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| Product | Description | |
|---|---|---|
| 14β,16β-Dihydroxy-3β-(β-D-glucopyranosyloxy)-5α-bufa-20,22-dienolide | 14β,16β-Dihydroxy-3β-(β-D-glucopyranosyloxy)-5α-bufa-20,22-dienolide is a remarkable natural compound renowned for its immense potential in studying an array of ailments such as cancer, inflammation and cardiovascular maladies. By proficiently deterring neoplastic proliferation and instigating apoptosis, this natural compound exhibits unyielding anticancer prowess. Group: Pharmaceutical. Alternative Names: AKOS040762541; 14??,16??-Dihydroxy-3??-(??-D-glucopyranosyloxy)-5??-bufa-20,22-dienolide; 1323952-04-0. CAS No. 1323952-04-0. Pack Sizes: 1 mg. Product ID: NP6156. Molecular formula: C30H44O10. Mole weight: 564.673. Custom synthesis is available. Send your inquiries for more information. |  London |
| 16,23-Oxidoalisol B | 16,23-Oxidoalisol B, a naturally occurring compound, exhibits remarkable potential as an antitumor agent. Its efficacy in impeding the progression of melanoma, colon cancer, and breast cancer cells has been identified and validated through several investigations. The compound's potential rests on its unique ability to trigger cell cycle arrest and apoptosis in cancerous cells - properties that make it an excellent target for developing novel cancer therapies. Group: Pharmaceutical. CAS No. 169326-06-1. Pack Sizes: 1 mg. Product ID: NP7117. Molecular formula: C30H46O4. Mole weight: 470.693. Custom synthesis is available. Send your inquiries for more information. | London |
| 16-Hydroxycleroda-3,13-dien-15,16-olide | 16-Hydroxycleroda-3,13-dien-15,16-olide is extracted from the unripe fruits of Polyalthia longifolia var. pendula. It is used as a candidate for autophagy inducers which can cause cell death in an alternative or supplement medicine for cancer therapy. It displays promising NO inhibitory activity at 10 ug/mL and shows anti-inflammatory activity. It induces apoptosis in CML K562 cells and regulates the expression of histone-modifying enzymes PRC2 complex. Group: Pharmaceutical. Alternative Names: 5-Hydroxy-4-[2-[[(1S)-1,2,3,4,4a,7,8,8abeta-octahydro-1alpha,2alpha,4aalpha,5-tetramethylnaphthalen]-1-yl]ethyl]furan-2(5H)-one. CAS No. 141979-19-3. Pack Sizes: 1 mg. Product ID: NP1411. Molecular formula: C20H30O3. Mole weight: 318.45. Custom synthesis is available. Send your inquiries for more information. | London |
| 25-Hydroxy-Cholesterol | 25-hydroxycholesterol is an inhibitor of human immunodeficiency virus replication in vitro. It induces apoptosis in human monocytic cell lines as well as in CEM cells associated with negative regulation of c-Myc. Group: Pharmaceutical. Alternative Names: (3β)-Cholest-5-ene-3,25-diol; Cholest-5-ene-3β,25-diol; 25-Hydroxy-5-cholestene-3β-ol; 5-Cholesten-3β,25-diol. CAS No. 2140-46-7. Pack Sizes: 200 mg. Product ID: B2693-000027. Molecular formula: C27H46O2. Mole weight: 402.65. Custom synthesis is available. Send your inquiries for more information. | London |
| 2,6-Dichloro-4-(2,4,6-triphenyl-1-pyridinio)phenolate | 2,6-Dichloro-4-(2,4,6-triphenyl-1-pyridinio)phenolate, commonly known as DCTPP, is a potent pharmaceutical agent utilized in the treatment of various types of cancer, including breast, lung, and ovarian cancer. Its modus operandi involves arresting the cell cycle and inducing apoptosis in cancerous cells by causing DNA damage at various sites. DCTPP's diverse functions extend beyond cancer treatment and could find valuable applications as an anti-inflammatory agent with pronounced activity against pro-inflammatory cytokines. Group: Pharmaceutical. CAS No. 121792-58-3. Pack Sizes: 25 mg. Product ID: B2699-154172. Molecular formula: C29H19Cl2NO. Mole weight: 468.37. Custom synthesis is available. Send your inquiries for more information. | London |
| 2,7-Dihydroxy-1,6-dimethylpyrene | 2,7-Dihydroxy-1,6-dimethylpyrene is an extraordinary polyaromatic hydrocarbon exhibiting exceptional pharmacological abilities within the research of natural compound. With remarkable prospects in studying an array of ailments, encompassing the treacherous afflication known as cancer, this natural compound gently impinges upon the cessation of cellular proliferation whilst summoning apoptosis. Group: Pharmaceutical. CAS No. 468103-76-6. Pack Sizes: 1 mg. Product ID: NP4884. Molecular formula: C18H14O2. Mole weight: 262.31. Custom synthesis is available. Send your inquiries for more information. | London |
| 2-Amino-2',5-dichlorobenzophenone | 2-Amino-2',5-dichlorobenzophenone is a key intermediate in the synthesis of pharmaceuticals and research chemicals. It is used in the production of anticancer drugs and antitumor agents due to its potential to inhibit cancer cell growth. Additionally, it finds application in the research of various diseases related to cell proliferation and apoptosis. Group: Pharmaceutical. Alternative Names: Methanone, (2-amino-5-chlorophenyl)(2-chlorophenyl)-; Benzophenone, 2-amino-2',5-dichloro-; 2,5'-Dichloro-2'-aminobenzophenone; 2-Amino-5-chloro-2'-chlorobenzophenone; 2',5-Dichloro-2-aminobenzophenone; NSC 611905. CAS No. 2958-36-3. Pack Sizes: 1mg;1g;10g. Product ID: NP2988. Molecular formula: C13H9Cl2NO. Mole weight: 266.12. Custom synthesis is available. Send your inquiries for more information. | London |
| 2'-Amino-2'-deoxy-b-D-arabino-5-methyluridine | 2'-Amino-2'-deoxy-b-D-arabino-5-methyluridine is a nucleoside analog with the ability to inhibit viral reverse transcriptase and DNA polymerase activities. It has been used in the development of antiviral drugs for the treatment of HIV and hepatitis B and C infections. Additionally, it has been studied for its potential use in cancer therapy due to its ability to induce apoptosis in cancer cells. Group: Pharmaceutical. Alternative Names: 2,4(1H,3H)-Pyrimidinedione, 1-(2-amino-2-deoxy-β-D-arabinofuranosyl)-5-methyl-; 2'-Amino-2'-deoxy-β-D-arabino-5-methyluridine. CAS No. 135304-48-2. Pack Sizes: 10 mg. Product ID: B1370-039073. Molecular formula: C10H15N3O5. Mole weight: 257.24. Custom synthesis is available. Send your inquiries for more information. | London |
