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| Product | Description | |
|---|---|---|
| Bedaquiline | 5mg Pack Size. Group: Bioactive Small Molecules, Building Blocks, Research Organics & Inorganics. Formula: C32H31BrN2O2. CAS No. 843663-66-1. Prepack ID : 90024262-5mg. Molecular Weight : 555.5047. |  |
| Bedaquiline | TMC207 is a first-in-class diarylquinoline compound with a novel mechanism of action, the inhibition of bacterial ATP synthase, and potent activity against drug-sensitive and drug-resistant TB. Group: Pharmaceutical. Alternative Names: Sirturo; TMC207; TMC-207; TMC 207; R207910; R-207910; R 207910. CAS No. 843663-66-1. Pack Sizes: 100 mg. Product ID: B0084-152490. Molecular formula: C32H31BrN2O2. Mole weight: 555.5. Custom synthesis is available. Send your inquiries for more information. |  London |
| Bedaquiline fumarate | Bedaquiline fumarate is an anti-tuberculosis drug which selectively inhibits the mycobacterial energy metabolism and found to be effective against all states of Mycobacterium tuberculosis. It possesses a unique mechanism of action that disrupts the activity of the mycobacterial adenosine triphosphate synthase. It has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis, however, its side effect profile limits its use against MDR-TB when no other effective regimen can be provided. Uses: Antitubercular agents. Group: Pharmaceutical. Alternative Names: (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol fumarate. CAS No. 845533-86-0. Pack Sizes: 200 mg. Product ID: B0084-463644. Molecular formula: C36H35BrN2O6. Mole weight: 671.58. Custom synthesis is available. Send your inquiries for more information. | London |
| rac-N-Desmethyl Bedaquiline | rac-N-Desmethyl Bedaquiline is an intermediate used in th synthesis of Bedaquiline, a medication approved for the treatment of active tuberculosis. Group: Pharmaceutical. Alternative Names: N-Monodesmethyl bedaquiline. CAS No. 654654-76-9. Pack Sizes: 1 g. Product ID: B2692-007095. Molecular formula: C31H29BrN2O2. Mole weight: 541.5. Custom synthesis is available. Send your inquiries for more information. | London |
| TBA-354 | TBA-354 is narrow spectrum and bactericidal in vitro against replicating and nonreplicating Mycobacterium tuberculosis, with potency similar to that of delamanid and greater than that of PA-824. TBA-354 maintains activity against Mycobacterium tuberculosis H37Rv isogenic monoresistant strains and clinical drug-sensitive and drug-resistant isolates. TBA-354 is 5 to 10 times more potent than PA-824, but selected mutants are cross-resistant to PA-824 and delamanid. TBA-354 is 2 to 4 times more potent than PA-824 when combined with bedaquiline, and when administered at a dose equivalent to that of PA-824, TBA-354 demonstrated superior sterilizing efficacy. TBA-354 has high bioavailability and a long elimination half-life. In vitro studies suggest a low risk of drug-drug interactions. Low-dose aerosol infection models of acute and chronic murine tuberculosis reveal time- and dose-dependent in vivo bactericidal activity that is at least as potent as that of delamanid and more potent than that of PA-824. Group: Pharmaceutical. Alternative Names: TBA-354, TBA 354, TBA354, SN31354, SN-31354, SN 31354. CAS No. 1257426-19-9. Pack Sizes: 100 mg. Product ID: B2693-463155. Molecular formula: C19H15F3N4O5. Mole weight: 436.34. Custom synthesis is available. Send your inquiries for more information. | London |
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