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| Product | Description | |
|---|---|---|
| BAR-501 | BAR-501, a UDCA derivative, is a selective GPBAR1 agonist devoid of any FXR agonistic activity. BAR-501 effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1, with a EC50 of 1 μM. Besides, it protects against development of portal hypertension in rodent models of liver injury and endothelial dysfunction. Group: Pharmaceutical. Alternative Names: 3R,5S,6S,7S,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol; BAR-501; BAR 501; BAR501. CAS No. 1632118-69-4. Pack Sizes: 10 mg. Product ID: B0084-482211. Molecular formula: C26H46O3. Mole weight: 406.651. Custom synthesis is available. Send your inquiries for more information. |  London |
| (3alpha,5beta,6beta,7alpha)-6-Ethylcholane-3,7,24-triol | An impurity of BAR-501 which is a selective GPBAR1 agonist devoid of any FXR agonistic activity. Group: Pharmaceutical. Alternative Names: (3R,5S,6S,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-17-[(2R)-5-hydroxypentan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol; (3R,5S,6S,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-17-[(2R)-5-hydroxypentan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol. CAS No. 1632118-70-7. Pack Sizes: 10 mg. Product ID: B1662-482217. Molecular formula: C26H46O3. Mole weight: 406.64. Custom synthesis is available. Send your inquiries for more information. | London |
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