| 2'-Amino-2'-deoxyuridine | 2'-Amino-2'-deoxyuridine, a nucleoside analogue, finds its use in chemotherapy as an anti-cancer agent. Its ability to cause DNA damage and trigger apoptosis in cancer cells stem from its selective integration in cancer cell DNA. Additionally, it offers immense potential in the field of oncology research, studying tumor cell differentiation and proliferation. Group: Pharmaceutical. Alternative Names: 2'-Amino-2'-deoxy-D-uridine; 2'-deoxy-2'-amino-uridine; 2,4(1H,3H)-pyrimidinedione, 1-(2-amino-2-deoxy-b-D-ribofuranosyl)-; 1-[(2R,3R,4S,5R)-3-amino-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione. CAS No. 26889-39-4. Pack Sizes: 1 g. Product ID: B2706-089006. Molecular formula: C9H13N3O5. Mole weight: 243.22. Custom synthesis is available. Send your inquiries for more information. | London |
| 2β-Hydroxygrandiflorenic acid | 2β-Hydroxygrandiflorenic acid, a natural triterpenoid, exhibits immense potential in suppressing tumor growth and inflammation. Its anti-proliferative and apoptosis-inducing properties have been tested and proved in various cancer cell lines, which corroborates its suitability as an anti-cancer remedy. Group: Pharmaceutical. Pack Sizes: 1 mg. Product ID: B0005-267653. Molecular formula: C20H28O3. Mole weight: 316.44. Custom synthesis is available. Send your inquiries for more information. | London |
| 2-butoxy-7-[[4-(1-pyrrolidinylmethyl)phenyl]methyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine | 2-butoxy-7-[[4-(1-pyrrolidinylmethyl)phenyl]methyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine, a medicinal molecule known for its kinase-inhibiting properties, has been identified as a potential candidate for cancer therapy due to its unique ability to induce apoptosis and inhibit the proliferation of malignant cells. With promising applications in the treatment of leukemia and lung cancer, this small-molecule inhibitor has the potential to address critical unmet clinical needs in cancer management. Its effectiveness and suitability as a therapeutic intervention call for further investigation in the field of oncology. Group: Pharmaceutical. Alternative Names: 5H-Pyrrolo[3,2-d]pyrimidin-4-amine, 2-butoxy-7-[[4-(1-pyrrolidinylmethyl)phenyl]methyl]-. CAS No. 1878111-20-6. Pack Sizes: 5 mg. Product ID: B0001-008679. Molecular formula: C22H29N5O. Mole weight: 379.51. Custom synthesis is available. Send your inquiries for more information. | London |
| 2'-Chloro-2'-deoxyadenosine | 2'-Chloro-2'-deoxyadenosine, an essential nucleoside analog in the biomedical field, exhibits profound therapeutic potential for the treatment of diverse ailments, encompassing specific leukemias and lymphomas. By impairing DNA synthesis and instigating apoptosis in malignant cells, this medication emerges as an indispensable asset in combating these pernicious diseases, heralding optimism for the enhancement of patient prognoses. Group: Pharmaceutical. Alternative Names: 2'-chlorodeoxyadenosine; 2'-Deoxy-2'-chloroadenosine; (2R,3R,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-chloro-2-(hydroxymethyl)tetrahydrofuran-3-ol. CAS No. 2627-62-5. Pack Sizes: 10 mg. Product ID: B1370-339143. Molecular formula: C10H12ClN5O3. Mole weight: 285.69. Custom synthesis is available. Send your inquiries for more information. | London |
| 2-Hydroxyphenanthrene | 2-Hydroxyphenanthrene, a naturally occurring compound, has garnered attention in the biomedical industry due to its remarkable antioxidant and antitumor activity. This multifaceted molecule has been reported to trigger apoptosis in cancer cells and suppress tumor development in animal models. Moreover, its therapeutic potential extends to neurodegenerative conditions, such as Alzheimer's and Parkinson's, where it holds promising results. This compound's diverse pharmacological mechanisms and noteworthy biological activities make it a subject of interest in current research. Uses: A metabolite of phenanthrene. Group: Pharmaceutical. Alternative Names: 2-Phenanthrol; 2-Phenanthrenol; 2-Hydroxy-phenanthrene. CAS No. 605-55-0. Pack Sizes: 5 mg. Product ID: B2699-015399. Molecular formula: C14H10O. Mole weight: 194.23. Custom synthesis is available. Send your inquiries for more information. | London |
| 2-Thiouridine | 2-Thiouridine, an esteemed biomedical marvel, is renowned for its profound efficacy in combatting malignant neoplasms and thwarting viral affections. This exalted nucleoside derivative ingeniously integrates itself into RNA, instigating the impeding of viral propagation and invoking apoptosis within neoplastic entities. Its exceptional anti-tumorigenic and antiviral prowess has propelled 2-Thiouridine to the vanguard of biomedical exploration and therapeutic breakthroughs. Group: Pharmaceutical. Alternative Names: 1-β-D-Ribofuranosyl-2-thiouracil; 1-(beta-D-ribofuranosyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one; 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one; Thiouridine. CAS No. 20235-78-3. Pack Sizes: 1 g. Product ID: B1370-331350. Molecular formula: C9H12N2O5S. Mole weight: 260.27. Custom synthesis is available. Send your inquiries for more information. | London |
| 3-Methyladenine | 3-Methyladenine is an autophagy inhibitor that protects cerebellar granule cells (CGCs) from apoptosis following serum/potassium deprivation. 3-Methyladenine inhibits phosphoinositide 3-kinase (PI3K) activity, which plays a key role in autophagy process. Group: Pharmaceutical. Alternative Names: NSC 66389; NSC-66389; NSC66389; 6-Amino-3-methylpurine; 3-MA; 3H-Purin-6-amine, 3-methyl-; 3-Methyl Adenine; 3-Methyl-6-aminopurine; N3-Methyladenine. CAS No. 5142-23-4. Pack Sizes: 250 mg. Product ID: B0084-070159. Molecular formula: C6H7N5. Mole weight: 149.15. Custom synthesis is available. Send your inquiries for more information. | London |
| 3-(Methylseleno)-L-alanine | 3-(Methylseleno)-L-alanine, a metabolite found in Escherichia coli (strain K12, MG1655), is an inhibitor of DMBA-induced mammary tumors. It has oral bioavailability and can induce cell apoptosis. Group: Pharmaceutical. Alternative Names: Se-methylselenocysteine; Methylselenocysteine; (R)-2-Amino-3-(methylselanyl)propanoic acid; Selenium-methylselenocystine. CAS No. 26046-90-2. Pack Sizes: 1 g. Product ID: BBF-05851. Molecular formula: C4H9NO2Se. Mole weight: 182.08. Custom synthesis is available. Send your inquiries for more information. | London |
| 4-Vinylsyringol | 4-Vinylsyringol, a phenolic compound with antioxidant properties, shows potential as a COX-2 inhibitor and is a flavoring agent extracted from crude canola oil. It may inhibit tumor cell growth while inducing cell apoptosis. Group: Pharmaceutical. Alternative Names: 2,6-Dimethoxy-4-ethenylphenol; 2,6-Dimethoxy-4-vinylphenol; 4-Vinyl-2,6-dimethoxyphenol; Canolol; Syringlyethene; Vinylsyringol; Phenol, 4-ethenyl-2,6-dimethoxy-; Phenol, 2,6-dimethoxy-4-vinyl-; 3,5-Dimethoxy-4-hydroxystyrene. CAS No. 28343-22-8. Pack Sizes: 100 mg. Product ID: B0001-453486. Molecular formula: C10H12O3. Mole weight: 180.2. Custom synthesis is available. Send your inquiries for more information. | London |
