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| Product | Description | |
|---|---|---|
| A01 | A01 is a high affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM), which attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Study showed that it potentiated BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells. Group: Pharmaceutical. Alternative Names: Smurf1-IN-A01; Smurf1INA01; Smurf1 IN A01; Smurf1 inhibitor A01; Smurf1-inhibitor-A01; A01; A 01; A-01; [4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone; SMURF1 inhibitor A01. CAS No. 1007647-73-5. Pack Sizes: 1mg;1g;10g. Product ID: 1007647-73-5. Molecular formula: C22H20ClF3N4O3S. Mole weight: 512.93. Custom synthesis is available. Send your inquiries for more information. |  London |
| AR-A014418 | AR-A014418 is an ATP-competitive inhibitor of glycogen synthase kinase 3β (GSK-3β), a serine/threonine protein kinase involved in multiple diseases including Alzheimer's disease and type 2 diabetes. Group: Pharmaceutical. Alternative Names: SN 4521; SN4521; SN-4521; AR-A 014418; AR-A014418; AR-A-014418; AR-AO-14418; GSK-3beta Inhibitor VIII; 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea. CAS No. 487021-52-3. Pack Sizes: 25 mg. Product ID: B0084-258809. Molecular formula: C12H12N4O4S. Mole weight: 308.312. Custom synthesis is available. Send your inquiries for more information. | London |
| AR-AO 14418-[d3] | AR-AO 14418-[d3] is a labelled analogue of AR-AO 14418, a Glycogen Synthase Kinase 3β (GSK-3β) inhibitor. Group: Pharmaceutical. Alternative Names: AR-AO 14418-d3; AR-A014418-d3. CAS No. 1216908-63-2. Pack Sizes: 5 mg. Product ID: BLP-014119. Molecular formula: C12H9D3N4O4S. Mole weight: 311.33. Custom synthesis is available. Send your inquiries for more information. | London |
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