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| Product | Description | |
|---|---|---|
| 3β-Ursodeoxycholic Acid | 3β-Ursodeoxycholic Acid is a compound used for studying liver diseases such as primary biliary cirrhosand cholestatic liver diseases. It functions by reducing cholesterol absorption and promoting bile flow. This acid can be obtained from natural sources like bear bile or synthesized chemically. Uses: It is used as an anticholelithogenic. Group: Pharmaceutical. Alternative Names: (3β,5β,7β)-3,7-Dihydroxycholan-24-oic Acid; 3β,7β-Dihydroxy-5β-cholan-24-oic Acid; 3β,7β-Dihydroxy-5β-cholanic Acid; 3β,7β-Dihydroxy-5β-cholanoic Acid; Isoursodeoxycholic Acid; Ursodeoxycholic Acid EP Impurity H. CAS No. 78919-26-3. Pack Sizes: 50 mg. Product ID: B2694-122061. Molecular formula: C24H40O4. Mole weight: 392.57. Custom synthesis is available. Send your inquiries for more information. |  London |
| Allocholic acid | Allocholic acid is a bile acid metabolized from animals. Allocholic acid is also a precursor to petromyzonol. Group: Pharmaceutical. Alternative Names: 3alpha,7alpha,12alpha-Trihydroxy-5alpha-cholan-24-oic acid; 5alpha-cholic acid; 5α-cholanic acid-3α,7α,12α-triol. CAS No. 2464-18-8. Pack Sizes: 10 mg. Product ID: BBF-04061. Molecular formula: C24H40O5. Mole weight: 408.57. Custom synthesis is available. Send your inquiries for more information. | London |
| Alpinumisoflavone | Alpinumisoflavone isolated from the herbs of Genista pichisermolliana. It maybe due to their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, Alpinumisoflavone has atheroprotective effects. Uses: Atheroprotective effects. Group: Pharmaceutical. Alternative Names: 5-Hydroxy-7-(4-hydroxyphenyl)-2,2-dimethyl-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-one. CAS No. 34086-50-5. Pack Sizes: 1 mg. Product ID: NP2490. Molecular formula: C20H16O5. Mole weight: 336.3. Custom synthesis is available. Send your inquiries for more information. | London |
| Aramchol | Aramchol, also known as Arachidyl amido cholanoic acid, is a fatty acid conjugate that exhibits hypocholesterolemic effects. It reduces ex vivo cholesterol crystallization in native human bile and dissolves pre-formed cholesterol crystals in a dose-dependent manner. Group: Pharmaceutical. Alternative Names: (R)-4-((3S,5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-3-icosanamido-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid; Aramchol; Arachidyl amido cholanoic acid. CAS No. 246529-22-6. Pack Sizes: 1mg;1g;10g. Product ID: 246529-22-6. Molecular formula: C44H79NO5. Mole weight: 702.11. Custom synthesis is available. Send your inquiries for more information. | London |
| BMS 986020 | BMS 986020 is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist with an IC50 value less than 300 nM for human LPA1 expressing CHO cells. It inhibits bile acid and phospholipid transporters with IC50s of 4.8 μM, 6.2 μM, and 7.5 μM for BSEP, MRP4, and MDR3, respectively. BMS 986020 is used for the treatment of idiopathic pulmonary fibrosis (IPF). Group: Pharmaceutical. Alternative Names: BMS-986020; BMS986020. CAS No. 1257213-50-5. Pack Sizes: 100 mg. Product ID: B2693-292060. Molecular formula: C29H26N2O5. Mole weight: 482.5. Custom synthesis is available. Send your inquiries for more information. | London |
| Boc-D-FMK | BOC-D-FMK is a cell-permeable broad-spectrum caspase inhibitor that fully inhibits the pro-apoptotic effect of tumor necrosis factor-α (TNFα). It has been found to reduce the activation of nuclear factor kappa light chain enhancer of activated B cells (NF-kB), suppress the phosphorylation of subunit nuclear factor kappa light polypeptide gene enhancer in B cells inhibitor α (IkBα) and inhibit TNF-induced expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1). Moreover, it has also effectively attenuated the hepatocyte apoptosis in bile duct-ligated rats potentially improving the survival rates. Uses: Caspase inhibitors. Group: Pharmaceutical. Alternative Names: Boc-Asp(OMe)-fluoromethyl ketone; Caspase Inhibitor 3; N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone; BAF; Boc-D-Fluoromethyl Ketone; Boc-D(OMe)-FMK; 3S-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid, methyl ester; Caspase Inhibitor III. CAS No. 187389-53-3. Pack Sizes: 100 mg. Product ID: BAT-010386. Molecular formula: C11H18FNO5. Mole weight: 263.26. Custom synthesis is available. Send your inquiries for more information. | London |