| 5-Deoxy-L-ribose phenylhydrazone | 5-Deoxy-L-ribose phenylhydrazone, an intriguing compound, has been the subject of numerous biomedical research studies, aimed at elucidating its impact on cellular metabolism, specifically glucose transport and metabolism. Additionally, this multifaceted compound has ignited significant interest due to its potential to treat diverse maladies, including cancer, owing to its tumor growth-inhibiting properties and apoptosis-inducing abilities. Group: Pharmaceutical. Alternative Names: L-Ribose, 5-deoxy-, phenylhydrazone. CAS No. 123168-30-9. Pack Sizes: 150 mg. Product ID: B1999-001003. Molecular formula: C11H16N2O3. Mole weight: 224.26. Custom synthesis is available. Send your inquiries for more information. | London |
| 6-Hydroxycoumurrayin | 6-Hydroxycoumurrayin, a naturally occurring metabolite derived from botanical sources, has garnered significant scientific interest for its potential anti-cancer properties. Diverse preclinical studies have demonstrated its potency in impeding cell proliferation and inducing apoptosis in different cancer types, such as pancreatic and breast tumors. Ongoing research efforts are underway to ascertain the therapeutic efficacy of 6-Hydroxycoumurrayin and its clinical utility as a novel anti-cancer agent. Group: Pharmaceutical. CAS No. 2188162-97-0. Pack Sizes: 5 mg. Product ID: NP1072. Molecular formula: C16H18O5. Mole weight: 290.32. Custom synthesis is available. Send your inquiries for more information. | London |
| 6-Shogaol | 6-Shogaol is a pungent constituent of ginger similar in chemical structure to gingerol. It has anti-inflammatory properties. lt was reported to have antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. lt effectively inhibit invasion and metastasis of hepatocellular carcinoma through diverse molecular mechanisms, including inhibition of the MAPK and PI3k/Akt pathways and NF-κB and STAT3 activities to suppress expression of MMP-2/-9 and uPA and block angiogenesis. lt inhibits the growth of human cancer cells and induces apoptosis in COLO 205 cells through modulation of mitochondrial functions regulated by reactive oxygen species (ROS). Uses: 6-shogaol exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation. it has a very strong antitussive (anti-cough) effect. Group: Pharmaceutical. Alternative Names: 1-(3-Methoxy-4-hydroxyphenyl)-4-decene-3-one; 1-(4-Hydroxy-3-methoxyphenyl)-4-decen-3-one. CAS No. 555-66-8. Pack Sizes: 50 mg. Product ID: NP5193. Molecular formula: C17H24O3. Mole weight: 276.37. Custom synthesis is available. Send your inquiries for more information. | London |
| 8-Bromo-cAMP sodium salt | 8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. It inhibits cell growth, decreases proliferation, increases differentiation and induces apoptosis. Group: Pharmaceutical. Alternative Names: 8-Br-3',5'-cyclo-adenosine monophosphate, sodium salt; 8-Br-3',5'-cyclo-AMP.Na; (8Br-cAMP) sodium salt; 8-Bromo-adenosine-3',5'-cyclic monophosphate, Sodium salt; 8-Br-cAMP sodium salt; 8-Bromoadenosine 3',5'-cyclic monophosphate sodium salt; Adenosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate), sodium salt (1:1). CAS No. 76939-46-3. Pack Sizes: 100 mg. Product ID: B1370-005325. Molecular formula: C10H10BrN5NaO6P. Mole weight: 430.08. Custom synthesis is available. Send your inquiries for more information. | London |
| 8-Shogaol | 8-Shogaol is extracted from the rhizomes of Zingber officinale Rosc. lt was able to induce apoptosis in a time- and concentration-dependent manner. Group: Pharmaceutical. Alternative Names: 1-(4-Hydroxy-3-methoxyphenyl)-4-dodecen-3-one. CAS No. 36700-45-5. Pack Sizes: 20 mg. Product ID: NP5141. Molecular formula: C19H28O3. Mole weight: 304.4. Custom synthesis is available. Send your inquiries for more information. | London |
| A-1331852 | A-1331852, a substituted benzothiazole, is a high affinity BH3 mimetic Ligand of BCL protein BCL-XL (Ki ≤ 10 pM). A-1331852 is an orally apoptosis-inducing agent that may have potential as improved cancer therapeutics. Group: Pharmaceutical. Alternative Names: 3-(1-(((3r,5r,7r)-adamantan-1-yl)methyl)-5-methyl-1H-pyrazol-4-yl)-6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)picolinic acid; A-1331852; A 1331852; A1331852; ABT-263; ABT-199; ABT 199; ABT199. CAS No. 1430844-80-6. Pack Sizes: 100 mg. Product ID: B0084-007703. Molecular formula: C38H38N6O3S. Mole weight: 658.81. Custom synthesis is available. Send your inquiries for more information. | London |
| A 410099.1 | A 410099.1 is a high affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells. Group: Pharmaceutical. Alternative Names: N-Methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-L-prolinamide hydrochloride. CAS No. 762274-58-8. Pack Sizes: 1mg;1g;10g. Product ID: 762274-58-8. Molecular formula: C27H40N4O3·HCl. Mole weight: 505.09. Custom synthesis is available. Send your inquiries for more information. | London |
| A 419259 trihydrochloride | Potent Hck inhibitor (IC50 = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including CD34+. Also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitro and in vivo. Group: Pharmaceutical. Alternative Names: A419259 trihydrochloride; A-419259 trihydrochloride; RK 20449 trihydrochloride; RK20449 trihydrochloride; RK-20449 trihydrochloride. CAS No. 1435934-25-0. Pack Sizes: 1mg;1g;10g. Product ID: 1435934-25-0. Molecular formula: C29H37Cl3N6O. Mole weight: 592. Custom synthesis is available. Send your inquiries for more information. | London |
| ABC-1183 | ABC-1183 is an inhibitor of glycogen synthase kinase 3 (GSK-3) alpha, glycogen synthase kinase 3 (GSK-3) beta and cyclin dependent kinase 9 (CDK-9). It can induce cell apoptosis and various signaling pathways. ABC-1183 shows toxicity to many cell lines in humans and mice. Group: Pharmaceutical. Alternative Names: ABC1183; ABC 1183; NSC797769; NSC-797769. CAS No. 1042735-18-1. Pack Sizes: 1mg;1g;10g. Product ID: 1042735-18-1. Molecular formula: C18H14N4OS. Mole weight: 334.39. Custom synthesis is available. Send your inquiries for more information. | London |
| ABT-100 | ABT-100 is an orally bioavailable farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity. Group: Pharmaceutical. Alternative Names: ABT 100; ABT100; A-367074; A 367074; A367074. CAS No. 450839-40-4. Pack Sizes: 1mg;1g;10g. Product ID: 450839-40-4. Molecular formula: C27H19F3N4O3. Mole weight: 504.47. Custom synthesis is available. Send your inquiries for more information. | London |
