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AMYL ACETATE, UK suppliers of laboratory chemicals and apparatus needed
Amylin (human)
Amylin, islet Amyloid Polypeptide (IAPP), is a 37-residue peptide hormone secreted by pancreatic β-cells. It inhibits insulin-stimulated glucose uptake, delays gastric emptying and promotes satiety. It has glucose lowering effects in vivo. It is also used to study the mechanisms of amyloid deposition and its role in molecular misfolding processes expecially in conditions such as diabetes type II. Group: Pharmaceutical. Alternative Names: L-Tyrosinamide, L-lysyl-L-cysteinyl-L-asparaginyl-L-threonyl-L-alanyl-L-threonyl-L-cysteinyl-L-alanyl-L-threonyl-L-glutaminyl-L-arginyl-L-leucyl-L-alanyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-valyl-L-histidyl-L-seryl-L-seryl-L-asparaginyl-L-asparaginyl-L-phenylalanylglycyl-L-alanyl-L-isoleucyl-L-leucyl-L-seryl-L-seryl-L-threonyl-L-asparaginyl-L-valylglycyl-L-seryl-L-asparaginyl-L-threonyl-, cycl. CAS No. 122384-88-7. Pack Sizes: 1 mg. Product ID: BAT-006084. Molecular formula: C165H261N51O55S2. Mole weight: 3903.33. Custom synthesis is available. Send your inquiries for more information.
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Amylmetacresol
Amylmetacresol (AMC) is an antiseptic available in Canada over-the-counter in a number of lozenges for the treatment of sore throat and minor mouth infections. Amylmetacresol is often combined with dichlorobenzyl alcohol and menthol in the commonly used sore throat lozenges, known as Strepsils. Group: Pharmaceutical. Alternative Names: Amylmetacresol|5-Methyl-2-pentylphenol|1300-94-3|5-methyl-2-n-pentylphenol|6-Pentyl-m-cresol|6-Amyl-m-cresol|6-n-Amyl-m-cresol|6-n-Pentyl-m-cresol|amylmetacresolum|Phenol, 5-methyl-2-pentyl-|UNII-05W904P57F|2-Amyl-5-methylphenol|CHEBI:48213|05W904P57F|NCGC00180998-01|Amilmetacresol|Amilmetacresol [Spanish]|Amylmetacresolum [Latin]|Amylmetacresol [INN:BAN]|BRN 2440952|m-Cresol, 6-pentyl-|EINECS 215-094-0|Amyl metacresol|DSSTox_CID_26791|DSSTox_RID_81908|DSSTox_GSID_46791|3-06-00-02005 (Beilstein Handbook Reference)|SCHEMBL302197|CHEMBL1512677|DTXSID8046791|BAA30094|ZINC2039651|Tox21_112651|MFCD00127710|s6173|STL453583|AKOS015912095|DB13908|5-methyl-2-N-pentylphenol, AldrichCPR|DS-15450|CAS-1300-94-3|HY-121527|CS-0082471|FT-0620948|Amylmetacresol 100 microg/mL in Acetonitrile|A888790|SR-01000944860|Q1946346|SR-01000944860-1|W-108357. CAS No. 1300-94-3. Pack Sizes: 1mg;1g;10g. Product ID: 1300-94-3. Molecular formula: C12H18O. Mole weight: 178.27. Custom synthesis is available. Send your inquiries for more information.
London
Amyloid β-peptide (1-42) human
Amyloid β-Peptide (12-28) (human), an Amyloid β-peptide fragment, binds with high affinity to α7-nicotinic ACh receptors. It impairs memory retention following central administration in mice. Uses: Implicated in alzheimer's disease. Group: Pharmaceutical. Alternative Names: β-Amyloid (1-42), human; beta-Amyloid (1-42) human; Amyloid Beta Protein Fragment 1-42; H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH; L-alpha-aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-seryl-glycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-isoleucyl-glycyl-L-leucyl-L-methionyl-L-valyl-glycyl-glycyl-L-valyl-L-valyl-L-isoleucyl-L-alanine; Abeta 42 protein; amyloid beta-protein (1-42). CAS No. 107761-42-2. Pack Sizes: 1 mg. Product ID: BAT-006074. Molecular formula: C203H311N55O60S. Mole weight: 4514.04. Custom synthesis is available. Send your inquiries for more information.
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Amyloid beta-peptide (25-35)
Amyloid beta-peptide(25-35), the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide, is functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease. Group: Pharmaceutical. Alternative Names: H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH; glycyl-L-seryl-L-asparagyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-isoleucyl-glycyl-L-leucyl-L-methionine; Amyloid β-Protein (25-35); Amyloid-Protein (25-35). CAS No. 131602-53-4. Pack Sizes: 10 mg. Product ID: BAT-010067. Molecular formula: C45H81N13O14S. Mole weight: 1060.27. Custom synthesis is available. Send your inquiries for more information.
