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| Product | Description | |
|---|---|---|
| Bendamustine Chloro Dimer Impurity | Bendamustine Chloro Dimer Impurity is an impurity of Bendamustine, a chemotherapy medication indicated for the treatment of chronic lymphocytic leukemia, multiple myeloma, and non-Hodgkin's lymphoma. Group: Pharmaceutical. CAS No. 1228551-91-4. Pack Sizes: 10 mg. Product ID: B2694-467289. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Bendamustine hydrochloride | Bendamustine hydrochloride is the hydrochloride salt of bendamustine, a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown, this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and, subsequently, apoptosis. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Group: Pharmaceutical. CAS No. 3543-75-7. Pack Sizes: 500 mg. Product ID: NP3323. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bendamustine Hydrochloride Impurities | Bendamustine Hydrochloride Impurities are analyzed in the biomedical field to ensure drug purity and efficacy in cancer treatment, specifically for hematological malignancies like chronic lymphocytic leukemia and non-Hodgkin's lymphoma. Their identification aids in refining cancer therapeutics and enhancing quality control in pharmaceutical production. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AZD3965 | AZD3965 is a selective inhibitor of monocarboxylate transporter 1 (MCT1) with a binding affinity of 1.6 nM, which is 6-fold selective over MCT2 and does not inhibit MCT4 at 10 μM. Both lactate transport and cell growth are potently inhibited by AZD3965 in lymphoma cell lines that preferentially express MCT1. Lactate transport inhibition in some cell lines also induces a cytotoxic effect. In vitro combination studies show that lactate transport inhibition can enhance the induction of cell death by doxorubicin. Blocking lactate transport in vitro also leads to a rapid inhibition of glucose uptake in the Raji Burkitt's lymphoma cell line. In vivo, AZD3965 is well tolerated and induces a dose- and time-dependent accumulation of lactate in the tumors, suppresses tumor growth and in the Raji model potentiates the effects of Rituxan, doxorubicin and bendamustine. The selective inhibition of lactate transport by the MCT1 inhibitor AZD3965 offers a novel mechanism for targeting the metabolic phenotype in tumors that preferentially express MCT1. Group: Pharmaceutical. CAS No. 1448671-31-5. Pack Sizes: 25 mg. Product ID: B2693-463251. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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