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| Product | Description | |
|---|---|---|
| Camptothecin Impurities | Camptothecin Impurities, integral to the biomedical domain, operate as reference standards indispensable for the meticulous evaluation and regulation of camptothecin-derived drugs. Their significance is pronounced in advancing oncological therapies, specifically in verifying the purity and efficacy of topoisomerase-inhibiting compounds, thus underpinning therapeutic innovation and safety. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| (±)-10-Hydroxycamptothecin | (±)-10-Hydroxycamptothecin is an alkaloid derived from the seed or root bark of the deciduous plant Camptotheca acuminata. It has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones. It exhibits anticancer and antiangiogenic activities. It can be used in cosmetics material. Group: Pharmaceutical. CAS No. 64439-81-2. Pack Sizes: 1 g. Product ID: B2703-051417. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 10-Hydroxycamptothecin | 10mg Pack Size. Group: Analytical Reagents, Biochemicals. Formula: C20H16N2O5. CAS No. 64439-81-2. Prepack ID : 23489857-10mg. Molecular Weight : 115.1768. |  |
| 7-Ethyl Camptothecin | The main reasons for the superior antitumor activity of 7-Ethylcamptothecin compared with CPT are as follows: (a) 7-Ethylcamptothecin had a stronger growth-inhibiting activity against tumor cells, and (b) 7-Ethylcamptothecin remained in the intestinal tract for a longer time and in higher amounts when administered in vivo. 7-Ethyl Camptothecin is a natural compound found in the barks of Camptotheca acuminata Decne, it can be used as a cosmetics material. Group: Pharmaceutical. CAS No. 78287-27-1. Pack Sizes: 10 g. Product ID: B2703-464837. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 9-Aminocamptothecin | 9-Aminocamptothecin is a water-insoluble camptothecin derivative and an inhibitor of the nuclear enzyme topoisomerase I, disrupting the repair of single-strand DNA breakages. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 91421-43-1. Pack Sizes: 100 mg. Product ID: NP0052. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 9-Methoxycamptothecin | Methoxycamptothecin, 9- is extracted from the barks of Camptotheca acuminata Decne. Group: Pharmaceutical. CAS No. 39026-92-1. Pack Sizes: 25 mg. Product ID: B2703-179938. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| S)-(+)-Camptothecin | 100mg Pack Size. Group: Antibiotics, Bioactive Small Molecules, Biochemicals. Formula: C20H16N2O4. CAS No. 7689-3-4. Prepack ID : 48231379-100mg. Molecular Weight : 348.35. | |
| CKD 602 | CKD-602 is a topoisomerase I inhibitor. It is a synthetic and water-soluble camptothecin derivative which forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. CKD-602 has a significant effect on intracerebral glioma growth, with animals having significantly smaller tumors than those in the control group. Group: Pharmaceutical. CAS No. 213819-48-8. Pack Sizes: 20 mg. Product ID: B0084-087456. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Exatecan Mesylate | Exatecan mesylate is a semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting the religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogs. Group: Pharmaceutical. CAS No. 169869-90-3. Pack Sizes: 500 mg. Product ID: BBF-04655. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan EP Impurity B | 10-Hydroxycamptothecin inhibits the growth of BT-20 and MDA-231 cell with IC50 of 34.3 nM and 7.27 nM, respectively, more potently than camptothecin (CPT) with IC50 of >500 nM. 10-Hydroxycamptothecin is also an impurity of Irinotecan, a Topoisomerase I inhibitor used for the treatment of colon cancer and small cell lung cancer. Uses: Anti-cancer. Group: Pharmaceutical. CAS No. 19685-09-7. Pack Sizes: 5 g. Product ID: B2703-086753. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Irinotecan Hydrochloride Trihydrate | The hydrochloride salt of Irinotecan. Irinotecan is a prodrug that can be activated to 7-ethyl-10-hydroxy-camptothecin (SN-38) by the carboxylesterase-converting enzyme. SN-38 inhibits topoisomerase I to suppress DNA replication and promote cell death. Group: Pharmaceutical. CAS No. 136572-09-3. Pack Sizes: 1 g. Product ID: B0084-057943. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Rubitecan | Rubitecan is a semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells. This agent also prevents repair of reversible single-strand DNA breaks. Group: Pharmaceutical. CAS No. 91421-42-0. Pack Sizes: 100 mg. Product ID: B2692-079493. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione | (S)-4-Ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione is a key intermediate for the synthesis of irinotecan and camptothecin analogues. It is also an ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Group: Pharmaceutical. CAS No. 110351-94-5. Pack Sizes: 10 g. Product ID: BBF-05888. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Topotecan hydrochloride | Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Uses: Topoisomerase i inhibitors. Group: Pharmaceutical. CAS No. 119413-54-6. Pack Sizes: 1 g. Product ID: NP0530. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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