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| Product | Description | |
|---|---|---|
| AC 264613 | AC 264613 is a potent and selective protease-activated receptor 2 (PAR2) agonist (pEC50 = 7.5). AC 264613 inhibits interferon regulatory factor 5 and decreases interleukin-12p40 production via lipopolysaccharide-stimulated macrophages. PI hydrolysis, Ca2+ mobilization and cellular proliferation are activated by AC 264613 in vitro (pEC50 = 6.9, 7.0 and 7.5, respectively). Group: Pharmaceutical. Alternative Names: AC-264613; AC 264613; AC264613; (±)-(3R,4S)-2-Oxo-4-phenyl-3-pyrollidinecarboxylic acid 2-[1-(3-bromophenyl)ethylidene]hydrazide. CAS No. 1051487-82-1. Pack Sizes: 1mg;1g;10g. Product ID: 1051487-82-1. Molecular formula: C19H18BrN3O2. Mole weight: 400.27. Custom synthesis is available. Send your inquiries for more information. |  London |
| AC-55541 | AC-55541 is a novel small-molecule protease-activated receptor 2(PAR2) agonist which displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation. It activated PAR2 signaling in cellular proliferation assays, phosphatidylinositol hydrolysis assays, and Ca(2+) mobilization assays, with potencies ranging from 200 to 1000 nM. It was well absorbed when administered intraperitoneally to rats, reaching micromolar peak plasma concentrations. It was stable to metabolism by liver microsomes and maintained sustained exposure in rats. Uses: Ac-55541 stimulates cell proliferation, phosphatidylinositol hydrolysis, and calcium mobilization. Group: Pharmaceutical. Alternative Names: AC-55541; AC 55541; AC55541. (2E)-2-[1-(3-Bromophenyl)ethylidene]α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineaceticacidhydrazide;AC 55541;alpha-(Benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid (2E)-2-[1-(3-bromophenyl)ethylidene]hydrazide;N-[2-[(2E)-2-[1-(3-bromophenyl)ethylidene]hydrazinyl]-2-oxo-1-(4-oxo-3H-phthalazin-1-yl)ethyl]benzamide. CAS No. 916170-19-9. Pack Sizes: 300 mg. Product ID: B0084-271988. Molecular formula: C25H20BrN5O3. Mole weight: 518.36. Custom synthesis is available. Send your inquiries for more information. | London |
| Bevirimat | Bevirimat, also known as MPC-4326 and PA-457, is an anti-HIV drug derived from a betulinic acid-like compound, first isolated from Syzygium claviflorum, a Chinese herb. It is believed to inhibit HIV by a novel mechanism, so-called maturation inhibition. Like protease inhibitors, bevirimat and other maturation inhibitors interfere with protease processing of newly translated HIV polyprotein precursor, called gag. Bevirimat prevents this viral replication by specifically inhibiting cleavage of the capsid protein (CA) from the SP1 spacer protein. Group: Pharmaceutical. Alternative Names: MPC4326; MPC 4326; MPC-4326; PA457; PA 457; PA-457; FH11327; FH-11327; FH 11327; YK FH312; Bevirimat; YKFH312. CAS No. 174022-42-5. Pack Sizes: 5 mg. Product ID: B0084-244897. Molecular formula: C36H56O6. Mole weight: 584.83. Custom synthesis is available. Send your inquiries for more information. | London |
| Boc-Gly-Gly-Phe-Gly-OH | Boc-Gly-Gly-Phe-Gly-OH is a self-assembly of N- and C-protected tetrapeptide. It is also a protease-cleavable linker for antibody-drug conjugates (ADCs). Group: Pharmaceutical. Alternative Names: N-tert-butoxycarbonyl-glycyl-glycyl-L-phenylalanyl-glycine; N-(tert-butoxycarbonyl)-glycylglycyl-L-phenylalanylglycine; (S)-12-Benzyl-2,2-dimethyl-4,7,10,13-tetraoxo-3-oxa-5,8,11,14-tetraazahexadecan-16-oic acid. CAS No. 187794-49-6. Pack Sizes: 250 mg. Product ID: BAT-009192. Molecular formula: C20H28N4O7. Mole weight: 436.46. Custom synthesis is available. Send your inquiries for more information. | London |
| Bortezomib USP Impurity G | Bortezomib USP Impurity G is an isomer of Bortezomib. It has been demonstrated to inhibit serine proteases shown to lower cellular Aβ concentrations, associated with Alzheimer's or hypertension. Group: Pharmaceutical. Alternative Names: (1S,2S)-Bortezomib; ((S)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid. CAS No. 1132709-14-8. Pack Sizes: 10 mg. Product ID: B0103-467636. Molecular formula: C19H25BN4O4. Mole weight: 384.243. Custom synthesis is available. Send your inquiries for more information. | London |
