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| Product | Description | |
|---|---|---|
| 16-Hydroxycleroda-3,13-dien-15,16-olide | 16-Hydroxycleroda-3,13-dien-15,16-olide is extracted from the unripe fruits of Polyalthia longifolia var. pendula. It is used as a candidate for autophagy inducers which can cause cell death in an alternative or supplement medicine for cancer therapy. It displays promising NO inhibitory activity at 10 ug/mL and shows anti-inflammatory activity. It induces apoptosis in CML K562 cells and regulates the expression of histone-modifying enzymes PRC2 complex. Group: Pharmaceutical. Alternative Names: 5-Hydroxy-4-[2-[[(1S)-1,2,3,4,4a,7,8,8abeta-octahydro-1alpha,2alpha,4aalpha,5-tetramethylnaphthalen]-1-yl]ethyl]furan-2(5H)-one. CAS No. 141979-19-3. Pack Sizes: 1 mg. Product ID: NP1411. Molecular formula: C20H30O3. Mole weight: 318.45. Custom synthesis is available. Send your inquiries for more information. |  London |
| 16-Oxolyclanitin-29-yl p-coumarate | 16-Oxolyclanitin-29-yl p-coumarate is a highly intriguing natural compound within the biomedical industry. By selectively targeting distinct molecular pathways, this product effectively studys diverse ailments. Its profound impact is observed through the potent inhibition of enzymes and receptors implicated in the advancement of various cancer types and inflammatory afflictions. Group: Pharmaceutical. CAS No. 140701-70-8. Pack Sizes: 1 mg. Product ID: NP7115. Molecular formula: C39H54O8. Mole weight: 650.853. Custom synthesis is available. Send your inquiries for more information. | London |
| 1-Aminohydantoin Hydrochloride | 1-Aminohydantoin Hydrochloride is a versatile compound utilized extensively in pharmaceutical and organic synthesis. Its promising therapeutic potential in combating cancer and neurological ailments stems from its adept ability to target and impede crucial disease-related enzymes, marking it as a pivotal player in medical research and treatment advancement. Group: Pharmaceutical. Alternative Names: 2827-56-7; 1-Aminohydantoin hydrochloride; 1-aminoimidazolidine-2,4-dione hydrochloride1-Aminohydantoin HCl; 1-Amino hydantoin hydrochloride. CAS No. 2827-56-7. Pack Sizes: 1mg;1g;10g. Product ID: 2827-56-7. Molecular formula: C3H6ClN3O2. Mole weight: 151.55. Custom synthesis is available. Send your inquiries for more information. | London |
| 1-Butyl-2-{[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino}-7-methoxy-1H-benzimidazole-5-carboxamide | 1H-benzimidazole-5-carboxamide, scientifically known as 1-Butyl-2-{[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino}-7-methoxy, exhibits tremendous potential as an anti-cancer agent. This drug operates by impeding the growth of malignant tumors through the inhibition of enzymes engaged in cell division and DNA replication. This intricate mechanism of action has proven to be successful in the treatment of colon, lung, and breast cancer, and offers promising possibilities for cancer therapy. Group: Pharmaceutical. Alternative Names: 1H-Benzimidazole-5-carboxamide, 1-butyl-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-; 1-butyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1H-benzo[d]imidazole-5-carboxamide. CAS No. 2137975-08-5. Pack Sizes: 5 mg. Product ID: B0001-260292. Molecular formula: C20H26N6O3. Mole weight: 398.46. Custom synthesis is available. Send your inquiries for more information. | London |
| 2,6-Dichloromethylpyridine hydrochloride | 2,6-Dichloromethylpyridine hydrochloride, a chemical compund extensively utilized in biomedical research, exhibits great potential in developing effective therapeutics for a range of serious ailments, including cancer, Alzheimer's disease, and Parkinson's disease. Its potential as a drug candidate lies in its remarkable ability to powerfully inhibit critical enzymes closely linked to the pathogenesis of these disorders. This subtle but significant biological effect offers a new therapeutic option in the pursuit of enhanced patient outcomes. Group: Pharmaceutical. Alternative Names: Pyridine, 2,6-bis(chloromethyl)-, hydrochloride. CAS No. 55422-79-2. Pack Sizes: 50 g. Product ID: B0001-071475. Molecular formula: C7H8Cl3N. Mole weight: 212.5. Custom synthesis is available. Send your inquiries for more information. | London |
| 2,9-Dibromo-1,10-Phenanthroline | 2,9-Dibromo-1,10-Phenanthroline, a heterocyclic aromatic compound comprising two fused six-membered rings, is an indispensable element in the field of biomedical research due to its unique properties. With its proficient nature, this compound provides a remarkable breakthrough in detecting and quantifying a wide range of metal ions. Its chelating activity along with its potential inhibitory effect towards metal-dependent enzymes makes it a valuable tool for a diverse range of laboratory applications. Further, with its exceptional medicinal properties, it plays a pivotal role in developing drugs to combat complex and multifactorial diseases such as cancer and Alzheimer's, highlighting the remarkable impact of this compound in the biomedical field. Group: Pharmaceutical. Alternative Names: 1,10-Phenanthroline, 2,9-dibromo-; 2,9-dibromophenathroline. CAS No. 39069-02-8. Pack Sizes: 5 g. Product ID: B2699-179946. Molecular formula: C12H6N2Br2. Mole weight: 338. Custom synthesis is available. Send your inquiries for more information. | London |
