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| Product | Description | |
|---|---|---|
| Ac-AAVALLPAVLLALLAP-DEVD-CHO trifluoroacetate salt | Ac-AAVALLPAVLLALLAP-DEVD-CHO is a composite of Ac-DEVD-CHO, a peptide inhibitor of caspase-3 and -7, and a cell-permeable hydrophobic sequence derived from K-FGF. Group: Pharmaceutical. Alternative Names: Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO; Ac-AAVALLPAVLLALLAP-DEVD-aldehyde; Ac-AAVALLPAVLLALLAPDEVD-CHO; ?Caspase-3 Inhibitor I; DEVD-CHO-CPP 32. Pack Sizes: 1mg;1g;10g. Molecular formula: C94H158N20O27·xCF3COOH. Mole weight: 2000.42. Custom synthesis is available. Send your inquiries for more information. |  London |
| Ac-AAVALLPAVLLALLAP-IETD-CHO trifluoroacetate salt | Ac-AAVALLPAVLLALLAP-IETD-CHO is a composite of Ac-IETD-CHO, a peptide inhibitor of caspase-8, and a cell-permeable hydrophobic sequence derived from K-FGF. Group: Pharmaceutical. Alternative Names: Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-CHO; Caspase-8 Inhibitor I. Pack Sizes: 1mg;1g;10g. Molecular formula: C95H162N20O26·xCF3COOH. Mole weight: 2000.4. Custom synthesis is available. Send your inquiries for more information. | London |
| Ac-AAVALLPAVLLALLAP-VAD-CHO trifluoroacetate salt | Ac-AAVALLPAVLLALLAP-VAD-CHO is a composite of Ac-VAD-CHO, a non-selective caspase inhibitor, and a cell-permeable hydrophobic sequence derived from K-FGF. Group: Pharmaceutical. Alternative Names: Caspase Inhibitor II; Ac-AAVALLPAVLLALLAP-VAD-aldehyde; Ac-AAVALLPAVLLALLAPVAD-CHO. Pack Sizes: 1mg;1g;10g. Molecular formula: C88H151N19O22·xCF3COOH. Mole weight: 1827.3. Custom synthesis is available. Send your inquiries for more information. | London |
| Ac-FLTD-CMK | Ac-FLTD-CMK is a potent and selective inhibitor of caspases 1, 5 and 4 (IC50 values = 46.7 nM, 0.33 μM, 1.49 μM, respectively) that inhibits gasdermin D (GSDMD) cleavage. Group: Pharmaceutical. Alternative Names: N-acetyl-Phe-Leu-Thr-Asp-chloromethylketone. CAS No. 2376255-48-8. Pack Sizes: 5 mg. Product ID: BAT-009973. Molecular formula: C26H37ClN4O8. Mole weight: 569.05. Custom synthesis is available. Send your inquiries for more information. | London |
| Ac-WEHD-AFC | Ac-WEHD-AFC is a fluorogenic substrate for group I caspases including caspase-1, -4, and -5. Caspase activity can be quantified by fluorescent detection of free AFC (7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm. Group: Pharmaceutical. Alternative Names: Caspase 1 (ICE) Substrate 3f; fluorogenic, Ac-WEHD-AFC; N-Acetyl-L-tryptophyl-L-alpha-glutamyl-L-histidyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-alpha-asparagine; N-Acetyl-Trp-Glu-His-Asp-7-amido-4-trifluoromethylcoumarin trifluoroacetate salt. CAS No. 210344-99-3. Pack Sizes: 50 mg. Product ID: BAT-010219. Molecular formula: C38H37F3N8O11. Mole weight: 838.7. Custom synthesis is available. Send your inquiries for more information. | London |
| Alsterpaullone | Alsterpaullone is a potent glycogen synthase kinase-3 inhibitor and a potential therapeutic agent for the treatment of Parkinson disease. Alsterpaullone is also known as 9-Nitropaullone and NSC 705701, which is a derivative of kenpaullone and an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Alsterpaullone induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Alsterpaullone is a derivative of kenpaullone with slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively. Group: Pharmaceutical. Alternative Names: 9-Nitropaullone; NSC 705701; 7,12-Dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one. CAS No. 237430-03-4. Pack Sizes: 50 mg. Product ID: B2693-103248. Molecular formula: C16H11N3O3. Mole weight: 293.3. Custom synthesis is available. Send your inquiries for more information. | London |