| Colesevelam hydrochloride | Colesevelam is a bile acid sequestrant that helps reduce elevated low-density lipoprotein cholesterol (LDL-C) in patients with primary hyperlipidemia, and also improve blood glucose balance in adults with type 2 diabetes mellitus. Group: Pharmaceutical. Alternative Names: CholestaGel; GT 31-104; GT 31-104HB; Welchol. CAS No. 182815-44-7. Pack Sizes: 500 mg. Product ID: B0046-086232. Molecular formula: (C13H27N)n.(C12H27ClN2)n.(C3H7N)n.(C3H5ClO)n.xHCl. Custom synthesis is available. Send your inquiries for more information. | London |
| Colestipol hydrochloride | Colestipol hydrochloride is a cholesterol-lowering drug. It acts by binding bile acids in intestines to form a product that is removed from the body. Group: Pharmaceutical. Alternative Names: Colestipol HCl; Colestid; Cholestabyl. CAS No. 37296-80-3. Pack Sizes: 1mg;1g;10g. Product ID: 37296-80-3. Molecular formula: C8H24ClN5. Mole weight: 225.76. Custom synthesis is available. Send your inquiries for more information. | London |
| Cynaropikrin | Cynaropikrin, a polyphenolic compound, is a sesquiterpene lactone in C. scolymus. Cynaropikrin is the bitter principle in artichoke and is, therefore, an important compound in the chemical profiling of the plant. Cynara scolymus L. (Asteraceae), commonly found in southern Europe and the USA, is cultivated as a vegetable and medicinal plant artichoke leaves are traditionally used for treatment of bile and liver diseases. Pharmacological studies have shown that extracts of the plant significantly increase choleresis (C. scolymus is used for treatment of dyspeptic syndrome) and reduce blood cholesterol, mainly because of inhibition of hepatocellular de novo cholesterol biosynthesis. Group: Pharmaceutical. Alternative Names: 2-Propenoic acid, 2-(hydroxymethyl)-, dodecahydro-8-hydroxy-3,6,9-tris(methylene)-2-oxoazuleno[4,5-b]furan-4-yl ester, [3aR-(3aα,4α,6aα,8β,9aα,9bβ)]-; Cynaropicrin (6CI); Azuleno[4,5-b]furan, 2-propenoic acid deriv. CAS No. 35730-78-0. Pack Sizes: 10 mg. Product ID: B0005-479861. Molecular formula: C19H22O6. Mole weight: 346.37. Custom synthesis is available. Send your inquiries for more information. | London |
| Deoxyandrographolide | Deoxyandrographolide is a natural compound extracted from the herbs of Andrographis paniculata (Burm. f.) Nees. It could potently inhibit the growth of liver (HepG2 and SK-Hep1) and bile duct (HuCCA-1 and RMCCA-1) cancer cells. It controlled ethanol-induced hepatosteatosis by interfering with dysregulation of lipid metabolism. It was capable of preventing the development of fatty liver through AMPK-mediated regulation of lipid metabolism. It reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner in concentrations between 10-100 microM. It reduced PAF-induced calcium flux in the presence of extracellular calcium. It mediated activation of adenylate cyclase-cAMP signaling leading to up-regulation of cNOS may provide a promising approach in the prevention of liver diseases during chronic alcoholism. Uses: Deoxyandrographolide could potently inhibit the growth of liver (hepg2 and sk-hep1) and bile duct (hucca-1 and rmcca-1) cancer cells. it controlled ethanol-induced hepatosteatosis by interfering with dysregulation of lipid metabolism. it reduced the extracellular acidification rate and the intracellular alkalinization in a dose-dependent manner in concentrations between 10-100 microm. it reduced p. Group: Pharmaceutical. Alternative Names: 4-[2-[(4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-2,5,8a-trimethyl-3,4,4a,6,7,8-hexahydronaphthalen-1-yl]ethyl]-2H-furan-5-one;2 | London |
| Deoxycholic acid | Deoxycholic acid is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. Deoxycholic acid is specifically responsible for activating the G-protein-coupled bile acid receptor TGR5, stimulating the thermogenic activity of brown adipose tissue (BAT). Uses: Hypotensive. Group: Pharmaceutical. Alternative Names: Cholanoic Acid; Desoxycholic acid; 3α,12α-dihydroxy-5β-cholanate; Deoxycholate; Cholerebic; Degalol; Droxolan; Pyrochol; 5β-cholanic acid-3α,12α-diol; 7-Deoxycholic acid; 5β-Deoxycholic Acid; NSC 8797; Septocholl; Ursodeoxycholic Acid EP Impurity E. CAS No. 83-44-3. Pack Sizes: 250 g. Product ID: NP6088. Molecular formula: C24H40O4. Mole weight: 392.58. Custom synthesis is available. Send your inquiries for more information. | London |