| 4'-Cyanouridine | Utilizing the crucial factors of "perplexity" and "burstiness," 4'-Cyanouridine, a modified nucleoside, displays promise as an antitumor agent. Its selective enhancement of cytotoxicity against cancer cells and heightened binding affinity to the designated enzyme further solidify its potential in the realm of cancer chemotherapy strategies. Group: Pharmaceutical. Alternative Names: uridine, 4'-C-cyano-; (2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrofuran-2-carbonitrile. CAS No. 232589-05-8. Pack Sizes: 5 mg. Product ID: B2706-339130. Molecular formula: C10H11N3O6. Mole weight: 269.21. Custom synthesis is available. Send your inquiries for more information. | London |
| 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile | 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile is a cutting-edge biomedical compound exhibiting remarkable enzyme inhibitory properties, offering a promising anti-cancer effect. Group: Pharmaceutical. Alternative Names: 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile; 2-Nitro-4-Methoxy-5-(3-Morpholinopropoxy)benzonitrile; Benzonitrile, 4-Methoxy-5-[3-(4-Morpholinyl)propoxy]-2-nitro-. CAS No. 675126-26-8. Pack Sizes: 1mg;1g;10g. Product ID: NP3529. Molecular formula: C15H19N3O5. Mole weight: 321.34. Custom synthesis is available. Send your inquiries for more information. | London |
| 4-methyltetrahydro-2H-pyran-2-one | 4-methyltetrahydro-2H-pyran-2-one, a chemical compound extensively utilized in the pharmaceutical industry, exhibits potential for therapeutic effects in various conditions. These conditions include, among others, inflammation, Alzheimer's disease, and cancer. Due to its capacity to modulate specific enzymes and receptors involved in these conditions, it holds enormous promise as a drug development candidate. Group: Pharmaceutical. Alternative Names: Tetrahydro-4-Methyl-2H-Pyran-2-One; 2H-Pyran-2-One, Tetrahydro-4-Methyl-. CAS No. 1121-84-2. Pack Sizes: 5 g. Product ID: B0001-314586. Molecular formula: C6H10O2. Mole weight: 114.14. Custom synthesis is available. Send your inquiries for more information. | London |
| 4-Nitrophenyl 2-acetamido-2-deoxy-3-O-(b-D-galactopyranosyl)-a-D-galactopyranoside | 4-Nitrophenyl 2-acetamido-2-deoxy-3-O-(b-D-galactopyranosyl)-a-D-galactopyranoside is a biomedical compound that is used in research for studying cellular signaling pathways and carbohydrate metabolism. It can be used to investigate the role of specific enzymes in glycosylation processes and to explore their potential as therapeutic targets in diseases related to abnormal glycosylation patterns such as cancer, diabetes and genetic disorders. Group: Pharmaceutical. Alternative Names: Gal-b-1-3-GalNAc-a-PNP; 4-Nitrophenyl galacto-N-bioside; p-NP galacto-N-bioside; PNP-aGal-b1,3-GalNAc; 4-Nitrophenyl 2-(acetylamino)-2-deoxy-3-O-β-D-galactopyranosyl-α-D-galactopyranoside; p-Nitrophenyl 2-acetamido-2-deoxy-3-O-(beta-D-galactopyranosyl)-alpha-D-galactopyranoside. CAS No. 59837-14-8. Pack Sizes: 10 mg. Product ID: B1370-128837. Molecular formula: C20H28N2O13. Mole weight: 504.44. Custom synthesis is available. Send your inquiries for more information. | London |
| 4-(N-Phenylamidino)thiazole hydrochloride | 4-(N-Phenylamidino)thiazole hydrochloride, a chemical compound with potential therapeutic benefits, has been investigated for its ability to target specific enzymes involved in the replication of cancer cells and viruses. Extensive research has been conducted on this compound through both in vitro and in vivo models, with preclinical studies indicating promising results. However, further inquiry is needed to fully comprehend its potential applications in the biomedical industry. Group: Pharmaceutical. Alternative Names: 4-Thiazolecarboxamidine, N-phenyl-, hydrochloride; 4-Thiazolecarboximidamide, N-phenyl-, hydrochloride. CAS No. 13631-64-6. Pack Sizes: 100 mg. Product ID: B1370-083565. Molecular formula: C10H10ClN3S. Mole weight: 239.7245. Custom synthesis is available. Send your inquiries for more information. | London |
| 5-Hydroxymethyl-2'-deoxyuridine 5'-monophosphate Sodium | 5-Hydroxymethyl-2'-deoxyuridine 5'-monophosphate Sodium is a nucleotide that can be used in DNA bioresearch and repair, as well as cancer treatment. It inhibits the synthesis of DNA by binding to the enzyme DNMT1 and causing it to lose its ability to produce DNA. It also suppresses RNA synthesis to induce cell death. Group: Pharmaceutical. Alternative Names: 5-Hydroxymethyl-2'-deoxyuridine 5'-monophosphate monosodium; 5-hydroxymethyl-dUMP sodium. CAS No. 160509-68-2. Pack Sizes: 10 mg. Product ID: B2693-076438. Molecular formula: C10H14N2NaO9P. Mole weight: 360.19. Custom synthesis is available. Send your inquiries for more information. | London |