| Aristololactam | The cytotoxic potency of Aristololactam I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase 3-dependent pathway. Group: Pharmaceutical. Alternative Names: aristololactam; 8-methoxy[1,3]benzodioxolo[6,5,4-cd]benzo[f]indol-5(6H)-one. CAS No. 13395-02-3. Pack Sizes: 10 mg. Product ID: B2703-223426. Molecular formula: C17H11NO4. Mole weight: 293.27. Custom synthesis is available. Send your inquiries for more information. | London |
| Bellidifolin | Bellidifolin is a xanthone that can be isolated from the plants of Gentiana species. Study shows that bellidifolin is a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica. Bellidifolin may contribute to the protective effects associated with nerve injury initiated by hypoxia by mechanisms related to inhibition of cell apoptosis independent of the ERK pathway, but may involve blockade of p38MAPK signaling pathway activation and downstream caspase-3 expression. Group: Pharmaceutical. Alternative Names: 1,5,8-Trihydroxy-3-methoxy-9H-xanthen-9-one. CAS No. 2798-25-6. Pack Sizes: 5 mg. Product ID: NP7359. Molecular formula: C14H10O6. Mole weight: 274.228. Custom synthesis is available. Send your inquiries for more information. | London |
| Belnacasan | Belnacasan is a potent and selective inhibitor of caspase-1 with Ki of 0.8 nM. Belnacasan inhibits interlukin-1β biosynthesis. Group: Pharmaceutical. Alternative Names: VX 765, VX765, VX-765, Belnacasan; (2S)-1-[(2S)-2-[(4-amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide. CAS No. 273404-37-8. Pack Sizes: 50 mg. Product ID: B0084-307700. Molecular formula: C24H33ClN4O6. Mole weight: 509. Custom synthesis is available. Send your inquiries for more information. | London |
| Betulinic acid | Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induces apoptosis through induction of changes in mitochondrial membrane potential, production of reactive oxygen species, and opening of mitochondrial permeability transition pores, resulting in the release of mitochondrial apogenic factors, activation of caspases, and DNA fragmentation. Betulinic acid is a natural compound found in the herbs of Ziziphus jujuba. It can be used in cosmetics material. Uses: Anti-melanogenic/antitumor/anti-hiv. Group: Pharmaceutical. Alternative Names: ALS357; ALS 357; ALS-357; Mairin; Lupatic Acid; 3beta-Hydroxy-20(29)-lupaene-28-oic acid. CAS No. 472-15-1. Pack Sizes: 10 g. Product ID: NP6980. Molecular formula: C30H48O3. Mole weight: 456.7. Custom synthesis is available. Send your inquiries for more information. | London |
| Birinapant | Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. As a SMAC mimetic and IAP antagonist, TL32711 binds to and inhibits the activity of IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. Alternative Names: TL-32711; TL32711; TL 32711. Birinapant. CAS No. 1260251-31-7. Pack Sizes: 100 mg. Product ID: B0084-462223. Molecular formula: C42H56F2N8O6. Mole weight: 806.957. Custom synthesis is available. Send your inquiries for more information. | London |