| E-64 | E-64 is an irreversible and selective cysteine protease inhibitor with IC50 of 9 nM for papain. Uses: For research used only. Group: Pharmaceutical. Alternative Names: L-trans-Epoxysuccinyl-Leu-4-guanidinobutylamide; Proteinase inhibitor E 64; 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-(2S,3S)-oxiranecarboxylic acid; Thiol protease inhibitor; trans-Epoxysuccinyl-L-leucylamido-(4-guanidino)butane; 2-Oxiranecarboxylic acid, 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, (2S,3S)-; L-Trans-Epoxysuccinyl-Leu-agmatine. CAS No. 66701-25-5. Pack Sizes: 50 mg. Product ID: BAT-015060. Molecular formula: C15H27N5O5. Mole weight: 357.41. Custom synthesis is available. Send your inquiries for more information. | London |
| Isopropyl ethanesulfonate | Propan-2-yl Ethane-1-sulfonate can be used as serine protease inhibitors to inhibit an increase in the blood gluocose level. Group: Pharmaceutical. Alternative Names: Ethanesulfonic acid isopropyl ester; Ethanesulfonic acid, isopropyl ester. CAS No. 14245-62-6. Pack Sizes: 1 g. Product ID: B2699-301730. Molecular formula: C5H12O3S. Mole weight: 152.21. Custom synthesis is available. Send your inquiries for more information. | London |
| Mesupron | Mesupron is the second generation serine protease inhibitor prodrug targeting the human urokinase plasminogen activator (uPA) system with potential antineoplastic and antimetastatic activities. Group: Pharmaceutical. Alternative Names: 1-Piperazinecarboxylic acid, 4-[(2S)-3-[3-[(hydroxyamino)iminomethyl]phenyl]-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulfonyl]amino]propyl]-, ethyl ester; Ethyl 4-[(2S)-3-[3-[(hydroxyamino)iminomethyl]phenyl]-1-oxo-2-[[[2,4,6-tris(1-methylethyl)phenyl]sulfonyl]amino]propyl]-1-piperazinecarboxylate; (S)-Ethyl 4-(3-(3-(N-hydroxycarbamimidoyl)phenyl)-2-(2,4,6-triisopropylphenylsulfonamido)propanoyl)piperazine-1-carboxylate; WX 671; WX671; WX-671. CAS No. 590368-25-5. Pack Sizes: 5 mg. Product ID: B0084-462232. Molecular formula: C32H47N5O6S. Mole weight: 629.82. Custom synthesis is available. Send your inquiries for more information. | London |
| Pepstatin A | Pepstatin A is a potent aspartic protease inhibitor, and also inhibits HIV replication.It is a hexa-peptide containing the unusual amino acid statine (Sta, (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid), having the sequence Isovaleryl-Val-Val-Sta-Ala-Sta (Iva-Val-Val-Sta-Ala-Sta). Uses: Protease inhibitors. Group: Pharmaceutical. Alternative Names: Pepstatin; NSC 272671; NSC-272671; NSC272671; Pepstatin A; Pepstatina; Pepstatinum; Pepstatin A. CAS No. 26305-03-3. Pack Sizes: 500 mg. Product ID: BAT-010775. Molecular formula: C34H63N5O9. Mole weight: 685.89. Custom synthesis is available. Send your inquiries for more information. | London |
| Pepstatin acetate | Acetylpepstatin is an aspartyl protease inhibitor that is effective against HIV-1 and HIV-2 protease. Group: Pharmaceutical. Alternative Names: Acetyl-pepstatin;Acetylpepstatin;28575-34-0;Acetyl pepstatin;(3S,4S)-4-[[(2S)-2-[[(3S,4S)-4-[[(2S)-2-[[(2S)-2-acetamido-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxy-6-methylheptanoyl]amino]propanoyl]amino]-3-hydroxy-6-methylheptanoic acid;Pepstatin A (acetate);L-Valinamide, N-(3-methyl-1-oxobutyl)-L-valyl-N-[4-[[2-[[1-(2-carboxy-1-hydroxyethyl)-3-methylbutyl]amino]-1-methyl-2-oxoethyl. CAS No. 28575-34-0. Pack Sizes: 10 mg. Product ID: BAT-010206. Molecular formula: C22H24F2N6O3. Mole weight: 458.5. Custom synthesis is available. Send your inquiries for more information. | London |
| PF 429242 dihydrochloride | PF 429242 is a reversible and competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM), a transcriptional regulators of cholesterol, fatty acid, and glucose metabolism. It reduces hepatic synthesis of cholesterol and fatty acid in mice. Group: Pharmaceutical. Alternative Names: PF-429242 dihydrochloride; PF429242 dihydrochloride. CAS No. 2248666-66-0. Pack Sizes: 100 mg. Product ID: B1370-291470. Molecular formula: C25H35N3O2·2HCl. Mole weight: 482.49. Custom synthesis is available. Send your inquiries for more information. | London |