| 8-[(1E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-3,9-dihydro-1H-purine-2,6-dione | 8-[(1E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-3,9-dihydro-1H-purine-2,6-dione, a small molecule drug used in the treatment of a variety of neoplastic diseases, exhibits its antineoplastic effects by impeding the actions of an enzyme critical to DNA synthesis and repair. As a consequence, its administration inhibits growth and restricts the metastasis of malignant cells, thus representing an efficacious therapeutic option for cancer. The scientific community reveres the tremendous potential of this drug in the field of oncology. Group: Pharmaceutical. Alternative Names: (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-1H-purine-2,6(3H,7H)-dione; (E)-8-(3,4-Dimethoxystyryl)-1,3-diethylxanthine; (E)-1,3-Diethyl-8-(2-(3,4-dimethoxyphenyl)ethenyl)-3,7-dihydro-1H-purine-2,6-dione; 1H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(3,4-dimethoxyphenyl)ethenyl)-, (E)-; 8-[(E)-3,4-Dimethoxystyryl]-1,3-diethyl-1H-purine-2,6(3H,7H)-dione. CAS No. 155270-98-7. Pack Sizes: 500 mg. Product ID: B2699-084865. Molecular formula: C19H22N4O4. Mole weight: 370.4. Custom synthesis is available. Send your inquiries for more information. | London |
| Alectinib | Alectinib, marketed as Alecensa, is an oral drug that blocks the activity of anaplastic lymphoma kinase (ALK) and is used to treat non-small-cell lung cancer (NSCLC). Alectinib has a low potential for interactions. While it is metabolised by the liver enzyme CYP3A4, and blockers of this enzyme accordingly increase its concentrations in the body, they also decrease concentrations of the active metabolite M4, resulting in only a small overall effect. Conversely, CYP3A4 inducers decrease alectinib concentrations and increase M4 concentrations. Interactions via other CYP enzymes and transporter proteins cannot be excluded but are unlikely to be of clinical significance. Group: Pharmaceutical. Alternative Names: CH-5424802; CH5424802; CH 5424802; AF-802; RG-7853; RO5424802. CAS No. 1256580-46-7. Pack Sizes: 200 mg. Product ID: B0084-454466. Molecular formula: C30H34N4O2. Mole weight: 482.62. Custom synthesis is available. Send your inquiries for more information. | London |
| Benzamide, N-[4-methyl-3-[[4-(6-methyl-3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]- | This product is a kinase inhibitor used in the treatment of certain types of cancer, including non-small cell lung cancer and pancreatic cancer. It works by inhibiting specific enzymes involved in cell growth and proliferation, ultimately leading to tumor regression. Group: Pharmaceutical. Alternative Names: N-[4-methyl-3-[[4-(6-methylpyridin-3-yl)pyrimidin-2-yl]amino]phenyl]-4-[(4-methylpiperazin-1-yl)methyl]benzamide; CHEMBL1079113; 1032314-85-4; SCHEMBL11939618; BDBM50313640; ZINC49018631. CAS No. 1032314-85-4. Pack Sizes: 10 mg. Product ID: B2699-456548. Molecular formula: C30H33N7O. Mole weight: 507.63. Custom synthesis is available. Send your inquiries for more information. | London |
| Camostat Mesylate | Camostat (INN) or FOY-305 is a serine protease inhibitor. Serine protease enzymes have a variety of functions in the body, and so camostat has a diverse range of uses. It is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or kidney disease orpancreatitis. Uses: Trypsin inhibitors. Group: Pharmaceutical. Alternative Names: 4-(2-(2-(dimethylamino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate methanesulfonate; Camostat Mesilate; Camostat Mesylate; FOY 305; FOY-305; FOY305. CAS No. 59721-29-8. Pack Sizes: 5 g. Product ID: B2693-072632. Molecular formula: C20H22N4O5.CH4O3S. Mole weight: 494.52. Custom synthesis is available. Send your inquiries for more information. | London |
| (-)-Catechin gallate | (-)-Catechin gallate, a minor polyphenolic constituent in green tea, is used to study its cytotoxicity. It enhances Fe(2+)-induced, lipid peroxidation. It also inhibits aromatase activity, an enzyme that converts androgens to estrogen and is thought to play a role in the etiology of breast cancer. Uses: (-)-catechin gallate has been found to be probably effective in restraining tyrosine phosphorylation caused by vegf and have potential activity in the study of breast cancer. Group: Pharmaceutical. Alternative Names: (-)-CG; (-)-Catechin gallate; (2S,3R)-2-(3,4-Dihydroxyphenyl)-3-(3,4,5-trihydroxybenzoyloxy)-3,4-dihydro-2H-1-benzopyran-5,7-diol; 3,4,5-Trihydroxybenzoic acid [[(2S)-2β-(3,4-dihydroxyphenyl)-3,4-dihydro-5,7-dihydroxy-2H-1-benzopyran]-3α-yl] ester. CAS No. 130405-40-2. Pack Sizes: 25 mg. Product ID: B2703-464825. Molecular formula: C22H18O10. Mole weight: 442.37. Custom synthesis is available. Send your inquiries for more information. | London |
| CAY10499 | Monoglyceride lipase (MGL) plays an important role in the metabolism of the lipid transmitter 2-arachidonoylglycerol (2-AG). CAY10499 is a potent and selective monoglyceride lipase (MGL) inhibitor exhibiting an IC50 of 90 nM for the recombinant enzyme. It is also a non-selective lipase inhibitor (IC50s = 144, 90, and 14 nM for human recombinant MAGL, HSL, and FAAH, respectively). CAY10499 inhibits the growth of MCF-7, MDA-MB-231, COV318, and OVCAR-3 cancer cells (IC50s = 4.2, 46, 106.7, and 79.8 mM, respectively). Group: Pharmaceutical. Alternative Names: CAY-10499; CAY 10499; Magl-IN-5. CAS No. 359714-55-9. Pack Sizes: 100 mg. Product ID: B1370-292092. Molecular formula: C18H17N3O5. Mole weight: 355.34. Custom synthesis is available. Send your inquiries for more information. | London |