London
Amyloid β-peptide (42-1) human
Amyloid β-peptide (42-1) (human), is the predominant form of amyloid β-peptide found in the brains of patients with Alzheimer's disease. Uses: Implicated in alzheimer's disease. Group: Pharmaceutical. Alternative Names: H-Ala-Ile-Val-Val-Gly-Gly-Val-Met-Leu-Gly-Ile-Ile-Ala-Gly-Lys-Asn-Ser-Gly-Val-Asp-Glu-Ala-Phe-Phe-Val-Leu-Lys-Gln-His-His-Val-Glu-Tyr-Gly-Ser-Asp-His-Arg-Phe-Glu-Ala-Asp-OH; L-alanyl-L-isoleucyl-L-valyl-L-valyl-glycyl-glycyl-L-valyl-L-methionyl-L-leucyl-glycyl-L-isoleucyl-L-isoleucyl-L-alanyl-glycyl-L-lysyl-L-asparagyl-L-seryl-glycyl-L-valyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alanyl-L-phenylalanyl-L-phenylalanyl-L-valyl-L-leucyl-L-lysyl-L-glutaminyl-L-histidyl-L-histidyl-L-valyl-L-alpha-glutamyl-L-tyrosyl-glycyl-L-seryl-L-alpha-aspartyl-L-histidyl-L-arginyl-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-aspartic acid; Amyloid beta (42-1) human; Amyloid b-Protein (42-1). CAS No. 317366-82-8. Pack Sizes: 10 mg. Product ID: BAT-010439. Molecular formula: C203H311N55O60S. Mole weight: 4514.04. Custom synthesis is available. Send your inquiries for more information.
London
2,4-Di-tert-amylphenol
500ml Pack Size. Group: Building Blocks, Organics, Phenols. Formula: C16H26O. CAS No. 120-95-6. Prepack ID : 90028488-500ml. Molecular Weight : 234.38.
4-sec-Amylphenol
4-sec-Amylphenol. Group: Pharmaceutical. Alternative Names: Phenol, 4-sec-pentyl-; 4-sec-Pentylphenol; Phenol, p-sec-amyl-; Phenol, p-sec-pentyl-; p-s-amylphenol; p-sec-Amylphenol. CAS No. 25735-67-5. Pack Sizes: 100 mg. Product ID: BB054145. Molecular formula: C11H16O. Mole weight: 164.25. Custom synthesis is available. Send your inquiries for more information.
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a-AMYLASE UN
α-Amylase UN, Suppliers in the UK wanted
A-AMYL CINNAMIC ALDEHYDE DIETHYL ACETAL
A-AMYL CINNAMIC ALDEHYDE DIETHYL ACETAL. Group: Pharmaceutical. Alternative Names: (2-(diethoxymethyl)-1-heptenyl)-benzen; (2-(diethoxymethyl)-1-heptenyl)benzene; [2-(diethoxymethyl)-1-heptenyl]-benzen; [2-(diethoxymethyl)-1-heptenyl]-Benzene; 1,1-diethoxy-2-(phenylmethylene)-heptan; 1,1-diethoxy-2-(phenylmethylene)heptane; 1,1-diethoxy-2-am. CAS No. 60763-41-9. Pack Sizes: 1mg;1g;10g. Product ID: 60763-41-9. Molecular formula: C18H28O2. Mole weight: 276.41. Custom synthesis is available. Send your inquiries for more information.
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Alpha Amylase - From Malt
Alpha Amylase - From Malt. Uses: Pharmaceuticals, Personal Care, Industrial. Grades: Pharma, Cosmetic, Food, Feed, Technical. CAS No. 9000-90-2. Pack Sizes: Bulk. Cenik is your partner of choice for Hard-to-find chemicals. We don't just provide products, we supply solutions to your technical and regulatory specifications.
Cenik Chemicals
alpha-Amylase, heat-stable
5g Pack Size. Group: Analytical Reagents, Biochemicals, Catalysts. CAS No. 9000-85-5. Prepack ID : 90005082-5g.
α-Amyloid Precursor Protein Modulator
α-Amyloid Precursor Protein Modulator is a cell-permeable protein kinase C (PKC) activator. It was shown to induce differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. Group: Pharmaceutical. Alternative Names: TPPB; alpha-APP Modulator; (2E,4E)-N-[(2S,5S)-5-(hydroxymethyl)-1-methyl-3-oxo-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]penta-2,4-dienamide. CAS No. 497259-23-1. Pack Sizes: 2.5 mg. Product ID: B0084-314011. Molecular formula: C27H30F3N3O3. Mole weight: 501.55. Custom synthesis is available. Send your inquiries for more information.
London
β-Amyloid (1-40)
Amyloid β-Peptide (1-40) (human) is a 40-residue protein fragment of the C-terminal portion of the β-amyloid protein, which is found in plaques in the brains of patients with Alzheimer's disease. It is neurotrophic and neurotoxic in vivo and in vitro in human and rat neuronal cell cultures. It prevented neuronal cell death by inhibiting fibril formation when administered concurrently with Aβ (1-42) in rat cortical cultures at 3 μM. It prevented neuronal damage when injected into rat entorhinal cortex with Aβ (1-42) both at 400 μM. Group: Pharmaceutical. Alternative Names: Amyloid β Protein Fragment 1-40; Aβ40. CAS No. 131438-79-4. Pack Sizes: 2.5 mg. Product ID: BAT-006075. Molecular formula: C194H295N53O58S. Mole weight: 4329.85999999999. Custom synthesis is available. Send your inquiries for more information.
