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| Product | Description | |
|---|---|---|
| 2-(2-(2-Aminoethoxy)ethoxy)acetic acid | H2N-PEG2-CH2COOH belongs to a polyethylene glycol (PEG) linker covalently bound to E3 Ligase binding group (E3LB) and protein binding group (PB). H2N-PEG2-CH2COOH is a PEG derivative containing an amino group with a terminal carboxylic acid. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. PEG Linkers may be useful in the development of antibody drug conjugates and PROTACs. Group: Pharmaceutical. CAS No. 134978-97-5. Pack Sizes: 1 g. Product ID: BAT-006212. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| 3-Acetyl-11-keto-beta-boswellic acid | AKBA is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator. Group: Pharmaceutical. CAS No. 67416-61-9. Pack Sizes: 100 mg. Product ID: NP7230. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 5-[(4-Hydroxy-3-methoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione | The compound 5-[(4-Hydroxy-3-methoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione finds applications in the biomedical domain as an antidiabetic medication. Its potential as an activator of the peroxisome proliferator-activated receptor gamma (PPARγ) has been acknowledged, presenting a promising approach towards the regulation of glucose metabolism and insulin sensitivity within the body. With demonstrated efficacy in the management of type 2 diabetes mellitus and associated complications, this synthetic compound presents a potential solution to this chronic condition. Group: Pharmaceutical. CAS No. 24044-50-6. Pack Sizes: 50 mg. Product ID: B0001-284767. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| 740 Y-P (TFA) | 740 Y-P is a cell-permeable phosphopeptide activator of PI3K. It binds to the p85 N- and C-terminal SH2 domains of PI3K but not to GST or the N-terminal domain of phospholipase C (PLC) in an affinity purification assay. And it displays mitogenic activity in C2 muscle cells and promotes survival of rat cerebellar granule neurons in vitro. Group: Pharmaceutical. Pack Sizes: 10 mg. Product ID: B1370-449751. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Abaloparatide acetate | Abaloparatide acetate, an effective and selective activator of the PTHR1 signaling pathway, is an analog of parathyroid hormone-related protein (PTHrP) used for the treatment of osteoporosis. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-016365. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl Hexapeptide-38 | Acetyl hexapeptide 38, also known as breast enhancement peptide, is a peroxisome proliferator-activated receptor-γ coactivator 1α antagonist for cellulite therapy. Acetyl Hexapeptide-38 stimulates peroxisome proliferator-activated receptor Gamma coactivator 1a(PGC-1a) expression and increases fatty tissue volume in specific areas. Group: Pharmaceutical. CAS No. 1400634-44-7. Pack Sizes: 1 g. Product ID: BAT-010077. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acid-Cy7-NHS ester | Acid-Cy7 NHS ester, an improved analog of Cy7? fluorophore, contains an acid group and an NHS ester. This reagent allows labeled biomolecules and dye labeled molecules to be subsequently used for various research and drug design related experiments. The carboxylic acid can react with primary amines in the presence of activators such as HATU and EDC. The NHS ester can also react with primary amines. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: A17-0183. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acid-PEG10-NHS ester | Acid-PEG10-NHS ester is a PEG linker containing a carboxylic acid and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-2433. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acid-PEG11-NHS ester | Acid-PEG11-NHS ester is a PEG linker containing a carboxylic acid and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Group: Pharmaceutical. CAS No. 2490419-65-1. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-1026. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acid-PEG12-NHS ester | Acid-PEG12-NHS ester is a PEG linker containing a carboxylic acid and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-0055. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acid-PEG12-t-butyl ester | Acid-PEG12-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. Please contact us for GMP-grade inquiries. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-4151. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acid-PEG13-NHS ester | Acid-PEG13-NHS ester is a PEG linker containing a carboxylic acid and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Group: Pharmaceutical. CAS No. 2152679-62-2. Pack Sizes: 1mg; 1g; 10g. Product ID: BP-501104. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acid-PEG14-t-butyl ester | Acid-PEG14-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. Please contact us for GMP-grade inquiries. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-4152. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acid-PEG1-NHS ester | Acid-PEG1-NHS ester is a PEG linker containing a carboxylic acid and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-1034. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acid-PEG2-NHS ester | Acid-PEG2-NHS ester is a PEG linker containing a carboxylic acid and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Group: Pharmaceutical. CAS No. 2752068-22-5. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-1035. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acid-PEG3-NHS ester | Acid-PEG3-NHS ester is a PEG linker containing a carboxylic acid and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Group: Pharmaceutical. CAS No. 1835759-79-9. Pack Sizes: 1mg; 1g; 10g. Product ID: BP-501559. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acid-PEG4-NHS ester | Acid-PEG4-NHS ester is a PEG linker containing a carboxylic acid and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-1036. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acid-PEG4-S-S-PEG4-acid | Acid-PEG4-SS-PEG4-acid is a homobifunctional cleavable linker with carboxylic acid groups at both sides. The terminal carboxylic acids can be reacted with primary amines in the presences of activators such as EDC and HATU to form stable amide bonds. The disulfide bonds can be cleaved by using Dithiothreitol (DTT) reagent. Group: Pharmaceutical. CAS No. 2055015-40-0. Pack Sizes: 1mg; 1g; 10g. Product ID: BP-501142. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acid-PEG5-NHS ester | Acid-PEG5-NHS ester is a PEG linker containing a carboxylic acid and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Group: Pharmaceutical. CAS No. 1343476-41-4. Pack Sizes: 1mg; 1g; 10g. Product ID: BP-501159. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acid-PEG5-TEMPO | Acid-PEG5-TEMPO is a PEG linker with a terminal carboxylic acid and TEMPO moiety. The terminal carboxylic acid can react with primary amines in the presence of activators such as EDC and HATU to form stable amide bonds. The hydrophilic PEG linker increases the water solubility of the compound. TEMPO is a stable radical with applications in chemistry and biochemistry. It is used as a radical marker, a structural probe for biological systems in conjunction with electron spin resonance spectroscopy, a reagent in organic synthesis, and as a mediator in controlled radical polymerization. It is commonly used as a catalyst in organic chemistry synthesis for the oxidation of primary alcohols to aldehydes. Please contact us for GMP-grade inquiries. Group: Pharmaceutical. CAS No. 2055040-79-2. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-4126. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acid-PEG6-NHS ester | Acid-PEG6-NHS ester is a PEG linker containing a carboxylic acid and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-1031. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acid-PEG7-NHS ester | Acid-PEG7-NHS ester is a PEG linker containing a carboxylic acid and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-1028. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acid-PEG8-NHS ester | Acid-PEG8-NHS ester is a PEG linker containing a carboxylic acid and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Product ID: BPG-1030. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acid-PEG9-NHS ester | Acid-PEG9-NHS ester is a PEG linker containing a carboxylic acid and an NHS ester. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. Group: Pharmaceutical. CAS No. 1895916-27-4. Pack Sizes: 1mg; 1g; 10g. Product ID: BP-500446. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| AG-490 | Tyrphostin AG490 is a JAK-2 specific inhibitor, which inhibits phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. Uses: Antineoplastic agents. Group: Pharmaceutical. CAS No. 133550-30-8. Pack Sizes: 25 mg. Product ID: B0084-164022. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| aleplasinin | Aleplasinin is a selective and potent inhibitor of PAI-1 (Plasminogen activator inhibitor-1). It has been used in the treatment of Alzheimer's disease. Group: Pharmaceutical. CAS No. 481629-87-2. Pack Sizes: 50 mg. Product ID: B1370-182315. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Alfacalcidol EP Impurity A | Alfacalcidol EP Impurity A is an impurity of Alfacalcidol, which is a non-selective VDR activator medication. Alfacalcidol improves mechanical bone strength and bone mass and suppresses osteoclastic bone resorption in vivo. Group: Pharmaceutical. CAS No. 65445-14-9. Pack Sizes: 5 mg. Product ID: B1960-485225. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Alfacalcidol EP Impurity B | Alfacalcidol EP Impurity B is an impurity of Alfacalcidol, which is a non-selective VDR activator medication. Alfacalcidol improves mechanical bone strength and bone mass and suppresses osteoclastic bone resorption in vivo. Group: Pharmaceutical. CAS No. 63181-13-5. Pack Sizes: 5 mg. Product ID: B1960-262191. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| α-Amyloid Precursor Protein Modulator | α-Amyloid Precursor Protein Modulator is a cell-permeable protein kinase C (PKC) activator. It was shown to induce differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. Group: Pharmaceutical. CAS No. 497259-23-1. Pack Sizes: 2.5 mg. Product ID: B0084-314011. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Azido-PEG3-acetic acid | N3-PEG3-CH2COOH is a PROTAC linker, which refers to the alkyl/ether composition. N3-PEG3-CH2COOH can be used in the synthesis of a series of PROTACs. N3-PEG3-CH2COOH is a PEG derivative containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. Group: Pharmaceutical. CAS No. 172531-37-2. Pack Sizes: 5 g. Product ID: B1370-291925. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Bardoxolone | Bardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is capable of activating the transcription factor peroxisome proliferator activator receptor-γ (PPARγ), its apoptotic effects in malignant cells have been shown to occur independently of PPAR&gamma. Bardoxolone was developed as an potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, serum creatine, which may in turn be beneficial to treat diabetic kidney diseases, cancer and thromboembolic events. Group: Pharmaceutical. CAS No. 218600-44-3. Pack Sizes: 25 mg. Product ID: B0084-427947. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| (±)-Bay K 8644 | (±)-Bay K 8644 is a L-type Ca2+ channel activator. It exhibits positive inotropic, vasoconstrictive and behavioral effects in vivo. Uses: Reprogramming. Group: Pharmaceutical. CAS No. 71145-03-4. Pack Sizes: 25 mg. Product ID: B2693-462890. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BI-3406 | BI-3406 is a potent and selective inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1). SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS, and mutants of RAS are major oncogenes and occur in many human cancers. Inhibition of SOS1 in a mutant KRAS cell line can suppress tumor growth. Group: Pharmaceutical. CAS No. 2230836-55-0. Pack Sizes: 5 mg. Product ID: B2693-363125. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Birinapant | Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. As a SMAC mimetic and IAP antagonist, TL32711 binds to and inhibits the activity of IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. CAS No. 1260251-31-7. Pack Sizes: 100 mg. Product ID: B0084-462223. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BL-918 | BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1). It induces cytoprotective autophagy for Parkinson's disease treatment. It protected against MPTP-induced motor dysfunction and loss of dopaminergic neurons by targeting ULK1-modulated autophagy in mouse models of PD. Group: Pharmaceutical. CAS No. 2101517-69-3. Pack Sizes: 25 mg. Product ID: B2693-291256. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BML-284 | BML-284 is potent, selective and cell-permeable Wnt signaling activator. It induces β-catenin and transcription factor (TCF)-dependent transcriptional activity in 293T cells in a dose dependent manner with an EC50 of 0.7 mM in vitro. Uses: Bml-284 may be a useful tool in the study of physiological processes that involve the wnt pathway. Group: Pharmaceutical. CAS No. 853220-52-7. Pack Sizes: 25 mg. Product ID: B0084-474867. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| BMS-911543 | BMS-911543 is an orally available JAK inhibitor with selectivity for JAK2. It inhibts JAK2, thereby preventing the JAK/STAT (signal transducer and activator of transcription) signaling cascade, including activation of STAT3. This may lead to an induction of tumor cell apoptosis and a decrease in cellular proliferation. Group: Pharmaceutical. CAS No. 1271022-90-2. Pack Sizes: 20 mg. Product ID: B0084-457828. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Carglumic Acid | Carglumic Acid is an activator of carbamoyl phosphate synthetase 1 (CPS1). It inhibits cell proliferation of a variety of cancer cell lines with IC50 values ranging from 5 to 7.5 nM. Group: Pharmaceutical. CAS No. 1188-38-1. Pack Sizes: 1 kg. Product ID: BAT-016472. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CDDO Imidazolide | CDDO Imidozolide is a synthetic triterpenoid as a Nrf2 signaling activator with highly active in suppressing cellular proliferation of human leukemia and breast cancer cell. Uses: Nrf2 signaling activator. Group: Pharmaceutical. CAS No. 443104-02-7. Pack Sizes: 10 mg. Product ID: B2693-474173. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Chrysoeriol | Chrysoeriol is a natural compound isolated from the herbs of Medicago sativa. Chrysoeriol can potently inhibit the induction of nitric oxide synthase by blocking activator protein 1 (AP-1) activation and its anti-inflammatory effects. Chrysoeriol can induce nod genes in rhizobium meliloti. Chrysoeriol can inhibit the downstream signal transduction pathways of platelet-derived growth factor (PDGF)-Rbeta, including ERK1/2, p38, and Akt phosphorylation, which suggests that chrysoeriol may be used for the prevention and treatment of vascular diseases during restenosis after coronary angioplasty. Group: Pharmaceutical. CAS No. 491-71-4. Pack Sizes: 25 mg. Product ID: NP2023. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cilofexor | Cilofexor is a farnesoid X receptor (FXR) agonist. Cilofexor inhibits binding of a synthetic peptide, comprising residues 676-700 of the steroid receptor coactivator 1 (SRC-1), to the farnesoid X receptor (FXR; EC50 = <25 nM in a FRET activity assay). Group: Pharmaceutical. CAS No. 1418274-28-8. Pack Sizes: 25 mg. Product ID: B2693-291596. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| CP21R7 | CP21R7 is a potent and selective GSK3β inhibitor. It acts as an activator of stem cells prior to the induction of differentiation of stem cells to endothelial and smooth muscle cells. Uses: Cp21r7 is a selective gsk-3β inhibitor which could probably influence luciferase activity at some extent. Group: Pharmaceutical. CAS No. 125314-13-8. Pack Sizes: 300 mg. Product ID: B0084-474432. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Cycloastragenol | Cycloastragenol, belongs to the triterpene saponins, is mainly obtained from the hydrolysis of Astragaloside IV. Cycloastradiol is the only telomerase activator found today. It delays the shortening of telomeres by increasing telomerase. Cycloastradiol is believed to have anti-aging effects. Cycloastragenol can be used in cosmetics material. Group: Pharmaceutical. CAS No. 78574-94-4. Pack Sizes: 50 mg. Product ID: NP6270. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Decursin | Decursin is a coumarin from The roots of Peucedanum ostruthium. Coumarins, such as decursinol and decursin, are known to be the major compounds of A. gigas. Angelica gigas roots have been widely used traditionally in Korean herbal medicine not only for the treatment of anaemia, but also as a sedative, an anodyne and a tonic. Studies have shown that decursin inhibits VEGF-mediated inner BRB breakdown through suppression of VEGFR-2 signaling pathway. And decursin is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. Uses: Enzyme activators. Group: Pharmaceutical. CAS No. 5928-25-6. Pack Sizes: 5 mg. Product ID: B2703-479866. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| δ-Tocotrienol | δ-Tocotrienol is from palm oil. Delta-tocotrienol is a potential angiogenic inhibitor that significantly suppresses human colorectal adenocarcinoma cells (DLD-1-CM)-induced tube formation, migration, and adhesion on human umbilical vein endothelial cells. Delta-tocotrienol is a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSCLC) cell proliferation, induce apoptosis and inhibit invasion, and thus offer a potential starting point for the design of novel anticancer agents. Delta-tocotrienol displays significant radioprotective effects that protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling. Group: Pharmaceutical. CAS No. 25612-59-3. Pack Sizes: 50 mg. Product ID: NP4617. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Diazoxide | Diazoxide is a potassium channel activator that causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. The cellular release of potassium switches off voltage-gated calcium ion channels which inhibits the generation of an action potential. Uses: Antihypertensive agents. Group: Pharmaceutical. CAS No. 364-98-7. Pack Sizes: 2 g. Product ID: B0084-474147. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Doxercalciferol | Doxercalciferol (Hectorol; 1.alpha.