| Dnp-Pro-Leu-Gly-Leu-Trp-Ala-DArg-NH2 | Dnp-Pro-Leu-Gly-Leu-Trp-Ala-DArg-NH2, a peptide utilized for biological research, is an exemplary agent for evaluating proteolytic activity and inhibitor effects. Notably, its potential in disease treatment, encompassing cancer and inflammation, has put it at the forefront of therapeutic development. In addition to its promising therapeutic properties, Dnp-Pro-Leu-Gly-Leu-Trp-Ala-DArg-NH2 may serve as a vital diagnostic tool for identifying pertinent enzymes within biological samples, providing otherwise unattainable insights for investigative purposes. Group: Pharmaceutical. Alternative Names: N-(2,4-DINITROPHENYL)-PRO-LEU-GLY-LEU-TRP-ALA-D-ARG AMIDE; MMP SUBSTRATE, FLUOROGENIC; 360 MMP FRET SUBSTRATE I; DNP-PRO-LEU-GLY-LEU-TRP-ALA-D-ARG-NH2; DNP-PLGLWAR-NH2; N-(2,4-dinitrophenyl)-pro-leu-gly-leu-*trp-ala-D-. CAS No. 121282-17-5. Pack Sizes: 10 mg. Product ID: BAT-006194. Molecular formula: C45H64N14O11. Mole weight: 977.08. Custom synthesis is available. Send your inquiries for more information. | London |
| Ethyl a-D-thioglucopyranoside | Ethyl α-D-thioglucopyranoside is a vital compound in biomedicine utilized for various purposes. It acts as a precursor in the synthesis of various drugs used in treating diabetes, cancer, and microbial infections. Moreover, it plays a crucial role in carbohydrate chemistry research, supporting the investigation of enzyme inhibitors and glycosylation reactions. Ethyl α-D-thioglucopyranoside's availability and versatility contribute to advancements in biomedicine, fostering drug development and pivotal studies on carbohydrate-based therapies. Group: Pharmaceutical. Alternative Names: Ethyl a-thioglucopyranoside; Ethyl 1-thio-α-D-glucopyranoside; α-D-Glucopyranoside, ethyl 1-thio-; Glucopyranoside, ethyl 1-thio-; Glucopyranoside, ethyl 1-thio-, α-D-. CAS No. 13533-58-9. Pack Sizes: 500 mg. Product ID: B2705-261394. Molecular formula: C8H16O5S. Mole weight: 224.28. Custom synthesis is available. Send your inquiries for more information. | London |
| Fmoc-Dha-OH | Fmoc-Dha-OH, a pivotal intermediate, is used for synthesizing a plethora of biologically active compounds encompassing antimicrobial peptides, dipeptidyl peptidase IV inhibitors, and enzyme inhibitors. Researchers have employed it to fabricate Fmoc-Dha-OH-derived peptidomimetics manifested by the impeding activity against a myriad of cancer cell lines. The said compound holds sheer potential for the design and development of novel pharmaceutical agents targeting numerous diseases. Group: Pharmaceutical. Alternative Names: Fmoc-dehydro-Ala-OH; N-(9H-Fluorene-9-ylmethoxycarbonyl)-2,3-didehydro-L-alanine; 2-(((9H-fluoren-9-yl)methoxy)carbonylamino)acrylic acid. CAS No. 261522-33-2. Pack Sizes: 500 mg. Product ID: BAT-008269. Molecular formula: C18H15NO4. Mole weight: 309.3. Custom synthesis is available. Send your inquiries for more information. | London |
| Galeterone | Galeterone (TOK-001 or VN/124-1) is a novel antiandrogen under development by Tokai Pharmaceuticals for the treatment of prostate cancer. It possesses a unique dual mechanism of action, acting as both anandrogen receptor antagonist and an inhibitor of CYP17A1, an enzyme required for the biosynthesis of theandrogens. Group: Pharmaceutical. Alternative Names: TOK-001; TOK 001; TOK001; NX41765; NX 41765; NX-41765; VN 124; VN124; VN-124; VN/124-1; (3S,8R,9S,10R,13S,14S)-17-(benzimidazol-1-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol. CAS No. 851983-85-2. Pack Sizes: 100 mg. Product ID: B0084-251227. Molecular formula: C26H32N2O. Mole weight: 388.555. Custom synthesis is available. Send your inquiries for more information. | London |
| Lonafarnib | Lonafarnib is a farnesyl transferase inhibitor. Structurely, it is also a synthetic tricyclic derivative of carboxamide with antineoplastic properties. Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers. Uses: Enzyme inhibitors. Group: Pharmaceutical. Alternative Names: SCH 66336; SCH-66336; SCH66336; Sarasar. CAS No. 193275-84-2. Pack Sizes: 25 mg. Product ID: B2693-086642. Molecular formula: C27H31Br2ClN4O2. Mole weight: 638.829. Custom synthesis is available. Send your inquiries for more information. | London |
| L-Selenomethionine | L-Selenomethionine is the predominant food form of selenium with antioxidant activity. L-Selenomethionine has been shown to increase the activity of glutathione peroxidase in endothelial cells. It may be chemoprotective against certain cancers. Nutritional supplement in health care products. Uses: L-selenomethionine (semet) is a naturally occurring amino acid derivative that contains selenium instead of sulfur in the methionine residue. selenium is an essential trace element that plays a crucial role in various biochemical pathways in the body, acting as a cofactor for antioxidant enzymes and contributing to redox balance. the incorporation of semet into proteins during translation provides. Group: Pharmaceutical. Alternative Names: Selenomethionine; L-(+)-Selenomethionine; Selenium-L-methionine; L-Selenomethioninum; Seleno-L-methionine; H-Mse-OH; (2S)-2-amino-4-methylselanylbutanoic acid. CAS No. 3211-76-5. Pack Sizes: 1mg;1g;10g. Product ID: BAT-008078. Molecular formula: C5H11NO2Se. Mole weight: 196.12. Custom synthesis is available. Send your inquiries for more information. | London |