| ABT-737 | ABT-737 is a potent, cell-permeable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki < 1 nM for all three proteins). It blocks the interaction of these proteins with pro-death proteins, leading to apoptosis. Group: Pharmaceutical. Alternative Names: ABT 737; ABT737; (R)-4-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenyl)sulfonyl)benzamide. CAS No. 852808-04-9. Pack Sizes: 100 mg. Product ID: B1370-139061. Molecular formula: C42H45ClN6O5S2. Mole weight: 813.43. Custom synthesis is available. Send your inquiries for more information. | London |
| ABTL-0812 | ABTL-0812 is an orally bioavailable, lipid analogue and inhibitor of raptor-mammalian target of rapamycin (mTOR), rictor-mTOR and dihydrofolate reductase with potential antineoplastic activity. It binds to and inhibits both mTORC1 and mTORC2, which may result in apoptosis and a decrease in proliferation in mTORC1/2-expressing tumor cells upon oral administration. It was developed by Ability Pharmaceuticals and is in phase I/II clinical trials for the treatment of solid tumors. It received orphan drug designation in the E.U. and in the U.S. for the treatment of neuroblastoma in 2015. Uses: Abtl-0812 has potential antineoplastic activity. it is used for the treatment of solid tumors. Group: Pharmaceutical. Alternative Names: ABTL0812; ABTL 0812; ABTL-0812; (9Z,12Z)-2-hydroxyoctadeca-9,12-dienoate. CAS No. 57818-44-7. Pack Sizes: 1mg;1g;10g. Product ID: 57818-44-7. Molecular formula: C18H31O3. Mole weight: 294.93. Custom synthesis is available. Send your inquiries for more information. | London |
| ACBI1 | ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis. Group: Pharmaceutical. Alternative Names: ACBI 1; ACBI-1; (2S,4R)-N-(2-(2-(4-((4-(3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)methyl)phenoxy)ethoxy)-4-(4-methylthiazol-5-yl)benzyl)-1-((S)-2-(1-fluorocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxypyrrolidine-2-carboxamide. CAS No. 2375564-55-7. Pack Sizes: 1mg;1g;10g. Product ID: 2375564-55-7. Molecular formula: C49H58FN9O7S. Mole weight: 936.12. Custom synthesis is available. Send your inquiries for more information. | London |
| Acelarin | Acelarin is a DNA synthesis inhibitor with EC50 of 0.2 nM. Acelarin is a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine. It is converted into the active metabolites dFdCDP and dFdCTP. dFdCDP can inhibit ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA replication; dFdCTP can be incorporated into DNA, resulting in premature termination of DNA replication and eventually induction of apoptosis. Phase III clinical trials for the treatment of Pancreatic cancer are on-going. Uses: Pancreatic cancer. Group: Pharmaceutical. Alternative Names: NUC-1031; NUC 1031; NUC1031; GTPL7389; GTPL 7389; GTPL-7389; SCHEMBL17171316; Benzyl (2S)-2-[({[(2R,3S,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy}(phenoxy)phosphoryl)amino]propanoate. CAS No. 840506-29-8. Pack Sizes: 50 mg. Product ID: B2693-476645. Molecular formula: C25H27F2N4O8P. Mole weight: 580.48. Custom synthesis is available. Send your inquiries for more information. | London |
| Acetylcorynoline | Acetylcorynoline, which can be extracted from the tubers of Corydalis ambigua, inhibits the maturing of bone marrow-derived dendritic cells in mice. However, it is only cytotoxic in amounts of greater than 20 μM. Acetylcorynoline may be one of the potent immunosuppressive agents through the blockage of dendritic cells maturation and function. Acetylcorynoline significantly decreases dopaminergic neuron degeneration induced by 6-hydroxydopamine in BZ555 strain; prevents α-synuclein aggregation; recovers lipid content in OW13 strain; restores food-sensing behavior, and dopamine levels; and prolongs life-span in 6-hydroxydopamine-treated N2 strain, thus showing its potential as a possible antiparkinsonian drug. Acetylcorynoline may exert its effects by decreasing egl-1 expression to suppress apoptosis pathways and by increasing rpn5 expression to enhance the activity of proteasomes. Uses: Antifungal/anti-inflammatory. Group: Pharmaceutical. Alternative Names: (5bR,6S,12bR)-5b,6,7,12b,13,14-Hexahydro-5b,13-dimethyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol 6-acetate; Corynoline acetate; O-Acetylcorynoline; [1,3]Benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol,5b,6,7,12b,13,14-hexahydro-5b,13-dimethyl-, 6-acetate, (5bR,6S,12bR)-. CAS No. 18797-80-3. Pack Sizes: 10 mg. Product ID: B2703-464490. Molecular formula: C23H23NO6. Mole weight: 409.43. Custom synthesis is available. Send your inqui | London |
| ADPM06 | ADPM06 is a nonporphyrin photodynamic therapeutic (PDT) agent, which is an established treatment modality for cancer. It exhibits IC50s in the micro-molar range in human tumor cells and induces apoptosis. Group: Pharmaceutical. Alternative Names: ADPM-06; ADPM 06; Azadipyrromethane. CAS No. 490035-90-0. Pack Sizes: 5 mg. Product ID: B2693-462646. Molecular formula: C34H24BBr2F2N3O2. Mole weight: 715.2. Custom synthesis is available. Send your inquiries for more information. | London |
| AEE-788 | AEE-788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. Group: Pharmaceutical. Alternative Names: AEE 788; AEE788; 6-[4-[(4-ethylpiperazin-1-yl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine. CAS No. 497839-62-0. Pack Sizes: 10 mg. Product ID: B0084-258485. Molecular formula: C27H32N6. Mole weight: 440.595. Custom synthesis is available. Send your inquiries for more information. | London |
| Afuresertib | Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2110183 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Group: Pharmaceutical. Alternative Names: GSK-2110183; GSK 2110183; GSK2110183; GSK-2110183B; GSK 2110183B; GSK2110183B. CAS No. 1047644-62-1. Pack Sizes: 50 mg. Product ID: B1370-109132. Molecular formula: C18H17Cl2FN4OS. Mole weight: 427.32. Custom synthesis is available. Send your inquiries for more information. | London |
| Aglain C | Aglain C, an organic alkaloid of natural origins, demonstrates anti-tumor activity, thus possessing potential application in diverse cancer treatment modalities. It elicits apoptosis, or cell death, in malignant cells, and exhibits anti-inflammatory properties. To ascertain its therapeutic value comprehensively, additional examination is warranted. Group: Pharmaceutical. Alternative Names: N-((S)-1-((2R,3S,4R,5R,10S)-5,10-dihydroxy-6,8-dimethoxy-2-(4-methoxyphenyl)-3-phenyl-2,3,4,5-tetrahydro-2,5-methanobenzo[b]oxepine-4-carbonyl)pyrrolidin-2-yl)-2-methylbutanamide. CAS No. 177468-85-8. Pack Sizes: 2 mg. Product ID: NP0163. Molecular formula: C36H42N2O8. Mole weight: 630.727. Custom synthesis is available. Send your inquiries for more information. | London |
