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| Product | Description | |
|---|---|---|
| Bardoxolone | Bardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is capable of activating the transcription factor peroxisome proliferator activator receptor-γ (PPARγ), its apoptotic effects in malignant cells have been shown to occur independently of PPARγ. Bardoxolone was developed as an potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, serum creatine, which may in turn be beneficial to treat diabetic kidney diseases, cancer and thromboembolic events. Group: Pharmaceutical. Alternative Names: CDDO; RTA 401; RTA401; RTA-401. CAS No. 218600-44-3. Pack Sizes: 25 mg. Product ID: B0084-427947. Molecular formula: C31H41NO4. Mole weight: 491.66. Custom synthesis is available. Send your inquiries for more information. |  London |
| Bardoxolone methyl | Bardoxolone methyl (also known as "RTA 402" and "CDDO-methyl ester") is an orally-available first-in-class synthetic triterpenoid belonging to the antioxidant inflammation modulator (AIM) class. It is the most potent known inducer of the Nrf2 pathway to enter clinical development and works to suppress both oxidative stress and inflammation. Uses: Bardoxolone methyl, also known as rta 402, is a semisynthetic derivative of oleanolic acid that has attracted much attention in the medical community for its potential to treat a variety of chronic diseases, especially chronic kidney disease (ckd). as a member of the antioxidant inflammatory modulator (aim) class of drugs, bardoxolone methyl exerts its therapeutic effects by targeting inflammation. Group: Pharmaceutical. Alternative Names: CDDO Methyl ester; CDDOMe; RTA 402; RTA-402; RTA402; TP-155; TP155; TP 155; 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid methyl ester; bardoxolone methyl; CDDO-Me; methyl 2-cyano-3,12-dioxoolean-1,9-dien-28-oate; (4aS,6aR,6bS,8aR,12aS,14bS)-Methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate. CAS No. 218600-53-4. Pack Sizes: 250 mg. Product ID: BAT-008967. Molecular formula: C32H43NO4. Mole weight: 505.7. Custom synthesis is available. Send your inquiries for more information. | London |
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