| Pseudolaric acid B | Pseudolaric acid B (PAB), which comes from the bark of Pseudolarix kaempferi Gordon, has diverse effects that are relevant to cancer therapy, including apoptosis of cancer cells (IC50 = ~1 μM), preventing angiogenesis, and inhibiting tumor growth in vivo. pseudolaric acid B can trigger apoptosis by decreasing Bcl-2 levels and activating caspase-3 protease. The future development of PAB as a cancer therapeutic is ongoing. Besides, PAB significantly suppressed proliferation of DU145 cells in a dose-dependent manner without obvious cytotoxicity. PAB may inhibit growth of HRPC DU145 cells and induce apoptosis through ROS generation and Bcl-2 degradation via the activation of the ubiquitin-proteasome pathway. Uses: Antifungal/antifertility. Group: Pharmaceutical. Alternative Names: PLAB; 1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylicacid,4a-(acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-,7-methyl ester, (3R,4S,4aS,9aR)-; Pseudolarix acid B; Pseudolaric acid. CAS No. 82508-31-4. Pack Sizes: 10 mg. Product ID: NP1536. Molecular formula: C23H28O8. Mole weight: 432.46. Custom synthesis is available. Send your inquiries for more information. | London |
| (S,R)-Bortezomib Hydroxyisopentyl Amide Analog | (S,R)-Bortezomib Hydroxyisopentyl Amide Analog is an isomer of Bortezomib. It has been demonstrated to inhibit serine proteases shown to lower cellular Aβ concentrations, associated with Alzheimer's or hypertension. Group: Pharmaceutical. Alternative Names: N-((S)-1-(((R)-1-Hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide; (R)-Hydroxy Des(boric Acid) Bortezomib; Bortezomib Hydroxy Impurity (1R,2S)-Isomer. CAS No. 289472-78-2. Pack Sizes: 25 mg. Product ID: B1370-150146. Molecular formula: C19H24N4O3. Mole weight: 356.43. Custom synthesis is available. Send your inquiries for more information. | London |
| Thiorphan | Thiorphan is a potent and specific enkephalinase inhibitor with antinociceptive activity. Uses: Protease inhibitors. Group: Pharmaceutical. Alternative Names: N-[2-(Mercaptomethyl)-1-oxo-3-phenylpropyl]glycine; 2-Mercaptomethyl-3-phenylpropionylaminoacetic Acid; D,L-3-Mercapto-2-benzylpropanoylglycine; (+/-)-Thiorphan. CAS No. 76721-89-6. Pack Sizes: 50 mg. Product ID: BAT-008030. Molecular formula: C12H15NO3S. Mole weight: 253.32. Custom synthesis is available. Send your inquiries for more information. | London |
| Tumulosic acid | Tumulosic acid is a triterpenoid found in Daedalea dickinsii and Wolfiporia cocos. It inhibits KLK5 protease activity with IC50 of 14.84 μM. Group: Pharmaceutical. Alternative Names: Tumulosic acid; 508-24-7; (2R)-2-[(3S,5R,10S,13R,14R,16R,17R)-3,16-dihydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methyl-5-methylideneheptanoic acid; Tumulosicacid; CHEMBL461484. CAS No. 508-24-7. Pack Sizes: 10 mg. Product ID: B2703-379034. Molecular formula: C31H50O4. Mole weight: 486.7. Custom synthesis is available. Send your inquiries for more information. | London |
| Ulinastatin | Ulinastatin is an acid-resistant protease inhibitor derived from human urine, acting as a potent anti-inflammatory agent. It was shown to inhibit the activities of a variety of enzymes, including trypsin, chymotrypsin, thrombin, kallikrein, plasmin, elastase, cathepsin, lipase, hyaluronidase, factors IXa, Xa, XIa, and XlIa, and polymorphonuclear leukocyte elastase. Group: Pharmaceutical. Alternative Names: Urinastatin; 2,4-Dioxaspiro[5.5]undec-8-ene, 3-(2-furanyl)-. CAS No. 80449-31-6. Pack Sizes: 1 g. Product ID: B2693-135299. Molecular formula: C13H16O3. Mole weight: 220.26. Custom synthesis is available. Send your inquiries for more information. | London |
| Z-Phe-DL-Ala-FMK | Z-FA-FMK is an irreversible cysteine protease inhibitor, and it also inhibits caspases-2, -3, -6, and -7. Z-FA-FMK suppresses the degradation of fibrillar collagen by fibroblasts and osteoclasts, and reduces LPS-induced cytokine production via inhibition of NF-kappaB-dependent gene expression in macrophages. Uses: Cysteine proteinase inhibitors. Group: Pharmaceutical. Alternative Names: Z-Phe-DL-Ala-fluoromethylketone; Zfa-fmk; benzyloxycarbonyl-Phe-Ala-fluormethylketone; benzyloxycarbonylphenylalanyl-alanine fluoromethyl ketone; Carbamic acid, N-((1S)-2-((3-fluoro-1-methyl-2-oxopropyl)amino)-2-oxo-1-(phenylmethyl)ethyl)-, phenylmethyl ester. CAS No. 197855-65-5. Pack Sizes: 50 mg. Product ID: B0084-209259. Molecular formula: C21H23FN2O4. Mole weight: 386.42. Custom synthesis is available. Send your inquiries for more information. | London |