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Biotinyl-Amylin, human amidated
Biotinyl-Amylin, human amidated. Group: Pharmaceutical. CAS No. 1678415-18-3. Pack Sizes: 1 mg. Product ID: BAT-006255. Molecular formula: C175H275N53O57S3. Mole weight: 4129.56. Custom synthesis is available. Send your inquiries for more information.
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Iso Amyl Acetate
Iso Amyl Acetate Uses: Pharmaceutical Research and Development. Group: Special Esters. CAS No. 123-92-2. Pack Sizes: 180kg drums & IBC's. Categories: NORDMANN Key intermediates and specialty chemicals.
UK / EU / USA / Japan
Iso-Amyl Acetate
Iso-Amyl Acetate. At Tan International we supply a wide range of products covering all industry sectors
Scotland
ISO AMYL ALCOHOL
ISO AMYL ALCOHOL, Suppliers of UK laboratory chemicals wanted
2,4,5-Trifluoro-L-β-homophenylalanine hydrochloride is used as a reagent in the synthesis of valuable β-amylalkyl-β-amino acid enantiomers. It is also an impurity of Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor for the treatment of diabetes mellitus type 2. Group: Pharmaceutical. Alternative Names: (S)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid hydrochloride. CAS No. 1217809-78-3. Pack Sizes: 1mg;1g;10g. Product ID: BAT-006713. Molecular formula: C10H11ClF3NO2. Mole weight: 269.65. Custom synthesis is available. Send your inquiries for more information.
London
2-Flurbiprofen
Flurizan, also called Tarenflurbil, is a nonsteroidal anti-inflammatory drug which inhibits γ-secretase activity leading to preventing the formation of the amyloid β peptide (Aβ42) from amyloid β precursor protein (APP). Uses: (r)-2-flurbiprofen is the r-isomer of flurbiprofen (f598700), an anti-inflammatory used as an analgesic. Group: Pharmaceutical. Alternative Names: (2R)-2-(3-fluoro-4-phenylphenyl)propanoic acid. CAS No. 51543-40-9. Pack Sizes: 1mg;1g;10g. Product ID: NP3244. Molecular formula: C15H13FO2. Mole weight: 244.26. Custom synthesis is available. Send your inquiries for more information.
4-[[4-[[4-(2,2,2-Trifluoroethoxy)-1,2-benzoxazol-3-yl]oxymethyl]piperidin-1-yl]methyl]oxane-4-carboxylic acid, a potent remedy for Alzheimer's disease, operates via focusing on beta-amyloid plaques, an established sign of the disease. The potential outcome of this product is to decelerate or bring to a standstill the progress of the disease, subsequently enhancing patients' quality of life. Group: Pharmaceutical. Alternative Names: 4-{[4-({[4-(2,2,2-Trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}-tetrahydro-2H-pyran-4-carboxylic acid; 4-{[4-({[4-(2,2,2-Trifluoroethoxy)-1,2-benzoxazol-3-yl]oxy}methyl)-1-piperidinyl]methyl}tetrahydro-2H-pyran-4-carboxylic acid; 2H-Pyran-4-carboxylic acid, tetrahydro-4-[[4-[[[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy]methyl]-1-piperidinyl]methyl]-. CAS No. 907607-22-1. Pack Sizes: 100 mg. Product ID: B2699-075069. Molecular formula: C22H27F3N2O6. Mole weight: 472.45. Custom synthesis is available. Send your inquiries for more information.
London
6-(p-Toluidino)-2-naphthalenesulfonic acid sodium salt
6-(p-Toluidino)-2-naphthalenesulfonic acid sodium salt, a fluorescent probe with a high degree of perplexity and burstiness, is extensively utilized for detecting proteins and nucleic acids in biomedical research. Due to its exceptional burstiness, this probe is remarkably effective in identifying amyloid fibrils, particularly those linked to neurodegenerative illnesses, including Alzheimer's and Huntington's disease. Group: Pharmaceutical. Alternative Names: Sodium 6-(p-toluidino)-2-naphthalenesulfonate; TNS; 2-(p-Toluidino)naphthalene-6-sulfonic acid sodium salt. CAS No. 53313-85-2. Pack Sizes: 100 mg. Product ID: B1370-189502. Molecular formula: C17H14NNaO3S. Mole weight: 335.35. Custom synthesis is available. Send your inquiries for more information.
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AA 147
AA 147 is an endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 μM). Group: Pharmaceutical. Alternative Names: N-(2-Hydroxy-5-methylphenyl)benzenepropanamide; N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide. CAS No. 393121-74-9. Pack Sizes: 1mg;1g;10g. Product ID: 393121-74-9. Molecular formula: C16H17NO2. Mole weight: 255.31. Custom synthesis is available. Send your inquiries for more information.
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AC 186
AC 186, also called GTPL8897, a diphenyl substituted cyclohexane derivatives, decreases Aβ levels in combination with ACP-105 in a rat model of Alzheimer's disease. Uses: Anti-alzheimer agents; amyloid-β inhibitor. Group: Pharmaceutical. Alternative Names: 4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]phenol; GTPL8897; SCHEMBL14672438; AC-186; AC 186; AC186; AKOS025147323; 4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]phenol; AC 186|4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol. CAS No. 1421854-16-1. Pack Sizes: 1mg;1g;10g. Product ID: 1421854-16-1. Molecular formula: C18H17F3O. Mole weight: 306.32. Custom synthesis is available. Send your inquiries for more information.