| Boc-D-FMK | BOC-D-FMK is a cell-permeable broad-spectrum caspase inhibitor that fully inhibits the pro-apoptotic effect of tumor necrosis factor-α (TNFα). It has been found to reduce the activation of nuclear factor kappa light chain enhancer of activated B cells (NF-kB), suppress the phosphorylation of subunit nuclear factor kappa light polypeptide gene enhancer in B cells inhibitor α (IkBα) and inhibit TNF-induced expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1). Moreover, it has also effectively attenuated the hepatocyte apoptosis in bile duct-ligated rats potentially improving the survival rates. Uses: Caspase inhibitors. Group: Pharmaceutical. Alternative Names: Boc-Asp(OMe)-fluoromethyl ketone; Caspase Inhibitor 3; N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone; BAF; Boc-D-Fluoromethyl Ketone; Boc-D(OMe)-FMK; 3S-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid, methyl ester; Caspase Inhibitor III. CAS No. 187389-53-3. Pack Sizes: 100 mg. Product ID: BAT-010386. Molecular formula: C11H18FNO5. Mole weight: 263.26. Custom synthesis is available. Send your inquiries for more information. | London |
| CroCin | Crocin is a water-soluble carotenoid pigment in saffron (Crocus sativus L.) with anti-inflammatory, antioxidant, anti-apoptosis, anti-asthma, anti-cancer, anti-allergy, relaxation of smooth muscle and hypolipidemic effects. Crocin inhibits tumor necrosis factor (TNF) α-induced pheochromocytoma (PC12) apoptosis by regulating the mRNA expression of Bcl-2 family proteins, which trigger downstream signals that ultimately lead to caspase-3 activation and subsequent cell death. Uses: Antioxidant, anticancer. Group: Pharmaceutical. Alternative Names: Crocin (Gardenia Fruits Extract); β-D-Glucopyranose, 6-O-β-D-glucopyranosyl-, 1,1'-[(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate]; 8,8'-Diapo-ψ,ψ-carotenedioic acid, bis(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl) ester; all-trans-Crocetin di-β-D-gentiobiosyl ester; Crocetin bis(gentiobiosyl) ester; Crocetin di(β-D-gentiobiosyl) ester; Crocetin di-β-gentiobiosyl ester; Crocetin digentiobioside; Crocin 1; Crocin 4; Crocin A; Crocin I; Kiriyasu Oil Yellow GY; trans-Crocetin di(β-D-gentiobiosyl) ester; Trans-crocin-1; trans-Crocin-1; Trans-crocin-4; α-Crocin. CAS No. 42553-65-1. Pack Sizes: 100 mg. Product ID: B2703-002922. Molecular formula: C44H64O24. Mole weight: 976.96. Custom synthesis is available. Send your inquiries for more information. | London |
| Cucurbitacin D | Source from rhizomes of Hemsleya amabilis Diels. It might be a new therapeutic option for the treatment of endometrial and ovarian cancers, also may be a potential therapeutic agent for β-hemoglobinopathies, including sickle cell anemia and β-thalassemia. And it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells. Uses: Antitumor, resistance to chemical carcinogens, protect liver. Group: Pharmaceutical. Alternative Names: 17-[(3E)-1,5-Dihydroxy-1,5-dimethyl-2-oxohex-3-en-1-yl]-2,16-dihydroxy-4,4,9,14-tetramethylestr-5-ene-3,11-dione. CAS No. 3877-86-9. Pack Sizes: 5 mg. Product ID: B0005-464521. Molecular formula: C30H44O7. Mole weight: 516.67. Custom synthesis is available. Send your inquiries for more information. | London |
| Diclofenac Potassium | Diclofenac potassium is a nonsteroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and as an analgesic reducing pain in certain conditions. It is a competitive inhibitor of cyclooxygenase (COX) that suppresses the production of prostaglandins. Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade. Uses: Nsaid. Group: Pharmaceutical. Alternative Names: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Potassium Salt; [o-(2,6-Dichloroanilino)phenyl]acetic Acid Monopotassium Salt; 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Monopotassium Salt; Caflam; Cataflam; K-fenak; Potassium diclofenac. CAS No. 15307-81-0. Pack Sizes: 20 g. Product ID: B0084-059596. Molecular formula: C14H10Cl2KNO2. Mole weight: 334.24. Custom synthesis is available. Send your inquiries for more information. | London |
