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| Product | Description | |
|---|---|---|
| MEK - Methyl Ethyl Ketone | MEK - Methyl Ethyl Ketone - 2 Butanone, Solvents. Mistral Industrial Chemicals our speciality is supplying Technical grade & Industrial grade chemicals in sizes from: 1Kg to 25Kg. We can also supply products in barrels & multiple bags / pallets. | Mistral Lab Supplies Northern Ireland |
| BURNER, MEKER | BURNER, MEKER, UK suppliers of laboratory chemicals wanted |  |
| BUTANONE (MEK) | BUTANONE (MEK), UK suppliers of laboratory chemicals wanted | |
| Methyl Ethyl Ketone (MEK) | Methyl Ethyl Ketone (MEK). At Tan International we supply a wide range of products covering all industry sectors |  Scotland |
| Methyl Ethyl Ketone (MEK) (2-Butanone) SG | 1lt Pack Size. Group: Analytical Reagents, Aroma Chemicals, Biochemicals, Building Blocks, Diagnostic Raw Materials, Solvents. Formula: C4H8O. CAS No. 78-93-3. Prepack ID : 39693881-1lt. Molecular Weight : 72.11. |  |
| Actein | Actein isolated from the roots of Cimicifuga racemosa. It inhibits the proliferation of human breast cancer cells by altering the activity of the ER IP3 receptor and Na,K-ATPase, inducing calcium release and modulating the NF-κB and MEK pathways. And it reduces free fatty acid and cholesterol content in the liver and inhibites the growth of human HepG2 liver cancer cells. Uses: Antihypertensive. Group: Pharmaceutical. CAS No. 18642-44-9. Pack Sizes: 1mg; 1g; 10g. Product ID: NP7187. Molecular formula: Custom synthesis is available. Send your inquiries for more information. |  London |
| BI-847325 | BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Group: Pharmaceutical. CAS No. 1207293-36-4. Pack Sizes: 10 mg. Product ID: B0084-470824. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Binimetinib | Binimetinib is an oral, highly selective MEK inhibitor. Group: Pharmaceutical. CAS No. 606143-89-9. Pack Sizes: 300 mg. Product ID: B0084-455720. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Butanone | Butanone, otherwise known as Methyl Ethyl Ketone, is a solvent that's widely valued for its anti-greasing properties. A colourless liquid with a sweet odour, it has a wide range of applications and is used to manufacture vinyl and resin. It's also commonly used as a cleaning agent. Butanone should only be used by competent persons and must be stored away from animals and children. Its flammability means it should also be kept away from oxidising materials. Uses: Paints, coatings. Group: General Chemicals. Alternative Names: 2-butanone, Methyl Ethyl Ketone, MEK. CAS No. 78-93-3. Pack Sizes: 2.5L, 25L. | Chemicals.co.uk |
| Cobimetinib | Cobimetinib (GDC-0973, RG7420) is a potent, orally available and highly selective MEK1 inhibitor with IC50 of 4.2 nM. It shows more than 100-fold selectively for MEK1 over MEK2 when tested against a panel of more than 100 serine-threonine and tyrosine kinases and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases. Group: Pharmaceutical. CAS No. 934660-93-2. Pack Sizes: 25 mg. Product ID: B0084-460683. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Encorafenib | Encorafenib, also known as LGX-818, is an orally available Raf kinase inhibitor with potential antineoplastic activity. LGX818 specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival. Group: Pharmaceutical. CAS No. 1269440-17-6. Pack Sizes: 150 mg. Product ID: B0084-462563. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Methyl Ethyl Ketone | Methyl Ethyl Ketone MEK. Uses: Epoxy solvent, cleaning. Group: Building. Alternative Names: MEK. Grades: Technical. CAS No. 78-93-3. Pack Sizes: 500ml, 5 litre. |  Plymouth UK |
| Methyl Ethyl Ketone | Methyl ethyl ketone, or MEK, is a colourless, pungent liquid with the chemical formula C4H8O. It has a wide range of applications and is a common ingredient in paint thinners/removers, lacquer and varnish, rubber cement and certain types of glue. It's also used to manufacture gums and resins. As methyl ethyl ketone is highly flammable, it can cause a vigorous reaction if it's exposed to a flame or spark. It can also irritate the skin on contact. Uses: Solvent, paint manufacturing. Group: Solvents. Alternative Names: 2-butanone, Methyl Acetone, MEK. CAS No. 78-93-3. Pack Sizes: 2.5L, 25 Litres. | Chemicals.co.uk |