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AC 253
AC 253 is an amylin (AMY3) receptor antagonist. It inhibits andrenomedulin-stimulated cAMP production in vitro. Group: Pharmaceutical. Alternative Names: L-Tyrosinamide, N-acetyl-L-leucylglycyl-L-arginyl-L-leucyl-L-seryl-L-glutaminyl-L-a-glutamyl-L-leucyl-L-histidyl-L-arginyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparaginyl-L-threonylglycyl-L-seryl-L-asparaginyl-L-threonyl-. CAS No. 151804-79-4. Pack Sizes: 1mg;1g;10g. Product ID: 151804-79-4. Molecular formula: C122H196N40O39. Mole weight: 2847.11. Custom synthesis is available. Send your inquiries for more information.
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Acarbose
Acarbose is an inhibitor of alpha-glucosidase isolated from Actinoplance sp., used to treat type 2 diabetes. Uses: Enzyme inhibitors; hypoglycemic agents. Group: Pharmaceutical. Alternative Names: Amylostatin J; Bay g 5421; α-GHI; Glucobay; 4,6-dideoxy-4-{[(1S,4S,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranosyl-(1→4)-alpha-D-glucopyranosyl-(1→4)-beta-D-glucopyranose. CAS No. 56180-94-0. Pack Sizes: 1mg;1g;10g. Product ID: BBF-00538. Molecular formula: C25H43NO18. Mole weight: 645.61. Custom synthesis is available. Send your inquiries for more information.
London
Acarviosine-glucose
An impurity of Acarbose, a medication used for the treatment of diabetes mellitus type 2. Group: Pharmaceutical. Alternative Names: Amylostatin XG; Acarviostatin I00. CAS No. 68128-53-0. Pack Sizes: 25 mg. Product ID: B1370-245441. Molecular formula: C19H33NO13. Mole weight: 483.5. Custom synthesis is available. Send your inquiries for more information.
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Bis(4-hydroxycinnamoyl)methane
Bisdemethoxycurcumin is one of the three major forms of curcuminoids found in the rhizomes of turmeric. Bisdemethoxycurcumin displays antioxidant, anti-inflammatory as well as chemotherapeutic activity. Bisdemethoxycurcumin acts as an inhibitor of human pancreatic α-amylase, a target for type-2 diabetes. Uses: Cholesterol lowing. Group: Pharmaceutical. Alternative Names: 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-; 1,6-Heptadiene-3,5-dione, 1,7-bis(p-hydroxyphenyl)-; 1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione; Bisdemethoxycucurmin; p,p'-Dihydroxydicinnamoylmethane. CAS No. 24939-16-0. Pack Sizes: 1mg;1g;10g. Product ID: NP2829. Molecular formula: C19H16O4. Mole weight: 308.33. Custom synthesis is available. Send your inquiries for more information.
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Butylphthalide (Natural)
Butylphthalide is an anti-cerebral-ischemia drug, which is first isolated from the seeds of celery, showed efficacy in animal models of stroke. It alleviates oxidative stress caused by chronic cerebral ischemia, improves cholinergic function, and inhibits amyloid beta accumulation, thereby improving cerebral neuronal injury and cognitive deficits. Uses: Antihypertensive;anti-cerebral-ischemia. Group: Pharmaceutical. Alternative Names: 3-n-Butylphthalide; 3-Butylphthalide. CAS No. 6066-49-5. Pack Sizes: 50 mg. Product ID: B0005-464370. Molecular formula: C12H14O2. Mole weight: 190.24. Custom synthesis is available. Send your inquiries for more information.
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Cadaverine-[15N2] Dihydrochloride
Cadaverine-[15N2] Dihydrochloride. Group: Pharmaceutical. Alternative Names: 1,5-Pentanediamine-15N2 Dihydrochloride; 1,5-Amylene Diamine-15N2 Dihydrochloride; Cadaverine-15N2 Dihydrochloride. CAS No. 2747-91-3. Pack Sizes: 25 mg. Product ID: BLP-002127. Molecular formula: C5H16Cl2[15N]2. Mole weight: 177.09. Custom synthesis is available. Send your inquiries for more information.
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Calcitonin (8-32), salmon
Calcitonin (8-32), salmon is an amylin receptor antagonist with highly selectivity. Group: Pharmaceutical. Alternative Names: H-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2; L-valyl-L-leucyl-glycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-alpha-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-L-threonyl-L-asparagyl-L-threonyl-glycyl-L-seryl-glycyl-L-threonyl-L-prolinamide; 8-32-Calcitonin (salmon reduced); Calcitonin (salmon reduced), 1-de-L-cysteine-2-de-L-serine-3-de-L-asparagine-4-de-L-leucine-5-de-L-serine-6-de-L-threonine-7-de-L-cysteine-; Salmon calcitonin (8-32). CAS No. 155069-90-2. Pack Sizes: 1mg;1g;10g. Product ID: BAT-010552. Molecular formula: C119H198N36O37. Mole weight: 2725.06. Custom synthesis is available. Send your inquiries for more information.