| Alisol B 23-acetate | Alisol B acetate is a triterpene from Rhizoma Alismatis (rhizomes of Alisma plantago-aquatica). It induces apoptosis in human prostate cancer cells. It produces protective effect against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regul. Group: Pharmaceutical. Alternative Names: (23S,24R)-24,25-Epoxy-11b,23-dihydroxy-8a,9b,14b-dammar-13(17)-en-3-one 23-acetate;Alisol B 23-acetate;(8α,9β,14β,23S,24R)-11β-Hydroxy-23-acetoxy-24,25-epoxy-5α-dammara-13(17)-ene-3-one;23-Acetylalismol B;23-O-Acetylalisol B;Alisol B monoacetate. CAS No. 26575-95-1. Pack Sizes: 20 mg. Product ID: NP7036. Molecular formula: C32H50O5. Mole weight: 514.74. Custom synthesis is available. Send your inquiries for more information. | London |
| Aloperine | Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties. Aloperine induces apoptosis and autophagy in HL-60 cells. Uses: Anti-inflammatory, antibacterial, antiviral, and antitumor. Group: Pharmaceutical. Alternative Names: (6R,6aR,13S,13aS)-1,3,4,6,6a,7,8,9,10,12,13,13a-Dodecahydro-2H-6,13-methanodipyrido[1,2-a:3',2'-e]azocine; (7-alpha,9-alpha)-9-De-2-piperidinyl-16,17-didehydro-ormosanine; Ormosanine, 16,17-didehydro-9-de-2-piperidinyl-, (7-alpha,9-alpha)-; Allopterin; 6,13-Methano-2H-dipyrido[1,2-a:3',2'-e]azocine,1,3,4,6,6a,7,8,9,10,12,13,13a-dodecahydro-,[6R-(6α,6aβ,13α,13aα)]-. CAS No. 56293-29-9. Pack Sizes: 1 g. Product ID: B2703-345494. Molecular formula: C15H24N2. Mole weight: 232.36. Custom synthesis is available. Send your inquiries for more information. | London |
| α-Tocotrienol | α-Tocotrienol is a form of vitamin E, a class of eight fat-soluble compounds. It was shown to induce apoptosis and inhibit proliferation, and down-regulate the fibroblast growth factor receptor-1 (FGFR1). Uses: Antioxidants. Group: Pharmaceutical. Alternative Names: (2R)-2,5,7,8-tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol. CAS No. 58864-81-6. Pack Sizes: 25 mg. Product ID: B0005-190073. Molecular formula: C29H44O2. Mole weight: 424.7. Custom synthesis is available. Send your inquiries for more information. | London |
| Alsterpaullone | Alsterpaullone is a potent glycogen synthase kinase-3 inhibitor and a potential therapeutic agent for the treatment of Parkinson disease. Alsterpaullone is also known as 9-Nitropaullone and NSC 705701, which is a derivative of kenpaullone and an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β). Alsterpaullone induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential. Alsterpaullone is a derivative of kenpaullone with slightly improved potency over kenpaullone, alsterpaullone selectively inhibits Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and GSK3α/β with IC50 values of 35, 15, 200, 40, and 4 nM, respectively. Group: Pharmaceutical. Alternative Names: 9-Nitropaullone; NSC 705701; 7,12-Dihydro-9-nitro-indolo[3,2-d][1]benzazepin-6(5H)-one. CAS No. 237430-03-4. Pack Sizes: 50 mg. Product ID: B2693-103248. Molecular formula: C16H11N3O3. Mole weight: 293.3. Custom synthesis is available. Send your inquiries for more information. | London |
| Amarogentin | Amarogentin exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin promotes apoptosis, arrests G2/M cell cycle and downregulates of PI3K/Akt/mTOR signalling pathways and displays immunomodulatory effects in human mast cells and keratinocytes. It inhibits the growth of SNU-16 human gastric cancer cells (IC50 = 12.4 μM) and increases apoptosis when used at a concentration of 50 μM. Amarogentin dose-dependently reduces tumor growth in a SNU-16 nude mouse xenograft model. Amarogentin may offer therapeutic potential for preventing or treating thromboembolic disorders, it prevents platelet activation through the inhibition of PLC γ2-PKC cascade and MAPK pathway. Group: Pharmaceutical. Alternative Names: sweroside-2'-(3'',5'',3'''-trihydroxydiphenyl)-2''-carboxylic acid ester; (4aS)-6α-[2-O-[(3,3',5-Trihydroxy-1,1'-biphenyl-2-yl)carbonyl]-β-D-glucopyranosyloxy]-5β-vinyl-4,4a,5,6-tetrahydro-1H,3H-pyrano[3,4-c]pyran-1-one. CAS No. 21018-84-8. Pack Sizes: 50 mg. Product ID: B1370-062768. Molecular formula: C29H30O13. Mole weight: 586.54. Custom synthesis is available. Send your inquiries for more information. | London |
| Antagonist G | Antagonist G is a substance P analog, which is a broad spectrum neuropeptide growth factor antagonist and antiproliferative agent. It was developed for the treatment of small cell lung cancer. It could inhibit neuropeptide-dependent and -independent proliferation of small cell lung cancer in vitro. It also inhibits growth of SCLC xenografts in mice in vivo. It blocks Swiss 3T3 cell growth induced by vasopressin, gastrin-releasing peptide and bradykinin. It activates JNK and stimulates apoptosis. It is an anticancer agent and is resistant to degradation by peptidases. Group: Pharmaceutical. Alternative Names: [Arg6,D-Trp7,9,N-MePhe8]-Substance P(6-11). CAS No. 115150-59-9. Pack Sizes: 1 mg. Product ID: BAT-006104. Molecular formula: C49H66N12O6S. Mole weight: 951.2. Custom synthesis is available. Send your inquiries for more information. | London |
| Arborinine | Arborinine is an alkaloid isolated from Erthela bahiensis. Arborinine was shown to inhibit splenocytes proliferation under ConA or PWM stimulation and promote apoptosis on splenocytes and thymocytes stimulated with PWM in 24h. It also decreases production of Interleukin-10 by splenocytes and thymocytes stimulated with ConA or PWM. Group: Pharmaceutical. Alternative Names: 1-hydroxy-2,3-dimethoxy-10-methylacridin-9-one. CAS No. 5489-57-6. Pack Sizes: 1 mg. Product ID: NP0701. Molecular formula: C16H15NO4. Mole weight: 285.299. Custom synthesis is available. Send your inquiries for more information. | London |