| Epieriocalyxin A | Epieriocalyxin A (EpiA), a diterpenoid isolated from I. eriocalyx, suppressed Caco-2 colon cancer cell growth. Western blot results showed that both JNK and ERK1/2 activation was decreased after Epieriocalyxin A treatment in a dose-dependent manner. Epieriocalyxin A increased the expression of caspase 3 and Bax, and decreased Bcl2 expression. Our results suggest that Epieriocalyxin A is a novel compound that induces colon cancer apoptosis. Epieriocalyxin A could be a potential drug for colon cancer therapy in the future. Uses: Anti-cancer. Group: Pharmaceutical. Alternative Names: Spiro[1H-7,9a-methanolocyclohepta[c]pyran-4(3H),1'-[3]cyclohexene]-6'-carboxaldehyde, 4a,5,6,7,8,9-hexahydro-5',5',8-trimethyl-1,2',9-trioxo-, (1'S,4aS,6'R,7R,8R,9aS)-. CAS No. 191545-24-1. Pack Sizes: 1 mg. Product ID: NP1352. Molecular formula: C20H24O5. Mole weight: 344.4. Custom synthesis is available. Send your inquiries for more information. | London |
| Eriocalyxin B | Eriocalyxin B, isolated from the herbs of Isodon eriocalyx, is a potent NF-kappaB inhibitor. Eriocalyxin B inhibited the NF-kappaB transcriptional activity but not that of cAMP response element-binding protein. eriocalyxin B reversibly interfered with the binding of p65 and p50 subunits to the DNA in a noncompetitive manner. Eriocalyxin B exerts potent antiinflammatory effects through selective modulation of pathogenic Th1 and Th17 cells by targeting critical signaling pathways. Besides, Eriocalyxin B induces apoptosis and cell cycle arrest in pancreatic adenocarcinoma cells through caspase- and p53-dependent pathways. Eriocalyxin B should be considered a candidate for pancreatic cancer treatment. Uses: Antiinflammatory. Group: Pharmaceutical. Alternative Names: Rabdosianone. CAS No. 84745-95-9. Pack Sizes: 1 mg. Product ID: NP1304. Molecular formula: C20H24O5. Mole weight: 344.4. Custom synthesis is available. Send your inquiries for more information. | London |
| GDC-0152 | GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0152 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2, which may inhibit their activities and promote the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Smac, the endogenous IAP antagonist, relies on its N-terminal four amino-acid motif for binding to IAPs. Group: Pharmaceutical. Alternative Names: GDC-0152; GDC0152; GDC 0152. CAS No. 873652-48-3. Pack Sizes: 50 mg. Product ID: B2693-462525. Molecular formula: C25H34N6O3S. Mole weight: 498.646. Custom synthesis is available. Send your inquiries for more information. | London |
| Ginsenoside-Rb3 | Ginsenoside Rb3 is a natural triterpenoid saponin. It has various pharmacological effects. It possesses the effect against isoproterenol-induced myocardial injury and heart function impairment, and that the mechanism of pharmacological action was related to the antioxidant activity of ginsenoside Rb3 at least in part. It could markedly protected OGD-Rep induced ischemic injury and the mechanisms maybe related to its suppression of the intracellular Ca2+ elevation and inhibition of apoptosis and caspase activity. It could be a promising candidate in the development of a novel class of anti-ischemic agent. Uses: Ginsenoside rb3 inhibits the upregulation of phospho-iκb-α and nuclear translocation of nf-κb subunit p65 induced by glucose deprivation then reperfusion. Group: Pharmaceutical. Alternative Names: (3b,12b)-3-[(2-O-b-D-Glucopyranosyl-b-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 6-O-(b-D-glucopyranosyl)-b-D-glucopyranoside; Gypenoside IV. CAS No. 68406-26-8. Pack Sizes: 20 mg. Product ID: NP7002. Molecular formula: C53H90O22. Mole weight: 1079.27. Custom synthesis is available. Send your inquiries for more information. | London |
