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| Product | Description | |
|---|---|---|
| Amyloid β-peptide (1-42) human | Amyloid β-Peptide (12-28) (human), an Amyloid β-peptide fragment, binds with high affinity to α7-nicotinic ACh receptors. It impairs memory retention following central administration in mice. Uses: Implicated in alzheimer's disease. Group: Pharmaceutical. CAS No. 107761-42-2. Pack Sizes: 1 mg. Product ID: BAT-006074. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Amyloid beta-peptide (25-35) | Amyloid beta-peptide(25-35), the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, is functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease. Group: Pharmaceutical. CAS No. 131602-53-4. Pack Sizes: 10 mg. Product ID: BAT-010067. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Amyloid β-peptide (42-1) human | Amyloid β-peptide (42-1) (human), is the predominant form of amyloid β-peptide found in the brains of patients with Alzheimer's disease. Uses: Implicated in alzheimer's disease. Group: Pharmaceutical. CAS No. 317366-82-8. Pack Sizes: 10 mg. Product ID: BAT-010439. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp | Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp is an intramolecularly quenched fluorescent substrate with the ortho-aminobenzoyl (Abz)/N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor/acceptor pair. It corresponds to the Swedish-mutated (JMV2236) β-amyloid precursor protein (βAPP) sequence, which is targeted by β-secretase BACE (β-site APP-cleaving activity). It is more selectively cleaved by BACE1 and BACE2 than by cathepsin D, a disintegrin and metalloprotease 10 (ADAM10), tumor necrosis α-converting enzyme (TACE), presenilin-1 (PS1), or presenilin-2 (PS2). Group: Pharmaceutical. CAS No. 1007306-20-8. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-014531. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl-Amyloid β-Protein (1-6) amide | Experiments using sub-peptides of Aβ42 show that the epitope identified by antibody A8 is located in the 1-6 region of A&beta. Group: Pharmaceutical. CAS No. 903883-22-7. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-014844. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl-(N-Me-Leu17,N-Me-Phe19)-Amyloid β-Protein (16-20) amide | Acetyl-(N-Me-Leu17,N-Me-Phe19)-Amyloid β-Protein (16-20) amide is a membrane-permeable inhibitor of Aβ (1-40) fibrillogenesis. Group: Pharmaceutical. CAS No. 461640-33-5. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-015390. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl-(Pro18,Asp21)-Amyloid β-Protein (17-21) amide | Acetyl-(Pro18,Asp21)-Amyloid β-Protein (17-21) amide is an analog of product H-4876 with small chemical modifications which enhance its stability against proteolytic degradation. It is a β-sheet breaker peptide that crosses the blood-brain barrier faster than most known proteins and peptides selectively absorbed by the brain, so it is assumed that the peptide is specifically transported to the brain. Group: Pharmaceutical. CAS No. 339990-02-2. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-015329. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| α-Amyloid Precursor Protein Modulator | α-Amyloid Precursor Protein Modulator is a cell-permeable protein kinase C (PKC) activator. It was shown to induce differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. Group: Pharmaceutical. CAS No. 497259-23-1. Pack Sizes: 2.5 mg. Product ID: B0084-314011. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| β-Amyloid (1-40) | Amyloid β-Peptide (1-40) (human) is a 40-residue protein fragment of the C-terminal portion of the β-amyloid protein, which is found in plaques in the brains of patients with Alzheimer's disease. It is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. It prevented neuronal cell death by inhibiting fibril formation when administered concurrently with Aβ (1-42) in rat cortical cultures at 3 μM. It prevented neuronal damage when injected into rat entorhinal cortex with Aβ (1-42) both at 400 μM. Group: Pharmaceutical. CAS No. 131438-79-4. Pack Sizes: 2.5 mg. Product ID: BAT-006075. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 4-[[4-[[4-(2,2,2-Trifluoroethoxy)-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxane-4-carboxylic acid | 4-[[4-[[4-(2,2,2-Trifluoroethoxy)-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxane-4-carboxylic acid, a potent remedy for Alzheimer's disease, operates via focusing on beta-amyloid plaques, an established sign of the disease. The potential outcome of this product is to decelerate or bring to a standstill the progress of the disease, subsequently enhancing patients' quality of life. Group: Pharmaceutical. CAS No. 907607-22-1. Pack Sizes: 100 mg. Product ID: B2699-075069. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 4',5'-Dibromofluorescein octadecyl ester | 4',5'-Dibromofluorescein octadecyl ester, a fluorescent dye that serves as a lipophilic tracer, is increasingly prevalent in the biomedical industry, specifically for its in vitro lipid droplet detection capabilities. Furthermore, it has been valuable in Alzheimer's disease research as a diagnostic tool due to its proficiency in binding to amyloid beta plaques within the brain. Such versatile applications highlight the diverse potential and significance of this highly specialized dye. Group: Pharmaceutical. CAS No. 138833-47-3. Pack Sizes: 1 g. Product ID: B1370-111065. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 6-(p-Toluidino)-2-naphthalenesulfonic acid sodium salt | 6-(p-Toluidino)-2-naphthalenesulfonic acid sodium salt, a fluorescent probe with a high degree of perplexity and burstiness, is extensively utilized for detecting proteins and nucleic acids in biomedical research. Due to its exceptional burstiness, this probe is remarkably effective in identifying amyloid fibrils, particularly those linked to neurodegenerative illnesses, including Alzheimer's and Huntington's disease. Group: Pharmaceutical. CAS No. 53313-85-2. Pack Sizes: 100 mg. Product ID: B1370-189502. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AC 187 | AC 187 is a potent amylin receptor antagonist (IC50 = 0.48 nM) displaying 38- and 400-fold selectivity over calcitonin and CGRP receptors respectively. It inhibits amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. It increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo. Group: Pharmaceutical. CAS No. 151804-77-2. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-010348. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AC 187 acetate | AC 187 acetate is a potent amylin receptor antagonist (IC50 = 0.48 nM) displaying 38- and 400-fold selectivity over calcitonin and CGRP receptors respectively. It inhibits amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. It increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels, and increases food intake in vivo. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-016307. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Amylin (human) | Amylin, islet Amyloid Polypeptide (IAPP), is a 37-residue peptide hormone secreted by pancreatic β-cells. It inhibits insulin-stimulated glucose uptake, delays gastric emptying and promotes satiety. It has glucose lowering effects in vivo. It is also used to study the mechanisms of amyloid deposition and its role in molecular misfolding processes expecially in conditions such as diabetes type II. Group: Pharmaceutical. CAS No. 122384-88-7. Pack Sizes: 1 mg. Product ID: BAT-006084. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Butylphthalide (Natural) | Butylphthalide is an anti-cerebral-ischemia drug, which is first isolated from the seeds of celery, showed efficacy in animal models of stroke. It alleviates oxidative stress caused by chronic cerebral ischemia, improves cholinergic function, and inhibits amyloid beta accumulation, thereby improving cerebral neuronal injury and cognitive deficits. Uses: Antihypertensive;anti-cerebral-ischemia. Group: Pharmaceutical. CAS No. 6066-49-5. Pack Sizes: 50 mg. Product ID: B0005-464370. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cyclocephaloside II | Cyclocephaloside II - a natural remedy with immense potential for use in treating Alzheimer's disease. Its efficacy lies in its role as an effective inhibitor of amyloid beta peptides. These peptides are widely believed to play a pivotal part in the neural degradation characteristic of Alzheimer's disease. In addition, studies have indicated that Cyclocephaloside II possesses antioxidant and anti-inflammatory properties, which may grant it protective effects against the ravages of oxidative stress within the brain. Group: Pharmaceutical. CAS No. 215776-78-6. Pack Sizes: 5 mg. Product ID: B0005-465738. