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| Product | Description | |
|---|---|---|
| ((1R,3R)-3-Amino-cyclopentyl)-carbamic Acid tert-Butyl Ester | ((1R,3R)-3-Amino-cyclopentyl)-carbamic Acid tert-Butyl Ester is used in the preparation of quinoline-3-carboxoamides as H-PGDS inhibitors as well as novel triazolo-pyrrolopyridines as Janus kinase 1 inhibitors. Group: Pharmaceutical. CAS No. 1009075-44-8. Pack Sizes: 1 g. Product ID: BB074488. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| Caftaric acid | Caftaric acid is a natural compound found in the juice of grapes. It is an inhibitor of the protein-protein interactions mediated by the Src-family kinases. Uses: Used in cancer therapy as an anticancer drug. Group: Pharmaceutical. CAS No. 67879-58-7. Pack Sizes: 250 mg. Product ID: B2703-075022. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Chrysophanol | Chrysophanic acid (Chrysophanol) is a natural anthraquinone with anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells. Chrysophanic acid preferentially blocked proliferation in SNU-C5 cells but not in other cell lines (HT7, HT29, KM12C, SW480, HCT116 and SNU-C4) with low levels of EGFR expression. Chrysophanic acid treatment in SNU-C5 cells inhibited EGF-induced phosphorylation of EGFR and suppressed activation of downstream signaling molecules, such as AKT, extracellular signal-regulated kinase (ERK) and the mammalian target of rapamycin (mTOR)/ribosomal protein S6 kinase (p70S6K). Chrysophanic acid (80 and 120 μm) significantly blocked cell proliferation when combined with the mTOR inhibitor, rapamycin. These findings offer the first evidence of anticancer activity for chrysophanic acid via EGFR/mTOR mediated signaling transduction pathway. Chrysophanol is a natural compound found in the roots and rhizomes of Rheum palmatum L. It can be used in cosmetics material. Uses: Anti-inflammatory. Group: Pharmaceutical. CAS No. 481-74-3. Pack Sizes: 1 g. Product ID: NP0901. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| FLAG peptide (TFA salt) | FLAG peptide, an eight amino acids peptide with an enterokinase-cleavage site, is a frequently applied hydrophilic and immunogenic fusion tag which was specifically designed to facilitate rapid purification by immunoaffinity chromatography. Group: Pharmaceutical. Pack Sizes: 25 mg. Product ID: BAT-016099. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Gemcitabine elaidate | Gemcitabine elaidate (also known as CO-101; CP-4126) is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Due to its lipophilicity, gemcitabine 5'-elaidic acid ester exhibits an increased cellular uptake and accumulation, resulting in an increased conversion to active metabolites, compared to gemcitabine. In addition, this formulation of gemcitabine may be less susceptible to deamination and deactivation by deoxycytidine deaminase. Group: Pharmaceutical. CAS No. 210829-30-4. Pack Sizes: 25 mg. Product ID: B2706-225221. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| O-Sulfonato-L-tyrosine sodium salt | O-Sulfonato-L-tyrosine sodium salt, an amino acid derivative utilized in biomedical research, presents itself as a valuable asset. Its application as a protein tyrosine phosphatase and kinase specificity substrate highlights its pertinence in the industry. Excitingly, it has been researched extensively for its anti-inflammatory attributes and could potentially offer new remedies for autoimmune diseases. Group: Pharmaceutical. CAS No. 98930-06-4. Pack Sizes: 100 mg. Product ID: BAT-006967. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| SKF-86002 | SKF-86002 is a p38 MAP kinase inhibitor, the IC50 is 0.1 - 1 μM. It potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes, the IC50 is1 μM. It also acts as an inhibitor of both cyclooxygenase (COX) and 5-lipoxygenase (5-LO). In vitro: SKF-86002 inhibited prostaglandin H2 synthase activity, the IC50 is 120 mM as well as prostanoid production by rat basophilic leukemia cells, the IC50 is mM and its sonicate ( the IC50 is 100 mM and human monocytes (the IC50 is 1 mM. It inhibited the generation of dihydroxyeicosatetraenoic acid and 5-hydroxyeicosatetraenoic acid by a high speed supernatant fraction of RBL-1 cells (the IC50 is 10 mM). It blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis in response to PAF or FMLP. Uses: Skf-86002 could potently inhibit lps-induced il-1 and tnf-α production in human monocytes. it acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase. Group: Pharmaceutical. CAS No. 72873-74-6. Pack Sizes: 300 mg. Product ID: B0084-195907. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Acetyl-L-glutamic acid | A substrate for acetylglutamate kinase. An inhibitor of N-acetyl-L-glutamate synthetase. Group: Pharmaceutical. CAS No. 1188-37-0. Pack Sizes: 1mg; 1g; 10g. Product ID: BAT-003849. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| N-Boc-1,2,3,6-tetrahydropyridine-4-boronic Acid Pinacol Ester | Reagent used for : Suzuki-Miyaura cross-coupling using palladium phosphine catalyst ; Palladium-catalyzed ligand-controlled regioselective Suzuki coupling ; Palladium-catalyzed Suzuki-Miyaura coupling ; Suzuki coupling followed by iodolactonization reaction ; Wrenchnolol derivative optimized for gene activation in cells Reagent used in Preparation of several enzymatic inhibitors and receptor ligands; Orally active anaplastic lymphoma kinase inhibitors ; Oxazolecarboxamides as diacylglycerol acyltransferase-1 inhibitors for treatment of obesity and diabetes ; 4-arylpiperidinyl amides and N-arylpiperidin-3-yl-cyclopropanecarboxamides as novel melatonin receptor ligands ; Quinazoline analogs as glucocerebrosidase inhibitors with chaperone activity for treatment of Gaucher disease, a lysosomal storage disorder ; Arylpiperazine and piperidine ethers as dual acting norepinephrine reuptake inhibitors and 5-HT1A partial agonists. Group: Pharmaceutical. CAS No. 286961-14-6. Pack Sizes: 100 g. Product ID: BB019917. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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