| Glaucocalyxin A | Glaucocalyxin A, which is extracted from the herbs of Rabdosia rubescens, inhibited Akt phosphorylation, suppressed proliferation, and promoted apoptosis in a dose-dependent manner, but not in normal glial cells. Glaucocalyxin A activated caspase-3, decreased BAD phosphorylation, and reduced the expression of X-linked inhibitor of apoptosis protein. Glaucocalyxin A inhibited collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GP? pathway. Uses: Antiplatelet/antithrombotic. Group: Pharmaceutical. Alternative Names: LeukaMenin F; Wangzaozin B; Leucamenin F. CAS No. 79498-31-0. Pack Sizes: 10 mg. Product ID: NP1506. Molecular formula: C20H28O4. Mole weight: 332.43. Custom synthesis is available. Send your inquiries for more information. | London |
| Lactonic Sophorolipid | Lactonic sophorolipid is a natural antimicrobial surfactant for oral hygiene. Lactonic sophorolipid, a potential anticancer agent, induces apoptosis in human HepG2 cells through the caspase-3 pathway. Uses: Widely used in oilfield field, environmental remediation field, agriculture, animal husbandry and aquaculture fields, daily chemicals, cleaning, personal care: it can replace chemical surfactants, with excellent surface performance, safety, biodegradability, strong detergency, low foam type and easy to rinse. Group: Pharmaceutical. Alternative Names: 17-L-[(2'-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-cis-9-octadecenoic acid 1',4''-lactone 6',6''-diacetate; Lactonic (di-acetylated) Sophorolipids; 9-Octadecenoic acid, 17-[[6-O-acetyl-2-O-(6-O-acetyl-β-D-glucopyranosyl)-β-D-glucopyranosyl]oxy]-, intramol. 1,4''-ester, (9Z,17S)-; 9-Octadecenoic acid, 17-[[6-O-acetyl-2-O-(6-O-acetyl-β-D-glucopyranosyl)-β-D-glucopyranosyl]oxy]-, intramol. 1,4''-ester, [S-(Z)]-. CAS No. 148409-20-5. Pack Sizes: 5 g. Product ID: B1370-003897. Custom synthesis is available. Send your inquiries for more information. | London |
| LCL-161 | LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. SMAC mimetic LCL161 binds to IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9, which play essential roles in apoptosis (programmed cell death), necrosis and inflammation. Group: Pharmaceutical. Alternative Names: LCL161; LCL 161; LCL-161. CAS No. 1005342-46-0. Pack Sizes: 25 mg. Product ID: B0084-462558. Molecular formula: C26H33FN4O3S. Mole weight: 500.633. Custom synthesis is available. Send your inquiries for more information. | London |
| Morin | Morin induces caspase-dependent apoptosis through extrinsic pathway by upregulating Fas receptor as well as through the intrinsic pathway by modulating Bcl-2 and IAP family members. Uses: Anti-cancer. Group: Pharmaceutical. Alternative Names: TIMTEC-BB SBB008853; MORIN; 3,5,7,2',4'-PENTAHYDROXYFLAVONE; 2',3,4',5,7-PENTAHYDROXYFLAVONE; FUSTIC; CI 75660; CI NO 75660; 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4h-1-benzopyran-4-on. CAS No. 480-16-0. Pack Sizes: 100 g. Product ID: B2703-092919. Molecular formula: C15H10O7. Mole weight: 302.24. Custom synthesis is available. Send your inquiries for more information. | London |