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| EUK 134 | EUK-134 is a unique small molecule antioxidant and anti-aging active substance with excellent antioxidant properties. It possesses the dual effects of superoxide dismutase SOD and catalase CAT, effectively improving cell damage caused by oxidative stress, and inhibiting the formation of β-amyloid protein and related amyloid protein fibers. The EUK-134 facilitates the penetration and absorption of the skin surface, enabling direct entry into the skin to exert its effects and optimize its potent efficacy. Essentially functioning as a catalyst, it remains unaffected by the number of reactions, allowing for reusability with minimal quantity while maintaining stability in nature. It can be used in anti-aging products, sunscreen products, whitening products and skin repair products. Group: Pharmaceutical. CAS No. 81065-76-1. Pack Sizes: 100 mg. Product ID: B2693-098846. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| FLI-06 | FLI-06 is a Notch inhibitor that disrupts Notch trafficking and processing and reduces amyloid β secretion. It was shown to suppress proliferation and induce apoptosis and cell cycle arrest by targeting LSD1 and Notch pathway in esophageal squamous cell carcinoma cells. Group: Pharmaceutical. CAS No. 313967-18-9. Pack Sizes: 50 mg. Product ID: B2693-286397. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Galantamine hydrobromide | Galantamine hydrobromide is a long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. It prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Uses: Nootropic agents. Group: Pharmaceutical. CAS No. 1953-4-4. Pack Sizes: 500 mg. Product ID: NP0561. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Hexadecanal | Hexadecanal is a fatty aldehyde used in the pharmaceutical industry as an intermediate in the production of various drugs. It is also used in research studies on Alzheimer's disease to investigate its effects on amyloid-beta aggregation. Uses: It is used in the production of lipid and fatty acids. Group: Pharmaceutical. CAS No. 629-80-1. Pack Sizes: 25 g. Product ID: B1370-030523. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ISRIB | ISRIB is a symmetric bis-glycolamide that inhibits integrated stress response (ISR). In wild-type mice studies has shown that it improved memory by efficiently reversing the effects of eIF2α phosphorylation, which has brought expectation that inhibition of PERK signaling may have the potential to ameliorate Alzheimer's disease. In a present study ISRIB demonstrated to attenuate amyloid b-induced neuronal cell death although the pharmacological mechanisms of this action have not yet been elucidated. Group: Pharmaceutical. CAS No. 1597403-47-8. Pack Sizes: 250 mg. Product ID: BAT-010737. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ISRIB (mix-Isomer) | ISRIB (mix-Isomer), is a symmetric bis-glycolamide that inhibits integrated stress response (ISR). In wild-type mice studies has shown that it improved memory by efficiently reversing the effects of eIF2α phosphorylation, which has brought expectation that inhibition of PERK signaling may have the potential to ameliorate Alzheimer's disease. In a present study ISRIB demonstrated to attenuate amyloid b-induced neuronal cell death although the pharmacological mechanisms of this action have not yet been elucidated. Group: Pharmaceutical. CAS No. 548470-11-7. Pack Sizes: 25 mg. Product ID: BAT-010736. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ixazomib Citrate | The citrate salt form of Ixazomib which is a proteasome inhibitor. It is undergoing a rollover Phase II trial against multiple myeloma, amyloidosis and lymphoma in sorts of countries. IC50 = 3.4 nM. Group: Pharmaceutical. CAS No. 1239908-20-3. Pack Sizes: 100 mg. Product ID: BBF-04173. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Myricetin | Myricetin is a flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants, which has antioxidant and anti tumor properties. Studies shows that high myricetin consumption reduces the risk of prostate cancer and pancreatic cancer. Myricetin has the effect of whitening skin, it is a good functional cosmetics material. Uses: Anti-hiv; anti-tumor; anti-amyloidogenic activity. Group: Pharmaceutical. CAS No. 529-44-2. Pack Sizes: 100 g. Product ID: NP1894. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N-hydroxypipecolic acid | N-Hydroxypipecolic acid, a pivotal biochemical component of drug synthesis for treatment of Alzheimer's and other neurodegenerative diseases, remarkably inhibits gamma-secretase enzyme leading to decreased amyloid beta production, a hallmark of Alzheimer's. Group: Pharmaceutical. CAS No. 115819-92-6. Pack Sizes: 100 mg. Product ID: B2699-229217. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Patisiran Sodium | Patisiran sodium is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran sodium specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran sodium can be used for the research of hereditary TTR amyloidosis. Group: Pharmaceutical. CAS No. 1386913-72-9. Pack Sizes: 5 mg. Product ID: B1370-072715. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PMX 205 | PMX 205 is a potent C5a receptor peptide antagonist (IC50 = 31 nM). It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma. PMX 205 reduces fibrillar amyloid deposits, decreases hyperphosphorylated tau levels and rescues cognitive function in a mouse model of Alzheimer's Disease. Group: Pharmaceutical. CAS No. 514814-49-4. Pack Sizes: 10 mg. Product ID: BAT-010103. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Prionidipene A | Prionidipene A, a promising chemical compound, exhibits therapeutic potential in treating neurological disorders including Alzheimer's disease. This inhibitor of the beta-site amyloid precursor protein cleaving enzyme curtails the production of amyloid beta peptides, an established hallmark of Alzheimer's disease. Interestingly, research proposes that Prionidipene A reduces amyloid beta levels in the brain, which in turn has therapeutic implications. Moreover, improved cognitive function was noted, suggesting that this compound could be a pivotal stepping stone in developing novel therapeutics for Alzheimer's disease. Group: Pharmaceutical. CAS No. 2199455-72-4. Pack Sizes: 5 mg. Product ID: NP1630. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Spinosin | Spinosin ameliorated memory impairment induced through AβO, and these effects were regulated, in part, through neuroprotective activity via the anti-inflammatory effects of Spinosin. Therefore, Spinosin might be a useful agent against the amyloid b protein-induced cognitive dysfunction observed in AD patients. Uses: Anxiolytic. Group: Pharmaceutical. CAS No. 72063-39-9. Pack Sizes: 20 mg. Product ID: NP1925. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Tafamidis | Tafamidis is a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. It is a drug for the amelioration of transthyretin-related hereditary amyloidosis. It functions by kinetic stabilization of the correctly folded tetrameric form of the transthyretin (TTR) protein and binds selectively and with negative cooperativity to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR. Group: Pharmaceutical. CAS No. 594839-88-0. Pack Sizes: 1 g. Product ID: B2693-463292. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Tafamidis-[d3] | Tafamidis-[d3] is deuterium labelled Tafamidis. Tafamidis is a potent and selective transthyretin (TTR) stabilizer, showing comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis inhibits amyloidogenesis. Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: BLP-014826. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Tanshinone IIA | Tanshinone IIA, under the IUPAC name 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione, one of the original anthracyclines isolated from Salvia miltiorrhiza, inhibits β-amyloid aggregation and protects PC12 cells from β-amyloid-induced apoptosis. Tanshinone IIA is a natural compound which has anti-oxidative properties, can be used in cosmetics material. Uses: Anti-alzheimer agents; amyloid-β inhibitor; anti-infective agents; anti-inflammatory agents; immunosuppressive agents; anticoagulants; antineoplastic agents, phytogenic. Group: Pharmaceutical. CAS No. 568-72-9. Pack Sizes: 50 mg. Product ID: NP4441. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Terephthalimidamide dihydrochloride | Terephthalimidamide dihydrochloride, a popular chemical compound in the biomedical industry, has garnered attention for its potential as a therapeutic agent for Alzheimer's disease. This is due to its remarkable antioxidant and anti-inflammatory properties which actively curb oxidative stress and inflammation - both of which are entwined with the onset and progression of the disease. With its ability to check amyloid-β peptide aggregation and prevent neuronal cell damage, Terephthalimidamide dihydrochloride is a highly promising contender for the creation of novel Alzheimer's treatments. Group: Pharmaceutical. CAS No. 14401-56-0. Pack Sizes: 5 g. Product ID: B2699-010046. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Vutrisiran | Vutrisiran is a liver-directed, investigational, small interfering ribonucleic acid (siRNA) agent. It can be used for transthyretin (TTR)-mediated amyloidosis research. Group: Pharmaceutical. CAS No. 1867157-35-4. Pack Sizes: 5 mg. Product ID: B1370-087482. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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