Androstane Dione Suppliers UK
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Δ4-Abiraterone Quick enquiry Where to buy Suppliers range | Δ4-Abiraterone (D4A) is an active metabolite of the CYP17A1 inhibitor abiraterone (Item No. 9002768).1 D4A is an androgen receptor antagonist (IC50 = 5.3 nM) that reduces expression of the androgen receptor target genes PSA, TMPRSS2, and FKBP5 in LNCaP, LAPC4, and C4-2 cell lines. It inhibits the cytochrome P450 (CYP) isoform CYP17A1 by 66.5% when used at a concentration of 1 nM. D4A (10 μM) also blocks SRD5A conversion of Δ4-androstenedione to 5α-androstanedione in LAPC4 cells. In vivo, D4A delays tumor progression in a VCaP mouse xenograft model and increases progression-free survival in a C4-2 mouse xenograft model. Group: Pharmaceuticals. Alternative Names: CB 7627; D4A. CAS No. 154229-21-7. Pack Sizes: 1mg; 1g; 10g. Product ID: 154229-21-7. Custom synthesis is available. Send your inquiries for more information. | London |