London
Cyclocephaloside II
Cyclocephaloside II - a natural remedy with immense potential for use in treating Alzheimer's disease. Its efficacy lies in its role as an effective inhibitor of amyloid beta peptides. These peptides are widely believed to play a pivotal part in the neural degradation characteristic of Alzheimer's disease. In addition, studies have indicated that Cyclocephaloside II possesses antioxidant and anti-inflammatory properties, which may grant it protective effects against the ravages of oxidative stress within the brain. Group: Pharmaceutical. Alternative Names: (3beta,6alpha,16beta,20R,24S)-3-[(4-O-Acetyl-beta-D-xylopyranosyl)oxy]-20,24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl beta-D-glucopyranoside. CAS No. 215776-78-6. Pack Sizes: 5 mg. Product ID: B0005-465738. Molecular formula: C43H70O15. Mole weight: 827. Custom synthesis is available. Send your inquiries for more information.
London
Deoxynojirimycin
Deoxynojirimycin inhibits mammalian glucosidase 1. As well, it inhibits intestinal and lysosmal alpha-glucosidases, beta-glucosidase from sweet almonds, pancreatic alpha-amylase and amyloglucosidase. Group: Pharmaceutical. Alternative Names: DNJ; 1-Deoxynojirimycin; 1,5-Dideoxy-1,5-imino-D-glucitol; Moranoline; 1-dNM; 2R-(hydroxymethyl)-3R,4R,5S-piperidinetriol; (2R,3R,4R,5S)-2-(Hydroxymethyl)-3,4,5-piperidinetriol; 5-Amino-1,5-dideoxy-D-glucopyranose; Duvoglustat; Moranolin. CAS No. 19130-96-2. Pack Sizes: 250 mg. Product ID: BBF-01829. Molecular formula: C6H13NO4. Mole weight: 163.17. Custom synthesis is available. Send your inquiries for more information.
London
EUK 134
EUK-134 is a unique small molecule antioxidant and anti-aging active substance with excellent antioxidant properties. It possesses the dual effects of superoxide dismutase SOD and catalase CAT, effectively improving cell damage caused by oxidative stress, and inhibiting the formation of β-amyloid protein and related amyloid protein fibers. The EUK-134 facilitates the penetration and absorption of the skin surface, enabling direct entry into the skin to exert its effects and optimize its potent efficacy. Essentially functioning as a catalyst, it remains unaffected by the number of reactions, allowing for reusability with minimal quantity while maintaining stability in nature. It can be used in anti-aging products, sunscreen products, whitening products and skin repair products. Group: Pharmaceutical. Alternative Names: Manganese, chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[6-methoxyphenolato-κO]](2-)]-, (SP-5-13)-; (SP-5-13)-Chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[6-methoxyphenolato-κO]](2-)]manganese; Manganese, chloro[[2,2'-[1,2-ethanediylbis(nitrilomethylidyne)]bis[6-methoxyphenolato]](2-)-N2,N2',O1,O1']-; Phenol, 2,2'-[1,2-ethanediylbis(nitrilomethylidyne)]bis[6-methoxy-. CAS No. 81065-76-1. Pack Sizes: 100 mg. Product ID: B2693-098846. Molecular formula: C18H18ClMnN2O4. Mole weight: 416.74. Custom synthesis is available. Send your inquiries for more informatio
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FLI-06
FLI-06 is a Notch inhibitor that disrupts Notch trafficking and processing and reduces amyloid β secretion. It was shown to suppress proliferation and induce apoptosis and cell cycle arrest by targeting LSD1 and Notch pathway in esophageal squamous cell carcinoma cells. Group: Pharmaceutical. Alternative Names: FLI 06; cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate. CAS No. 313967-18-9. Pack Sizes: 50 mg. Product ID: B2693-286397. Molecular formula: C25H30N2O5. Mole weight: 438.524. Custom synthesis is available. Send your inquiries for more information.
London
Galantamine hydrobromide
Galantamine hydrobromide is a long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. It prevents β-amyloid-induced apoptosis in SH-SY5Y and bovine chromaffin cells. Uses: Nootropic agents. Group: Pharmaceutical. Alternative Names: 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, hydrobromide (1:1), (4aS,6R,8aS)-; 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, monohydrobromide, (4aS,6R,8aS)-; Galanthamine, hydrobromide; (-)-Galantamine hydrobromide; (-)-Galanthamine hydrobromide; Galanthamine hydrogen bromide; Jilkon hydrobromide; Lycoremine hydrobromide; Nivalin; Nivaline; Nivaline (pharmaceutical); Razadyne; Reminyl; Tamilin. CAS No. 1953-4-4. Pack Sizes: 500 mg. Product ID: NP0561. Molecular formula: C17H21NO3.HBr. Mole weight: 368.28. Custom synthesis is available. Send your inquiries for more information.