| Arg-Gly-Asp-Ser | Arg-Gly-Asp-Ser is an integrin binding sequence that inhibits integrin receptor function. It is a tetrapeptide found on fibronectin, fibrinogen α, and von Willebrand factor, but not vitronectin or collagen. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, iNOS and MMP-9. It inhibits thrombin-induced binding of platelets to fibronectin, fibrinogen α, and von Willebrand factor. It promotes cell attachment and abrogates apoptosis via the mitochondrial pathway in osteoblasts in vitro. It also blocks the attachment of certain pathogens to cells. Uses: Platelet aggregation inhibitors. Group: Pharmaceutical. Alternative Names: Arg Gly Asp Ser; RGDS peptide; Fibronectin Inhibitor. CAS No. 91037-65-9. Pack Sizes: 100 mg. Product ID: BAT-010205. Molecular formula: C15H27N7O8. Mole weight: 433.42. Custom synthesis is available. Send your inquiries for more information. | London |
| Aristololactam | The cytotoxic potency of Aristololactam I is higher than that of AA-I and that the cytotoxic effects of these molecules are mediated through the induction of apoptosis in a caspase 3-dependent pathway. Group: Pharmaceutical. Alternative Names: aristololactam; 8-methoxy[1,3]benzodioxolo[6,5,4-cd]benzo[f]indol-5(6H)-one. CAS No. 13395-02-3. Pack Sizes: 10 mg. Product ID: B2703-223426. Molecular formula: C17H11NO4. Mole weight: 293.27. Custom synthesis is available. Send your inquiries for more information. | London |
| ARV-825 | ARV-825 is a BRD4 inhibitor based on PROTAC technology. ARV-825 recruits BRD4 to E3 ubiquitin ligase cereblon, resulting in the degradation of BRD4. In post-myeloproliferative neoplasm secondary (s) AML cell lines, treatment with ARV-825 induces apoptosis and inhibits cell proliferation. Group: Pharmaceutical. Alternative Names: 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide. CAS No. 1818885-28-7. Pack Sizes: 100 mg. Product ID: B1370-474664. Molecular formula: C46H47ClN8O9S. Mole weight: 923.44. Custom synthesis is available. Send your inquiries for more information. | London |
| AT13148 | AT13148 is an orally available multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity. It can block phosphorylation of AKT, p70S6K, PKA, ROCK and SGK substrates, and induce apoptosis in cancer cells. Group: Pharmaceutical. Alternative Names: AT-13148; (1S)-2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol. CAS No. 1056901-62-2. Pack Sizes: 50 mg. Product ID: B0084-462670. Molecular formula: C17H16ClN3O. Mole weight: 313.78. Custom synthesis is available. Send your inquiries for more information. | London |
| AT-406 | AT-406 is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3 (with Ki of 66.4 nM), cIAP1-BIR3(with Ki of 1.9 nM) and cIAP2-BIR3 (with Ki of 5.1 nM), respectively. Group: Pharmaceutical. Alternative Names: AT406; AT 406; SM-406; SM 406; SM406; ARRY-334543; ARRY 334543; ARRY334543. CAS No. 1071992-99-8. Pack Sizes: 100 mg. Product ID: B0084-454116. Molecular formula: C32H43N5O4. Mole weight: 561.71. Custom synthesis is available. Send your inquiries for more information. | London |
| AT7519 HCl | AT-7519 is an orally bioavailable small molecule CDK inhibitor with potential antineoplastic activity. AT7519M selectively binds to and inhibits cyclin dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. Group: Pharmaceutical. Alternative Names: AT7519 HCl; AT 7519 HCl; AT-7519 HCl. CAS No. 902135-91-5. Pack Sizes: 10 mg. Product ID: B0084-100271. Molecular formula: C16H18Cl3N5O2. Mole weight: 418.71. Custom synthesis is available. Send your inquiries for more information. | London |
| Avapritinib | BLU-285 is a potent and selective inhibitor of exon 17 mutant KIT (IC50 = 0.27 nM for KIT D816V). BLU-285 showed dose-dependent, robust anti-tumor efficacy in a TKI-resistant KIT exon 11/17 mutant GIST PDX model through inhibition of tumor growth, proliferation, KIT signaling and induction of apoptosis. Group: Pharmaceutical. Alternative Names: (1S)-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine; BLU-285; BLU 285; BLU285; UNII-513P80B4YJ; SCHEMBL16652297. CAS No. 1703793-34-3. Pack Sizes: 10 mg. Product ID: B0084-007732. Molecular formula: C26H27FN10. Mole weight: 498.56. Custom synthesis is available. Send your inquiries for more information. | London |
| Azoramide | Azoramide is a modulator of the unfolded protein response with antidiabetic activity. It is a dual-function endoplasmic reticulum (ER) modulator in vitro. It improves endoplasmic reticulum (ER) protein-folding ability and stimulates the expression of ER chaperones to protect cells against ER stress in multiple systems. It regulates ER folding and secretion capacity without inducing ER stress. It might have the protective effects of enhancing chaperone expression and reducing protein synthesis without inducing cytotoxicity and apoptosis. It showed potent antidiabetic activity in two independent mouse models of obesity by protecting pancreatic β cell function against ER stress and improving insulin sensitivity in vivo. It improves glucose homeostasis in mice with genetic obesity and diet-induced obesity. Group: Pharmaceutical. Alternative Names: N-[2-[2-(4-Chlorophenyl)-4-thiazolyl]ethyl]butanamide. CAS No. 932986-18-0. Pack Sizes: 100 mg. Product ID: B1370-474920. Molecular formula: C15H17ClN2OS. Mole weight: 308.82. Custom synthesis is available. Send your inquiries for more information. | London |
| BDA-366 | BDA-366 is a small-molecule antagonist of Bcl2-BH4 domain with high affinity and selectivity for Bcl2-BH4. BDA-366 induces apoptosis in multiple myeloma cells via Bcl2 conformational change. Group: Pharmaceutical. Alternative Names: BDA-366; BDA 366; BDA366; 1-[[(2S)-3-(diethylamino)-2-hydroxypropyl]amino]-4-[[(2S)-oxiran-2-yl]methylamino]anthracene-9,10-dione. CAS No. 1909226-00-1. Pack Sizes: 300 mg. Product ID: B0084-053991. Molecular formula: C24H29N3O4. Mole weight: 423.513. Custom synthesis is available. Send your inquiries for more information. | London |
| Belinostat | Belinostat is a hydroxamic acid-type histone deacetylase (HDAC) inhibitor. Belinostat targets HDAC enzymes to inhibit tumor cell proliferation and angiogenesis, induce apoptosis and promote cellular differentiation. Uses: Antineoplastic agents. Group: Pharmaceutical. Alternative Names: Belinostat; PXD 101; Beleodaq; PDX101; PX 105684; PXD-101; PXD101; (E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide. CAS No. 414864-00-9. Pack Sizes: 100 mg. Product ID: B0084-141764. Molecular formula: C15H14N2O4S. Mole weight: 318.347. Custom synthesis is available. Send your inquiries for more information. | London |