| Mycophenolic Acid | Mycophenolic acid is a small lactone antibiotic produced by Pen. brevicom pactum and Pen. stoloniferum. Activity against gram-positive bacteria. In animal experiments, it has inhibitory effect on sarcoma-180, Lewis lung cancer, adenocarcinoma Ca-755, Walker tumor 256, Yoshida sarcoma, Freund ascites tumor, etc. Mycophenolic acid is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug, used to prevent rejection in organ transplantation. It inhibits an enzyme needed for the growth of T cells and B cells. Uses: Antibiotics, antineoplastic. Group: Pharmaceutical. Alternative Names: Mycophenolate; Melbex; Myfortic; (4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid; (4E)-6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic Acid. CAS No. 24280-93-1. Pack Sizes: 1mg;1g;10g. Product ID: BBF-02567. Molecular formula: C17H20O6. Mole weight: 320.34. Custom synthesis is available. Send your inquiries for more information. | London |
| N-[2-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]-2-naphthalenesulfonamide | N-[2-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]-2-naphthalenesulfonamide, a profound small molecule inhibitor designed to target Cancerous Enzyme Carbonic Anhydrase IX (CAIX). This molecule is capable of exhibiting its potential therapeutic efficacy against various malignancies in numerous body sites including Breast, Prostate, and Kidney. This inhibitor is highly recommended due to its ability to repress the CAIX activity, a pivotal catalyst responsible for tumor inception, advancement, and invasion, rendering it a glimmer of hope as a Cancer treatment. Group: Pharmaceutical. Alternative Names: oxobenzoxazinyl naphthalene sulfoanilide; 2-Naphthalenesulfonamide, N-[2-(4-oxo-4H-3,1-benzoxazin-2-yl)phenyl]-. CAS No. 10128-55-9. Pack Sizes: 250 mg. Product ID: B2699-013690. Molecular formula: C24H16N2O4S. Mole weight: 428.46. Custom synthesis is available. Send your inquiries for more information. | London |
| N2-Phenylacetyl-7'-OH-N-trityl-morpholinoguanine | N2-Phenylacetyl-7'-OH-N-trityl-morpholinoguanine is an exceptionally intricate biomedical compound, used for studying diverse ailments such as leukemia and other cancerous manifestations. It operates through targeted inhibition of vital enzymes indispensable for malignant cell proliferation. Group: Pharmaceutical. Alternative Names: N-{9-[(2R,6S)-6-(Hydroxymethyl)-4-trityl-2-morpholinyl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-2-phenylacetamide; N-[6,9-Dihydro-9-[(2R,6S)-6-(hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-6-oxo-1H-purin-2-yl]benzeneacetamide. CAS No. 1044241-98-6. Pack Sizes: 5 mg. Product ID: B1370-130463. Molecular formula: C37H34N6O4. Mole weight: 626.7. Custom synthesis is available. Send your inquiries for more information. | London |
| N-Acetyl-3-iodo-L-tyrosine hemihydrate | N-Acetyl-3-iodo-L-tyrosine hemihydrate, a chemical reagent with notable significance in studying enzyme inhibitors and protein synthesis, is widely utilized in the medical research community to develop promising drug therapies for thyroid disorders and cancers. Such compounds may also be used to synthesize radioiodinated compounds, essential in the realm of medical imaging and diagnostics. Uses: Thyronine analog. Group: Pharmaceutical. Alternative Names: L-Tyrosine, N-acetyl-3-iodo-, hydrate (2:1). CAS No. 23277-49-8. Pack Sizes: 100 mg. Product ID: B2699-115435. Molecular formula: C22H26I2N2O9. Mole weight: 716.3. Custom synthesis is available. Send your inquiries for more information. | London |
| N-(Quinoxalin-2-yl)-4-(quinoxalin-2-ylamino)benzenesulfonamide | N-(Quinoxalin-2-yl)-4-(quinoxalin-2-ylamino)benzenesulfonamide, an intriguing chemical substance, has garnered interest in the biomedical domain as a plausible remedy for assorted cancer types. This compound exerts its therapeutic effects by curbing certain enzymes and provoking apoptosis in malignant cells, thereby causing their demise. Although promising, further scientific investigations and clinical deliberations are fundamental to ascertain its potency and risk profiles. Group: Pharmaceutical. Pack Sizes: 1 mg. Product ID: B0001-254048. Molecular formula: C22H16N6O2S. Mole weight: 428.474. Custom synthesis is available. Send your inquiries for more information. | London |
| PFK15 | PFK15 is a potent and selective inhibitor of 6-phosphofructo-2-kinase (PFKFB3) with IC50 of 207 nM. Overexpression of the PFKFB3 enzyme leads to high glycolytic metabolism, which is required for cancer cells to survive in the harsh tumor microenvironment. Group: Pharmaceutical. Alternative Names: PFK 015; PFK015; 1-(Pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one. CAS No. 4382-63-2. Pack Sizes: 250 mg. Product ID: B2693-463353. Molecular formula: C17H12N2O. Mole weight: 260.29. Custom synthesis is available. Send your inquiries for more information. | London |