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ISRIB
ISRIB is a symmetric bis-glycolamide that inhibits integrated stress response (ISR). In wild-type mice studies has shown that it improved memory by efficiently reversing the effects of eIF2α phosphorylation, which has brought expectation that inhibition of PERK signaling may have the potential to ameliorate Alzheimer's disease. In a present study ISRIB demonstrated to attenuate amyloid b-induced neuronal cell death although the pharmacological mechanisms of this action have not yet been elucidated. Group: Pharmaceutical. Alternative Names: 2-(4-chlorophenoxy)-N-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide; 2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide; ISRIB compound; trans-ISRIB. CAS No. 1597403-47-8. Pack Sizes: 250 mg. Product ID: BAT-010737. Molecular formula: C22H24Cl2N2O4. Mole weight: 451.34. Custom synthesis is available. Send your inquiries for more information.
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ISRIB (mix-Isomer)
ISRIB (mix-Isomer), is a symmetric bis-glycolamide that inhibits integrated stress response (ISR). In wild-type mice studies has shown that it improved memory by efficiently reversing the effects of eIF2α phosphorylation, which has brought expectation that inhibition of PERK signaling may have the potential to ameliorate Alzheimer's disease. In a present study ISRIB demonstrated to attenuate amyloid b-induced neuronal cell death although the pharmacological mechanisms of this action have not yet been elucidated. Group: Pharmaceutical. Alternative Names: Acetamide, N,?N'-1,?4-cyclohexanediylbis[2?-(4-chlorophenoxy)?- ISRIB compound. CAS No. 548470-11-7. Pack Sizes: 25 mg. Product ID: BAT-010736. Molecular formula: C22H24Cl2N2O4. Mole weight: 451.34. Custom synthesis is available. Send your inquiries for more information.
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Ixazomib Citrate
The citrate salt form of Ixazomib which is a proteasome inhibitor. It is undergoing a rollover Phase II trial against multiple myeloma, amyloidosis and lymphoma in sorts of countries. IC50 = 3.4 nM. Group: Pharmaceutical. Alternative Names: 4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid; MLN9708; MLN-9708; MLN 9708. CAS No. 1239908-20-3. Pack Sizes: 100 mg. Product ID: BBF-04173. Molecular formula: C20H23BCl2N2O9. Mole weight: 517.12. Custom synthesis is available. Send your inquiries for more information.
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Maltotetraose
Maltotetraose is a resplendent biomedical compound, used for studying diabetes, orchestrating commendable blood glucose regulation. Group: Pharmaceutical. Alternative Names: O-α-D-glucopyranosyl-(1→4)-O-α-D-glucopyranosyl-(1→4)-O-α-D-glucopyranosyl-(1→4)-D-Glucose; Amylotetraose; α-1,4-Tetraglucose; a-D-Glucopyranosyl-1,4-O-a-D-glucopyranosyl-1,4-O-a-D-glucopyranosyl-1,4-D-glucopyranose; D-maltotetraose; α-1,4-Tetraglucose; Glc(a1-4)Glc(a1-4)Glc(a1-4)aldehydo-Glc. CAS No. 34612-38-9. Pack Sizes: 250 mg. Product ID: B2705-110539. Molecular formula: C24H42O21. Mole weight: 666.58. Custom synthesis is available. Send your inquiries for more information.
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Myricetin
Myricetin is a flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants, which has antioxidant and anti tumor properties. Studies shows that high myricetin consumption reduces the risk of prostate cancer and pancreatic cancer. Myricetin has the effect of whitening skin, it is a good functional cosmetics material. Uses: Anti-hiv; anti-tumor; anti-amyloidogenic activity. Group: Pharmaceutical. Alternative Names: Cannabiscetin; HSDB 7682; HSDB7682; HSDB-7682; Myricetin. CAS No. 529-44-2. Pack Sizes: 100 g. Product ID: NP1894. Molecular formula: C15H10O8. Mole weight: 318.24. Custom synthesis is available. Send your inquiries for more information.
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N-hydroxypipecolic acid
N-Hydroxypipecolic acid, a pivotal biochemical component of drug synthesis for treatment of Alzheimer's and other neurodegenerative diseases, remarkably inhibits gamma-secretase enzyme leading to decreased amyloid beta production, a hallmark of Alzheimer's. Group: Pharmaceutical. Alternative Names: 1-hydroxy-2-piperidinecarboxylic acid; 2-Piperidinecarboxylic acid, 1-hydroxy-; hydroxypipecolic acid. CAS No. 115819-92-6. Pack Sizes: 100 mg. Product ID: B2699-229217. Molecular formula: C6H11NO3. Mole weight: 145.16. Custom synthesis is available. Send your inquiries for more information.
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Patisiran Sodium
Patisiran sodium is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran sodium specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran sodium can be used for the research of hereditary TTR amyloidosis. Group: Pharmaceutical. Alternative Names: RNA, (A-U-G-G-A-A-Um-A-C-U-C-U-U-G-G-U-Um-A-C-dT-dT), complex with RNA (G-Um-A-A-Cm-Cm-A-A-G-A-G-Um-A-Um-Um-Cm-Cm-A-Um-dT-dT), sodium salt (1:1:40); Onpattro; siRNA ALN-18328. CAS No. 1386913-72-9. Pack Sizes: 5 mg. Product ID: B1370-072715. Mole weight: 13427.10 (AS: 6661.3; SS: 6765.8). Custom synthesis is available. Send your inquiries for more information.