| Morin hydrate | Morin is a natural compound isolated from Maclura pomifera (Osage orange). Morin induces caspase-dependent apoptosis through extrinsic pathway by upregulating Fas receptor as well as through the intrinsic pathway by modulating Bcl-2 and IAP family members. Uses: Anti-cancer. Group: Pharmaceutical. Alternative Names: 4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-, hydrate (1:x); 2-(2,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one hydrate (1:x); 4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-, hydrate; Flavone, 2',3,4',5,7-pentahydroxy-, hydrate; 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one hydrate. CAS No. 654055-01-3. Pack Sizes: 100 g. Product ID: B2703-465104. Molecular formula: C15H10O7.xH2O. Mole weight: 302.24 (anhydrous basis). Custom synthesis is available. Send your inquiries for more information. | London |
| (-)-Perillic acid | (S)-(-)-Perillic acid, a terpenoid plant, may act to elicit cytotoxicity, induces cell apoptosis and cell cycle arrest, and increases the levell of Bax, Bcl2, p21 and caspase-3 proteins. Group: Pharmaceutical. Alternative Names: (S)-4-(1-Methylethenyl)-1-cyclohexene-1-carboxylic acid; (S)-4-Isopropenylcyclohexene-1-carboxylic acid; L(-)-Perillic acid; (S)-(-)-Perillic acid. CAS No. 23635-14-5. Pack Sizes: 5 g. Product ID: B1370-204586. Molecular formula: C10H14O2. Mole weight: 166.22. Custom synthesis is available. Send your inquiries for more information. | London |
| Plitidepsin | Plitidepsin is a cyclic depsipeptide isolated from the marine tunicate Aplidium albicans. Plitidepsin shows potent anticancer activity against a large variety of cultured human cancer cells, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation. This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth. Group: Pharmaceutical. Alternative Names: aplidin; aplidine; plitidepsin; dehydrodidemnin B. CAS No. 137219-37-5. Pack Sizes: 1 mg. Product ID: BAT-010093. Molecular formula: C57H87N7O15. Mole weight: 1110.34. Custom synthesis is available. Send your inquiries for more information. | London |
| Pseudolaric acid B | Pseudolaric acid B (PAB), which comes from the bark of Pseudolarix kaempferi Gordon, has diverse effects that are relevant to cancer therapy, including apoptosis of cancer cells (IC50 = ~1 μM), preventing angiogenesis, and inhibiting tumor growth in vivo. pseudolaric acid B can trigger apoptosis by decreasing Bcl-2 levels and activating caspase-3 protease. The future development of PAB as a cancer therapeutic is ongoing. Besides, PAB significantly suppressed proliferation of DU145 cells in a dose-dependent manner without obvious cytotoxicity. PAB may inhibit growth of HRPC DU145 cells and induce apoptosis through ROS generation and Bcl-2 degradation via the activation of the ubiquitin-proteasome pathway. Uses: Antifungal/antifertility. Group: Pharmaceutical. Alternative Names: PLAB; 1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylicacid,4a-(acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-,7-methyl ester, (3R,4S,4aS,9aR)-; Pseudolarix acid B; Pseudolaric acid. CAS No. 82508-31-4. Pack Sizes: 10 mg. Product ID: NP1536. Molecular formula: C23H28O8. Mole weight: 432.46. Custom synthesis is available. Send your inquiries for more information. | London |
| Saikosaponin C | Saikosaponin C is extracted from the root of Bupleurum chinense DC. It efficiently inhibited LPS-induced apoptotic cell death via inhibition of caspase-3 activation and caspase-3-mediated-FAK degradation. It exhibits anti-HBV activity. It may have the potential for therapeutic angiogenesis but is not suitable for cancer therapy. Group: Pharmaceutical. Alternative Names: (3beta,4alpha,16beta)-13,28-Epoxy-16,23-dihydroxyolean-11-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranoside; [13,28-Epoxy-16β-hydroxyolean-11-en-3β-yl] 4-O-(6-deoxy-α-L-mannopyranosyl)-6-O-(β-D-glucopyranosyl)-β-D-glucopyranoside; (3β,16β)-13,28-Epoxy-16-hydroxyolean-11-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-[β-D-glucopyranosyl-(1→6)]-β-D-glucopyranoside; Cyclosaponin C. CAS No. 20736-08-7. Pack Sizes: 20 mg. Product ID: NP7007. Molecular formula: C48H78O17. Mole weight: 927.12. Custom synthesis is available. Send your inquiries for more information. | London |