| Bortezomib | Bortezomib is a potent, reversible and selective 20S proteasome inhibitor with a Ki of 0.6 nM. It is an antineoplastic agent that is used in treatment of refractory multiple myeloma and certain lymphomas. Group: Pharmaceutical. Alternative Names: PS-341; PS 341; PS341; LDP 341; LDP-341; LDP341; MLN341; MLN-341; MLN 341; B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid; Velcade; ((R)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid; N-[(1R)-1-(Dihydroxyboryl)-3-methylbutyl]-Nα-(2-pyrazinylcarbonyl)-L-phenylalaninamide. CAS No. 179324-69-7. Pack Sizes: 1 g. Product ID: BBF-05860. Molecular formula: C19H25BN4O4. Mole weight: 384.24. Custom synthesis is available. Send your inquiries for more information. | London |
| Corosolic acid | Corosolic acid, that is isolated from the barks of Lagerstroemia speciosa, contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts its anticancer activity against colon cancer cells by promoting the N-terminal phosphorylation and subsequent proteasomal degradation of β-catenin. Besides, Corosolic acid induced apoptosis in colorectal cancer (CRC), rendering this compound a potential anticancer agent for the treatment of CRC. Corosolic acid, as a new plant medicine for preventing and treating obesity and type II diabetes, and a functional natural health food and pharmaceutical raw material, has become a popular product in the market. Uses: Anti-angiogenic/anticancer. Group: Pharmaceutical. Alternative Names: 2-A-HYDROXYURSOLIC ACID; 2ALPHA-HYDROXYURSOLIC ACID; 2,3-DIHYDROXYURS-12-EN-28-OIC ACID; HYDROXYURSOLIC ACID; COROSOLIC ACID; Corsolicacid; Corosolic; (2a,3b)-2,3-Dihydroxy-urs-12-en-28-oic acid. CAS No. 4547-24-4. Pack Sizes: 50 mg. Product ID: NP7232. Molecular formula: C30H48O4. Mole weight: 472.7. Custom synthesis is available. Send your inquiries for more information. | London |
| Ixazomib Citrate | The citrate salt form of Ixazomib which is a proteasome inhibitor. It is undergoing a rollover Phase II trial against multiple myeloma, amyloidosis and lymphoma in sorts of countries. IC50 = 3.4 nM. Group: Pharmaceutical. Alternative Names: 4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid; MLN9708; MLN-9708; MLN 9708. CAS No. 1239908-20-3. Pack Sizes: 100 mg. Product ID: BBF-04173. Molecular formula: C20H23BCl2N2O9. Mole weight: 517.12. Custom synthesis is available. Send your inquiries for more information. | London |
| Steviol | Steviol is a diterpenoiic carboxylic alcohol and is isolated from the herbs of Stevia rebaudiana. It is the aglycon derivative of natural sweetener steviol glycosides and is found to be highly mutagenic compared to Stevioside. It inhibits the proliferation of the gastrointestinal cancer cells and the human osteosarcoma U2OS cell line in a dose- and time-dependent manner. It also inhibits human organic anion transporters (hOATs) in uptake assays using murine cells from the S2 segment of proximal tubules. It is selective for hOAT1 and hOAT3 over hOAT2 and hOAT4. It increases CYP3A29 expression and enhances pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity. It can be used to treat polycystic kidney disease. It can promote proteasome and lysosome-mediated AQP2 degradation and slow cyst growth by reducing AQP2 transcription. Group: Pharmaceutical. Alternative Names: (4α)-13-Hydroxy-kaur-16-en-18-oic Acid; 13-Hydroxy-kaur-16-en-18-oic Acid; 13-Hydroxykaurenoic Acid; Ent-13-hydroxy-kauran-16-en-19-oic Acid; 1H-2,10a-Ethanophenanthrene; 13-O-Glucosylsteviol; Hydroxydehydrostevic Acid; (4R,4aS,6aR,9S,11aR,11bS)-9-hydroxy-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carboxylic acid. CAS No. 471-80-7. Pack Sizes: 20 mg. Product ID: NP1541. Molecular formula: C20H30O3. Mole weight: 318.45. Custom synthesis is available. Send your inquiries for more information | London |
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