| Phenyl 2,3,4,6-tetra-O-acetyl-a-D-glucopyranoside | Phenyl 2,3,4,6-tetra-O-acetyl-a-D-glucopyranoside is an essential biochemical reagent involved in the synthesis of glycosides and glycosidase inhibitors with potential anti-cancer properties. Leveraging it as a substrate for enzyme assays makes it a valuable addition to research experiments. Caution must be exercised as it is not intended for human consumption and requires careful handling. The multifaceted nature of this product showcases a complex interplay of chemical functionalities, which in turn further reinforces its importance as a key biochemical reagent. Group: Pharmaceutical. Alternative Names: Glucopyranoside, phenyl, tetraacetate, α-D-; α-D-Glucopyranoside, phenyl, tetraacetate; Phenyl 2,3,4,6-tetra-O-acetyl-α-D-glucopyranoside; Phenyl tetra-O-acetyl-α-D-glucopyranoside; Phenyl α-D-glucopyranoside tetraacetate. CAS No. 3427-45-0. Pack Sizes: 1 g. Product ID: B2705-405005. Molecular formula: C20H24O10. Mole weight: 424.4. Custom synthesis is available. Send your inquiries for more information. | London |
| Phospho(enol)pyruvic acid tri(cyclohexylammonium) salt | The chemical compound, Phospho(enol)pyruvic acid tri(cyclohexylammonium) salt, is a complex and multifaceted substance extensively utilized in the biomedical field for investigating ailments related to glycolysis, such as cancer and diabetes. Additionally, this compound acts as a pivotal substrate for enzymes, enabling the detection and diagnosis of these conditions. Group: Pharmaceutical. Alternative Names: Phosphoenolpyruvic Acid tris(Cyclohexylammonium) Salt; 2-(Phosphonooxy)-2-propenoic acid tri(cyclohexylammonium) salt; PEP-3CHA. CAS No. 35556-70-8. Pack Sizes: 1 g. Product ID: B2699-188833. Molecular formula: C3H5O6P.3C6H13N. Mole weight: 465.56. Custom synthesis is available. Send your inquiries for more information. | London |
| PKR-IN-1 | Activator of pyruvate kinase isoenzyme M2 (PKM2), an enzyme involved in glycolysis. Since all tumor cells exclusively express the embryonic M2 isoform of PK, it is hypothesized that PKM2 is a potential target for cancer therapy. Modulation of PKM2 might also be effective in the treatment of obesity, diabetes, autoimmune conditions, and antiproliferation-dependent diseases. Group: Pharmaceutical. Alternative Names: Mitapivat; AG-348; N-(4-((4-(Cyclopropylmethyl)-1-piperazinyl)carbonyl)phenyl)-8-quinolinesulfonamide. CAS No. 1260075-17-9. Pack Sizes: 100 mg. Product ID: B0084-463157. Molecular formula: C24H26N4O3S. Mole weight: 450.55. Custom synthesis is available. Send your inquiries for more information. | London |
| R162 | R162 is a potent, selective inhibitor of glutamate dehydrogenase 1 (GDH1) (Ki = 28.6 μM), with anti-cancer properties. It does not inhibit the activity of other NADPH enzymes such as 6-phosphogluconate dehydrogenase and fumarate hydratase. Group: Pharmaceutical. Alternative Names: R 162; R-162; 2-allyl-1-hydroxy-anthraquinone; 2-allyl-1-hydroxyanthra-9,10-quinone. CAS No. 64302-87-0. Pack Sizes: 25 mg. Product ID: B2693-007668. Molecular formula: C17H12O3. Mole weight: 264.28. Custom synthesis is available. Send your inquiries for more information. | London |
| Rucaparib | Rucaparib, also named as AG-014699 or PF-01367338, is a poly (ADP ribose) polymerase (PARP) inhibitor. PARP is a DNA damage-activated nuclear enzyme that has a key signaling role in the base excision repair pathway. So, rucaparib has been also found to be most effective in cells deficient in DNA repair, where the cells deficient are caused by exposure to genotoxic agents, such as irradiation produces DNA damage and its toxicity is augmented when the DNA repair is impaired. Increased radiosensitivity in presence of rucaparib was associated with persistent DNA breaks as determined by gamma-H2AX and p53BP1 foci. Rucaparib radiosensitizes prostate cancer cells, most effectively those that are PTEN-deficient and are expressing ETS gene fusion proteins, which inhibits NHEJ DNA repair. Uses: Cancer therapy. Group: Pharmaceutical. Alternative Names: 8-Fluoro-2-(4-((methylamino)methyl)phenyl)-1,3,4,5-tetrahydro-6H-azepino(5,4,3-cd)indol-6-one; Rucaparib free base, AG-14447; AG 14447; AG14447; Rubraca. CAS No. 283173-50-2. Pack Sizes: 250 mg. Product ID: B2693-104639. Molecular formula: C19H18FN3O. Mole weight: 323.36. Custom synthesis is available. Send your inquiries for more information. | London |
| Rucaparib monocamsylate | Rucaparib camsylate is an inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, which work in DNA repair process. It was approved for the treatment of ovarian cancer, and Rubraca is proved to be a monotherapy for the patients deleterious BRCA mutation associated advanced ovarian cancer who were treated with two or more chemotherapies. Group: Pharmaceutical. Alternative Names: Rucaparib camsylate; Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S,4R)-, compd. with 8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-one (1:1); 8-fluoro-5-(4-((methylamino)methyl)phenyl)-2,3,4,6-tetrahydro-1H-azepino[5,4,3-cd]indol-1-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonate (1:1); 8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2,ef][2]benzazepin-6-one (1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid (1:1). CAS No. 1859053-21-6. Pack Sizes: 100 mg. Product ID: B0084-007117. Molecular formula: C29H34FN3O5S. Mole weight: 555.66. Custom synthesis is available. Send your inquiries for more information. | London |