| Silidianin | Silydianin is an active constituent of Silybium marianum and is known the exhibit anti-inflammatory activity which regulates caspase-3 activation which affects cell membranes and acts as a free radical scavenger. Group: Pharmaceutical. Alternative Names: Silidianine; (+)-2,3α,3aα,7a-Tetrahydro-7aα-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-(3α,5,7-trihydroxy-4-oxo-2β-chromanyl)-3,6-methanobenzofuran-7(6αH)-one; [3R-[3α,3aβ,4(2R*,3R*),6α,7aβ,8R*]]-4-(3,4-Dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl)-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-3,6-methanobenzofuran-7(6H)-one; (3R,3aR,6R,7aR,8R)-4-[(2R,3R)-3,4-dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-3,6-methanobenzofuran-7(6H)-one. CAS No. 29782-68-1. Pack Sizes: 100 mg. Product ID: B2703-464840. Molecular formula: C25H22O10. Mole weight: 482.4. Custom synthesis is available. Send your inquiries for more information. | London |
| Spathulenol | Spathulenol is isolated from the herbs of Salvia sclarea. It shows the capacity to inhibit proliferation in the lymphocytes, inducing apoptosis in these cells possibly through a caspase-3 independent pathway. Uses: Immunoinhibitory effect. Group: Pharmaceutical. Alternative Names: (1aR,4aR,7S,7aR,7bR)-1,1,7-Trimethyl-4-methylenedecahydro-1H-cyclopropa[e]azulen-7-ol; 10(14)-aromadendren-4-ol. CAS No. 6750-60-3. Pack Sizes: 5 mg. Product ID: NP5608. Molecular formula: C15H24O. Mole weight: 220.35. Custom synthesis is available. Send your inquiries for more information. | London |
| VER-155008 | VER-155008 is an adenosine-derived inhibitor of heat shock protein 70 (Hsp70; IC50 = 0.5 μM) that is selective over Hsp90. It targets the nucleotide-binding domain (NBD) of Hsp70 and similarly binds the NBDs of Hsp70 cognates Hsc70 (Ki = 10 μM) and glucose-regulated protein 78 (Grp78; KD = 80 nM). VER-155008 inhibits the proliferation of human breast and colon cancer cell lines, inducing apoptosis or caspase-independent cell death. It induces the proteasome-dependent degradation of Hsp90 client proteins and potentiates the apoptotic activity of Hsp90 inhibitors. VER-15508 also triggers paraptosis in anaplastic thyroid carcinoma cells. Group: Pharmaceutical. Alternative Names: 8-(3,4-Dichlorobenzyl)amino-5'-O-(4-cyanobenzyl)adenosine; C07; VER 155008; VER155008; 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-Adenosine; 4-((((2R,3S,4R,5R)-5-(6-amino-8-(3,4-dichlorobenzylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)methyl)benzonitrile. CAS No. 1134156-31-2. Pack Sizes: 100 mg. Product ID: B1370-272446. Molecular formula: C25H23Cl2N7O4. Mole weight: 556.4. Custom synthesis is available. Send your inquiries for more information. | London |
| Vitexin | Vitexin is a class of nature lignan compounds isolated from the seeds of Vitex trifolia L. What different from the classic lignans is its action and anticancer effect is mediated by the mechanisms, vitexin-induced antitumor effect and cytotoxic activity is exerted through proapoptotic process, which is mediated by a decreased Bcl-2/Bax ratio and activation of caspases. Vitexin inhibits the activities of anti-nociceptive, anti-spasmodic and anti-oxidant. Uses: Anti-nociceptive; anti-spasmodic; anti-oxidant. Group: Pharmaceutical. Alternative Names: 8-D-Glucosyl-4,5,7-trihydroxy-flavone; 8-C-b-D-Glucopyranosylapigenin; Oritentoside. CAS No. 3681-93-4. Pack Sizes: 50 mg. Product ID: NP1869. Molecular formula: C21H20O10. Mole weight: 432.38. Custom synthesis is available. Send your inquiries for more information. | London |
