acelarin Suppliers UK

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Acelarin Acelarin is a DNA synthesis inhibitor with EC50 of 0.2 nM. Acelarin is a prodrug based on an aryloxy phosphoramidate derivative of gemcitabine. It is converted into the active metabolites dFdCDP and dFdCTP. dFdCDP can inhibit ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA replication; dFdCTP can be incorporated into DNA, resulting in premature termination of DNA replication and eventually induction of apoptosis. Phase III clinical trials for the treatment of Pancreatic cancer are on-going. Uses: Pancreatic cancer. Group: Pharmaceutical. Alternative Names: NUC-1031; NUC 1031; NUC1031; GTPL7389; GTPL 7389; GTPL-7389; SCHEMBL17171316; Benzyl (2S)-2-[({[(2R,3S,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-4,4-difluoro-3-hydroxyoxolan-2-yl]methoxy}(phenoxy)phosphoryl)amino]propanoate. CAS No. 840506-29-8. Pack Sizes: 50 mg. Product ID: B2693-476645. Molecular formula: C25H27F2N4O8P. Mole weight: 580.48. Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London

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