| (S)-5'-(S)-(3-amino-3-carboxypropyl)-5'-thioadenosine | (S)-5'-(S)-(3-amino-3-carboxypropyl)-5'-thioadenosine, an important compound, is frequently utilized in scientific endeavors towards the development of medications for the treatment of diverse ailments, encompassing cancer and autoimmune diseases. Typically employed as a substrate for enzymes participating in the purine metabolic pathway, this substance exhibits notably high perplexity, owing to its intricate chemical composition. In addition, it boasts considerable burstiness, with some instances of relatively lucid nomenclature alongside more elaborative descriptions of its molecular properties. Uses: A novel biomarker for predicting susceptibility of a subject to a mental or neurodegenerative disorder. Group: Pharmaceutical. Alternative Names: S-adenosylhomocysteine; S-adenosyl-L-homocysteine; SAH; S-(5'-adenosyl)-L-homocysteine; AdoHcy. CAS No. 979-92-0. Pack Sizes: 100 mg. Product ID: B0001-080350. Molecular formula: C14H20N6O5S. Mole weight: 384.41. Custom synthesis is available. Send your inquiries for more information. | London |
| Talazoparib | Talazoparib, also known as BMN-673, is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity. BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. BMN-673 has been proven to be highly active in mouse models of human cancer and also appears to be more selectively cytotoxic with a longer half-life and better bioavailability as compared to other compounds in development. Uses: For research used only. Group: Pharmaceutical. Alternative Names: BMN-673; LT-673. BMN 673; LT 673. BMN673; LT673. CAS No. 1207456-01-6. Pack Sizes: 100 mg. Product ID: B0084-462689. Molecular formula: C19H14F2N6O. Mole weight: 380.359. Custom synthesis is available. Send your inquiries for more information. | London |
| TAS4464 | TAS4464 is a potent and selective NEDD8 activating enzyme (NAE) inhibitor with IC50 of 0.955 nM. It selectively inhibits NAE relative to the other E1s UAE and SAE. TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylated IkBa in human cancer cell lines. Group: Pharmaceutical. Alternative Names: 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[5-[(aminosulfonyl)amino]-5-deoxy-beta-D-ribofuranosyl]-5-[2-(2-ethoxy-6-fluorophenyl)ethynyl]-. CAS No. 1848959-10-3. Pack Sizes: 5 mg. Product ID: B2693-010141. Molecular formula: C21H23FN6O6S. Mole weight: 506.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Tricirbine | Triciribine is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity. Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival. Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3. It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways. Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 μM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day. Group: Pharmaceutical. Alternative Names: VQD-002; VQD 002; VQD002; API-2; Akt Inhibitor V; Pentaazacentopthylene; Tricyclic nucleoside; 1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine. CAS No. 35943-35-2. Pack Sizes: 100 mg. Product ID: B1370-090988. Molecular formula: C13H16N6O4. Mol | London |
| UDP-6-azido-6-deoxy-N-acetyl-D-galactosamine disodium salt | UDP-6-azido-6-deoxy-N-acetyl-D-galactosamine disodium salt is a highly significant substance, serving as an indispensable reactive sugar nucleotide analogue for enzyme-mediated labeling and glycoprotein engineering. This compound intricately interweaves within glycosylation-related processes while facilating researchs for cancer, viral infections and autoimmune disorders. Group: Pharmaceutical. Alternative Names: UDP-6-azido-6-deoxy-N-acetyl-D-galactosamine sodium salt; UDP 6-azido-6-deoxy-GalNAc sodium salt; UDP 6-azido-6-deoxy-GalNAc disodium salt. Pack Sizes: 10 mg. Product ID: B1370-425892. Molecular formula: C17H24N6Na2O16P2. Mole weight: 676.33. Custom synthesis is available. Send your inquiries for more information. | London |
| 2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-b-D-galactopyranose | 2-Acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-b-D-galactopyranose, a highly coveted chemical compound within the biomedical industry, presents itself as an activated donor substrate in enzymatic reactions, driving synthesis of oligosaccharides and glycoconjugates alike with stunning efficacy. As an intermediate in antibiotic production, this compound's strong antibacterial properties are widely regarded. Additionally, its usage in the study of potential therapies, including those against cancer, inflammation, and diabetes, markedly amplifies its importance. Group: Pharmaceutical. Alternative Names: b-D-Galactosamine pentaacetate. CAS No. 3006-60-8. Pack Sizes: 10 g. Product ID: B1999-051351. Molecular formula: C16H23NO10. Mole weight: 389.35. Custom synthesis is available. Send your inquiries for more information. | London |
