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| Product | Description | |
|---|---|---|
| ACID STORAGE CABINET | ACID STORAGE CABINET, Suppliers of laboratory chemicals wanted in the United Kingdom |  |
| A-971432 | This active molecular is a selective S1P5 (Sphingosine-1-Phosphate Receptor 5) agonist originated by AbbVie for the treatment of neurodegenerative disorders. A 971432 is highly selective for S1P5 with IC50 value of 6 nM for S1P5, 362 nM for S1P1 and >10 μM for S1P3. A 971432 improves blood-brain barrier integrity in an in vitro model and reverses age-related cognitive decline in mice. S1P5 agonists have been reported as an innovative mechanism for the treatment of neurodegenerative disorders including Alzheimer's disease and lysosomal storage disorders such as Niemann-Pick disease. Uses: Neurodegenerative disorder;lysosomal storage disorders. Group: Pharmaceutical. Alternative Names: A971432; A 971432; 1-(4-((3,4-Dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic Acid. CAS No. 1240308-45-5. Pack Sizes: 1mg;1g;10g. Product ID: 1240308-45-5. Molecular formula: C18H17Cl2NO3. Mole weight: 366.24. Custom synthesis is available. Send your inquiries for more information. |  London |
| Methylcobalamin | Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms. Bacteria-derived hydroxocobalamin (OHCbl) and CNCbl are converted in humans to useful coenzyme forms to support metabolic processes such as mitochondrial methylmalonylcoenzyme A mutase conversion of methylmalonic acid (MMA) to succinate to link lipid and carbohydrate metabolism, and activation of methionine synthase, the rate limiting step in the synthesis of methionine. Group: Pharmaceutical. Alternative Names: Cobinamide, Co-methyl-, dihydrogen phosphate (ester), inner salt, 3'-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3); Cobinamide, Co-methyl deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole; Cobinamide, Co-methyl deriv., hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-α-D. CAS No. 13422-55-4. Pack Sizes: 1mg;1g;10g. Product ID: NP3442. Molecular formula: C63H91CoN13O14P. Mole weight: 1344.38. Custom synthesis is available. Send your inquiries for more information. | London |
| N-Boc-1,2,3,6-tetrahydropyridine-4-boronic Acid Pinacol Ester | Reagent used for : Suzuki-Miyaura cross-coupling using palladium phosphine catalyst ; Palladium-catalyzed ligand-controlled regioselective Suzuki coupling ; Palladium-catalyzed Suzuki-Miyaura coupling ; Suzuki coupling followed by iodolactonization reaction ; Wrenchnolol derivative optimized for gene activation in cells Reagent used in Preparation of several enzymatic inhibitors and receptor ligands; Orally active anaplastic lymphoma kinase inhibitors ; Oxazolecarboxamides as diacylglycerol acyltransferase-1 inhibitors for treatment of obesity and diabetes ; 4-arylpiperidinyl amides and N-arylpiperidin-3-yl-cyclopropanecarboxamides as novel melatonin receptor ligands ; Quinazoline analogs as glucocerebrosidase inhibitors with chaperone activity for treatment of Gaucher disease, a lysosomal storage disorder ; Arylpiperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists. Group: Pharmaceutical. Alternative Names: 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester; tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylate. CAS No. 286961-14-6. Pack Sizes: 100 g. Product ID: BB019917. Molecular formula: C16H28NO4B. Mole weight: 309.21. Custom synthesis is available. Send your inquiries for more information. | London |
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