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| Product | Description | |
|---|---|---|
| (S,R,S)-AHPC | (S,R,S)-AHPC (MDK7526) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC (MDK7526) can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells. Group: Pharmaceutical. Alternative Names: MDK7526; VH032-NH2; VHL ligand 1. CAS No. 1448297-52-6. Pack Sizes: 100 mg. Product ID: BAT-008961. Molecular formula: C22H30N4O3S. Mole weight: 430.56. Custom synthesis is available. Send your inquiries for more information. |  London |
| (S,R,S)-AHPC-C10-NH2 dihydrochloride | (S,R,S)-AHPC-C10-NH2 dihydrochloride is a synthetic E3 ligand-linker conjugate containing a von-Hippel-Lindau (VHL) ligand based on (S,R,S)-AHPC and a C10 alkyl linker with terminal amine for covalent binding, which is an intermediate in the synthesis of a PROTAC degradation agent targeting BET. Group: Pharmaceutical. Alternative Names: VH032-C10-NH2 dihydrochloride. CAS No. 2341796-75-4. Pack Sizes: 50 mg. Product ID: B1370-292453. Molecular formula: C33H53Cl2N5O4S. Mole weight: 686.78. Custom synthesis is available. Send your inquiries for more information. | London |
| (S,R,S)-AHPC-Me | E3 ligase Ligand 1A is a VH032 derivate for conjugation reactions of PROTAC, which can hijack VHL as the E3 ubiquitin ligase component. Group: Pharmaceutical. Alternative Names: (S,R,S)-AHPC-Me; VHL ligand 2; E3 ligase Ligand 1A; 1-(2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-[1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide. CAS No. 1948273-02-6. Pack Sizes: 1 g. Product ID: B2693-291831. Molecular formula: C23H32N4O3S. Mole weight: 444.59. Custom synthesis is available. Send your inquiries for more information. | London |
| (S,R,S)-AHPC-PEG1-azide | (S,R,S)-AHPC-PEG1-azide is a crosslinker-E3 ligase ligand conjugate consisting of a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with terminal azide for click chemistry with a target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation. Group: Pharmaceutical. Alternative Names: E3 ligase Ligand-Linker Conjugates 3; (S,R,S)-AHPC-PEG1-N3; (2S,4R)-1-((S)-2-(2-(2-Azidoethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide. CAS No. 2101200-09-1. Pack Sizes: 100 mg. Product ID: B1370-285264. Molecular formula: C26H35N7O5S. Mole weight: 557.67. Custom synthesis is available. Send your inquiries for more information. | London |
| (S,R,S)-AHPC-PEG2-NH2 hydrochloride | (S,R,S)-AHPC-PEG2-NH2 hydrochloride is a crosslinker-E3 ligase ligand conjugate consisting of a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with terminal amine for reactivity with a carboxyl group on the target ligand. It has been used as a degrader building block in PROTAC for targeted protein degradation. Group: Pharmaceutical. Alternative Names: E3 ligase Ligand-Linker Conjugates 6; VHL Ligand-Linker Conjugates 3 hydrochloride. CAS No. 2097973-72-1. Pack Sizes: 100 mg. Product ID: B1370-285252. Molecular formula: C28H42ClN5O6S. Mole weight: 612.18. Custom synthesis is available. Send your inquiries for more information. | London |
| Protein degrader 1 hydrochloride | Protein degrader 1 hydrochloride is a building block used in the synthesis of PROTAC for the recruitment of the von Hippel-Lindau (VHL) protein. Group: Pharmaceutical. Alternative Names: (S,R,S)-AHPC hydrochloride; (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride. CAS No. 1448189-80-7. Pack Sizes: 25 mg. Product ID: B0084-007385. Molecular formula: C22H31ClN4O3S. Mole weight: 467.02. Custom synthesis is available. Send your inquiries for more information. | London |
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