| Pam3CSK4 | Pam3CSK4 is a TLR 1/2 agonist and a cell-permeable, water-soluble synthetic tripalmitoylated lipopeptide that mimics the acylated amino terminus of bacterial LPs. Bacterial LPs are a family of pro-inflammatory cell wall components found in both Gram-positive and Gram-negative bacteria. Pam3CSK4 is a potent activator of the pro-inflammatory transcription factor NF-κB. It induces production of TNF-α, superoxide, NO, and IL-6, stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells, promotes differentiation of naive CD4+ T cells into Th17 cells, and enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2. It is used in prevention of inflammation caused by certain bacterial infection. Group: Pharmaceutical. CAS No. 112208-00-1. Pack Sizes: 5 mg. Product ID: BAT-009049. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| PD0325901 | PD-0325901 is a potent bioavailable and selective MEK inhibitor, which targets mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with potential antineoplastic activity. MEK inhibitor PD325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation. The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. Uses: Reprogramming, self-renewal. Group: Pharmaceutical. CAS No. 391210-10-9. Pack Sizes: 100 mg. Product ID: B0084-091588. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| RGB-286638 Free base | RGB-286638 is a novel CDK inhibitor. It inhibited several tyrosine and serine/threonine non-CDK enzymes, i.e. GSK-3β, TAK1, AMPK, Jak2, MEK1. It demonstrated equimolar (50nM) activity in freshly isolated tumor cells from MM patients, while manifesting less cytotoxicity in healthy donor PBMCs. It reduced the phosphorylation of Rb at S807/811 in MM.1S and MM.1R cells, but had no effects on p-Rb S780. Group: Pharmaceutical. CAS No. 784210-88-4. Pack Sizes: 100 mg. Product ID: B0084-463330. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Selumetinib | Selumetinib, also known as AZD6244, is an orally bioavailable small molecule with potential antineoplastic activity. Selumetinib inhibits mitogen-activated protein kinase kinases (MEK or MAPK/ERK kinases) 1 and 2, which may prevent the activation of MEK1/2-dependent effector proteins and transcription factors, and so may inhibit cellular proliferation in MEK-overexpressing tumor cells. MEK 1 and 2 are dual-specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various tumor cell types, and are drivers of diverse cellular activities, including cellular proliferation. Check for active clinical trials or closed clinical trials using this agent. Group: Pharmaceutical. CAS No. 606143-52-6. Pack Sizes: 5 g. Product ID: B0084-095434. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Thiazovivin | Thiazovivin is a selective, cell permeable small molecule that directly targets Rho-associated kinase (ROCK). In addition, Thiazovivin protects human embryonic stem cells (hESCs) in the absence of ECM by regulating E-cadherin mediated cell-cell interaction. This observation suggests that Thiazovivin promotes cell survival. In other studies Thiazovivin, in combination with inhibitors of the TGF-β receptor and MEK pathway, has shown to improve reprogramming efficiency by more than 200-fold. Uses: Reprogramming, self-renewal. Group: Pharmaceutical. CAS No. 1226056-71-8. Pack Sizes: 25 mg. Product ID: B0084-286727. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Trametinib | A MEK inhibitor that suppresses MEK1 and MEK2 with IC50 of 0.92 and 1.8 nM and no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. It has been approved by FDA, in combination with Tafilnar, for the treatment of metastatic anaplastic thyroid cancer (ATC) with BRAF V600E mutation. Group: Pharmaceutical. CAS No. 871700-17-3. Pack Sizes: 500 mg. Product ID: B0084-307744. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
| Trametinib impurities | Trametinib impurities, arising during the synthesis of the melanoma therapeutic Trametinib, are vital for validating the compound's purity and therapeutic effectiveness. By ensuring rigorous assessment of these by-products, their influence on MEK1 and MEK2 protein inhibition, essential in halting cancer proliferation, is meticulously maintained, safeguarding treatment integrity. Group: Pharmaceutical. Pack Sizes: 1mg; 1g; 10g. Molecular formula: Custom synthesis is available. Send your inquiries for more information. | London |
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