| Z-DEVD-FMK | Z-DEVD-FMK is a cell-permeant, irreversible caspase-3 inhibitor that can be used as an anaesthetic agent. It has been shown to suppress tumor cell apoptosis. Uses: Cysteine proteinase inhibitors. Group: Pharmaceutical. Alternative Names: Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK; Caspase-3 Inhibitor; Z-D(OMe)E(Ome)VD(OMe)-FMK; benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone; Caspase-3 Inhibitor II; Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone; Z-DEVD-fluoromethylketone. CAS No. 210344-95-9. Pack Sizes: 10 mg. Product ID: BAT-010236. Molecular formula: C30H41FN4O12. Mole weight: 668.67. Custom synthesis is available. Send your inquiries for more information. | London |
| Z-IETD-FMK | Z-IETD-FMK is a selective and cell permeable caspase 8 inhibitor. Z-IETD-FMK inhibits T cell proliferation induced by PHA or anti-CD3 plus anti-CD28 without toxicity of resting T cells. Group: Pharmaceutical. Alternative Names: caspase-8 inhibitor; Z-IE(OMe)TD(OMe)-FMK; Z-Ile-Glu(OMe)-Thr-Asp(OMe)-CH2F; Z-Ile-Glu(OMe)-Thr-Asp(OMe) fluoromethylketone; N-benzyloxycarbonyl-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone. CAS No. 210344-98-2. Pack Sizes: 50 mg. Product ID: BAT-010389. Molecular formula: C30H43FN4O11. Mole weight: 654.69. Custom synthesis is available. Send your inquiries for more information. | London |
| Z-Phe-DL-Ala-FMK | Z-FA-FMK is an irreversible cysteine protease inhibitor, and it also inhibits caspases-2, -3, -6, and -7. Z-FA-FMK suppresses the degradation of fibrillar collagen by fibroblasts and osteoclasts, and reduces LPS-induced cytokine production via inhibition of NF-kappaB-dependent gene expression in macrophages. Uses: Cysteine proteinase inhibitors. Group: Pharmaceutical. Alternative Names: Z-Phe-DL-Ala-fluoromethylketone; Zfa-fmk; benzyloxycarbonyl-Phe-Ala-fluormethylketone; benzyloxycarbonylphenylalanyl-alanine fluoromethyl ketone; Carbamic acid, N-((1S)-2-((3-fluoro-1-methyl-2-oxopropyl)amino)-2-oxo-1-(phenylmethyl)ethyl)-, phenylmethyl ester. CAS No. 197855-65-5. Pack Sizes: 50 mg. Product ID: B0084-209259. Molecular formula: C21H23FN2O4. Mole weight: 386.42. Custom synthesis is available. Send your inquiries for more information. | London |
| Z-VAD-FMK | Z-VAD-FMK is a broad spectrum pan-caspase inhibitor that inhibits the intracellular activation of caspase-like proteases. Group: Pharmaceutical. Alternative Names: Z-VAD (OMe)-FMK; Caspase Inhibitor I. CAS No. 187389-52-2. Pack Sizes: 25 mg. Product ID: BAT-010214. Molecular formula: C22H30FN3O7. Mole weight: 467.49. Custom synthesis is available. Send your inquiries for more information. | London |
| Z-VDVAD-FMK | Z-VDVAD-FMK is a cell-permeant and irreversible caspase-2 inhibitor and can inhibits apoptosis in various cell lines. Group: Pharmaceutical. Alternative Names: Z-VD(OMe)VAD(OMe)-FMK; Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethyl ketone; benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethylketone; L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-|A-aspartyl-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester; Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK. CAS No. 210344-92-6. Pack Sizes: 50 mg. Product ID: BAT-010375. Molecular formula: C32H46FN5O11. Mole weight: 695.74. Custom synthesis is available. Send your inquiries for more information. | London |
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