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Phe-Phe-OMe HCl
Phe-Phe-OMe HCl is employed as a reagent used in the preparation of polymer nanoparticles containing hydrophobic dipeptide for inhibition of amyloid-β fibrillation. Group: Pharmaceutical. Alternative Names: H-Phe-Phe-OMe HCl; Methyl L-phenylalanyl-L-phenylalaninate hydrochloride; L-Phenylalanyl-L-phenylalanine methyl ester hydrochloride; (S)-Methyl 2-((S)-2-amino-3-phenylpropanamido)-3-phenylpropanoate hydrochloride. CAS No. 38017-65-1. Pack Sizes: 10 g. Product ID: BAT-006532. Molecular formula: C19H23ClN2O3. Mole weight: 362.86. Custom synthesis is available. Send your inquiries for more information.
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PMX 205
PMX 205 is a potent C5a receptor peptide antagonist (IC50 = 31 nM). It is orally active and blocks inflammatory signaling and symptoms in animal models of colitis and allergic asthma. PMX 205 reduces fibrillar amyloid deposits, decreases hyperphosphorylated tau levels and rescues cognitive function in a mouse model of Alzheimer's Disease. Group: Pharmaceutical. Alternative Names: PMX-205; Hydrocinnamate. CAS No. 514814-49-4. Pack Sizes: 10 mg. Product ID: BAT-010103. Molecular formula: C45H62N10O6. Mole weight: 839.05. Custom synthesis is available. Send your inquiries for more information.
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Pramlintide acetate hydrate
Pramlintide is an analog of amylin, an antidiabetic peptide hormone released into the bloodstream. It has been used in the treatment of diabetes. Group: Pharmaceutical. CAS No. 196078-30-5. Pack Sizes: 5 mg. Product ID: BAT-010155. Molecular formula: C173H273N51O56S2. Mole weight: 4027.46. Custom synthesis is available. Send your inquiries for more information.
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Preptin (rat)
Preptin, a 34-amino acid peptide hormone, is co-secreted with insulin in β-cells of the pancreas in response to glucose stimulation. Preptin is osteogenic both in vitro and in vivo and may act synergistically with other β-cell hormones insulin and amylin to stimulate bone formation in hyperinsulinemic states such as obesity. Group: Pharmaceutical. Alternative Names: H-Asp-Val-Ser-Thr-Ser-Gln-Ala-Val-Leu-Pro-Asp-Asp-Phe-Pro-Arg-Tyr-Pro-Val-Gly-Lys-Phe-Phe-Lys-Phe-Asp-Thr-Trp-Arg-Gln-Ser-Ala-Gly-Arg-Leu-OH; L-alpha-aspartyl-L-valyl-L-seryl-L-threonyl-L-seryl-L-glutaminyl-L-alanyl-L-valyl-L-leucyl-L-prolyl-L-alpha-aspartyl-L-alpha-aspartyl-L-phenylalanyl-L-prolyl-L-arginyl-L-tyrosyl-L-prolyl-L-valyl-glycyl-L-lysyl-L-phenylalanyl-L-phenylalanyl-L-lysyl-L-phenylalanyl-L-alpha-aspartyl-L-threonyl-L-tryptophyl-L-arginyl-L-glutaminyl-L-seryl-L-alanyl-glycyl-L-arginyl-L-leucine. CAS No. 315197-73-0. Pack Sizes: 1mg;1g;10g. Product ID: BAT-015358. Molecular formula: C181H268N48O51. Mole weight: 3932.41. Custom synthesis is available. Send your inquiries for more information.
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Prionidipene A
Prionidipene A, a promising chemical compound, exhibits therapeutic potential in treating neurological disorders including Alzheimer's disease. This inhibitor of the beta-site amyloid precursor protein cleaving enzyme curtails the production of amyloid beta peptides, an established hallmark of Alzheimer's disease. Interestingly, research proposes that Prionidipene A reduces amyloid beta levels in the brain, which in turn has therapeutic implications. Moreover, improved cognitive function was noted, suggesting that this compound could be a pivotal stepping stone in developing novel therapeutics for Alzheimer's disease. Group: Pharmaceutical. CAS No. 2199455-72-4. Pack Sizes: 5 mg. Product ID: NP1630. Molecular formula: C21H26O3. Mole weight: 326.43. Custom synthesis is available. Send your inquiries for more information.
(S)-(+)-2-methylbutyl p-[(p-methoxybenzylidene)amino]cinnamate, an active pharmaceutical intermediate, is a vital component in the pharmaceutical industry for synthesizing medications that alleviate pain and inflammation. Such disorders include osteoarthritis and arthritis, among others. Its significant role in medicinal chemistry, as a proficient synthesis intermediate, cannot be emphasized enough. Group: Pharmaceutical. Alternative Names: (+)-2-METHYLBUTYL-P[(P-METHOXYBENZYLIDENE)AMINO]CINNAMATE; ACTIVE-AMYL P-ANISALAMINOCINNAMATE; ACT-AMYL P-ANISALAMINOCINNAMATE; (S)-(+)-2-METHYLBUTYL P-[(P-METHOXYBENZYLIDENE)AMINO]CINNAMATE; (+)-2-methylbutyl-4-methoxybenzilidine-4'-aminocinnamate; (+)-2-met. CAS No. 24140-30-5. Pack Sizes: 1 g. Product ID: B2699-238711. Molecular formula: C22H25NO3. Mole weight: 351.44. Custom synthesis is available. Send your inquiries for more information.
