1009104 85 1 Suppliers UK

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Product
Smad3 Inhibitor, SIS3 Smad3 Inhibitor, SIS 3 is an inhibitor of SMAD3, which is a receptor-regulated intracellular protein that functions downstream of TGF-β as well as activin receptors and mediates their signaling. It plays an important role in cell proliferation, apoptosis, differentiation and formation of extracellular matrix. It is a cell-permeable pyrrolopyridine compound that selectively inhibits TGF-β1-dependent Smad3 phosphorylation and Smad3-mediated cellular signaling. It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts. Group: Pharmaceutical. CAS No. 1009104-85-1. Pack Sizes: 25 mg. Product ID: B0084-310534. Molecular formula: Custom synthesis is available. Send your inquiries for more information. BOC Sciences
London

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