-Hydroxyvitamin D2) is a synthetic analog of vitamin D; is a Vitamin D2 analog that acts as a vitamin D receptor activator (VDRA). Group: Pharmaceutical. CAS No. 54573-75-0. Pack Sizes: 25 mg. Product ID: B1959-485206. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ETC-1002 | ETC-1002 is a novel, first-in-class, orally available, once-daily LDL-C lowering small molecule and is activator of hepatic AMP-activated protein kinase (AMPK). It also has potent inhibitory activity against hepatic ATP-citrate lyase. Group: Pharmaceutical. CAS No. 738606-46-7. Pack Sizes: 250 mg. Product ID: B0084-463320. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Etelcalcetide hydrochloride | Etelcalcetide is a calcium-sensing receptor agonist as a D-amino peptide calcimimetic for the treatment of secondary hyperparathyroidism. It can bind to and activate the CaSR (calcium-sensing receptor) in the parathyroid gland as an allosteric activator, resulting in PTH reduction and suppression. Amgen Inc. announced its submission of a New Drug Application to the FDA for etelcalcetide in Aug 2015. Group: Pharmaceutical. CAS No. 1334237-71-6. Pack Sizes: 10 mg. Product ID: B0084-475311. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Fmoc-N-amido-PEG12-propionic acid | Fmoc-N-amido-PEG12-propionic acid is a PEG linker containing a protected amino group and a carboxylic acid. The carboxylic acid can be reacted with amino groups in the presence of activators. Group: Pharmaceutical. CAS No. 1952360-91-6. Pack Sizes: 100 mg. Product ID: B2699-278820. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ganoderic acid A | Ganoderic acid A has been reported to exhibit antitumor activity, which is mainly mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. Uses: Anti-tumor effects, hepatoprotection, and 5-alpha reductase inhibition. Group: Pharmaceutical. CAS No. 81907-62-2. Pack Sizes: 20 mg. Product ID: NP7000. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| GDC-0152 | GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0152 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2, which may inhibit their activities and promote the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Smac, the endogenous IAP antagonist, relies on its N-terminal four amino-acid motif for binding to IAPs. Group: Pharmaceutical. CAS No. 873652-48-3. Pack Sizes: 50 mg. Product ID: B2693-462525. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ICA-069673 | ICA-069673 is an orally active, potent and selective KCNQ2/Q3 potassium channel activator (IC50= 0.69 μM) with 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5 (EC50s = 14.3 μM). Group: Pharmaceutical. CAS No. 582323-16-8. Pack Sizes: 100 mg. Product ID: B2693-007304. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| IXA4 | IXA4 is a highly selective and non-toxic IRE1/XBP1s activator, which activates the IRE1/XBP1s signaling, regardless of the global activation of the unfolded protein response (UPR) or other stress-responsive signaling pathways, such as heat shock response or oxidative stress response. IXA4 reduces APP secretion by activating IRE1. IXA4 therapy improves systemic glucose metabolism and hepatic insulin action through IRE1-dependent liver transcriptomic remodeling, thereby reducing glucose production and steatosis. IXA4-stimulated IRE1 activation also enhances pancreatic function. Group: Pharmaceutical. CAS No. 1185329-96-7. Pack Sizes: 100 mg. Product ID: B1370-382267. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| LCL-161 | LCL161 is an orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. SMAC mimetic LCL161 binds to IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9, which play essential roles in apoptosis (programmed cell death), necrosis and inflammation. Group: Pharmaceutical. CAS No. 1005342-46-0. Pack Sizes: 25 mg. Product ID: B0084-462558. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| LTI-291 | LTI-291 is a glucocerebrosidase (Gcase) activator for the treatment of Parkinson's disease (PD). Group: Pharmaceutical. CAS No. 1919820-28-2. Pack Sizes: 10 mg. Product ID: B0084-284752. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Mesupron | Mesupron is the second generation serine protease inhibitor prodrug targeting the human urokinase plasminogen activator (uPA) system with potential antineoplastic and antimetastatic activities. Group: Pharmaceutical. CAS No. 590368-25-5. Pack Sizes: 5 mg. Product ID: B0084-462232. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| MK-8722 | MK-8722 is a potent pan-AMPK activator that improves glucose homeostasis but induces cardiac hypertrophy. AMPK has long been of interest as a target for the treatment of Type 2 Diabetes Mellitus. Group: Pharmaceutical. CAS No. 1394371-71-1. Pack Sizes: 100 mg. Product ID: B2693-373163. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ML 297 | ML 297 is a Kir3.1/3.2 (GIRK1/2) channel activator with IC50 values of 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3. Group: Pharmaceutical. CAS No. 1443246-62-5. Pack Sizes: 100 mg. Product ID: B2693-169428. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ML 67-33 | ML 67-33 is a K2P potassium channel activator that increases channel currents by activating core gating apparatus of channels. Group: Pharmaceutical. CAS No. 1443290-89-8. Pack Sizes: 25 mg. Product ID: B1370-291155. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| ML SA1 | ML SA1 is an activator of TRPML channels. It can induce TRPML-mediated Ca2+ release from lysosomes and reduce cholesterol accumulation in Niemann-Pick type C macrophages. Group: Pharmaceutical. CAS No. 332382-54-4. Pack Sizes: 1 g. Product ID: B2693-169420. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Nicorandil Impurity 4 | An impurity of Nicorandil, which is a potassium channel activator and vasodilatory drug. Group: Pharmaceutical. CAS No. 1798026-96-6. Pack Sizes: 10 mg. Product ID: B2694-478106. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| NV-5138 | NV-5138, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 possesses rapid antidepressant effects. Group: Pharmaceutical. CAS No. 2095886-80-7. Pack Sizes: 25 mg. Product ID: BAT-014016. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Omecamtiv mecarbil | Omecamtiv mecarbil is a cardiac-specific myosin activator with an EC50 of 0.6 μM. Group: Pharmaceutical. CAS No. 873697-71-3. Pack Sizes: 25 mg. Product ID: B0084-307758. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PACAP-38 (31-38) (human, chicken, mouse, ovine, porcine, rat) | An activator of cAMP formation. It stimulates sympathetic neuronal NPY and catecholamine production. Group: Pharmaceutical. CAS No. 138764-85-9. Pack Sizes: 5 mg. Product ID: BAT-006205. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Pam3CSK4 | Pam3CSK4 is a TLR 1/2 agonist and a cell-permeable, water-soluble synthetic tripalmitoylated lipopeptide that mimics the acylated amino terminus of bacterial LPs. Bacterial LPs are a family of pro-inflammatory cell wall components found in both Gram-positive and Gram-negative bacteria. Pam3CSK4 is a potent activator of the pro-inflammatory transcription factor NF-κB. It induces production of TNF-α, superoxide, NO, and IL-6, stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells, promotes differentiation of naive CD4+ T cells into Th17 cells, and enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2. It is used in prevention of inflammation caused by certain bacterial infection. Group: Pharmaceutical. CAS No. 112208-00-1. Pack Sizes: 5 mg. Product ID: BAT-009049. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PAR-2 (1-6) (mouse, rat) | PAR-2 (1-6) (mouse, rat) is a PAR2 activator. It can be used to explore signaling through PAR2 in cells. Group: Pharmaceutical. CAS No. 164081-25-8. Pack Sizes: 10 mg. Product ID: BAT-006097. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Peretinoin | Peretinoin, also known as NIK-333, orally available, acyclic retinoid with potential antineoplastic and chemopreventive activities. Peretinoin binds to and activates nuclear retinoic acid receptors (RAR), which in turn recruit coactivator proteins and promote, with other transcriptional complexes, the transcription of target genes. As a result, this agent may modulate the expression of genes involved in the regulation of cell proliferation, cell differentiation, and apoptosis of both normal and tumor cells. Group: Pharmaceutical. CAS No. 81485-25-8. Pack Sizes: 10 mg. Product ID: B0084-305467. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PF 06409577 | PF 06409577 is a potent and selective allosteric activator of AMPK (EC50 values are 7 and >40000 nM for AMPKα1β1γ1 and AMPKα1β2γ1, respectively) for the potential treatment of diabetic nephropathy. PF-06409577 showed efficacy in a preclinical model of diabetic nephropathy. Group: Pharmaceutical. CAS No. 1467057-23-3. Pack Sizes: 100 mg. Product ID: B2693-170035. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PKG Drug G1 | PKG drug G1 is an activator of protein kinase GIα (PKGIα). It induces vasodilation and blood pressure reduction through the C42 PKG Iα independent mechanism. Group: Pharmaceutical. CAS No. 374703-78-3. Pack Sizes: 100 mg. Product ID: B2693-373024. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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