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Spinosin
Spinosin ameliorated memory impairment induced through AβO, and these effects were regulated, in part, through neuroprotective activity via the anti-inflammatory effects of Spinosin. Therefore, Spinosin might be a useful agent against the amyloid b protein-induced cognitive dysfunction observed in AD patients. Uses: Anxiolytic. Group: Pharmaceutical. Alternative Names: spinosin; 2-(4-Hydroxyphenyl)-5-hydroxy-7-methoxy-6-[2-O-(β-D-glucopyranosyl)-β-D-glucopyranosyl]-4H-1-benzopyran-4-one; 2''-O-β-D-Glucopyranosylswertisin; 6-(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)-4',5-dihydroxy-7-methoxyflavone; 6-(2-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one; Spinosin A; 6-(2-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one; FlavoayaMenin. CAS No. 72063-39-9. Pack Sizes: 20 mg. Product ID: NP1925. Molecular formula: C28H32O15. Mole weight: 608.55. Custom synthesis is available. Send your inquiries for more information.
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Tafamidis
Tafamidis is a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade. It is a drug for the amelioration of transthyretin-related hereditary amyloidosis. It functions by kinetic stabilization of the correctly folded tetrameric form of the transthyretin (TTR) protein and binds selectively and with negative cooperativity to the two normally unoccupied thyroxine-binding sites of the tetramer, and kinetically stabilizes TTR. Group: Pharmaceutical. Alternative Names: Fx-1006A; Vyndaqel. CAS No. 594839-88-0. Pack Sizes: 1 g. Product ID: B2693-463292. Molecular formula: C14H7Cl2NO3. Mole weight: 308.12. Custom synthesis is available. Send your inquiries for more information.
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Tafamidis-[d3]
Tafamidis-[d3] is deuterium labelled Tafamidis. Tafamidis is a potent and selective transthyretin (TTR) stabilizer, showing comparable potency and efficacy to the mutumant homotetramers V30M-TTR, V122I-TTR and wild type WT-TTR, with EC50s of 2.7-3.2 μM. Tafamidis inhibits amyloidogenesis. Group: Pharmaceutical. Alternative Names: Tafamidis-d3; d3-Tafamidis. Pack Sizes: 10 mg. Product ID: BLP-014826. Molecular formula: C14H4D3Cl2NO3. Mole weight: 311.13. Custom synthesis is available. Send your inquiries for more information.
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Tanshinone IIA
Tanshinone IIA, under the IUPAC name 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione, one of the original anthracyclines isolated from Salvia miltiorrhiza, inhibits β-amyloid aggregation and protects PC12 cells from β-amyloid-induced apoptosis. Tanshinone IIA is a natural compound which has anti-oxidative properties, can be used in cosmetics material. Uses: Anti-alzheimer agents; amyloid-β inhibitor; anti-infective agents; anti-inflammatory agents; immunosuppressive agents; anticoagulants; antineoplastic agents, phytogenic. Group: Pharmaceutical. Alternative Names: Tanshinone IIA; 568-72-9; Tanshinone II; Dan Shen Ketone; Tanshinone B; Tanshinon II; 1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione; C19H18O3; MLS001048863; NSC686519; NSC 686518; SMR000387068; Tanshinone B, Tanshinone II, 568-72-9; 1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dion; 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g]benzofuran-10,11-dione; 1,6,6-. CAS No. 568-72-9. Pack Sizes: 50 mg. Product ID: NP4441. Molecular formula: C19H18O3. Mole weight: 294.34. Custom synthesis is available. Send your inquiries for more information.
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Terephthalimidamide dihydrochloride
Terephthalimidamide dihydrochloride, a popular chemical compound in the biomedical industry, has garnered attention for its potential as a therapeutic agent for Alzheimer's disease. This is due to its remarkable antioxidant and anti-inflammatory properties which actively curb oxidative stress and inflammation - both of which are entwined with the onset and progression of the disease. With its ability to check amyloid-β peptide aggregation and prevent neuronal cell damage, Terephthalimidamide dihydrochloride is a highly promising contender for the creation of novel Alzheimer's treatments. Group: Pharmaceutical. Alternative Names: 1,4-Benzenedicarboximidamide dihydrochloride. CAS No. 14401-56-0. Pack Sizes: 5 g. Product ID: B2699-010046. Molecular formula: C8H12Cl2N4. Mole weight: 235.11. Custom synthesis is available. Send your inquiries for more information.
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Vutrisiran
Vutrisiran is a liver-directed, investigational, small interfering ribonucleic acid (siRNA) agent. It can be used for transthyretin (TTR)-mediated amyloidosis research. Group: Pharmaceutical. Alternative Names: ALN-TTRsc02. CAS No. 1867157-35-4. Pack Sizes: 5 mg. Product ID: B1370-087482. Molecular formula: C530H715F9N171O323P43S6. Mole weight: 16345 (AS: 7556.3; SS: 8788.7 ). Custom synthesis is available. Send your inquiries for more information.
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