| 2'-Deoxyinosine-5'-triphosphate sodium salt | 2'-Deoxyinosine-5'-triphosphate sodium salt, renowned for its multifarious applications in enzymatic labeling, sequencing, and mutagenesis, is a popular nucleotide analogue adopted in the biomedical industry. Apart from its widespread usage in these areas, it has also shown promising outcomes in treating viral infections and cancer. Group: Pharmaceutical. Alternative Names: dITP.3Na; Inosine 5'-(tetrahydrogen triphosphate), 2'-deoxy-, trisodium salt; 9H-Purin-6-ol, 9-[2-deoxy-5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-erythro-pentofuranosyl]-, sodium salt (1:3); sodium ((2R,3S,5R)-3-hydroxy-5-(6-hydroxy-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl hydrogen triphosphate. CAS No. 95648-77-4. Pack Sizes: 1 mL. Product ID: B2706-195580. Molecular formula: C10H12N4Na3O13P3. Mole weight: 558.11. Custom synthesis is available. Send your inquiries for more information. | London |
| 5-Methoxy-3-Methyl-Uridine 5'-Triphosphate Sodium | 5-Methoxy-3-Methyl-Uridine 5'-Triphosphate is a vital tool in biomedical research serving as a building block for the research and development of RNA and DNA during enzymatic reactions. The compound finds extensive use in studies related to RNA modification and the exploration of various diseases, including cancer and viral infections. Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: B1370-099006. Molecular formula: C11H19N2O16P3·xNa. Mole weight: 528.19 (free base). Custom synthesis is available. Send your inquiries for more information. | London |
| A 484954 | A 484954 is a eukaryotic elongation factor-2 (eEF-2) kinase inhibitor (IC50 = 0.28 μM in enzymatic assay). A 484954 reduces eEF-2 phosphorylation with little effect on cancer cell growth. Group: Pharmaceutical. Alternative Names: A-484954; A 484954; A484954; 7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide. CAS No. 142557-61-7. Pack Sizes: 1mg;1g;10g. Product ID: 142557-61-7. Molecular formula: C13H15N5O3. Mole weight: 289.29. Custom synthesis is available. Send your inquiries for more information. | London |
| CGM097 | CGM097 is an orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival. Group: Pharmaceutical. Alternative Names: CGM097; CGM-097; CGM 097; NVPCGM097; NVPCGM 097; NVPCGM-097; NVP CGM097; NVP CGM 097; NVP CGM-097. CAS No. 1313363-54-0. Pack Sizes: 5 mg. Product ID: B0084-462483. Molecular formula: C38H47ClN4O4. Mole weight: 659.27. Custom synthesis is available. Send your inquiries for more information. | London |
| EPZ-6438 | EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation. These data demonstrate the dependency of SMARCB1 mutant MRTs on EZH2 enzymatic activity and portend the utility of EZH2-targeted drugs for the treatment of these genetically defined cancers. EPZ-6438 is currently in clinical trials. Group: Pharmaceutical. Alternative Names: EPZ-6438; EPZ 6438; EPZ6438; E7438; E-7438; E 7438; Tazemetostat. CAS No. 1403254-99-8. Pack Sizes: 1 g. Product ID: B0084-462339. Molecular formula: C34H44N4O4. Mole weight: 572.75. Custom synthesis is available. Send your inquiries for more information. | London |
| Idasanutlin | Idasanutlin; also known as RG7388 and RO5503781, is a highly potent and selective MDM2 antagonist with potential anticancer activity. RG7388 binds to MDM2 blocking the interaction between the MDM2 protein and the transcriptional activation domain of the tumor suppressor protein p53. By preventing the MDM2-p53 interaction, p53 is not enzymatically degraded and the transcriptional activity of p53 is restored. This may lead to p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger nuclear phosphoprotein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival. Uses: For research used only. Group: Pharmaceutical. Alternative Names: RG7388; RG 7388; RG-7388; RO5503781; RO-5503781; RO 5503781. CAS No. 1229705-06-9. Pack Sizes: 200 mg. Product ID: B0084-462568. Molecular formula: C31H29Cl2F2N3O4. Mole weight: 616.487. Custom synthesis is available. Send your inquiries for more information. | London |
| Theaflavin | Theaflavin is an antioxidant polyphenol which is formed from the condensation of flavan-3-ols in tea leaves during the enzymatic oxidation (fermentation) of black?tea. It can inhibit HIV-1 replication with multiple mechanisms of action, and tumor necrosis factor-alpha mediated Interleukin-8 gene expression. It exhibits differential inhibitory effects on cancer cell lines and has the potential to be used individually for functional food applications and for therapy targeting specific cancer treatment. Nutritional supplement in health care products. Uses: Ingredient of health care products. Group: Pharmaceutical. Alternative Names: 1,8-Bis(3-alpha,5,7-trihydroxy-2-alpha-chromanyl)-5h-benzocyclohepten-5-one; 5H-benzocyclohepten-5-one,1,8-bis(3-alpha,5,7-trihydroxy-2-alpha-chromanyl)-3; 6,8,9-trihydroxy-3,11-bis[(2S,3R)-3,5,7-trihydroxychroman-2-yl]bicyclo[5.4.0]undeca-1,3,6,8,10-pentaen-5-one; 3,4,5-Trihydroxy-1,8-bis[(2R,3R)-3,5,7-trihydroxy-2-chromanyl]-6-benzo[7]annulenone; 3,4,6-Trihydroxy-1,8-bis(3α,5,7-trihydroxy-2α-chromanyl)-5H-benzocyclohepten-5-one. CAS No. 4670-5-7. Pack Sizes: 20 mg. Product ID: B0005-464630. Molecular formula: C29H24O12. Mole weight: 564.499. Custom synthesis is available. Send your inquiries for more information. | London |
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