonitrile. CAS No. 1134156-31-2. Pack Sizes: 100 mg. Product ID: B1370-272446. Molecular formula: C25H23Cl2N7O4. Mole weight: 556.4. Custom synthesis is available. Send your inquiries for more information. | London |
| Vitexin | Vitexin is a class of nature lignan compounds isolated from the seeds of Vitex trifolia L. What different from the classic lignans is its action and anticancer effect is mediated by the mechanisms, vitexin-induced antitumor effect and cytotoxic activity is exerted through proapoptotic process, which is mediated by a decreased Bcl-2/Bax ratio and activation of caspases. Vitexin inhibits the activities of anti-nociceptive, anti-spasmodic and anti-oxidant. Uses: Anti-nociceptive; anti-spasmodic; anti-oxidant. Group: Pharmaceutical. Alternative Names: 8-D-Glucosyl-4,5,7-trihydroxy-flavone; 8-C-b-D-Glucopyranosylapigenin; Oritentoside. CAS No. 3681-93-4. Pack Sizes: 50 mg. Product ID: NP1869. Molecular formula: C21H20O10. Mole weight: 432.38. Custom synthesis is available. Send your inquiries for more information. | London |
Our database is helping our users find suppliers everyday.