| Bellidifolin | Bellidifolin is a xanthone that can be isolated from the plants of Gentiana species. Study shows that bellidifolin is a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica. Bellidifolin may contribute to the protective effects associated with nerve injury initiated by hypoxia by mechanisms related to inhibition of cell apoptosis independent of the ERK pathway, but may involve blockade of p38MAPK signaling pathway activation and downstream caspase-3 expression. Group: Pharmaceutical. Alternative Names: 1,5,8-Trihydroxy-3-methoxy-9H-xanthen-9-one. CAS No. 2798-25-6. Pack Sizes: 5 mg. Product ID: NP7359. Molecular formula: C14H10O6. Mole weight: 274.228. Custom synthesis is available. Send your inquiries for more information. | London |
| Bendamustine hydrochloride | Bendamustine hydrochloride is the hydrochloride salt of bendamustine, a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown, this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and protein synthesis inhibition, and, subsequently, apoptosis. Bendamustine may differ from other alkylators in that it may be more potent in activating p53-dependent stress pathways and inducing apoptosis; it may induce mitotic catastrophe; and it may activate a base excision DNA repair pathway rather than an alkyltransferase DNA repair mechanism. Group: Pharmaceutical. Alternative Names: SDX-105 (Cytostasane) HCl; SDX 105 (Cytostasane) HCl; SDX105 (Cytostasane) HCl. CAS No. 3543-75-7. Pack Sizes: 500 mg. Product ID: NP3323. Molecular formula: C16H21Cl2N3O2.HCl. Mole weight: 394.72. Custom synthesis is available. Send your inquiries for more information. | London |
| Betulinic acid | Betulinic acid is a pentacyclic lupane-type triterpene derivative of betulin with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induces apoptosis through induction of changes in mitochondrial membrane potential, production of reactive oxygen species, and opening of mitochondrial permeability transition pores, resulting in the release of mitochondrial apogenic factors, activation of caspases, and DNA fragmentation. Betulinic acid is a natural compound found in the herbs of Ziziphus jujuba. It can be used in cosmetics material. Uses: Anti-melanogenic/antitumor/anti-hiv. Group: Pharmaceutical. Alternative Names: ALS357; ALS 357; ALS-357; Mairin; Lupatic Acid; 3beta-Hydroxy-20(29)-lupaene-28-oic acid. CAS No. 472-15-1. Pack Sizes: 10 g. Product ID: NP6980. Molecular formula: C30H48O3. Mole weight: 456.7. Custom synthesis is available. Send your inquiries for more information. | London |
| BI-2536 | BI-2563 is a small molecule compound with potential antineoplastic activities. BI 2536 binds to and inhibits Polo-like kinase 1 (Plk1), resulting in mitotic arrest, disruption of cytokinesis, and apoptosis in susceptible tumor cell populations. Plk1, a serine/threonine-protein kinase, is a key regulator of multiple processes fundamental to mitosis and cell division. Group: Pharmaceutical. Alternative Names: BI2536; BI 2536; (R)-4-((8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl)amino)-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide. CAS No. 755038-02-9. Pack Sizes: 50 mg. Product ID: B1370-076522. Molecular formula: C28H39N7O3. Mole weight: 521.65. Custom synthesis is available. Send your inquiries for more information. | London |
| Birinapant | Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. As a SMAC mimetic and IAP antagonist, TL32711 binds to and inhibits the activity of IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. Alternative Names: TL-32711; TL32711; TL 32711. Birinapant. CAS No. 1260251-31-7. Pack Sizes: 100 mg. Product ID: B0084-462223. Molecular formula: C42H56F2N8O6. Mole weight: 806.957. Custom synthesis is available. Send your inquiries for more information. | London |
| Bis[rhodium(α,α,α',α'-tetramethyl-1,3-benzenedipropionic acid)] | Bis[rhodium(a,a,a#,a#-tetramethyl-1,3-benzenedipropionic acid)] offers a compelling avenue in the realm of anticancer therapeutics. Its efficacy is underscored by a multifaceted approach, encompassing the arrest of cancer cell proliferation and the orchestration of apoptosis induction across diverse malignancies. Group: Pharmaceutical. Alternative Names: Rh2(esp)2; Bis[(α,α,α',α'-tetramethyl-1,3-phenylenebispropionic acid)rhodium; Bis[rhodium(alpha,alpha,alpha',alpha'-tetramethyl-1,3-benzenedipropionic acid)]. CAS No. 819050-89-0. Pack Sizes: 250 mg. Product ID: B1370-034220. Molecular formula: C32H40O8Rh2. Mole weight: 758.48. Custom synthesis is available. Send your inquiries for more information. | London |
| BMS-777607 | BMS-777607 is a novel prodrug of the dual Met/VEGFR-2 inhibitor. It shows antitumor activity, inducing apoptosis and decreasing proliferation and migration. Group: Pharmaceutical. Alternative Names: BMS817378; BMS 817378; BMS-817378; BMS 777607; BMS777607; ASLAN 002; ASLAN-002; ASLAN002. CAS No. 1025720-94-8. Pack Sizes: 50 mg. Product ID: B2693-456491. Molecular formula: C25H19ClF2N4O4. Mole weight: 512.893. Custom synthesis is available. Send your inquiries for more information. | London |
| BMS-911543 | BMS-911543 is an orally available JAK inhibitor with selectivity for JAK2. It inhibts JAK2, thereby preventing the JAK/STAT (signal transducer and activator of transcription) signaling cascade, including activation of STAT3. This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation. Group: Pharmaceutical. Alternative Names: BMS 911543. CAS No. 1271022-90-2. Pack Sizes: 20 mg. Product ID: B0084-457828. Molecular formula: C23H28N8O. Mole weight: 432.532. Custom synthesis is available. Send your inquiries for more information. | London |
| Boc-D-FMK | BOC-D-FMK is a cell-permeable broad-spectrum caspase inhibitor that fully inhibits the pro-apoptotic effect of tumor necrosis factor-α (TNFα). It has been found to reduce the activation of nuclear factor kappa light chain enhancer of activated B cells (NF-kB), suppress the phosphorylation of subunit nuclear factor kappa light polypeptide gene enhancer in B cells inhibitor α (IkBα) and inhibit TNF-induced expression of intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1). Moreover, it has also effectively attenuated the hepatocyte apoptosis in bile duct-ligated rats potentially improving the survival rates. Uses: Caspase inhibitors. Group: Pharmaceutical. Alternative Names: Boc-Asp(OMe)-fluoromethyl ketone; Caspase Inhibitor 3; N-Boc-L-aspartic acid 4-methyl ester fluoromethyl ketone; BAF; Boc-D-Fluoromethyl Ketone; Boc-D(OMe)-FMK; 3S-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-pentanoic acid, methyl ester; Caspase Inhibitor III. CAS No. 187389-53-3. Pack Sizes: 100 mg. Product ID: BAT-010386. Molecular formula: C11H18FNO5. Mole weight: 263.26. Custom synthesis is available. Send your inquiries for more information. | London |
