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| Product | Description | |
|---|---|---|
| 14β,16β-Dihydroxy-3β-(β-D-glucopyranosyloxy)-5α-bufa-20,22-dienolide | 14β,16β-Dihydroxy-3β-(β-D-glucopyranosyloxy)-5α-bufa-20,22-dienolide is a remarkable natural compound renowned for its immense potential in studying an array of ailments such as cancer, inflammation and cardiovascular maladies. By proficiently deterring neoplastic proliferation and instigating apoptosis, this natural compound exhibits unyielding anticancer prowess. Group: Pharmaceutical. CAS No. 1323952-04-0. Pack Sizes: 1 mg. Product ID: NP6156. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| 16,23-Oxidoalisol B | 16,23-Oxidoalisol B, a naturally occurring compound, exhibits remarkable potential as an antitumor agent. Its efficacy in impeding the progression of melanoma, colon cancer, and breast cancer cells has been identified and validated through several investigations. The compound's potential rests on its unique ability to trigger cell cycle arrest and apoptosis in cancerous cells - properties that make it an excellent target for developing novel cancer therapies. Group: Pharmaceutical. CAS No. 169326-06-1. Pack Sizes: 1 mg. Product ID: NP7117. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 16-Hydroxycleroda-3,13-dien-15,16-olide | 16-Hydroxycleroda-3,13-dien-15,16-olide is extracted from the unripe fruits of Polyalthia longifolia var. pendula. It is used as a candidate for autophagy inducers which can cause cell death in an alternative or supplement medicine for cancer therapy. It displays promising NO inhibitory activity at 10 ug/mL and shows anti-inflammatory activity. It induces apoptosis in CML K562 cells and regulates the expression of histone-modifying enzymes PRC2 complex. Group: Pharmaceutical. CAS No. 141979-19-3. Pack Sizes: 1 mg. Product ID: NP1411. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 25-Hydroxy-Cholesterol | 25-hydroxycholesterol is an inhibitor of human immunodeficiency virus replication in vitro. It induces apoptosis in human monocytic cell lines as well as in CEM cells associated with negative regulation of c-Myc. Group: Pharmaceutical. CAS No. 2140-46-7. Pack Sizes: 200 mg. Product ID: B2693-000027. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 2,6-Dichloro-4-(2,4,6-triphenyl-1-pyridinio)phenolate | 2,6-Dichloro-4-(2,4,6-triphenyl-1-pyridinio)phenolate, commonly known as DCTPP, is a potent pharmaceutical agent utilized in the treatment of various types of cancer, including breast, lung, and ovarian cancer. Its modus operandi involves arresting the cell cycle and inducing apoptosis in cancerous cells by causing DNA damage at various sites. DCTPP's diverse functions extend beyond cancer treatment and could find valuable applications as an anti-inflammatory agent with pronounced activity against pro-inflammatory cytokines. Group: Pharmaceutical. CAS No. 121792-58-3. Pack Sizes: 25 mg. Product ID: B2699-154172. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 2'-Amino-2'-deoxyuridine | 2'-Amino-2'-deoxyuridine, a nucleoside analogue, finds its use in chemotherapy as an anti-cancer agent. Its ability to cause DNA damage and trigger apoptosis in cancer cells stem from its selective integration in cancer cell DNA. Additionally, it offers immense potential in the field of oncology research, studying tumor cell differentiation and proliferation. Group: Pharmaceutical. CAS No. 26889-39-4. Pack Sizes: 1 g. Product ID: B2706-089006. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 2β-Hydroxygrandiflorenic acid | 2β-Hydroxygrandiflorenic acid, a natural triterpenoid, exhibits immense potential in suppressing tumor growth and inflammation. Its anti-proliferative and apoptosis-inducing properties have been tested and proved in various cancer cell lines, which corroborates its suitability as an anti-cancer remedy. Group: Pharmaceutical. Pack Sizes: 1 mg. Product ID: B0005-267653. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 2-butoxy-7-[[4-(1-pyrrolidinylmethyl)phenyl]methyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine | 2-butoxy-7-[[4-(1-pyrrolidinylmethyl)phenyl]methyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine, a medicinal molecule known for its kinase-inhibiting properties, has been identified as a potential candidate for cancer therapy due to its unique ability to induce apoptosis and inhibit the proliferation of malignant cells. With promising applications in the treatment of leukemia and lung cancer, this small-molecule inhibitor has the potential to address critical unmet clinical needs in cancer management. Its effectiveness and suitability as a therapeutic intervention call for further investigation in the field of oncology. Group: Pharmaceutical. CAS No. 1878111-20-6. Pack Sizes: 5 mg. Product ID: B0001-008679. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 2-Hydroxyphenanthrene | 2-Hydroxyphenanthrene, a naturally occurring compound, has garnered attention in the biomedical industry due to its remarkable antioxidant and antitumor activity. This multifaceted molecule has been reported to trigger apoptosis in cancer cells and suppress tumor development in animal models. Moreover, its therapeutic potential extends to neurodegenerative conditions, such as Alzheimer's and Parkinson's, where it holds promising results. This compound's diverse pharmacological mechanisms and noteworthy biological activities make it a subject of interest in current research. Uses: A metabolite of phenanthrene. Group: Pharmaceutical. CAS No. 605-55-0. Pack Sizes: 5 mg. Product ID: B2699-015399. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 3-Methyladenine | 3-Methyladenine is an autophagy inhibitor that protects cerebellar granule cells (CGCs) from apoptosis following serum/potassium deprivation. 3-Methyladenine inhibits phosphoinositide 3-kinase (PI3K) activity, which plays a key role in autophagy process. Group: Pharmaceutical. CAS No. 5142-23-4. Pack Sizes: 250 mg. Product ID: B0084-070159. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 3-(Methylseleno)-L-alanine | 3-(Methylseleno)-L-alanine, a metabolite found in Escherichia coli (strain K12, MG1655), is an inhibitor of DMBA-induced mammary tumors. It has oral bioavailability and can induce cell apoptosis. Group: Pharmaceutical. CAS No. 26046-90-2. Pack Sizes: 1 g. Product ID: BBF-05851. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 4-Vinylsyringol | 4-Vinylsyringol, a phenolic compound with antioxidant properties, shows potential as a COX-2 inhibitor and is a flavoring agent extracted from crude canola oil. It may inhibit tumor cell growth while inducing cell apoptosis. Group: Pharmaceutical. CAS No. 28343-22-8. Pack Sizes: 100 mg. Product ID: B0001-453486. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 5-Deoxy-L-ribose phenylhydrazone | 5-Deoxy-L-ribose phenylhydrazone, an intriguing compound, has been the subject of numerous biomedical research studies, aimed at elucidating its impact on cellular metabolism, specifically glucose transport and metabolism. Additionally, this multifaceted compound has ignited significant interest due to its potential to treat diverse maladies, including cancer, owing to its tumor growth-inhibiting properties and apoptosis-inducing abilities. Group: Pharmaceutical. CAS No. 123168-30-9. Pack Sizes: 150 mg. Product ID: B1999-001003. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 6-Hydroxycoumurrayin | 6-Hydroxycoumurrayin, a naturally occurring metabolite derived from botanical sources, has garnered significant scientific interest for its potential anti-cancer properties. Diverse preclinical studies have demonstrated its potency in impeding cell proliferation and inducing apoptosis in different cancer types, such as pancreatic and breast tumors. Ongoing research efforts are underway to ascertain the therapeutic efficacy of 6-Hydroxycoumurrayin and its clinical utility as a novel anti-cancer agent. Group: Pharmaceutical. CAS No. 2188162-97-0. Pack Sizes: 5 mg. Product ID: NP1072. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 6-Shogaol | 6-Shogaol is a pungent constituent of ginger similar in chemical structure to gingerol. It has anti-inflammatory properties. lt was reported to have antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. lt effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-κB and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis. lt inhibits the growth of human cancer cells and induces apoptosis in COLO 205 cells through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). Uses: 6-shogaol exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation. it has a very strong antitussive (anti-cough) effect. Group: Pharmaceutical. CAS No. 555-66-8. Pack Sizes: 50 mg. Product ID: NP5193. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 8-Shogaol | 8-Shogaol is extracted from the rhizomes of Zingber officinale Rosc. lt was able to induce apoptosis in a time- and concentration-dependent manner. Group: Pharmaceutical. CAS No. 36700-45-5. Pack Sizes: 20 mg. Product ID: NP5141. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| A-1331852 | A-1331852, a substituted benzothiazole, is a high affinity BH3 mimetic Ligand of BCL protein BCL-XL (Ki ≤ 10 pM). A-1331852 is an orally apoptosis-inducing agent that may have potential as improved cancer therapeutics. Group: Pharmaceutical. CAS No. 1430844-80-6. Pack Sizes: 100 mg. Product ID: B0084-007703. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ABT-737 | ABT-737 is a potent, cell-permeable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki < 1 nM for all three proteins). It blocks the interaction of these proteins with pro-death proteins, leading to apoptosis. Group: Pharmaceutical. CAS No. 852808-04-9. Pack Sizes: 100 mg. Product ID: B1370-139061. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ABT 737-[d8] | Labelled ABT-737. ABT-737 is a potent, cell-permeable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki < 1 nM for all three proteins). It blocks the interaction of these proteins with pro-death proteins, leading to apoptosis. Group: Pharmaceutical. CAS No. 1217686-68-4. Pack Sizes: 1mg; 1g; 10g. Product ID: BLP-003187. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ac-DEVD-CMK | Ac-DEVD-CMK is a cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, -7, -8, and -10. It is commonly used at concentrations up to 100 μM to examine the role of caspase-3-dependent apoptosis in biological systems. Group: Pharmaceutical. CAS No. 285570-60-7. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-015391. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acelarin | Acelarin is a DNA synthesis inhibitor with EC50 of 0.2 nM. Acelarin is a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine. It is converted into the active metabolites dFdCDP and dFdCTP. dFdCDP can inhibit ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA replication; dFdCTP can be incorporated into DNA, resulting in premature termination of DNA replication and eventually induction of apoptosis. Phase III clinical trials for the treatment of Pancreatic cancer are on-going. Uses: Pancreatic cancer. Group: Pharmaceutical. CAS No. 840506-29-8. Pack Sizes: 50 mg. Product ID: B2693-476645. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetylcorynoline | Acetylcorynoline, which can be extracted from the tubers of Corydalis ambigua, inhibits the maturing of bone marrow-derived dendritic cells in mice. However, it is only cytotoxic in amounts of greater than 20 μM. Acetylcorynoline may be one of the potent immunosuppressive agents through the blockage of dendritic cells maturation and function. Acetylcorynoline significantly decreases dopaminergic neuron degeneration induced by 6-hydroxydopamine in BZ555 strain; prevents α-synuclein aggregation; recovers lipid content in OW13 strain; restores food-sensing behavior, and dopamine levels; and prolongs life-span in 6-hydroxydopamine-treated N2 strain, thus showing its potential as a possible antiparkinsonian drug. Acetylcorynoline may exert its effects by decreasing egl-1 expression to suppress apoptosis pathways and by increasing rpn5 expression to enhance the activity of proteasomes. Uses: Antifungal/anti-inflammatory. Group: Pharmaceutical. CAS No. 18797-80-3. Pack Sizes: 10 mg. Product ID: B2703-464490. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetylcysteine-15N | Acetylcysteine-15N (N-Acetylcysteine-15N) is the 15N-labeled Acetylcysteine. Acetylcysteine is a mucolytic agent which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor, a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell Apoptosis. Acetylcysteine also has anti-influenza virus activities. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acivicin | Acivicin is an isoxazole antibiotic isolated from Streptomyces. sviceus. Acivicin is a glutamine analog that irreversibly inhibits glutamine-dependent amidotransferases involved in nucleotide and amino acid biosynthesis (Kis = 10 and 560 μM for anthranilate synthase and glutamate synthase, respectively) as a potent antitumor antibiotic that induces apoptosis in human lymphoblastoid cells. Acivicin is an inhibitor of GGT used for solid tumor research. Uses: Protease inhibitor. Group: Pharmaceutical. CAS No. 42228-92-2. Pack Sizes: 1mg; 1g; 10g. Product ID: BBF-00541. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Actinodaphnine | Actinodaphnine, an alkaloid found in Cassytha filiformis and Neolitsea sericea, acts as an apoptosis inducer, plant metabolite, topoisomerase inhibitor, antifungal agent, antibacterial agent, antitumor agent, and platelet aggregation inhibitor. Group: Pharmaceutical. CAS No. 517-69-1. Pack Sizes: 1mg; 1g; 10g. Product ID: NP0776. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Actinonin | Actinonin, a natural antibacterial agent produced by Actinomyces, is a potent reversible peptide deformylase (PDF) inhibitor with Ki of 0.28 nM. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin induces apoptosis and has antiproliferative and antitumor activities. Uses: Anti-bacterial agents. Group: Pharmaceutical. CAS No. 13434-13-4. Pack Sizes: 1mg; 1g; 10g. Product ID: BBF-00543. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ADPM06 | ADPM06 is a nonporphyrin photodynamic therapeutic (PDT) agent, which is an established treatment modality for cancer. It exhibits IC50s in the micro-molar range in human tumor cells and induces apoptosis. Group: Pharmaceutical. CAS No. 490035-90-0. Pack Sizes: 5 mg. Product ID: B2693-462646. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AEE-788 | AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. Group: Pharmaceutical. CAS No. 497839-62-0. Pack Sizes: 10 mg. Product ID: B0084-258485. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Aglain C | Aglain C, an organic alkaloid of natural origins, demonstrates anti-tumor activity, thus possessing potential application in diverse cancer treatment modalities. It elicits apoptosis, or cell death, in malignant cells, and exhibits anti-inflammatory properties. To ascertain its therapeutic value comprehensively, additional examination is warranted. Group: Pharmaceutical. CAS No. 177468-85-8. Pack Sizes: 2 mg. Product ID: NP0163. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Alisol B 23-acetate | Alisol B acetate is a triterpene from Rhizoma Alismatis (rhizomes of Alisma plantago-aquatica). It induces apoptosis in human prostate cancer cells. It produces protective effect against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regul. Group: Pharmaceutical. CAS No. 26575-95-1. Pack Sizes: 20 mg. Product ID: NP7036. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Aloperine | Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties. Aloperine induces apoptosis and autophagy in HL-60 cells. Uses: Anti-inflammatory, antibacterial, antiviral, and antitumor. Group: Pharmaceutical. CAS No. 56293-29-9. Pack Sizes: 1 g. Product ID: B2703-345494. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| α-Tocotrienol | α-Tocotrienol is a form of vitamin E, a class of eight fat-soluble compounds. It was shown to induce apoptosis and inhibit proliferation, and down-regulate the fibroblast growth factor receptor-1 (FGFR1). Uses: Antioxidants. Group: Pharmaceutical. CAS No. 58864-81-6. Pack Sizes: 25 mg. Product ID: B0005-190073. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Alsterpaullone | Alsterpaullone is a potent glycogen synthase kinase-3 inhibitor and a potential therapeutic agent for the treatment of Parkinson disease. Alsterpaullone is also known as 9-Nitropaullone and NSC 705701, which is a derivative of kenpaullone and an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Alsterpaullone induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Alsterpaullone is a derivative of kenpaullone with slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively. Group: Pharmaceutical. CAS No. 237430-03-4. Pack Sizes: 50 mg. Product ID: B2693-103248. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Antagonist G | Antagonist G is a substance P analog, which is a broad spectrum neuropeptide growth factor antagonist and antiproliferative agent. It was developed for the treatment of small cell lung cancer. It could inhibit neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro. It also inhibits growth of SCLC xenografts in mice in vivo. It blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. It activates JNK and stimulates apoptosis. It is an anticancer agent and is resistant to degradation by peptidases. Group: Pharmaceutical. CAS No. 115150-59-9. Pack Sizes: 1 mg. Product ID: BAT-006104. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Arborinine | Arborinine is an alkaloid isolated from Erthela bahiensis. Arborinine was shown to inhibit splenocytes proliferation under ConA or PWM stimulation and promote apoptosis on splenocytes and thymocytes stimulated with PWM in 24h. It also decreases production of Interleukin-10 by splenocytes and thymocytes stimulated with ConA or PWM. Group: Pharmaceutical. CAS No. 5489-57-6. Pack Sizes: 1 mg. Product ID: NP0701. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Aristololactam | The cytotoxic potency of Aristololactam I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase 3-dependent pathway. Group: Pharmaceutical. CAS No. 13395-02-3. Pack Sizes: 10 mg. Product ID: B2703-223426. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ARV-825 | ARV-825 is a BRD4 inhibitor based on PROTAC technology. ARV-825 recruits BRD4 to E3 ubiquitin ligase cereblon, resulting in the degradation of BRD4. In post-myeloproliferative neoplasm secondary (s) AML cell lines, treatment with ARV-825 induces apoptosis and inhibits cell proliferation. Group: Pharmaceutical. CAS No. 1818885-28-7. Pack Sizes: 100 mg. Product ID: B1370-474664. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AT13148 | AT13148 is an orally available multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity. It can block phosphorylation of AKT, p70S6K, PKA, ROCK and SGK substrates, and induce apoptosis in cancer cells. Group: Pharmaceutical. CAS No. 1056901-62-2. Pack Sizes: 50 mg. Product ID: B0084-462670. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AT-406 | AT-406 is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3 (with Ki of 66.4 nM), cIAP1-BIR3(with Ki of 1.9 nM) and cIAP2-BIR3 (with Ki of 5.1 nM), respectively. Group: Pharmaceutical. CAS No. 1071992-99-8. Pack Sizes: 100 mg. Product ID: B0084-454116. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AT7519 HCl | AT-7519 is an orally bioavailable small molecule CDK inhibitor with potential antineoplastic activity. AT7519M selectively binds to and inhibits cyclin dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. Group: Pharmaceutical. CAS No. 902135-91-5. Pack Sizes: 10 mg. Product ID: B0084-100271. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Avapritinib | BLU-285 is a potent and selective inhibitor of exon 17 mutant KIT (IC50 = 0.27 nM for KIT D816V). BLU-285 showed dose-dependent, robust anti-tumor efficacy in a TKI-resistant KIT exon 11/17 mutant GIST PDX model through inhibition of tumor growth, proliferation, KIT signaling and induction of apoptosis. Group: Pharmaceutical. CAS No. 1703793-34-3. Pack Sizes: 10 mg. Product ID: B0084-007732. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Azoramide | Azoramide is a modulator of the unfolded protein response with antidiabetic activity. It is a dual-function endoplasmic reticulum (ER) modulator in vitro. It improves endoplasmic reticulum (ER) protein-folding ability and stimulates the expression of ER chaperones to protect cells against ER stress in multiple systems. It regulates ER folding and secretion capacity without inducing ER stress. It might have the protective effects of enhancing chaperone expression and reducing protein synthesis without inducing cytotoxicity and apoptosis. It showed potent antidiabetic activity in two independent mouse models of obesity by protecting pancreatic β cell function against ER stress and improving insulin sensitivity in vivo. It improves glucose homeostasis in mice with genetic obesity and diet-induced obesity. Group: Pharmaceutical. CAS No. 932986-18-0. Pack Sizes: 100 mg. Product ID: B1370-474920. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BDA-366 | BDA-366 is a small-molecule antagonist of Bcl2-BH4 domain with high affinity and selectivity for Bcl2-BH4. BDA-366 induces apoptosis in multiple myeloma cells via Bcl2 conformational change. Group: Pharmaceutical. CAS No. 1909226-00-1. Pack Sizes: 300 mg. Product ID: B0084-053991. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Belinostat | Belinostat is a hydroxamic acid-type histone deacetylase (HDAC) inhibitor. Belinostat targets HDAC enzymes to inhibit tumor cell proliferation and angiogenesis, induce apoptosis and promote cellular differentiation. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 414864-00-9. Pack Sizes: 100 mg. Product ID: B0084-141764. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bellidifolin | Bellidifolin is a xanthone that can be isolated from the plants of Gentiana species. Study shows that bellidifolin is a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica. Bellidifolin may contribute to the protective effects associated with nerve injury initiated by hypoxia by mechanisms related to inhibition of cell apoptosis independent of the ERK pathway, but may involve blockade of p38MAPK signaling pathway activation and downstream caspase-3 expression. Group: Pharmaceutical. CAS No. 2798-25-6. Pack Sizes: 5 mg. Product ID: NP7359. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bendamustine hydrochloride | Bendamustine hydrochloride is the hydrochloride salt of bendamustine, a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown, this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and, subsequently, apoptosis. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Group: Pharmaceutical. CAS No. 3543-75-7. Pack Sizes: 500 mg. Product ID: NP3323. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Betulinic acid | Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induces apoptosis through induction of changes in mitochondrial membrane potential, production of reactive oxygen species, and opening of mitochondrial permeability transition pores, resulting in the release of mitochondrial apogenic factors, activation of caspases, and DNA fragmentation. Betulinic acid is a natural compound found in the herbs of Ziziphus jujuba. It can be used in cosmetics material. Uses: Anti-melanogenic/antitumor/anti-hiv. Group: Pharmaceutical. CAS No. 472-15-1. Pack Sizes: 10 g. Product ID: NP6980. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Birinapant | Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. As a SMAC mimetic and IAP antagonist, TL32711 binds to and inhibits the activity of IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. CAS No. 1260251-31-7. Pack Sizes: 100 mg. Product ID: B0084-462223. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BMS-777607 | BMS-777607 is a novel prodrug of the dual Met/VEGFR-2 inhibitor. It shows antitumor activity, inducing apoptosis and decreasing proliferation and migration. Group: Pharmaceutical. CAS No. 1025720-94-8. Pack Sizes: 50 mg. Product ID: B2693-456491. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BMS-911543 | BMS-911543 is an orally available JAK inhibitor with selectivity for JAK2. It inhibts JAK2, thereby preventing the JAK/STAT (signal transducer and activator of transcription) signaling cascade, including activation of STAT3. This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation. Group: Pharmaceutical. CAS No. 1271022-90-2. Pack Sizes: 20 mg. Product ID: B0084-457828. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Boc-D-FMK | BOC-D-FMK is a cell-permeable broad-spectrum caspase inhibitor that fully inhibits the pro-apoptotic effect of tumor necrosis factor-α (TNFα). It has been found to reduce the activation of nuclear factor kappa light chain enhancer of activated B cells (NF-kB), suppress the phosphorylation of subunit nuclear factor kappa light polypeptide gene enhancer in B cells inhibitor α (IkBα) and inhibit TNF-induced expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1). Moreover, it has also effectively attenuated the hepatocyte apoptosis in bile duct-ligated rats potentially improving the survival rates. Uses: Caspase inhibitors. Group: Pharmaceutical. CAS No. 187389-53-3. Pack Sizes: 100 mg. Product ID: BAT-010386. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bruceine D | Bruceine D is extracted from the barks of Ailanthus altissima. It is an inhibitor of hepatocellular carcinoma growth and inhibits the growth of three pancreatic cancer cell lines, which acts by targeting β-catenin/jagged1 pathways. It also induces cytotoxicity in Capan-2 cells by inducing cellular apoptosis involving the mitochondrial pathway. It may be used as a lead compound for new viricides, or a natural viricide. Group: Pharmaceutical. CAS No. 21499-66-1. Pack Sizes: 10 mg. Product ID: NP1540. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Butin | Butin is a natural flavonoid found in the seeds of Cassia tora. Butin has activity of antioxidant, which can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction. Uses: Antioxidant. Group: Pharmaceutical. CAS No. 492-14-8. Pack Sizes: 10 mg. Product ID: NP2469. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| C16 Ceramide | C16 ceramide is an endogenous ceramide, generated by ceramide synthase 6 (CerS6), that acts as a lipid second messenger to regulate apoptosis and stress signaling. It has also been found to activate NF-κB and PKCζ3. Uses: A predominant, rather hydrophobic natural ceramide. activates a cytosolic serine/threonine protein phosphatase in t9 cells; induces egf receptor phosphorylation in a-431 cells; stimulates ceramide-activated protein kinase. Group: Pharmaceutical. CAS No. 24696-26-2. Pack Sizes: 100 mg. Product ID: B1370-059982. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Carmustine | Carmustine is antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. It is used in the treatment of brain tumors, multiple myeloma and some lymphomas. Group: Pharmaceutical. CAS No. 154-93-8. Pack Sizes: 5 g. Product ID: B2693-465289. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CBS9106 | CBS9106, also known as BMS-566419, is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity. CRM1 plays an important role in the nuclear export of cargo proteins bearing nuclear exporting signal sequences. CBS9106 inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells, including multiple myeloma cells. CBS9106 reduces CRM1 protein levels significantly without affecting CRM1 mRNA expression. Oral administration of CBS9106 significantly suppresses tumor growth and prolongs survival in mice bearing tumor xenograft without a significant loss in body weight. A reduced level of CRM1 protein is also observed in tumor xenografts isolated from mice treated with CBS9106. Taken together, these results indicate that CBS9106 is a novel reversible CRM1 inhibitor and a promising clinical candidate. Group: Pharmaceutical. CAS No. 1076235-04-5. Pack Sizes: 10 mg. Product ID: B1370-462313. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CC122 | CC122 is a novel agent for DLBCL. It is an orally available pleiotropic pathway modulator. It has antitumor and immunomodulatory activity. It is used for the treatment of chronic lymphocytic leukemia. It binds CRBN and degrades Aiolos and Ikaros resulting in a mimicry of IFN signaling and apoptosis in DLBCL. It inhibits proliferation and induces apoptosis in ABC and GCB DLBCL in vitro. It was developed by Celgene Corporation(CELG) and was in clinic phase 2 trial. Uses: Cc122 has antitumor and immunomodulatory activity. it is used for the treatment of chronic lymphocytic leukemia. Group: Pharmaceutical. CAS No. 1015474-32-4. Pack Sizes: 25 mg. Product ID: B0084-474963. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CC-223 | CC-223, a mTOR kinase inhibitor, has been found to be effective in inducing the apoptosis and reducing the proliferation of tumor cells. It is still under Phase I/II clinical trial by Celgene Corporation. IC50: 16 nM. Uses: Cc-223 is a mtor kinase inhibitor that has been found to be effective in inducing the apoptosis and reducing the proliferation of tumor cells. Group: Pharmaceutical. CAS No. 1228013-30-6. Pack Sizes: 300 mg. Product ID: B0084-474093. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cerdulatinib HCl | Cerdulatinib is a dual SYK/JAK inhibitor. It significantly reduces cell viability in a subset of NHL cell lines, and induces apoptosis in BCR-signaling competent NHL cell lines. Group: Pharmaceutical. CAS No. 1369761-01-2. Pack Sizes: 10 mg. Product ID: B0084-463402. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CGM097 | CGM097 is an orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, p53/HDM2 interaction inhibitor CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited, which may result in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator of the p53 pathway, often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival. Group: Pharmaceutical. CAS No. 1313363-54-0. Pack Sizes: 5 mg. Product ID: B0084-462483. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Chelerythrine | Chelerythrine is a benzophenanthridine alkaloid extracted from the plant Greater celandine (Chelidonium majus). It is a potent, selective, and cell-permeable protein kinase C inhibitor. It is also the major active natural product found in the plant Zanthoxylum clava-herculis, exhibiting anti-bacterial activity against Staphylococcus aureus. Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy. Uses: Antibacterial agent. Group: Pharmaceutical. CAS No. 34316-15-9. Pack Sizes: 50 mg. Product ID: NP0509. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cinobufagin | Cinobufagin can inhibite the proliferation of U-2OS cells, and induce cell apoptosis. The potential mechanism of Cinobufagin-induced apoptosis may be related to the mitochondria-mediated pathway. Uses: An important cardenolidal steroid. Group: Pharmaceutical. CAS No. 470-37-1. Pack Sizes: 25 mg. Product ID: NP6092. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cirsimaritin | Cirsimaritin is purified from the herbs of Microtea debilis. Cirsimaritin has the potential use in patients with congestive heart failure that can mitigate cardiac remodeling and left ventricular dysfunction through augmenting myocardial autophagy and decreasing matrix metalloproteinase-2&9 activities. Cirsimaritin inhibits the growth of tumor cells and induces mitochondrial apoptosis in human gallbladder carcinoma cell line (GBC-SD), and it triggers endoplasmic reticulum (ER) stress and down-regulates the phosphorylation of Akt. Cirsimaritin shows moderate anti-proliferative activity against COLO-205 cells with IC 50 values of 13.1uM. Cirsimaritin increases tyrosinase activity and melanin content in murine B16F10 melanoma cells by activation of CREB as well as upregulation of MITF and tyrosinase expression in a dose-dependent manner; support the putative application of cirsimaritin in ultraviolet photoprotection and hair coloration treatments. Group: Pharmaceutical. CAS No. 6601-62-3. Pack Sizes: 5 mg. Product ID: NP2021. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cisplatin | Cisplatin induces cytotoxicity by interaction with DNA to form DNA adducts which activate several signal transduction pathways, including Erk, p53, p73, and MAPK, which culminates in the activation of apoptosis. It is used in several types of cancer. Uses: Antineoplastic agent. Group: Pharmaceutical. CAS No. 15663-27-1. Pack Sizes: 2 g. Product ID: BBF-03995. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Coenzyme Q9 | Coenzyme Q9 is a co-enzyme that is lipid solumbe compononet of cell membranes. It is useful in electron and proton transport of liposome systems. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis. Group: Pharmaceutical. CAS No. 303-97-9. Pack Sizes: 50 mg. Product ID: B2699-305013. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Coronarin D | Coronarin D, a natural labdane-type diterpene found in the rhizomes of Hedychium coronarium,inhibits NF-kappaB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis. Coronarin D exhibits promising antifungal activity against C. Uses: Antif-ungal. Group: Pharmaceutical. CAS No. 119188-37-3. Pack Sizes: 1 mg. Product ID: NP1382. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Coronarin D ethyl ether | Coronarin D ethyl ether is a natural diterpenoid found in the rhizomes of Hedychium coronarium, it leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis by inhibiting NF-KB activation pathway. And vitro, coronarin D shows promising antifungal activity against C. albicans. Uses: Antifungal. Group: Pharmaceutical. CAS No. 138965-89-6. Pack Sizes: 1 mg. Product ID: NP1391. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Corosolic acid | Corosolic acid, that is isolated from the barks of Lagerstroemia speciosa, contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts its anticancer activity against colon cancer cells by promoting the N-terminal phosphorylation and subsequent proteasomal degradation of β-catenin. Besides, Corosolic acid induced apoptosis in colorectal cancer (CRC), rendering this compound a potential anticancer agent for the treatment of CRC. Corosolic acid, as a new plant medicine for preventing and treating obesity and type II diabetes, and a functional natural health food and pharmaceutical raw material, has become a popular product in the market. Uses: Anti-angiogenic/anticancer. Group: Pharmaceutical. CAS No. 4547-24-4. Pack Sizes: 50 mg. Product ID: NP7232. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Crocin | Crocin is a water-soluble carotenoid pigment in saffron (Crocus sativus L.) with anti-inflammatory, antioxidant, anti-apoptosis, anti-asthma, anti-cancer, anti-allergy, relaxation of smooth muscle and hypolipidemic effects. Crocin inhibits tumor necrosis factor (TNF) α-induced pheochromocytoma (PC12) apoptosis by regulating the mRNA expression of Bcl-2 family proteins, which trigger downstream signals that ultimately lead to caspase-3 activation and subsequent cell death. Uses: Antioxidant, anticancer. Group: Pharmaceutical. CAS No. 42553-65-1. Pack Sizes: 100 mg. Product ID: B2703-002922. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cucurbitacin D | Source from rhizomes of Hemsleya amabilis Diels. It might be a new therapeutic option for the treatment of endometrial and ovarian cancers, also may be a potential therapeutic agent for β-hemoglobinopathies, including sickle cell anemia and β-thalassemia. And it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells. Uses: Antitumor, resistance to chemical carcinogens, protect liver. Group: Pharmaceutical. CAS No. 3877-86-9. Pack Sizes: 5 mg. Product ID: B0005-464521. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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