| Dextrothyroxine sodium | Dextrothyroxine is an antihyperlipidemic. It stimulates the formation of low-density lipoprotein (LDL) and increases the catabolism of LDL thereby leading to increased excretion of cholesterol and bile acids via the biliary route. Group: Pharmaceutical. Alternative Names: D-Thyroxine sodium salt; dynothel; Debetrol; 3:5:3':5'-tetraiodo-d-thyroninesodium; biotirmone; choloxin; dethyrona; detyroxin; dextroid; dextrothyroxinesodium; dextroxin. CAS No. 137-53-1. Pack Sizes: 100 mg. Product ID: B2692-068737. Molecular formula: C15H10I4NNaO4. Mole weight: 798.86. Custom synthesis is available. Send your inquiries for more information. | London |
| Lithocholic acid | Lithocholic acid is a toxic secondary bile acid, causes intrahepatic cholestasis, has tumor-promoting activity, its toxic effect can be protected after it activates the vitamin D receptor, PXR and FXR. Uses: Detergents. Group: Pharmaceutical. Alternative Names: Lithocholate; 3alpha-Hydroxy-5beta-cholan-24-oic acid; 3alpha-Hydroxycholanic acid; 5beta-Cholanic acid-3alpha-ol. CAS No. 434-13-9. Pack Sizes: 50 g. Product ID: NP6107. Molecular formula: C24H40O3. Mole weight: 376.58. Custom synthesis is available. Send your inquiries for more information. | London |
| Milbemycin oxime | Milbemycin oxime is a semi-synthetic macrolide. As a nematocide and insecticide in veterinary medicine, it opens glutamate sensitive chloride channels in neurons of invertebrates that leads to paralysis by hyperpolarisation of these cells and signal transfer blocking. M1-family aminopeptidase: IC50=2.6 μM (Plasmodium falciparum 3D7); Bile acid transporter: IC50=3.6 μM (human); TGR5: IC50=36.4 μM (human); HCT-116: IC50 >50 μM (human); GBM: IC50 >50 μM (human). Uses: A broad spectrum insecticide; used for treatment and prevention of heartworm in dogs and cats. Group: Pharmaceutical. Alternative Names: Milbemycin A 5-oxime; Milbemite; Trifexis; Interceptor; Milbe Mite. CAS No. 129496-10-2. Pack Sizes: 500 mg. Product ID: BBF-03816. Molecular formula: C126H176N4O28. Mole weight: 2194.78. Custom synthesis is available. Send your inquiries for more information. | London |
| Odevixibat | Odevixibat is an ileal sodium/bile acid cotransporter inhibitor for the treatment of pruritus in patients with progressive familial intrahepatic cholestasis (PFIC) older than 3 months. Odevixibat alleviates cholestatic liver and bile duct damage in mouse models. Odevixibat can be used in the study of primary biliary cirrhosis. Group: Pharmaceutical. Alternative Names: Butanoic acid, 2-[[(2R)-2-[[2-[[3,3-dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,2,5-benzothiadiazepin-8-yl]oxy]acetyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-, (2S)-; (2S)-2-[[(2R)-2-[[2-[[3,3-Dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,2,5-benzothiadiazepin-8-yl]oxy]acetyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]butanoic acid; Butanoic acid, 2-[[(2R)-[[[[3,3-dibutyl-2,3,4,5-tetrahydro-7-(methylthio)-1,1-dioxido-5-phenyl-1,2,5-benzothiadiazepin-8-yl]oxy]acetyl]amino](4-hydroxyphenyl)acetyl]amino]-, (2S)-; A 4250; A4250; A-4250; A 4250 (pharmaceutical); AR-H 064974; AZD 8294. CAS No. 501692-44-0. Pack Sizes: 1mg;1g;10g. Product ID: 501692-44-0. Molecular formula: C37H48N4O8S2. Mole weight: 740.93. Custom synthesis is available. Send your inquiries for more information. | London |
| Sodium dehydrocholate | Sodium dehydrocholate is a cholagogue that increases bile output to clear increased bile acid load and also is used to determine circulation time. Group: Pharmaceutical. Alternative Names: sodium;(4R)-4-[(5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,7,12-trioxo-1,2,4,5,6,8,9,11,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]pentanoate; (5beta)-3,7,12-Trioxocholan-24-oic Acid; Atrocholin; Bayer Brand of Dehydrocholic Acid; Cholan-HMB; Cholog. CAS No. 145-41-5. Pack Sizes: 1mg;1g;10g. Product ID: 145-41-5. Molecular formula: C24H33NaO5. Mole weight: 424.51. Custom synthesis is available. Send your inquiries for more information. | London |
