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| Product | Description | |
|---|---|---|
| 2-((Z)-5-((E)-2-methyl-3-phenylallylidene)-2,4-dioxothiazolidin-3-yl)acetic acid | An impurity of Epalrestat, a carboxylic acid-based inhibitor of aldose reductase. Group: Pharmaceutical. CAS No. 794510-29-5. Pack Sizes: 10 mg. Product ID: B2694-343860. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Atorvastatin N-(3,5-Dihydroxy-7-heptanoic Acid)amide | Atorvastatin N-(3,5-Dihydroxy-7-heptanoic Acid)amide is a prominent compound in the research of dyslipidemia and associated cardiovascular disorders. Its efficacious mechanism of action lies in its tremendous capacity to inhibit HMG-CoA reductase, a pivotal enzyme profoundly engaged in the intricate process of cholesterol biosynthesis. Uses: Atorvastatin (a791750) impurity. Group: Pharmaceutical. CAS No. 1105067-87-5. Pack Sizes: 10 mg. Product ID: B0190-258830. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Ganoderic acid A | Ganoderic acid A has been reported to exhibit antitumor activity, which is mainly mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. Uses: Anti-tumor effects, hepatoprotection, and 5-alpha reductase inhibition. Group: Pharmaceutical. CAS No. 81907-62-2. Pack Sizes: 20 mg. Product ID: NP7000. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Gemcitabine elaidate | Gemcitabine elaidate (also known as CO-101; CP-4126) is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Due to its lipophilicity, gemcitabine 5'-elaidic acid ester exhibits an increased cellular uptake and accumulation, resulting in an increased conversion to active metabolites, compared to gemcitabine. In addition, this formulation of gemcitabine may be less susceptible to deamination and deactivation by deoxycytidine deaminase. Group: Pharmaceutical. CAS No. 210829-30-4. Pack Sizes: 25 mg. Product ID: B2706-225221. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Leucovorin Calcium | leucovorin calcium is an active metabolite of folic acid (also called folinic acid and citrovorum factor), which does not require metabolism by dihydrofolate reductase, the molecular target of folate antagonist-type chemotherapeutic drugs. Leucovorin calcium counteracts the toxic effects of these medications, 'rescuing' the patient while permitting the antitumor activity of the folate antagonist. This agent also potentiates the effects of fluorouracil and its derivatives by stabilizing the binding of the drug's metabolite to its target enzyme, thus prolonging drug activity. Group: Pharmaceutical. CAS No. 1492-18-8. Pack Sizes: 5 g. Product ID: B2693-301409. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Methotrexate disodium | Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia). Group: Pharmaceutical. CAS No. 7413-34-5. Pack Sizes: 1 g. Product ID: B1335-076226. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Des(2-methylbutyryl) Lovastatin Hydroxy Acid Sodium Salt | An impurity of Lovastatin. Lovastatin is an HMG CoA reductase inhibitor used to treat high blood cholesterol. Group: Pharmaceutical. CAS No. 132294-94-1. Pack Sizes: 10 mg. Product ID: B2694-255494. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Simvastatin hydroxy acid sodium salt | A metabolite of Simvastatin. Simvastatin is a lipid-lowering drug that inhibits HMG-CoA reductase. It is in the statin class of medications and works by decreasing the manufacture of cholesterol by the liver. Group: Pharmaceutical. CAS No. 101314-97-0. Pack Sizes: 100 mg. Product ID: B2694-479622. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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