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| Product | Description | |
|---|---|---|
| A37 | A37 is an aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor (IC50 = 4.6 μM; Ki = 300 nM). It competitively binds to the aldehyde binding pocket of ALDH1A1, resulting in the disruption of spheroid formation and a decrease of cell viability in ovarian cancer cells in vitro. Group: Pharmaceutical. Alternative Names: Ethyl 2-[[3,4-dihydro-4-oxo-3-[3-(1-pyrrolidinyl)propyl][1]benzothieno[3,2-d]pyrimidin-2-yl]thio]acetate; CM037; CM-037; CM 037; A37; A-37; A 37. CAS No. 896795-60-1. Pack Sizes: 1mg;1g;10g. Product ID: 896795-60-1. Molecular formula: C21H25N3O3S2. Mole weight: 431.57. Custom synthesis is available. Send your inquiries for more information. |  London |
| AZD0364 | AZD-0364 is a potent and selective ERK2 inhibitor, which has an IC50 value of 0.6 nM. AZD-0364 is measured in the A375 phospho-p90RSK assays with IC50s of 5.7 nM. AZD-0364 can inhibit the growth of a panel of cancer cell lines. The combination of Selumetinib and AZD-0364 ethanesulfonic acid results in a reduction in tumor growth. Group: Pharmaceutical. Alternative Names: AZD-0364; AZD 0364; tizaterkib. CAS No. 2097416-76-5. Pack Sizes: 25 mg. Product ID: B2693-291616. Molecular formula: C24H24F2N8O2. Mole weight: 494.5. Custom synthesis is available. Send your inquiries for more information. | London |
| JNK-IN-8 | JNK-IN-8 inhibits c-Jun phosphorylation in HeLa and A375 cells with EC50 of 486 nM and 338 nM, respectively. Uses: Protein kinase inhibitors. Group: Pharmaceutical. Alternative Names: JNK-IN-8; JNK-IN 8; JNK-IN8; JNK Inhibitor XVI; c-Jun N-terminal Kinase Inhibitor XVI. CAS No. 1410880-22-6. Pack Sizes: 20 mg. Product ID: B0084-463416. Molecular formula: C29H29N7O2. Mole weight: 507.59. Custom synthesis is available. Send your inquiries for more information. | London |
| LY3009120 | LY03009120 is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1. Group: Pharmaceutical. Alternative Names: LY3009120; LY-3009120; LY 3009120; DP4978; DP 4978; DP-4978. CAS No. 1454682-72-4. Pack Sizes: 100 mg. Product ID: B2693-470864. Molecular formula: C23H29FN6O. Mole weight: 424.51. Custom synthesis is available. Send your inquiries for more information. | London |
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