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| Product | Description | |
|---|---|---|
| Acetyl-(Pro18,Asp21)-Amyloid β-Protein (17-21) amide | Acetyl-(Pro18,Asp21)-Amyloid β-Protein (17-21) amide is an analog of product H-4876 with small chemical modifications which enhance its stability against proteolytic degradation. It is a β-sheet breaker peptide that crosses the blood-brain barrier faster than most known proteins and peptides selectively absorbed by the brain, so it is assumed that the peptide is specifically transported to the brain. Group: Pharmaceutical. CAS No. 339990-02-2. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-015329. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| AMG-3969 | AMG-3969 is a potent and selective disruptor of glucokinase-glucokinase regulatory protein interaction (GK-GKRP). AMG-3969 can modulate the blood glucose levels in rodent models of diabetes. Group: Pharmaceutical. CAS No. 1361224-53-4. Pack Sizes: 100 mg. Product ID: B0084-053994. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BIS(1-BUTYLPENTYL) DECANE-1,10-DIYL DIGLUTARATE | Abbreviated as Sec or U, in older publications also as Se-Cys, as a building block of selenoproteins, this 21st proteinogenic amino acid exists naturally in three domains of life, but not in every lineage. Uses: Used for the characterization of total sodium concentration in human blood plasma; also used for the preparation of nitrite-selective membrane electrode, used for the potentiometric determination of nad(p)h coenzymes. Group: Pharmaceutical. CAS No. 101342-76-1. Pack Sizes: 1 g. Product ID: B0001-236189. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Byakangelicol | Byakangelicol is a furanocoumarin derivative which shows inhibitory effects against P-glycoprotein at the blood-brain barrier. It acts as an anti-proliferative agent causing G2/M arrest in melanoma cells. Group: Pharmaceutical. CAS No. 26091-79-2. Pack Sizes: 10 mg. Product ID: B2703-465418. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Carmustine | Carmustine is antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. It is used in the treatment of brain tumors, multiple myeloma and some lymphomas. Group: Pharmaceutical. CAS No. 154-93-8. Pack Sizes: 5 g. Product ID: B2693-465289. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Colesevelam hydrochloride | Colesevelam is a bile acid sequestrant that helps reduce elevated low-density lipoprotein cholesterol (LDL-C) in patients with primary hyperlipidemia, and also improve blood glucose balance in adults with type 2 diabetes mellitus. Group: Pharmaceutical. CAS No. 182815-44-7. Pack Sizes: 500 mg. Product ID: B0046-086232. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| C-Reactive Protein (CRP) (174-185) | The fragment of C-Reactive Protein, a marker in the blood increasing in response to the inflammation in the body. Group: Pharmaceutical. CAS No. 160369-86-8. Pack Sizes: 5 mg. Product ID: BAT-006208. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| C-Reactive Protein (CRP) (77-82) | The fragment of C-Reactive Protein, a marker in the blood increasing in response to the inflammation in the body. Group: Pharmaceutical. CAS No. 130349-01-8. Pack Sizes: 5 mg. Product ID: BAT-006207. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CZ415 | CZ415 is a highly selective potent mTOR inhibitor with little activity on other lipid and protein kinases with efficacy in a collagen induced arthritis model and exhibits excellent cell permeability. In the issue, Bergamini et al., who has identified CZ415, confirmed with its extraordinary selectivity, drug-like properties and proven efficacy in vivo, CZ415 represents an ideal molecule for the pharmacological investigation of mTOR pathophysiological role in vivo. Assessed in dose response format from HEK293T cells after treatment with CZ415: 1. inhibition of S6RP (downstream of mTORC1) phosphorylation in HEK293T: IC50 = 14.5 nM; 2. inhibition of Akt (mTORC2 substrate) phosphorylation in HEK293T: IC50 = 14.8 nM; 3. inhibition of IFNγ release in stimulated human whole blood: IC50 = 226 nM. Group: Pharmaceutical. CAS No. 1429639-50-8. Pack Sizes: 5 mg. Product ID: B0084-474821. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Dimethyl-l-arginine | Dimethyl-l-arginine is naturally found in blood plasma. It is produced from the continual protein modification processes in the cytoplasm of all human cells. Uses: Enzyme inhibitors. Group: Pharmaceutical. CAS No. 30315-93-6. Pack Sizes: 250 mg. Product ID: B0350-054018. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Enzastaurin | Enzastaurin is a protein kinase C beta inhibitor with 6- to 20-fold selectivity against PKCα, PKCγ and PKC&epsilon. Binding to the ATP-binding site, enzastaurin selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden. Group: Pharmaceutical. CAS No. 170364-57-5. Pack Sizes: 200 mg. Product ID: B0084-085618. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Exherin | Exherin, also known as ADH-1, is a small, cyclic pentapeptide vascular-targeting agent with potential antineoplastic and antiangiogenic activities. ADH-1 selectively and competitively binds to and blocks N-cadherin, which may result in disruption of tumor vasculature, inhibition of tumor cell growth, and the induction of tumor cell and endothelial cell apoptosis. N-cadherin, a cell- surface transmembrane glycoprotein of the cadherin superfamily of proteins involved in calcium-mediated cell-cell adhesion and signaling mechanisms; may be upregulated in some aggressive tumors and the endothelial cells and pericytes of some tumor blood vessels. Group: Pharmaceutical. CAS No. 229971-81-7. Pack Sizes: 10 mg. Product ID: BAT-010745. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ezetimibe Phenoxy Glucuronide-[d4] | Ezetimibe Phenoxy Glucuronide-[d4] is the labelled analogue of Ezetimibe Phenoxy Glucuronide, which is a metabolite of Ezetimibe. Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Group: Pharmaceutical. CAS No. 1426174-41-5. Pack Sizes: 10 mg. Product ID: BLP-005427. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Genistein | Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. Genistein is developed to be an antitumor agent. Genistein has antioxidant effect, it can be used in cosmetics material. It is a plant polyphenol that can inhibit tyrosinase, block melanin synthesis, reduce skin pigment intensity, absorb UV, prevent photoaging, reduce sun damage and age spot formation, and whiten and lighten spots. It also has the anti-glycation and antibacterial effect, can effectively improve skin tone and skin texture, prevent the generation of age spots, remove red bloodlines, and improve skin blood microcirculation. Uses: Antitumor agent. Group: Pharmaceutical. CAS No. 446-72-0. Pack Sizes: 5 g. Product ID: BBF-01840. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Larotaxel | Larotaxel is a semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier. Group: Pharmaceutical. CAS No. 156294-36-9. Pack Sizes: 50 mg. Product ID: B2693-244933. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Naringin | Naringin inhibits hepatic P-glycoprotein (P-gp) and some drug-metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions. Naringin can be used as an edible additive, mainly for gum, refreshing drinks, etc. It is a plant polyphenol that can inhibit tyrosinase, block melanin synthesis, reduce skin pigment intensity, absorb UV, prevent photoaging, reduce sun damage and age spot formation, and whiten and lighten spots. It also has the anti-glycation and antibacterial effect, can effectively improve skin tone and skin texture, prevent the generation of age spots, remove red bloodlines, and improve skin blood microcirculation. Uses: Antioxidant, anticancer, anti-atherogenic. Group: Pharmaceutical. CAS No. 10236-47-2. Pack Sizes: 250 g. Product ID: NP1904. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Norverapamil | Norverapamil is a metabolite of Verapamil. Verapamil is a medication used for the treatment of high blood pressure, chest pain from not enough blood flow to the heart, and supraventricular tachycardia. Norverapamil is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor. Uses: Calcium channel blockers. Group: Pharmaceutical. CAS No. 67018-85-3. Pack Sizes: 5 mg. Product ID: B0001-192715. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| OXi-4503 | OXi-4503 is the diphosphate prodrug of the stilbenoid combretastatin A1, originally isolated from the plant Combretum caffrum, with vascular-disrupting and antineoplastic activities. Upon administration, combretastatin A1 diphosphate (CA1P) is dephosphorylated to the active metabolite combretastatin A1 (CA1), which promotes rapid microtubule depolymerization; endothelial cell mitotic arrest and apoptosis, destruction of the tumor vasculature, disruption of tumor blood flow and tumor cell necrosis may ensue. In addition, orthoquinone intermediates, metabolized from combretastatin A1 by oxidative enzymes found to be elevated levels in some tumor types, may bind to tumor cell thiol-specific antioxidant proteins and DNA, and stimulate oxidative stress by enhancing superoxide/hydrogen peroxide production. CA1 binds to tubulin at the same site as colchicine but with higher affinity. Group: Pharmaceutical. CAS No. 288847-35-8. Pack Sizes: 100 mg. Product ID: B0084-353235. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PKG Drug G1 | PKG drug G1 is an activator of protein kinase GIα (PKGIα). It induces vasodilation and blood pressure reduction through the C42 PKG Iα independent mechanism. Group: Pharmaceutical. CAS No. 374703-78-3. Pack Sizes: 100 mg. Product ID: B2693-373024. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| SB239063 | SB239063 is a potent p38MAPK inhibitor. SB 239063 had an IC(50) of 44 nM for inhibition of recombinant purified human p38alpha. In lipopolysaccharide-stimulated human peripheral blood monocytes, SB 239063 inhibited interleukin-1 and tumor necrosis factor-alpha production. SB 239063 may be useful for the treatment of asthma and other inflammatory disorders. Uses: Protein kinase inhibitors. Group: Pharmaceutical. CAS No. 193551-21-2. Pack Sizes: 100 mg. Product ID: B2693-196670. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Silybin A | Silymarin, isolated from the herb of Silybum marianum (L.) Gaertn, is an antioxidant or free radical scavenger. Silymarin and Prunella vulgaris improve antioxidant status in blood and liver, and positively affect plasma lipoprotein profile in an experimental model of dietary induced hypertriglyceridemia. Both in vitro and animal research suggest that Silymarin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins. Silymarin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells. Silymarin treatment in type II diabetic patients for 4 months has a beneficial effect on improving the glycemic profile. Treatment with silymarin may reduce the lipoperoxidation of cell membranes and insulin resistance, significantly decreasing endogenous insulin overproduction and the need for exogenous insulin administration. Silybin is a natural compound also can be used in cosmetics material. Uses: Protective agents. Group: Pharmaceutical. CAS No. 22888-70-6. Pack Sizes: 100 g. Product ID: NP1920. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Verteporfin | Verteporfin is a potent second-generation photosensitizing agent derived from porphyrin. It is used as a photosensitizer for photodynamic therapy to eliminate abnormal blood vessels in the eye that are associated with conditions such as macular degeneration. Verteporfin also suppresses the formation of autophagosome via targeting p62, which binds both polyubiquitinated proteins destined for degradation and LC3 on autophagosomal membranes. Group: Pharmaceutical. CAS No. 129497-78-5. Pack Sizes: 20 mg. Product ID: B0084-082919. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Vitamin K2(45) | Vitamin K2(45), renowned for its significance in the biomedical research, stands as a paramount nutrient in studyting osteoporosand cardiovascular ailments. Its pivotal function lies in the activation of blood clotting proteins and the regulation of calcium metabolism. Employing its distinctive architecture, Vitamin K2(45) bolsters skeletal well-being by studying bone mineral density and diminishing the susceptibility to fractures. Uses: Vitamin (prothrombogenic). Group: Pharmaceutical. CAS No. 523-39-7. Pack Sizes: 500 mg. Product ID: B2694-015160. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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