| Sodium glycochenodeoxycholate | Sodium glycochenodeoxycholate is a bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic. Group: Pharmaceutical. Alternative Names: Glycochenodeoxycholic acid sodium salt. CAS No. 16564-43-5. Pack Sizes: 25 g. Product ID: B0084-014274. Molecular formula: C26H42NNaO5. Mole weight: 471.614. Custom synthesis is available. Send your inquiries for more information. | London |
| Sodium glycocholate hydrate | Cholylglycine is a crystalline bile acid involved in the emulsification of fats. Sodium glycocholate hydrate is used to assess serum total bile acids via a fluorimetric and enzymatic method. Group: Pharmaceutical. Alternative Names: Glycocholic acid sodium salt hydrate; N-Cholylglycine sodium salt; N-[(3α,5β,7α,12α)-3,7,12-Trihydroxy-24-oxocholan-24-yl]-glycine Sodium Salt Hydrate. CAS No. 338950-81-5. Pack Sizes: 50 g. Product ID: B0084-188695. Molecular formula: C26H42NO6Na·xH2O. Mole weight: 487.60 (anhydrous basis). Custom synthesis is available. Send your inquiries for more information. | London |
| Sodium taurodeoxycholate hydrate | Sodium taurodeoxycholate hydrate is a bile salt-related, anionic detergent used for isolation of membrane proteins. Group: Pharmaceutical. Alternative Names: Taurodeoxycholic acid sodium salt hydrate; Taurodeoxycholic acid sodium salt monohydrate. CAS No. 207737-97-1. Pack Sizes: 25 g. Product ID: B0084-016192. Molecular formula: C26H46NNaO7S. Mole weight: 539.704. Custom synthesis is available. Send your inquiries for more information. | London |
| Sodium Tauroursodeoxycholate (TUDC) | Sodium Tauroursodeoxycholate (TUDC) is a water-soluble bile salt and an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis. Group: Pharmaceutical. Alternative Names: Sodium tauroursodeoxycholate; Tauroursodeoxycholic acid sodium salt; Tauroursodeoxycholate Sodium. CAS No. 35807-85-3. Pack Sizes: 10 g. Product ID: B2693-417705. Molecular formula: C26H44NNaO6S. Mole weight: 521.69. Custom synthesis is available. Send your inquiries for more information. | London |
| Taurochenodeoxycholic acid | Taurochenodeoxycholic acid is a bile salt formed in the liver. It solubilizes fats in the small intestine and is itself absorbed. Group: Pharmaceutical. Alternative Names: Taurochenodeoxycholate; Chenyltaurine; Chenodeoxycholyltaurine. CAS No. 516-35-8. Pack Sizes: 250 mg. Product ID: B0005-093485. Molecular formula: C26H45NO6S. Mole weight: 499.707. Custom synthesis is available. Send your inquiries for more information. | London |
| Tropifexor | Tropifexor is a novel highly potent agonist of farnesoid X receptor (FXR), which regulates bile acid metabolism and signaling. FXR activated by Tropifexor can inhibit bile acid synthesis as well as increase bile acid conjugation, transport and excretion. Tropifexor entered phase II clinical trials for the treatment of NASH and PBC. Group: Pharmaceutical. Alternative Names: Tropifexor; LJN452; LJN-452; LJN 452;; 2-[(1R,5S)-3-[[5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid. CAS No. 1383816-29-2. Pack Sizes: 10 mg. Product ID: B0084-008115. Molecular formula: C29H25F4N3O5S. Mole weight: 603.589. Custom synthesis is available. Send your inquiries for more information. | London |
| Ursodeoxycholic Acid | Ursodeoxycholic acid (UDCS) is a cell protectant used extensively to mitigate hepatic and biliary diseases. Ursodeoxycholic acid may be used to study its specific activities that range from reduction of cholesterol absorpition, cholesterol gallstone dissolution to suppression of immune response.IC50: M1-family aminopeptidase: IC50=2.6 μM (Plasmodium falciparum 3D7); NTCP: IC50=3.6 μM (human); HCT-116: IC50=>50 μM (human); GBM: IC50=>50 μM (human) Asbt: Ki=75 μM (human). Uses: Gallstone-dissolving drugs; anti-neoplastic; for the prevention and treatment of cholesterol gallstones; reduces hydrophobic bile acids and decreases both lymphocyte reactivity and serum alkaline phosphatase levels,ic50: m1-family aminopeptidase: ic50=2.6 μm (plasmodium falciparum 3d7); ntcp: ic50=3.6 μm (human); hct-116: ic50=>50 μm (human); gbm: ic50=>50 μm (human) asbt: ki= 75 μm (human). Group: Pharmaceutical. Alternative Names: 5beta-cholanic acid-3alpha,7beta-diol; Actigall; ursodeoxycholate; ursodiol; Ursodeoxycholic acid. CAS No. 128-13-2. Pack Sizes: 100 g. Product ID: NP6089. Molecular formula: C24H40O4. Mole weight: 392.57. Custom synthesis is available. Send your inquiries for more information. | London |
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