| Bruceine D | Bruceine D is extracted from the barks of Ailanthus altissima. It is an inhibitor of hepatocellular carcinoma growth and inhibits the growth of three pancreatic cancer cell lines, which acts by targeting β-catenin/jagged1 pathways. It also induces cytotoxicity in Capan-2 cells by inducing cellular apoptosis involving the mitochondrial pathway. It may be used as a lead compound for new viricides, or a natural viricide. Group: Pharmaceutical. Alternative Names: Nsc318801; (1beta,11beta,12alpha,15beta)-13,20-Epoxy-1,11,12,14,15-pentahydroxypicras-3-ene-2,16-dione; Picras-3-ene-2,16-dione,13,20-epoxy-1,11,12,14,15-pentahydroxy-, (1b,11b,12a,15b)-; (1R,2S,3R,3aR,3a1R,4R,6aR,7aS,11S,11aS)-1,2,3a,4,11-pentahydroxy-3,8,11a-trimethyl-1,2,3,3a,4,7,7a,11,11a,11b-decahydro-5H-3,3a1-(epoxymethano)dibenzo[de,g]chromene-5,10(6aH)-dione. CAS No. 21499-66-1. Pack Sizes: 10 mg. Product ID: NP1540. Molecular formula: C20H26O9. Mole weight: 410.42. Custom synthesis is available. Send your inquiries for more information. | London |
| Butin | Butin is a natural flavonoid found in the seeds of Cassia tora. Butin has activity of antioxidant, which can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction. Uses: Antioxidant. Group: Pharmaceutical. Alternative Names: (2S)-7,3',4'-Trihydroxyflavanone;(S)-2-(3,4-Dihydroxyphenyl)-2,3-dihydro-7-hydroxy-4H-1 -benzopyran-4-one;4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydro xy-, (S)-. CAS No. 492-14-8. Pack Sizes: 10 mg. Product ID: NP2469. Molecular formula: C15H12O5. Mole weight: 272.25. Custom synthesis is available. Send your inquiries for more information. | London |
| C16 Ceramide | C16 ceramide is an endogenous ceramide, generated by ceramide synthase 6 (CerS6), that acts as a lipid second messenger to regulate apoptosis and stress signaling. It has also been found to activate NF-κB and PKCζ3. Uses: A predominant, rather hydrophobic natural ceramide. activates a cytosolic serine/threonine protein phosphatase in t9 cells; induces egf receptor phosphorylation in a-431 cells; stimulates ceramide-activated protein kinase. Group: Pharmaceutical. Alternative Names: C16 Ceramide (d18:1/16:0); N-(hexadecanoyl)-sphing-4-enine; N-Palmitoylsphingosine. CAS No. 24696-26-2. Pack Sizes: 100 mg. Product ID: B1370-059982. Molecular formula: C34H67NO3. Mole weight: 537.9. Custom synthesis is available. Send your inquiries for more information. | London |
| Carmustine | Carmustine is antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. It is used in the treatment of brain tumors, multiple myeloma and some lymphomas. Group: Pharmaceutical. Alternative Names: 1,3-Bis(2-chloroethyl)-1-nitrosourea; BCNU; Carmustin. CAS No. 154-93-8. Pack Sizes: 5 g. Product ID: B2693-465289. Molecular formula: C5H9Cl2N3O2. Mole weight: 214.05. Custom synthesis is available. Send your inquiries for more information. | London |
| Casuarinin | Casuarinin is a tannin isolated from the bark of Terminalia arjuna. It can induce apoptosis and cell cycle arrest. Group: Pharmaceutical. Alternative Names: [(15β)-11-De(6-carboxy-2,3,4-trihydroxyphenyl)-16,18-dideoxy-16,18-[(4,4',5,5',6,6'-hexahydroxybiphenyl-2,2'-diyl)bis(carbonyloxy)]neovescalin]17-(3,4,5-trihydroxybenzoate). CAS No. 79786-01-9. Pack Sizes: 5 mg. Product ID: B1370-277360. Molecular formula: C41H28O26. Mole weight: 936.65. Custom synthesis is available. Send your inquiries for more information. | London |
| CBS9106 | CBS9106, also known as BMS-566419, is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity. CRM1 plays an important role in the nuclear export of cargo proteins bearing nuclear exporting signal sequences. CBS9106 inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells, including multiple myeloma cells. CBS9106 reduces CRM1 protein levels significantly without affecting CRM1 mRNA expression. Oral administration of CBS9106 significantly suppresses tumor growth and prolongs survival in mice bearing tumor xenograft without a significant loss in body weight. A reduced level of CRM1 protein is also observed in tumor xenografts isolated from mice treated with CBS9106. Taken together, these results indicate that CBS9106 is a novel reversible CRM1 inhibitor and a promising clinical candidate. Group: Pharmaceutical. Alternative Names: SL-801; SL801; SL 801; CBS-9106; CBS 9106; BMS-566419; BMS566419; BMS 566419; 1H-Pyrrole-2,5-dione, 1-[[6-chloro-5-(trifluoromethyl)-2-pyridinyl]amino]-3-[(3,3-dimethylbutoxy)methyl]-4-methyl-. CAS No. 1076235-04-5. Pack Sizes: 10 mg. Product ID: B1370-462313. Molecular formula: C18H21ClF3N3O3. Mole weight: 419.83. Custom synthesis is available. Send your inquiries for more information. | London |
| CC122 | CC122 is a novel agent for DLBCL. It is an orally available pleiotropic pathway modulator. It has antitumor and immunomodulatory activity. It is used for the treatment of chronic lymphocytic leukemia. It binds CRBN and degrades Aiolos and Ikaros resulting in a mimicry of IFN signaling and apoptosis in DLBCL. It inhibits proliferation and induces apoptosis in ABC and GCB DLBCL in vitro. It was developed by Celgene Corporation(CELG) and was in clinic phase 2 trial. Uses: Cc122 has antitumor and immunomodulatory activity. it is used for the treatment of chronic lymphocytic leukemia. Group: Pharmaceutical. Alternative Names: 3-(5-Amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione;CC-122; CC122; CC 122. CAS No. 1015474-32-4. Pack Sizes: 25 mg. Product ID: B0084-474963. Molecular formula: C14H14N4O3. Mole weight: 286.29. Custom synthesis is available. Send your inquiries for more information. | London |
| CC-223 | CC-223, a mTOR kinase inhibitor, has been found to be effective in inducing the apoptosis and reducing the proliferation of tumor cells. It is still under Phase I/II clinical trial by Celgene Corporation. IC50: 16 nM. Uses: Cc-223 is a mtor kinase inhibitor that has been found to be effective in inducing the apoptosis and reducing the proliferation of tumor cells. Group: Pharmaceutical. Alternative Names: CC-223; CC 223; CC223; UNII-I8RA3543SY; I8RA3543SY; 7-(6-(2-Hydroxypropan-2-yl)pyridin-3-yl)-1-(trans-4-methoxycyclohexyl)-3,4-dihydropyrazino(2,3-b)pyrazin-2(1H)-one; 7-(6-(2-Hydroxypropan-2-yl)pyridin-3-yl)-1-(trans-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyraz. CAS No. 1228013-30-6. Pack Sizes: 300 mg. Product ID: B0084-474093. Molecular formula: C21H27N5O3. Mole weight: 397.47. Custom synthesis is available. Send your inquiries for more information. | London |
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